Cited by 784Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune cells in cancer

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Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin

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Tamoutounour, Samira, Guilliams, Martin, Montanana Sanchis, Frédéric, Liu, Hong, Terhorst, Dorothea, Malosse, Camille, Pollet, Emeline, Ardouin, Laurence, Luche, Hervé, Sanchez, Cindy, Dalod, Marc, Malissen, Bernard, Henri, Sandrine·2013·Immunity

DOI 10.1016/j.immuni.2013.10.004

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Abstract

In the skin, the lack of markers permitting the unambiguous identification of macrophages and of conventional and monocyte-derived dendritic cells (DCs) complicates understanding of their contribution to skin integrity and to immune responses. By combining CD64 and CCR2 staining, we successfully identified each of these cell types and studied their origin, transcriptomic signatures, and migratory and T cell stimulatory properties. We also analyzed the impact of microbiota on their development and their contribution to skin inflammation during contact hypersensitivity. Dermal macrophages had a unique scavenging role and were unable to migrate and activate T cells. Conventional dermal DCs excelled both at migrating and activating T cells. In the steady-state dermis, monocyte-derived DCs are continuously generated by extravasated Ly-6C(hi) monocytes. Their T cell stimulatory capacity combined with their poor migratory ability made them particularly suited to activate skin-tropic T cells. Therefore, a high degree of functional specialization occurs among the mononuclear phagocytes of the skin.

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Authors: Tamoutounour, S., Guilliams, M., Montanana Sanchis, F., Liu, H., Terhorst, D., Malosse, C., Pollet, E., Ardouin, L., Luche, H., Sanchez, C., Dalod, M., Malissen, B., & Henri, S.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Malissen, Bernard
Henri, Sandrine
ORCID: Guilliams, Martin
Liu, Hong
Ardouin, Laurence
Luche, Hervé
Dalod, Marc
Malissen, Bernard
Henri, Sandrine
Venue: Immunity
Publisher: Elsevier BV
Published: 2013-11
Volume: 39
Issue: 5
Pages: 925-938
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2013.10.004
OpenAlex: W2091487793
Semantic Scholar: 635234bed33c89ab8095a4fc56cfec78ea9dbe11
Cited by: 783
References: 25
Citations by year: 2026: 22 · 2025: 25 · 2024: 53 · 2023: 63 · 2022: 63 · 2021: 68 · 2020: 72 · 2019: 71 · 2018: 75 · 2017: 93 · 2016: 66 · 2015: 64 · 2014: 46
FWCI: 32.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 378 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders: European Commission (223404)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: dermal macrophages, myeloid dendritic cells, monocyte-derived dendritic cells, skin immune cells, monocyte origin, CD64, CCR2, Ly6C, T cell activation, dendritic cell migration, skin microbiome, contact hypersensitivity, skin inflammation, mononuclear phagocytes, gene expression signatures
MeSH terms: Animals, Antigens, Differentiation, Chemotaxis, Leukocyte, Chromatography, Gel, Dendritic Cells, Dermatitis, Contact, Langerhans Cells, Lymphocyte Cooperation, Macrophages, Monocytes, Radiation Chimera, Skin, Specific Pathogen-Free Organisms, Staining and Labeling, Immunophenotyping, Receptors, IgG, Gene Expression Regulation, Developmental, Cell Lineage, Dermis, Principal Component Analysis, CD11b Antigen, Mice, Receptors, CCR2, Transcriptome, Microbiota

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Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin

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