The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cervicovaginal Bacteria Are a Major Modulator of Host Inflammatory Responses in the Female Genital Tract
Open accessAbstract
Colonization by Lactobacillus in the female genital tract is thought to be critical for maintaining genital health. However, little is known about how genital microbiota influence host immune function and modulate disease susceptibility. We studied a cohort of asymptomatic young South African women and found that the majority of participants had genital communities with low Lactobacillus abundance and high ecological diversity. High diversity communities strongly correlated with genital pro-inflammatory cytokine concentrations in both cross-sectional and longitudinal analyses. Transcriptional profiling suggested that genital antigen presenting cells sense gram-negative bacterial products in situ via Toll-like receptor 4 signaling, contributing to genital inflammation through activation of the NF-κB signaling pathway and recruitment of lymphocytes by chemokine production. Our study proposes a mechanism by which cervicovaginal microbiota impact genital inflammation and thereby may affect a woman's reproductive health, including her risk of acquiring HIV.
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Cites
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Background
Cited by
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Self-citationThe immune response to Prevotella bacteria in chronic inflammatory disease
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Self-citationVaginal bacteria modify HIV tenofovir microbicide efficacy in African women
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Randomized Trial of Lactin-V to Prevent Recurrence of Bacterial Vaginosis
Cohen, C. R., Wierzbicki, M. R., French, A. L., Morris, S., Newmann, S., Reno, H., Green, L., Miller, S., Powell, J., Parks, T., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1915254 · Cited by 377
Metadata
- Authors
- Anahtar, M. N., Byrne, E. H., Doherty, K. E., Bowman, B. A., Yamamoto, H. S., Soumillon, M., Padavattan, N., Ismail, N., Moodley, A., Sabatini, M. E., Ghebremichael, M. S., Nusbaum, C., Huttenhower, C., Virgin, H. W., Ndung’u, T., Dong, K. L., Walker, B. D., Fichorova, R. N., & Kwon, D. S.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 42
- Issue
- 5
- Pages
- 965-976
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1919603305
- Cited by
- 795
- References
- 10
- FWCI
- 33.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Anahtar, M. N., Byrne, E. H., Doherty, K. E., Bowman, B. A., Yamamoto, H. S., Soumillon, M., Padavattan, N., Ismail, N., Moodley, A., Sabatini, M. E., Ghebremichael, M. S., Nusbaum, C., Huttenhower, C., Virgin, H. W., Ndung’u, T., Dong, K. L., Walker, B. D., Fichorova, R. N., & Kwon, D. S. (2015). Cervicovaginal Bacteria Are a Major Modulator of Host Inflammatory Responses in the Female Genital Tract. Immunity. https://doi.org/10.1016/j.immuni.2015.04.019
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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