The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity
Open accessAbstract
Recognition of pathogens by innate and adaptive immune cells instructs rapid alterations of cellular processes to promote effective resolution of infection. To accommodate increased bioenergetic and biosynthetic demands, metabolic pathways are harnessed to maximize proliferation and effector molecule production. In parallel, activation initiates context-specific gene-expression programs that drive effector functions and cell fates that correlate with changes in epigenetic landscapes. Many chromatin- and DNA-modifying enzymes make use of substrates and cofactors that are intermediates of metabolic pathways, providing potential cross talk between metabolism and epigenetic regulation of gene expression. In this review, we discuss recent studies of T cells and macrophages supporting a role for metabolic activity in integrating environmental signals with activation-induced gene-expression programs through modulation of the epigenome and speculate as to how this may influence context-specific macrophage and T cell responses to infection.
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1 retracted
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InfluentialMolecular and cellular insights into T cell exhaustion
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Grebe, A., Hoss, F., & Latz, E. (2018) · Circulation Research · doi:10.1161/circresaha.118.311362 · Cited by 926
Immunosenescence: molecular mechanisms and diseases
Liu, Z., Liang, Q., Ren, Y., Guo, C., Ge, X., Wang, L., Cheng, Q., Luo, P., Zhang, Y., & Han, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01451-2 · Cited by 960
Monocyte-macrophages and T cells in atherosclerosis
Tabas, I., & Lichtman, A. H. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.008 · Cited by 646
Glycolysis – a key player in the inflammatory response
Soto‐Heredero, G., Gómez de las Heras, M. M., Gabandé‐Rodríguez, E., Oller, J., & Mittelbrunn, M. (2020) · The FEBS Journal · doi:10.1111/febs.15327 · Cited by 641
The impact of cellular metabolism on chromatin dynamics and epigenetics
Reid, M. A., Dai, Z., & Locasale, J. W. (2017) · Nature Cell Biology · doi:10.1038/ncb3629 · Cited by 515
Metadata
- Authors
- Phan, A. T., Goldrath, A. W., & Glass, C. K.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 46
- Issue
- 5
- Pages
- 714-729
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2616687840
- Cited by
- 293
- References
- 151
- FWCI
- 13.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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