Gut microbiome and aging: physiological and mechanistic insights
Open accessAbstract
) and is exposed to innumerable microorganisms from the mother as well as the surrounding environment. Concurrently, the host responses to these microbes during early life manifest during the development of an otherwise hitherto immature immune system. The human gut microbiome, which comprises an extremely diverse and complex community of microorganisms inhabiting the intestinal tract, keeps on fluctuating during different stages of life. While these deviations are largely natural, inevitable and benign, recent studies show that unsolicited perturbations in gut microbiota configuration could have strong impact on several features of host health and disease. Our microbiota undergoes the most prominent deviations during infancy and old age and, interestingly, our immune health is also in its weakest and most unstable state during these two critical stages of life, indicating that our microbiota and health develop and age hand-in-hand. However, the mechanisms underlying these interactions are only now beginning to be revealed. The present review summarizes the evidences related to the age-associated changes in intestinal microbiota and vice-versa, mechanisms involved in this bi-directional relationship, and the prospective for development of microbiota-based interventions such as probiotics for healthy aging.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A core, albeit individualized, microbial profile develops in adulthood that is relatively stable and resilient in the absence of extreme external stressors.
“Although continued development of the microbiota in adolescence has been indicated in some studies, a core, albeit individualized, microbial profile develops in adulthood that is relatively stable and resilient in the absence of extreme external stressors (e.g., dietary changes or antibiotic treatment) (233-235).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [235]
In general, microbial diversity decreases and numbers of beneficial bacteria reduce, whereas facultative anaerobes and opportunists or even proinflammatory pathogenic bacteria increase when compared with younger individuals.
“In general, microbial diversity decreases and numbers of beneficial bacteria (bifidobacteria, lactobacilli, Clostridium cluster XIVa, F. prausnitzii) reduce, whereas facultative anaerobes and opportunists or even proinflammatory pathogenic bacteria (Escherichia spp., Enterobacteriaceae spp., Bacteroides spp., C. difficile, etc.) increase when compared with younger individuals (235, 295, 296).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [235]
The gut microbiome can modulate many host physiological processes including metabolism, cognitive function, innate immunity, and cellular senescence, thereby potentially contributing to frailty, dysfunction, and disease.
“The gut microbiome can modulate many of the host physiological processes including metabolism, cognitive function, innate immunity as well as cellular senescence, thereby potentially contributing to frailty, dysfunction, and disease (44,47).”
From Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice (2021) · cites this paper as [44]
Gut microbiota imbalance (dysbiosis) is associated with the development of age-associated disorders and reduced survival.
“Emerging evidence suggests that the gut microbiota imbalance (dysbiosis) is associated with the development of age-associated disorders and reduced survival (44).”
From Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice (2021) · cites this paper as [44]
The microbiota change drastically over the course of the host's lifetime, and aging is correlated with a reduction in microbial diversity and alterations in microbiota composition.
“The microbiota change drastically over the course of host’s lifetime, and aging is correlated with a reduction in microbial diversity and alterations in microbiota composition (24,44).”
From Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice (2021) · cites this paper as [44]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · see citing works
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · see citing works
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385 · see citing works
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774 · see citing works
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760 · see citing works
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works
Dissemination and growth of cancer cells in metastatic sites
Chambers, A. F., Groom, A. C., & MacDonald, I. C. (2002) · Nature reviews. Cancer · doi:10.1038/nrc865 · Cited by 3,920 · see citing works
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315 · see citing works
Gut microbiota composition correlates with diet and health in the elderly
Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · see citing works
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910 · see citing works
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877 · see citing works
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739 · see citing works
Review article: the role of butyrate on colonic function
HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03562.x · Cited by 2,721 · see citing works
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677 · see citing works
Human nutrition, the gut microbiome and the immune system
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588 · see citing works
The Placenta Harbors a Unique Microbiome
Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494 · see citing works
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232 · see citing works
Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health
Ríos-Covián, D., Ruas‐Madiedo, P., Margollés, A., Gueimonde, M., Reyes‐Gavilán, C. G. D. L., & Salazar, N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00185 · Cited by 2,215 · see citing works
Butyrate improves insulin sensitivity and increases energy expenditure in mice
Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes · doi:10.2337/db08-1637 · Cited by 2,204 · see citing works
Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits
De Vadder, F., Kovatcheva-Datchary, P., Goncalves, D., Vinera, J., Zitoun, C., Duchampt, A., Bäckhed, F., & Mithieux, G. (2014) · Cell · doi:10.1016/j.cell.2013.12.016 · Cited by 2,200 · see citing works
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K., & Bultman, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.018 · Cited by 2,003 · cited 2× · see citing works
“[148] Donohoe DR, Garge N, Zhang X, Sun W, O’Connell TM, Bunger MK, Bultman SJ.”
BackgroundIvanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770 · see citing works
Composition, variability, and temporal stability of the intestinal microbiota of the elderly
Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754 · see citing works
The enteric nervous system and neurogastroenterology
Furness, J. B. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.32 · Cited by 1,619 · see citing works
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · cited 2× · see citing works
“thereby instigating an abnormal (hyper) inflammatory responses eventually affecting (disturbing) the gut-brain communication [84, 90, 93, 103, 104, 109, 112, 124, 158].”
