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The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut
Open accessAbstract
SUMMARY Interactions between the nervous and immune systems enable the gut to respond to the variety of dietary products that it absorbs, the broad spectrum of pathogens that it encounters, and the diverse microbiome that it harbors. The enteric nervous system (ENS) senses and reacts to the dynamic ecosystem of the gastrointestinal (GI) tract by translating chemical cues from the environment into neuronal impulses that propagate throughout the gut, and into other organs in the body including the central nervous system (CNS). This review will describe the current understanding of the anatomy and physiology of the GI tract, focusing on the ENS and the mucosal immune system. We highlight emerging literature that the ENS is essential for important aspects of microbe-induced immune responses in the gut. While most basic and applied research in neuroscience has focused on the brain, the proximity of the ENS to the immune system and its interface with the external environment suggest that novel paradigms for nervous system function await discovery.
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“Communication between gut microbes and the CNS is mediated by a combination of immune, enteric, and neural pathways that provide physical and chemical connections between the CNS and the periphery, and several experimental paradigms have been used to demonstrate that gut microbes influence many facets of CNS physiolog…”
BackgroundSelf-citation
Metadata
- Authors
- Yoo, B. B., & Mazmanian, S. K.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 46
- Issue
- 6
- Pages
- 910-926
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2654510028
- Cited by
- 474
- References
- 44
- FWCI
- 33.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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