The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism
Abstract
Host RNA helps promote viral replication: Viruses exploit host metabolic networks for survival. Wang et al. identified a long noncoding RNA (lncRNA) that enhances replication of multiple viruses in both mouse and human cells (see the Perspective by Kotzin et al ). The expression of this cytoplasmic lncRNA was induced by viruses and independent of type I interferon. The lncRNA directly bound to and stimulated the metabolic enzyme glutamic-oxaloacetic transaminase. This viral strategy may have relevance for clinical diseases involving metabolic dysfunction and viral infection. Science , this issue p. 1051 ; see also p. 993
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Genome-scale CRISPR-Cas9 knockout screening in human cells
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30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology
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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
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Cited by
Epigenetic regulation of the innate immune response to infection
Zhang, Q., & Cao, X. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0151-6 · Cited by 366
Self-citationLiu, J., Zhang, X., Chen, K., Cheng, Y., Liu, S., Xia, M., Chen, Y., Zhu, H., Li, Z., & Cao, X. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.021 · Cited by 351
Self-citationLong Noncoding RNAs: Molecular Modalities to Organismal Functions
Rinn, J. L., & Chang, H. Y. (2020) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-012708 · Cited by 282
Borst, P. (2020) · IUBMB Life · doi:10.1002/iub.2367 · Cited by 252
Metadata
- Authors
- Wang, P., Xu, J., Wang, Y., & Cao, X.
- Venue
- Science
- Published
- 2017-11-24
- Volume
- 358
- Issue
- 6366
- Pages
- 1051-1055
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2766398869
- Cited by
- 313
- References
- 39
- FWCI
- 13.08
- Type
- journal article
- Language
- en
- Open access
- closed
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