BackgroundInteractions between commensal intestinal bacteria and the immune system
Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,607 · see citing works
Odamaki, T., Kato, K., Sugahara, H., Hashikura, N., Takahashi, S., Xiao, J.-Z., Abe, F., & Osawa, R. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0708-5 · Cited by 1,521 · see citing works
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkïla, J., Monti, D., Satokari, R., Franceschi, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010667 · Cited by 1,483 · see citing works
Antibiotics, birth mode, and diet shape microbiome maturation during early life
Bokulich, N. A., Chung, J., Battaglia, T., Henderson, N., Jay, M., Li, H., D. Lieber, A., Wu, F., Perez-Perez, G. I., Chen, Y., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7121 · Cited by 1,469 · see citing works
Metformin improves healthspan and lifespan in mice
Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works
Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., Loukov, D., Schenck, L. P., Jury, J., Foley, K. P., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.002 · Cited by 1,322 · see citing works
Kelly, C. P., Pothoulakis, C., & LaMont, J. T. (1994) · New England Journal of Medicine · doi:10.1056/nejm199401273300406 · Cited by 1,320 · see citing works
Low counts of Faecalibacterium prausnitzii in colitis microbiota
Sokol, H., Seksik, P., Furet, J. P., Firmesse, O., Nion-Larmurier, I., Beaugerie, L., Cosnes, J., Corthier, G., Marteau, P., & Doré, J. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20903 · Cited by 1,275 · see citing works
Diet, gut microbiota and immune responses
Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology · doi:10.1038/ni0111-5 · Cited by 1,261 · see citing works
O’Toole, P. W., & Jeffery, I. B. (2015) · Science · doi:10.1126/science.aac8469 · Cited by 1,202 · see citing works
Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
Bouskra, D., Brézillon, C., Bérard, M., Werts, C., Varona, R., Boneca, I. G., & Eberl, G. (2008) · Nature · doi:10.1038/nature07450 · Cited by 1,107 · see citing works
Collado, M. C., Rautava, S., Aakko, J., Isolauri, E., & Salminen, S. (2016) · Scientific Reports · doi:10.1038/srep23129 · Cited by 1,098 · see citing works
Mueller, S., Saunier, K., Hanisch, C., Norin, E., Alm, L., Midtvedt, T., Cresci, A., Silvi, S., Orpianesi, C., Verdenelli, M. C., et al. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.2.1027-1033.2006 · Cited by 1,006 · see citing works
Commensal bacteria calibrate the activation threshold of innate antiviral immunity
Abt, M. C., Osborne, L. C., Monticelli, L. A., Doering, T. A., Alenghat, T., Sonnenberg, G. F., Paley, M. A., Antenus, M., Williams, K. L., Erikson, J., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.04.011 · Cited by 993 · see citing works
Interactions Between the Intestinal Microbiome and Liver Diseases
Schnabl, B., & Brenner, D. A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.020 · Cited by 971 · see citing works
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism
Cabreiro, F., Au, C., Leung, K.-Y., Vergara-Irigaray, N., Cochemé, H. M., Noori, T., Weinkove, D., Schuster, E., Greene, N. D. E., & Gems, D. (2013) · Cell · doi:10.1016/j.cell.2013.02.035 · Cited by 967 · see citing works
Intestinal barrier function in health and gastrointestinal disease
Camilleri, M., Madsen, K., Spiller, R., Van Meerveld, B. G., & Verne, G. N. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01921.x · Cited by 908 · see citing works
Christensen, H. R., Frøkiær, H., & Pestka, J. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.171 · Cited by 905 · see citing works
Grölund, M., Lehtonen, O. ‐., Eerola, E., & Kero, P. O. (1999) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199901000-00007 · Cited by 873 · see citing works
Molecular Monitoring of Succession of Bacterial Communities in Human Neonates
Favier, C. F., Vaughan, E. E., de Vos, W. M., & Akkermans, A. D. L. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.1.219-226.2002 · Cited by 859 · see citing works
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration
Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Physiology · doi:10.1113/jp273106 · Cited by 813 · see citing works
Bartosch, S., Fite, A., Macfarlane, G. T., & McMurdo, M. E. T. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.6.3575-3581.2004 · Cited by 762 · cited 4× · see citing works
“between gut microbiota and host chronological aging 276 are still limited [8, 36, 73], but a reduced gut 277 microbiota diversity has been speculated to be asso278 ciated with increased old-age frailty [23, 31, 74, 75].”
BackgroundInfluentialDynamics and stabilization of the human gut microbiome during the first year of life
Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.012 · Cited by 738 · see citing works
Therapeutic Potential of Fecal Microbiota Transplantation
Smits, L. P., Bouter, K. E. C., de Vos, W. M., Borody, T. J., & Nieuwdorp, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.058 · Cited by 717 · see citing works
Jiménez, E., Fernández, L., Marín, M. L., Martı́n, R., Odriozola, J. M., Nueno‐Palop, C., Narbad, A., Olivares, M. M., Xaus, J., & Rodríguez, J. M. (2005) · Current Microbiology · doi:10.1007/s00284-005-0020-3 · Cited by 681 · see citing works
Leaky Gut As a Danger Signal for Autoimmune Diseases
Mu, Q., Kirby, J. L., Reilly, C. M., & Luo, X. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00598 · Cited by 618 · see citing works
IL-1β Causes an Increase in Intestinal Epithelial Tight Junction Permeability
Al-Sadi, R. M., & Ma, T. Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4641 · Cited by 601 · see citing works
Hickson, M., D'Souza, A. L., Muthu, N., Rogers, T. R., Want, S., Rajkumar, C., & Bulpitt, C. J. (2007) · BMJ · doi:10.1136/bmj.39231.599815.55 · Cited by 599 · see citing works
Kleessen, B., Sykura, B., Zunft, H. ‐., & Blaut, M. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.5.1397 · Cited by 573 · see citing works
Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis
Westfall, S., Lomis, N., Kahouli, I., Dia, S. Y., Singh, S. P., & Prakash, S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2550-9 · Cited by 551 · see citing works
Stevens, B. R., Goel, R., Seungbum, K., Richards, E. M., Holbert, R. C., Pepine, C. J., & Raizada, M. K. (2018) · Gut · doi:10.1136/gutjnl-2017-314759 · Cited by 508 · see citing works
Probiotics, their health benefits and applications for developing healthier foods: a review
Nagpal, R., Kumar, A., Kumar, M., Behare, P. V., Jain, S., & Yadav, H. (2012) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2012.02593.x · Cited by 496 · see citing works
Self-citationGill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.6.833 · Cited by 485 · cited 1× · see citing works
“[175] Gill HS, Rutherfurd KJ, Cross ML, Gopal PK.”
