The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut
Open accessAbstract
SUMMARY Interactions between the nervous and immune systems enable the gut to respond to the variety of dietary products that it absorbs, the broad spectrum of pathogens that it encounters, and the diverse microbiome that it harbors. The enteric nervous system (ENS) senses and reacts to the dynamic ecosystem of the gastrointestinal (GI) tract by translating chemical cues from the environment into neuronal impulses that propagate throughout the gut, and into other organs in the body including the central nervous system (CNS). This review will describe the current understanding of the anatomy and physiology of the GI tract, focusing on the ENS and the mucosal immune system. We highlight emerging literature that the ENS is essential for important aspects of microbe-induced immune responses in the gut. While most basic and applied research in neuroscience has focused on the brain, the proximity of the ENS to the immune system and its interface with the external environment suggest that novel paradigms for nervous system function await discovery.
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Cites
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The gut microbiota–brain axis in behaviour and brain disorders
Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149
Self-citationGut microbiome and aging: physiological and mechanistic insights
Nagpal, R., Mainali, R., Ahmadi, S., Wang, S., Singh, R., Kavanagh, K., Kitzman, D. W., Kushugulova, A., Marotta, F., & Yadav, H. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-170030 · Cited by 670
Anxiety, depression, and the microbiome: A role for gut peptides
Lach, G., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0585-0 · Cited by 573
Microbiome–microglia connections via the gut–brain axis
Abdel-Haq, R., Schlachetzki, J. C. M., Glass, C. K., & Mazmanian, S. K. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180794 · Cited by 471
“Communication between gut microbes and the CNS is mediated by a combination of immune, enteric, and neural pathways that provide physical and chemical connections between the CNS and the periphery, and several experimental paradigms have been used to demonstrate that gut microbes influence many facets of CNS physiolog…”
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Metadata
- Authors
- Yoo, B. B., & Mazmanian, S. K.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 46
- Issue
- 6
- Pages
- 910-926
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2654510028
- Cited by
- 474
- References
- 44
- FWCI
- 33.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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