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Cited by 344

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model

Open access
Li, Chunfeng, Deng, Yong-Qiang, Wang, Shuo, Ma, Feng, Aliyari, Roghiyh, Huang, Xing-Yao, Zhang, Na-Na, Watanabe, Momoko, Dong, Hao-Long, Liu, Ping, Li, Xiao-Feng, Ye, Qing, Tian, Min, Hong, Shuai, Fan, Junwan, Zhao, Hui, Li, Lili, Vishlaghi, Neda, Buth, Jessie E., Au, Connie, Liu, Ying, Lu, Ning, Du, Peishuang, Qin, F. Xiao-Feng, Zhang, Bo, Gong, Danyang, Dai, Xinghong, Sun, Ren, Novitch, Bennett G., Xu, Zhiheng, Qin, Cheng-Feng, Cheng, Genhong·2017·Immunity
DOI 10.1016/j.immuni.2017.02.012
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Abstract

SUMMARY Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV infection have not been fully elucidated, and effective therapeutics are not currently available. Herein, we demonstrated that cholesterol‐25‐hydroxylase (CH25H) was induced in response to ZIKV infection and that its enzymatic product, 25‐hydroxycholesterol (25HC), was a critical mediator of host protection against ZIKV. Synthetic 25HC addition inhibited ZIKV infection in vitro by blocking viral entry, and treatment with 25HC reduced viremia and conferred protection against ZIKV in mice and rhesus macaques. 25HC suppressed ZIKV infection and reduced tissue damage in human cortical organoids and the embryonic brain of the ZIKV‐induced mouse microcephaly model. Our findings highlight the protective role of CH25H during ZIKV infection and the potential use of 25HC as a natural antiviral agent to combat ZIKV infection and prevent ZIKV‐associated outcomes, such as microcephaly. HIGHLIGHTSCH25H and its enzymatic product, 25HC, inhibit ZIKV entry in vitro25HC attenuates ZIKV‐associated viremia and disease in mice and non‐human primates25HC prevents ZIKV infection in human cortical organoids25HC protects fetal mice from microcephaly caused by ZIKV infection &NA; Zika virus (ZIKV) presents a major challenge to the global health system. Li et al. find that 25‐hydroxycholesterol (25HC) inhibits ZIKV infection in monkeys and human cortical organoids and protects mice from microcephaly. 25HC has potential as a first‐line antiviral agent to combat a broad array of pathogenic species, including ZIKV.

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Metadata

Authors
Li, C., Deng, Y.-Q., Wang, S., Ma, F., Aliyari, R., Huang, X.-Y., Zhang, N.-N., Watanabe, M., Dong, H.-L., Liu, P., Li, X.-F., Ye, Q., Tian, M., Hong, S., Fan, J., Zhao, H., Li, L., Vishlaghi, N., Buth, J. E., Au, C., Liu, Y., Lu, N., Du, P., Qin, F. X.-F., Zhang, B., Gong, D., Dai, X., Sun, R., Novitch, B. G., Xu, Z., Qin, C.-F., & Cheng, G.
Venue
Immunity
Publisher
Elsevier BV
Published
2017-03
Volume
46
Issue
3
Pages
446-456
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2017.02.012
OpenAlex
W2598033793
Cited by
344
References
48
FWCI
36.29
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. https://app.cochat.ai/papers/10.1016/j.immuni.2017.02.012
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Li, C., Deng, Y.-Q., Wang, S., Ma, F., Aliyari, R., Huang, X.-Y., Zhang, N.-N., Watanabe, M., Dong, H.-L., Liu, P., Li, X.-F., Ye, Q., Tian, M., Hong, S., Fan, J., Zhao, H., Li, L., Vishlaghi, N., Buth, J. E., . . . Cheng, G. (2017). 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. Immunity. https://doi.org/10.1016/j.immuni.2017.02.012

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.