BackgroundThe Enteric Network: Interactions between the Immune and Nervous Systems of the Gut
Yoo, B. B., & Mazmanian, S. K. (2017) · Immunity · doi:10.1016/j.immuni.2017.05.011 · Cited by 479 · see citing works
Hopkins, M. J., & Macfarlane, G. T. (2002) · Journal of Medical Microbiology · doi:10.1099/0022-1317-51-5-448 · Cited by 473 · see citing works
Neyrinck, A. M., Possemiers, S., Druart, C., Van de Wiele, T., De Backer, F., Cani, P. D., Larondelle, Y., & Delzenne, N. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020944 · Cited by 465 · see citing works
Gut microbiota: A player in aging and a target for anti-aging intervention
Vaiserman, A. M., Koliada, A. K., & Marotta, F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.01.001 · Cited by 465 · see citing works
Self-citationVulevic, J., Drakoularakou, A., Yaqoob, P., Tzortzis, G., & Gibson, G. R. (2008) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26242 · Cited by 451 · see citing works
Finch, C. E., & Ruvkun, G. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.435 · Cited by 446 · see citing works
Sato, J., Kanazawa, A., Ikeda, F., Yoshihara, T., Goto, H., Abe, H., Komiya, K., Kawaguchi, M., Shimizu, T., Ogihara, T., et al. (2014) · Diabetes Care · doi:10.2337/dc13-2817 · Cited by 438 · see citing works
Signatures of early frailty in the gut microbiota
Jackson, M. A., Jeffery, I. B., Beaumont, M., Bell, J. T., Clark, A. G., Ley, R. E., O’Toole, P. W., Spector, T. D., & Steves, C. J. (2016) · Genome Medicine · doi:10.1186/s13073-016-0262-7 · Cited by 436 · see citing works
Composition and temporal stability of the gut microbiota in older persons
Jeffery, I. B., Lynch, D. B., & O’Toole, P. W. (2016) · The ISME Journal · doi:10.1038/ismej.2015.88 · Cited by 421 · see citing works
(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease
Buford, T. W. (2017) · Microbiome · doi:10.1186/s40168-017-0296-0 · Cited by 409 · see citing works
Development of the human gastrointestinal microbiota and insights from high-throughput sequencing
Dominguez-Bello, M. G., Blaser, M. J., Ley, R. E., & Knight, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.011 · Cited by 405 · see citing works
The role of DNA damage and repair in aging through the prism of Koch-like criteria
Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.02.001 · Cited by 387 · see citing works
Compartmentalized and systemic control of tissue immunity by commensals
Belkaid, Y., & Naik, S. (2013) · Nature Immunology · doi:10.1038/ni.2604 · Cited by 382 · see citing works
Ageing of the human metaorganism: the microbial counterpart
Biagi, E., Candela, M., Fairweather‐Tait, S. J., Franceschi, C., & Brigidi, P. (2011) · AGE · doi:10.1007/s11357-011-9217-5 · Cited by 365 · see citing works
Frailty in older adults: insights and interventions.
Espinoza, S. E., & Walston, J. D. (2005) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.72.12.1105 · Cited by 362 · see citing works
Functional metagenomic profiling of intestinal microbiome in extreme ageing
Rampelli, S., Candela, M., Turroni, S., Biagi, E., Collino, S., Franceschi, C., O'Toole, P. W., & Brigidi, P. (2013) · Aging · doi:10.18632/aging.100623 · Cited by 359 · see citing works
Microbiota controls the homeostasis of glial cells in the gut lamina propria
Kabouridis, P. S., Lasrado, R., McCallum, S., Chng, S. H., Snippert, H. J., Clevers, H., Pettersson, S., & Pachnis, V. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.037 · Cited by 358 · see citing works
The Intestinal Metabolome: An Intersection Between Microbiota and Host
Ursell, L. K., Haiser, H. J., Treuren, W. V., Garg, N., Reddivari, L., Vanamala, J., Dorrestein, P. C., Turnbaugh, P. J., & Knight, R. D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.03.001 · Cited by 357 · see citing works
Microbial Genetic Composition Tunes Host Longevity
Han, B., Sivaramakrishnan, P., Lin, C.-C., Neve, I. A. A., He, J., Tay, L. W. R., Sowa, J. N., Sizovs, A., Du, G., Wang, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.036 · Cited by 353 · see citing works
Vulevic, J., Juric, A., Tzortzis, G., & Gibson, G. R. (2013) · The Journal of Nutrition · doi:10.3945/jn.112.166132 · Cited by 349 · see citing works
Human intestinal microbiota and healthy ageing
Tiihonen, K., Ouwehand, A. C., & Rautonen, N. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.10.004 · Cited by 346 · see citing works
Haenen, D., Zhang, J., Souza da Silva, C., Bosch, G., van der Meer, I. M., van Arkel, J., van den Borne, J. J. G. C., Pérez Gutiérrez, O., Smidt, H., Kemp, B., et al. (2013) · The Journal of Nutrition · doi:10.3945/jn.112.169672 · Cited by 341 · see citing works
Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration
Friedland, R. P. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142841 · Cited by 338 · see citing works
Org, E., Blum, Y., Kasela, S., Mehrabian, M., Kuusisto, J., Kangas, A. J., Soininen, P., Wang, Z., Ala‐Korpela, M., Hazen, S. L., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1194-2 · Cited by 330 · see citing works
Luna, R. A., & Foster, J. A. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.10.007 · Cited by 325 · see citing works
Davis, L. M. G., Martínez, I., Walter, J., Goin, C., & Hutkins, R. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025200 · Cited by 321 · see citing works
Intestinal microbiota influence the early postnatal development of the enteric nervous system
Collins, J., Borojevic, R., Verdu, E. F., Huizinga, J. D., & Ratcliffe, E. M. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12236 · Cited by 318 · see citing works
Schwab, L., Goroncy, L., Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mócsai, A., Reichardt, W., Karlsson, F. J., Radhakrishnan, S. V., Hanke, K., et al. (2014) · Nature Medicine · doi:10.1038/nm.3517 · Cited by 302 · see citing works
McVey Neufeld, K. A., Mao, Y. K., Bienenstock, J., Foster, J. A., & Kunze, W. A. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12049 · Cited by 299 · see citing works
Recycling Metchnikoff: Probiotics, the Intestinal Microbiome and the Quest for Long Life
Mackowiak, P. A. (2013) · Frontiers in Public Health · doi:10.3389/fpubh.2013.00052 · Cited by 294 · see citing works
Chang, J., Leong, R. W., Wasinger, V. C., Ip, M., Yang, M., & Phan, T. G. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.05.056 · Cited by 286 · see citing works
Grasset, E., Puel, A., Charpentier, J., Collet, X., Christensen, J. E., Tercé, F., & Burcelin, R. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.013 · Cited by 280 · see citing works
The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases
Zapata, H. J., & Quagliarello, V. J. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13310 · Cited by 279 · see citing works
Obata, Y., & Pachnis, V. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.07.044 · Cited by 278 · see citing works
Ageing and gut microbes: Perspectives for health maintenance and longevity
Biagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., & Brigidi, P. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.005 · Cited by 276 · cited 2× · see citing works
“717 Since prebiotics are ‘favorite’ foods for probiotics, 718 combining them as “synbiotics” for preventive as 719 well as therapeutic health effects could be envis720 aged for better gut and overall health [46, 163].”
