The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Dynamic Changes in Chromatin Accessibility Occur in CD8 + T Cells Responding to Viral Infection
Open accessAbstract
Summary In response to acute infection, naive CD8+ T cells expand, differentiate into effector cells and then contract to a long-lived pool of memory cells after pathogen clearance. During chronic infections or in tumors, CD8+ T cells acquire an “exhausted” phenotype. Here we present genome-wide comparisons of chromatin accessibility and gene expression from endogenous CD8+ T cells responding to acute and chronic viral infection using ATAC-seq and RNA-seq. Acquisition of effector, memory or exhausted phenotypes was associated with stable changes in chromatin accessibility away from the naive T cell state. Regions differentially-accessible between functional subsets in vivo were enriched for binding sites of transcription factors known to regulate these subsets, including E2A, BATF, IRF4, T-bet and TCF1. Exhaustion-specific accessible regions were enriched for consensus binding sites for NFAT and Nr4a family members, indicating that chronic stimulation confers a unique accessibility profile on exhausted cells.
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BackgroundThe accessible chromatin landscape of the human genome
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Metadata
- Authors
- Scott-Browne, J. P., López-Moyado, I. F., Trifari, S., Wong, V., Chavez, L., Rao, A., & Pereira, R. M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 45
- Issue
- 6
- Pages
- 1327-1340
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2560265676
- Cited by
- 313
- References
- 13
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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