The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation
Open accessAbstract
SUMMARY Follicular helper T (Tfh) cells are crucial for germinal center (GC)formation andhumoraladaptiveimmunity. Mechanisms underlying Tfh cell differentiation in peripheral and mucosal lymphoid organs are incompletely understood. We report here that mTOR kinase complexes 1 and 2 (mTORC1 and mTORC2) are essential for Tfh cell differentiation and GC reaction under steady state and after antigen immunization and viral infection. Loss of mTORC1 and mTORC2 in T cells exerted distinct effects on Tfh cell signature gene expression, whereas increased mTOR activity promoted Tfh responses. Deficiency of mTORC2 impaired CD4+ T cell accumulation and immunoglobulin A production and aberrantly induced the transcription factor Foxo1. Mechanistically, the costimulatory molecule ICOS activated mTORC1 and mTORC2 to drive glycolysis and lipogenesis, and glucose transporter 1-mediated glucose metabolism promoted Tfh cell responses. Altogether, mTOR acts as a central node in Tfh cells by linking immune signals to anabolic metabolism and transcriptional activity.
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Cites
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 1×
“The proto-oncogene Myc mediates metabolic reprogramming of T cells responding to antigen stimulation (Wang et al., 2011).”
Self-citationShi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803
Self-citationMetabolic Regulation of T Lymphocytes
MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244
Self-citationFollicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
Chung, Y., Tanaka, S., Chu, F., Nurieva, R. I., Martinez, G. J., Rawal, S., Wang, Y.-H., Lim, H., Reynolds, J. M., Zhou, X.-H., et al. (2011) · Nature Medicine · doi:10.1038/nm.2426 · Cited by 1,120
Regulation and function of mTOR signalling in T cell fate decisions
Chi, H. (2012) · Nature Reviews Immunology · doi:10.1038/nri3198 · Cited by 1,035
Self-citationFinlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K., & Cantrell, D. A. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112607 · Cited by 596
Awe, O., Hufford, M. M., Wu, H., Pham, D., Chang, H.-C., Jabeen, R., Dent, A. L., & Kaplan, M. H. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500780 · Cited by 27
Cited by
Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
Li, X., Wenes, M., Romero, P., Huang, S. C.-C., Fendt, S.-M., & Ho, P.-C. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0203-7 · Cited by 733
Saravia, J., Chapman, N. M., & Chi, H. (2019) · Cellular & Molecular Immunology · doi:10.1038/s41423-019-0220-6 · Cited by 489
Self-citationGerminal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
Ersching, J., Efeyan, A., Mesin, L., Jacobsen, J. T., Pasqual, G., Grabiner, B. C., Dominguez-Sola, D., Sabatini, D. M., & Victora, G. D. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.005 · Cited by 308
Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity
Phan, A. T., Goldrath, A. W., & Glass, C. K. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.016 · Cited by 293
Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation
Howden, A. J. M., Hukelmann, J. L., Brenes, A., Spinelli, L., Sinclair, L. V., Lamond, A. I., & Cantrell, D. A. (2019) · Nature Immunology · doi:10.1038/s41590-019-0495-x · Cited by 231
Metadata
- Authors
- Zeng, H., Cohen, S., Guy, C., Shrestha, S., Neale, G., Brown, S. A., Cloer, C., Kishton, R. J., Gao, X., Youngblood, B., Do, M., Li, M. O., Locasale, J. W., Rathmell, J. C., & Chi, H.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 45
- Issue
- 3
- Pages
- 540-554
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2519255293
- Cited by
- 345
- References
- 7
- FWCI
- 18.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. https://app.cochat.ai/papers/10.1016/j.immuni.2016.08.017
- The paper
- Zeng, H., Cohen, S., Guy, C., Shrestha, S., Neale, G., Brown, S. A., Cloer, C., Kishton, R. J., Gao, X., Youngblood, B., Do, M., Li, M. O., Locasale, J. W., Rathmell, J. C., & Chi, H. (2016). mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. Immunity. https://doi.org/10.1016/j.immuni.2016.08.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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