BackgroundInnervation of the gastrointestinal tract: Patterns of aging
Phillips, R. J., & Powley, T. L. (2007) · Autonomic Neuroscience · doi:10.1016/j.autneu.2007.04.005 · Cited by 272 · see citing works
Hooda, S., Boler, B. M. V., Serao, M. C. R., Brulc, J. M., Staeger, M. A., Boileau, T. W., Dowd, S. E., Fahey, G. C., & Swanson, K. S. (2012) · The Journal of Nutrition · doi:10.3945/jn.112.158766 · Cited by 272 · see citing works
Collino, S., Montoliu, I., Martin, F.-P. J., Scherer, M., Mari, D., Salvioli, S., Bucci, L., Ostan, R., Monti, D., Biagi, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056564 · Cited by 270 · see citing works
Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?
Brahe, L. K., Astrup, A., & Larsen, L. H. (2013) · Obesity Reviews · doi:10.1111/obr.12068 · Cited by 264 · see citing works
Commensal bacteria modulate cullin‐dependent signaling via generation of reactive oxygen species
Kumar, A., Wu, H., Collier-Hyams, L. S., Hansen, J. M., Li, T., Yamoah, K., Pan, Z., Jones, D. P., & Neish, A. S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601867 · Cited by 264 · see citing works
Guillemard, E., Tondu, F., Lacoin, F., & Schrezenmeir, J. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991395 · Cited by 257 · see citing works
Gut microbiota and diabetes: from pathogenesis to therapeutic perspective
Burcelin, R., Sérino, M., Chabo, C., Blasco‐Baqué, V., & Amar, J. (2011) · Acta Diabetologica · doi:10.1007/s00592-011-0333-6 · Cited by 256 · see citing works
Romero, R., Erez, O., Hüttemann, M., Maymon, E., Panaitescu, B., Conde-Agudelo, A., Pacora, P., Yoon, B. H., & Grossman, L. I. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.003 · Cited by 253 · see citing works
Mäkivuokko, H., Tiihonen, K., Tynkkynen, S., Paulin, L. G., & Rautonen, N. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991553 · Cited by 243 · see citing works
Gut permeability and mucosal inflammation: bad, good or context dependent
Ahmad, R., Sorrell, M. F., Batra, S. K., Dhawan, P., & Singh, A. B. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.128 · Cited by 243 · see citing works
Piazzon, M. C., Calduch-Giner, J. À., Fouz, B., Estensoro, I., Simó‐Mirabet, P., Puyalto, M., Karalazos, V., Palenzuela, O. R., Sitjà‐Bobadilla, A., & Pérez‐Sánchez, J. (2017) · Microbiome · doi:10.1186/s40168-017-0390-3 · Cited by 238 · see citing works
Köhler, C. A., Maes, M. H. J., Slyepchenko, A., Berk, M., Solmi, M., Lanctôt, K. L., & Carvalho, A. D. S. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160907093807 · Cited by 234 · see citing works
Bacterial Translocation from the Gut to the Distant Organs: An Overview
Nagpal, R., & Yadav, H. (2017) · Annals of Nutrition and Metabolism · doi:10.1159/000479918 · Cited by 234 · see citing works
Self-citationRea, M. C., O’Sullivan, Ó., Shanahan, F., O’Toole, P. W., Stanton, C., Ross, R. P., & Hill, C. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.05176-11 · Cited by 224 · see citing works
Biological aging and the human gut microbiota
Maffei, V. J., Kim, S., Blanchard, E., Luo, M., Jazwinski, S. M., Taylor, C. M., & Welsh, D. A. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx042 · Cited by 219 · see citing works
Comalada, M., Bailón, E., de Haro, O., Lara‐Villoslada, F., Xaus, J., Zarzuelo, A., & Gálvez, J. (2006) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-006-0092-x · Cited by 207 · see citing works
Microbe-host interactions: influence of the gut microbiota on the enteric nervous system
Hyland, N. P., & Cryan, J. F. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.06.027 · Cited by 207 · see citing works
To be or not to be a pathogen: that is the mucosally relevant question
Sansonetti, P. J. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.77 · Cited by 198 · see citing works
Zwielehner, J., Liszt, K. I., Handschur, M., Laßl, C., Lapin, A., & Haslberger, A. G. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.04.002 · Cited by 196 · see citing works
Comparison of fecal microflora of elderly persons in rural and urban areas of Japan
Benno, Y., Endo, K., Mizutani, T., Namba, Y., Komori, T., & MITSUOKA, T. (1989) · Applied and Environmental Microbiology · doi:10.1128/aem.55.5.1100-1105.1989 · Cited by 195 · see citing works
Molecular Analysis of Fecal Microbiota in Elderly Individuals Using 16S rDNA Library and T‐RFLP
Hayashi, H., Sakamoto, M., Kitahara, M., & Benno, Y. (2003) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2003.tb03418.x · Cited by 189 · see citing works
Probiotics and prebiotics and health in ageing populations
Duncan, S. H., & Flint, H. J. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.02.004 · Cited by 187 · see citing works
Probiotics, prebiotics and synbiotics: A role in chemoprevention for colorectal cancer?
