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Cited by 784Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune cells in cancer

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin

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Tamoutounour, Samira, Guilliams, Martin, Montanana Sanchis, Frédéric, Liu, Hong, Terhorst, Dorothea, Malosse, Camille, Pollet, Emeline, Ardouin, Laurence, Luche, Hervé, Sanchez, Cindy, Dalod, Marc, Malissen, Bernard, Henri, Sandrine·2013·Immunity
DOI 10.1016/j.immuni.2013.10.004
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Abstract

In the skin, the lack of markers permitting the unambiguous identification of macrophages and of conventional and monocyte-derived dendritic cells (DCs) complicates understanding of their contribution to skin integrity and to immune responses. By combining CD64 and CCR2 staining, we successfully identified each of these cell types and studied their origin, transcriptomic signatures, and migratory and T cell stimulatory properties. We also analyzed the impact of microbiota on their development and their contribution to skin inflammation during contact hypersensitivity. Dermal macrophages had a unique scavenging role and were unable to migrate and activate T cells. Conventional dermal DCs excelled both at migrating and activating T cells. In the steady-state dermis, monocyte-derived DCs are continuously generated by extravasated Ly-6C(hi) monocytes. Their T cell stimulatory capacity combined with their poor migratory ability made them particularly suited to activate skin-tropic T cells. Therefore, a high degree of functional specialization occurs among the mononuclear phagocytes of the skin.

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Metadata

Authors
Tamoutounour, S., Guilliams, M., Montanana Sanchis, F., Liu, H., Terhorst, D., Malosse, C., Pollet, E., Ardouin, L., Luche, H., Sanchez, C., Dalod, M., Malissen, B., & Henri, S.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
  • Malissen, Bernard
  • Henri, Sandrine
ORCID
Venue
Immunity
Publisher
Elsevier BV
Published
2013-11
Volume
39
Issue
5
Pages
925-938
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2013.10.004
OpenAlex
W2091487793
Semantic Scholar
635234bed33c89ab8095a4fc56cfec78ea9dbe11
Cited by
783
References
25
Citations by year
2026: 22 · 2025: 25 · 2024: 53 · 2023: 63 · 2022: 63 · 2021: 68 · 2020: 72 · 2019: 71 · 2018: 75 · 2017: 93 · 2016: 66 · 2015: 64 · 2014: 46
FWCI
32.42
Type
journal article
Language
en
Open access
Licence
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders
European Commission (223404)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
dermal macrophages, myeloid dendritic cells, monocyte-derived dendritic cells, skin immune cells, monocyte origin, CD64, CCR2, Ly6C, T cell activation, dendritic cell migration, skin microbiome, contact hypersensitivity, skin inflammation, mononuclear phagocytes, gene expression signatures
MeSH terms
Animals, Antigens, Differentiation, Chemotaxis, Leukocyte, Chromatography, Gel, Dendritic Cells, Dermatitis, Contact, Langerhans Cells, Lymphocyte Cooperation, Macrophages, Monocytes, Radiation Chimera, Skin, Specific Pathogen-Free Organisms, Staining and Labeling, Immunophenotyping, Receptors, IgG, Gene Expression Regulation, Developmental, Cell Lineage, Dermis, Principal Component Analysis, CD11b Antigen, Mice, Receptors, CCR2, Transcriptome, Microbiota

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