Geier, M. S., Butler, R. N., & Howarth, G. S. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.10.3296 · Cited by 186 · see citing works
Aging of the myenteric plexus: neuronal loss is specific to cholinergic neurons
Phillips, R. J., Kieffer, E. J., & Powley, T. L. (2003) · Autonomic Neuroscience · doi:10.1016/s1566-0702(03)00072-9 · Cited by 181 · see citing works
Walton, G., van den Heuvel, E. G. H. M., Kosters, M. H. W., Rastall, R. A., Tuohy, K. M., & Gibson, G. R. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004697 · Cited by 173 · see citing works
Manipulation of the Microbiota for Treatment of IBS and IBD—Challenges and Controversies
Shanahan, F., & Quigley, E. M. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.050 · Cited by 172 · see citing works
Immune responses to commensal and environmental microbes
Pamer, E. G. (2007) · Nature Immunology · doi:10.1038/ni1526 · Cited by 169 · see citing works
Cevenini, E., Caruso, C., Candore, G., Capri, M., Nuzzo, D., Duro, G., Rizzo, C., Colonna‐Romano, G., Lio, D., Carlo, D., et al. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883840 · Cited by 166 · see citing works
Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging
Qi, Y., Goel, R., Kim, S., Richards, E. M., Carter, C. S., Pepine, C. J., Raizada, M. K., & Buford, T. W. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.05.018 · Cited by 165 · see citing works
Oh, K. J., Lee, S. E., Jung, H., Kim, G., Romero, R. J., & Yoon, B. H. (2010) · Journal of Perinatal Medicine · doi:10.1515/jpm.2010.040 · Cited by 162 · see citing works
In Vitro and In Vivo Antioxidant Activity of Bifidobacterium animalis 01 Isolated from Centenarians
Shen, Q., Shang, N., & Li, P. (2010) · Current Microbiology · doi:10.1007/s00284-010-9827-7 · Cited by 154 · see citing works
Kelsall, B. L., & Leon, F. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00292.x · Cited by 154 · see citing works
(2015) · PubMed · Cited by 152 · see citing works
The enteric nervous system promotes intestinal health by constraining microbiota composition
Rolig, A. S., Mittge, E. K., Ganz, J., Troll, J. V., Melancon, E., Wiles, T. J., Alligood, K., Stephens, W. Z., Eisen, J. S., & Guillemin, K. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2000689 · Cited by 152 · see citing works
Nagpal, R., Tsuji, H., Takahashi, T., Nomoto, K., Kawashima, K., Nagata, S., & Yamashiro, Y. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01388 · Cited by 152 · see citing works
Self-citationHe, F., Ouwehand, A. C., Isolauri, E., Hosoda, M., Benno, Y., & Salminen, S. (2001) · Current Microbiology · doi:10.1007/s002840010315 · Cited by 150 · see citing works
Nagpal, R., Tsuji, H., Takahashi, T., Kawashima, K., Nagata, S., Nomoto, K., & Yamashiro, Y. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01997 · Cited by 150 · see citing works
Self-citation<i>Bifidobacterium</i>microbiota and parameters of immune function in elderly subjects
Ouwehand, A. C., Bergsma, N., Parhiala, R., Lahtinen, S., Gueimonde, M., Finne-Soveri, H., Strandberg, T., Pitkälä, K., & Salminen, S. (2008) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2008.00392.x · Cited by 148 · see citing works
Restricted diet rescues rat enteric motor neurones from age related cell death
Cowen, T., Johnson, R. J. R., Soubeyre, V., & Santer, R. M. (2000) · Gut · doi:10.1136/gut.47.5.653 · Cited by 147 · see citing works
Aging of the mammalian gastrointestinal tract: a complex organ system
Saffrey, M. J. (2013) · AGE · doi:10.1007/s11357-013-9603-2 · Cited by 139 · see citing works
Nagata, S., Asahara, T., Ohta, T., Yamada, T., Kondo, S., Bian, L., Wang, C., Yamashiro, Y., & Nomoto, K. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451100064x · Cited by 136 · see citing works
Bouhnik, Y., Achour, L., Paineau, D., Riottot, M., Attar, A., & Bornet, F. R. J. (2007) · Nutrition Journal · doi:10.1186/1475-2891-6-42 · Cited by 134 · see citing works
Thrasivoulou, C., Soubeyre, V., Ridha, H., Giuliani, D., Giaroni, C., Michael, G. J., Saffrey, M. J., & Cowen, T. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00214.x · Cited by 132 · see citing works
Excessive folate synthesis limits lifespan in the C. elegans: E. coliaging model
Virk, B., Correia, G. D. S., Dixon, D. P., Feyst, I., Jia, J., Oberleitner, N., Briggs, Z., Hodge, E., Edwards, R., Ward, J. M., et al. (2012) · BMC Biology · doi:10.1186/1741-7007-10-67 · Cited by 123 · see citing works
Cellular changes in the enteric nervous system during ageing
Saffrey, M. J. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.03.015 · Cited by 121 · see citing works
The human superorganism – Of microbes and men
Sleator, R. D. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.08.047 · Cited by 118 · see citing works
O'Mahony, D., O'Leary, P., & Quigley, E. (2002) · Drugs & Aging · doi:10.2165/00002512-200219070-00005 · Cited by 117 · see citing works
The impact of ageing on the intestinal epithelial barrier and immune system
Man, A., Gicheva, N., & Nicoletti, C. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.04.001 · Cited by 114 · see citing works
Moro‐García, M. A., Alonso‐Arias, R., BALTADJIEVA, M., Benítez, C. F., Barrial, M. A. F., Ruisánchez, E. D., Santos, R. A., Sánchez, M. Á., Miján, J. S., & López‐Larrea, C. (2012) · AGE · doi:10.1007/s11357-012-9434-6 · Cited by 114 · see citing works
Britton, E., & McLaughlin, J. T. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112002807 · Cited by 110 · see citing works
Enteric neurodegeneration in ageing
Camilleri, M., Cowen, T., & Koch, T. R. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.01072.x · Cited by 109 · see citing works
Reduced intestinal motility, mucosal barrier function, and inflammation in aged monkeys
Mitchell, E. L., Davis, A., Brass, K., Dendinger, M. D., Barner, R., Gharaibeh, R. Z., Fodor, A. A., & Kavanagh, K. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0725-y · Cited by 106 · see citing works
Self-citationEvidence For Early Aging in the Mucosal Immune System
Koga, T., McGhee, J. R., Kato, H., Kato, R., Kiyono, H., & Fujihashi, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.5352 · Cited by 105 · see citing works
Age-related changes in the morphology of the myenteric plexus of the human colon
Menachem Hanani, A., Fellig, Y., Udassin, R., & Freund, H. R. (2004) · Autonomic Neuroscience · doi:10.1016/j.autneu.2004.05.007 · Cited by 104 · see citing works
Nagpal, R., Kurakawa, T., Tsuji, H., Takahashi, T., Kawashima, K., Nagata, S., Nomoto, K., & Yamashiro, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-10711-5 · Cited by 104 · see citing works
Self-citationLoss of glia and neurons in the myenteric plexus of the aged Fischer�344 rat
Phillips, R. J., Kieffer, E. J., & Powley, T. L. (2004) · Anatomy and Embryology · doi:10.1007/s00429-004-0426-x · Cited by 103 · see citing works
Slyepchenko, A., Maes, M. H. J., Machado‐Vieira, R., Anderson, G., Solmi, M., Sanz, Y., Berk, M., Köhler, C. A., & Carvalho, A. F. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160922165706 · Cited by 103 · see citing works
Gavini, F., Cayuela, C., Antoine, J., Lecoq, C., Lefebvre, B., Membré, J., & Neut, C. (2001) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v13i1.7998 · Cited by 98 · see citing works
Lahtinen, S. J., Forssten, S. D., Aakko, J., Granlund, L., Rautonen, N., Salminen, S., Viitanen, M. H., & Ouwehand, A. C. (2011) · AGE · doi:10.1007/s11357-011-9208-6 · Cited by 98 · see citing works
Hall, K. E., Proctor, D. D., Fisher, L. J., & Rose, S. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.06.013 · Cited by 97 · see citing works
Gut microbiota in health and disease: an overview focused on metabolic inflammation
Nagpal, R., Kumar, M., Yadav, A. K., Hemalatha, R., Yadav, H., Marotta, F., & Yamashiro, Y. (2016) · Beneficial Microbes · doi:10.3920/bm2015.0062 · Cited by 97 · see citing works
Self-citationProbiotics modulate the Bifidobacterium microbiota of elderly nursing home residents
Lahtinen, S. J., Tammela, L. I., Korpela, J., Parhiala, R., Ahokoski, H., Mykkänen, H. M., & Salminen, S. (2008) · AGE · doi:10.1007/s11357-008-9081-0 · Cited by 96 · see citing works
Compositional dynamics of the human intestinal microbiota with aging: Implications for health
Lakshminarayanan, B., Stanton, C., O’Toole, P. W., & Ross, R. P. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0549-6 · Cited by 91 · see citing works
Foong, J. P. P., Nguyen, T. V., Furness, J. B., Bornstein, J. C., & Young, H. M. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.225938 · Cited by 91 · see citing works
Broad segmental progeroid changes in short-lived <i>Ercc1</i> <sup>−/Δ7</sup> mice
Dollé, M. E. T., Kuiper, R. V., Roodbergen, M., Robinson, J., de Vlugt, S., Wijnhoven, S. W. P., Beems, R. B., de la Fonteyne, L., de With, P., van der Pluijm, I., et al. (2011) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v1i0.7219 · Cited by 91 · see citing works
(2007) · PubMed · Cited by 90 · see citing works
Gavini, F., Cayuela, C., Antoine, J.-M., Lecoq, C., Lefebvre, B., Membré, J., & Neut, C. (2001) · Microbial Ecology in Health and Disease · doi:10.1080/089106001750071690 · Cited by 90 · see citing works
Molecular monitoring of the development of intestinal microbiota in Japanese infants
Tsuji, H., Oozeer, R., Matsuda, K., Matsuki, T., Ohta, T., Nomoto, K., Tanaka, R., Kawashima, M., Kawashima, K., Nagata, S., et al. (2012) · Beneficial Microbes · doi:10.3920/bm2011.0038 · Cited by 86 · see citing works
Effect of prebiotics on the human gut microbiota of elderly persons
Toward, R. E., Montandon, S., Walton, G., & Gibson, G. R. (2012) · Gut Microbes · doi:10.4161/gmic.19411 · Cited by 86 · see citing works
Intestinal aganglionosis is associated with early and sustained disruption of the colonic microbiome
Ward, N. L., Pieretti, A. C., Dowd, S. E., Cox, S. B., & Goldstein, A. M. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01937.x · Cited by 85 · see citing works
Annaert, P., Brouwers, J., Bijnens, A., Lammert, F., Tack, J. F., & Augustijns, P. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.10.005 · Cited by 85 · see citing works
Clostridium difficile Infection in the Elderly
Keller, J. M., & Surawicz, C. M. (2013) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2013.10.008 · Cited by 82 · see citing works
Fecal Microbiota Transplantation for the Management of Clostridium difficile Infection
Rao, K. K., & Young, V. B. (2015) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2014.11.009 · Cited by 78 · see citing works
Nier, A., Engstler, A. J., Maier, I. B., & Bergheim, I. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183282 · Cited by 76 · see citing works
Intestinal dysbiosis and bacterial enteroinvasion in a murine model of Hirschsprung’s disease
Pierre, J. F., Barlow, A. J., Erickson, C. S., Heneghan, A. F., LEVERSON, G. E., Dowd, S. E., Epstein, M. L., Kudsk, K. A., & Gosain, A. (2014) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2014.01.060 · Cited by 73 · see citing works
Small intestinal permeability in older adults
Valentini, L., Ramminger, S., Haas, V., Postrach, E., Werich, M., Fischer, A., Koller, M., Swidsinski, A., Bereswill, S., Lochs, H., et al. (2014) · Physiological Reports · doi:10.1002/phy2.281 · Cited by 73 · see citing works
Yang, H., Liu, S., Ibrahim, S. A., Zhao, L., Jiang, J., Sun, W.-F., & Ren, F. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.03.010 · Cited by 71 · see citing works
Small intestinal permeability in older adults
Valentini, L., Ramminger, S., Haas, V., Postrach, E., Werich, M., Fischer, A., Koller, M., Swidsinski, A., Bereswill, S., Lochs, H., et al. (2014) · Physiological Reports · doi:10.14814/phy2.281 · Cited by 68 · see citing works
Role of the Gut Microbiota in Age-Related Chronic Inflammation
Rehman, T. (2012) · Endocrine, Metabolic & Immune Disorders-Drug Targets · doi:10.2174/187153012803832620 · Cited by 67 · see citing works
Vries, P. D., Soret, R., Suply, E., Héloury, Y., & Neunlist, M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00092.2010 · Cited by 67 · see citing works
Paun, A., & Danska, J. S. (2016) · Pediatric Diabetes · doi:10.1111/pedi.12424 · Cited by 67 · see citing works
Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat
Phillips, R. J., Walter, G. C., Ringer, B. E., Higgs, K. M., & Powley, T. L. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.07.025 · Cited by 66 · see citing works
Newton, J. L., Jordan, N., Pearson, J. P., Williams, G., Allen, A., & James, O. (2000) · Gerontology · doi:10.1159/000022151 · Cited by 60 · see citing works
Sanduzzi‐Zamparelli, M., Compare, D., Coccoli, P., Rocco, A., Nardone, O. M., Marrone, G., Gasbarrini, A., Grieco, A., Nardone, G., & Miele, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081225 · Cited by 59 · see citing works
Matsumoto, M., & Benno, Y. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.50464 · Cited by 56 · see citing works
Immunosenescence and Anti-Immunosenescence Therapies: The Case of Probiotics
Candore, G., Balistreri, C. R., Colonna‐Romano, G., Grimaldi, M. P., Lio, D., Listı̀, F., Scola, L., Vasto, S., & Caruso, C. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0662 · Cited by 55 · see citing works
Age- and Diet-Related Increase in Transepithelial Colon Permeability of Fischer 344 Rats
Mullin, J. M., Valenzano, M. C., Verrecchio, J. J., & Kothari, R. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020191412285 · Cited by 54 · see citing works
Nagpal, R., Tsuji, H., Takahashi, T., Nomoto, K., Kawashima, K., Nagata, S., & Yamashiro, Y. (2017) · Beneficial Microbes · doi:10.3920/bm2016.0216 · Cited by 53 · see citing works
Self-citationThe Intestinal Epithelial Barrier: Does It Become Impaired with Age?
Meier, J., & Sturm, A. (2009) · Digestive Diseases · doi:10.1159/000228556 · Cited by 50 · see citing works
Myenteric neuron numbers are maintained in aging mouse distal colon
Gamage, P. P. K. M., Ranson, R. N., Patel, B. A., Yeoman, M. S., & Saffrey, M. J. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12114 · Cited by 47 · see citing works
Ileal myenteric plexus in aged guinea‐pigs: loss of structure and calretinin‐immunoreactive neurones
Abalo, R., rivera, A. J., Vera, G., & Martin, M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00612.x · Cited by 45 · see citing works
An, H. M., Baek, E. H., Jang, S., Lee, D. K., Kim, M. J., Kim, J. R., Lee, K. O., Park, J. G., & Ha, N. J. (2010) · Nutrition Journal · doi:10.1186/1475-2891-9-5 · Cited by 44 · see citing works
Kim, Y.-R., Volpert, G., Shin, K., Kim, S., Shin, S., Lee, Y., Sung, S. H., Lee, Y., Ahn, J., Pewzner‐Jung, Y., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13267 · Cited by 42 · see citing works
Morphological changes in the enteric nervous system of aging and APP23 transgenic mice
Ginneken, C. J. V., Schäfer, K., Dam, D. V., Huygelen, V., & Deyn, P. P. D. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.030 · Cited by 41 · see citing works
Myers, J. S. (2008) · Rehabilitation Nursing · doi:10.1002/j.2048-7940.2008.tb00215.x · Cited by 37 · see citing works
Yamada, M., Arai, H., Yoshimura, K., Kajiwara, Y., Sonoda, T., Nishiguchi, S., & Aoyama, T. (2012) · The Journal of frailty & aging · doi:10.14283/jfa.2012.12 · Cited by 35 · see citing works
Faecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection
Koenigsknecht, M. J., & Young, V. B. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328365d326 · Cited by 30 · see citing works
Age-related gene expression analysis in enteric ganglia of human colon after laser microdissection
Hetz, S., Acikgoez, A., Moll, C., Jahnke, H., Robitzki, A. A., Metzger, R., & eMetzger, R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00276 · Cited by 26 · see citing works
Abalo, R., Vera, G., Rivera, A. J., & Martín, M. I. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.04.004 · Cited by 26 · see citing works
Early-Life Gut Microbial Composition
Yamashiro, Y., & Nagpal, R. (2015) · Journal of Pediatric Biochemistry · doi:10.1055/s-0035-1564573 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Malnutrition in Older Adults—Recent Advances and Remaining Challenges
Norman, K., Haß, U., & Pirlich, M. (2021) · Nutrients · doi:10.3390/nu13082764 · Cited by 775 · see citing works
The Gut Microbiota and Inflammation: An Overview
Bander, Z. A., Nitert, M. D., Mousa, A., & Naderpoor, N. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17207618 · Cited by 783 · see citing works
The Gut Virome Database Reveals Age-Dependent Patterns of Virome Diversity in the Human Gut
Gregory, A., Zablocki, O., Zayed, A. A., Howell, A., Bolduc, B., & Sullivan, M. B. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.08.003 · Cited by 635 · see citing works
Nagpal, R., Neth, B. J., Wang, S., Craft, S., & Yadav, H. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.032 · Cited by 653 · see citing works
Self-citationAntimicrobial Stewardship: Fighting Antimicrobial Resistance and Protecting Global Public Health
Majumder, M. A. A., Rahman, S., Cohall, D., Bharatha, A., Singh, K., Haque, M., & Hilaire, M. G.-S. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s290835 · Cited by 668 · see citing works
Gut microbiota and Covid-19- possible link and implications
Dhar, D., & Mohanty, A. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198018 · Cited by 608 · see citing works
Rosser, E. C., Piper, C. J. M., Matei, D. E., Blair, P. A., Rendeiro, A. F., Orford, M., Alber, D. G., Krausgruber, T., Catalan, D., Klein, N., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.003 · Cited by 579 · see citing works
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Jafarzadeh-Esfehani, R., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 562 · see citing works
The Microbiota–Gut–Brain Axis in Psychiatric Disorders
Góralczyk-Bińkowska, A., Szmajda‐Krygier, D., & Kozłowska, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911245 · Cited by 534 · see citing works
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
The aging gut microbiome and its impact on host immunity
Bosco, N., & Noti, M. (2021) · Genes and Immunity · doi:10.1038/s41435-021-00126-8 · Cited by 418 · see citing works
Diet, Microbiota and Gut-Lung Connection
Anand, S., & Mande, S. S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02147 · Cited by 409 · see citing works
Zhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 410 · see citing works
Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 389 · see citing works
Self-citationGut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease
Violi, F., Cammisotto, V., Bartimoccia, S., Pignatelli, P., Carnevale, R., & Nocella, C. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00737-2 · Cited by 384 · see citing works
<scp>Meta‐Analysis</scp> of Gut Dysbiosis in Parkinson's Disease
Nishiwaki, H., Ito, M., Ishida, T., Hamaguchi, T., Maeda, T., Kashihara, K., Tsuboi, Y., Ueyama, J., Shimamura, T., Mori, H., et al. (2020) · Movement Disorders · doi:10.1002/mds.28119 · Cited by 370 · see citing works
Gut–organ axis: a microbial outreach and networking
Ahlawat, S., Asha, A., & Sharma, K. K. (2020) · Letters in Applied Microbiology · doi:10.1111/lam.13333 · Cited by 363 · see citing works
Oral Microbiome: A Review of Its Impact on Oral and Systemic Health
Krishnamurthy, H. K., Bosco, J., Jayaraman, V., Krishna, K., Wang, T., Bei, K., & Rajasekaran, J. J. (2024) · Microorganisms · doi:10.3390/microorganisms12091797 · Cited by 402 · see citing works
Human gut microbiome aging clock based on taxonomic profiling and deep learning
Galkin, F., Mamoshina, P., Aliper, A., Lane, E., Moskalev, V., Gladyshev, V. N., & Zhavoronkov, A. (2020) · iScience · doi:10.1016/j.isci.2020.101199 · Cited by 292 · see citing works
Microbiota succession throughout life from the cradle to the grave
Martino, C., Dilmore, A. H., Burcham, Z. M., Metcalf, J. L., Jeste, D., & Knight, R. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00768-z · Cited by 275 · see citing works
Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement
Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276 · see citing works
Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota
Anjana, A., & Tiwari, S. K. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.851140 · Cited by 272 · see citing works
Ketogenic Diet and Microbiota: Friends or Enemies?
Paoli, A., Mancin, L., Bianco, A., Thomas, E., Mota, J. F., & Piccini, F. (2019) · Genes · doi:10.3390/genes10070534 · Cited by 265 · see citing works
Ahmadi, S., Wang, S., Nagpal, R., Wang, B., Jain, S., Razazan, A. P., Mishra, S. P., Zhu, X., Wang, Z., Kavanagh, K., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.132055 · Cited by 261 · see citing works
Self-citationNi, Y., Yang, X., Zheng, L., Wang, Z., Wu, L., Jiang, J., Yang, T., Ma, L., & Fu, Z. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900603 · Cited by 255 · see citing works
Synergistic anti-inflammatory effects and mechanisms of combined phytochemicals
Zhang, L., Virgous, C. K., & Si, H. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.03.009 · Cited by 248 · see citing works
Saccon, T. D., Nagpal, R., Yadav, H., Cavalcante, M. B., Nunes, A. D. D. C., Schneider, A., Gesing, A., Hughes, B., Yousefzadeh, M., Tchkonia, T., et al. (2021) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glab002 · Cited by 247 · see citing works
Self-citationThe role of T cells in age-related diseases
Carrasco, E., Heras, M. M. G. D. L., Gabandé‐Rodríguez, E., Desdín-Micó, G., Aranda, J. F., & Mittelbrunn, M. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00557-4 · Cited by 244 · see citing works
Livshits, G., & Kalinkovich, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100980 · Cited by 239 · see citing works
Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer
Park, S.-Y., Hwang, B.-O., Lim, M., Ok, S.-H., Lee, S., Chun, K., Park, K.-K., Hu, Y., Chung, W., & Song, N. (2021) · Cancers · doi:10.3390/cancers13092124 · Cited by 237 · see citing works
Wang, S., Ahmadi, S., Nagpal, R., Jain, S., Mishra, S. P., Kavanagh, K., Zhu, X., Wang, Z., McClain, D. A., Kritchevsky, S. B., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00137-4 · Cited by 228 · see citing works
Self-citationSarris, J., Ravindran, A., Yatham, L., Marx, W., Rucklidge, J., McIntyre, R., Akhondzadeh, S., Benedetti, F., Caneo, C., Cramer, H., et al. (2022) · World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.2013041 · Cited by 190 · see citing works
Inflammaging: Implications in Sarcopenia
Antuña, E., Cachán-Vega, C., Bermejo-Millo, J. C., Potes, Y., Caballero, B., Vega‐Naredo, I., Coto‐Montes, A. M., & García-González, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315039 · Cited by 223 · see citing works
Vaiserman, A. M., Romanenko, M., Півень, Л. В., Moseiko, V., Lushchak, O. V., Kryzhanovska, N., Gurianov, V. G., & Koliada, A. K. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01903-7 · Cited by 216 · see citing works
The links between the gut microbiome, aging, modern lifestyle and Alzheimer's disease
Askarova, S., Umbayev, B., Masoud, A.-R., Kaiyrlykyzy, A., Safarova, Y., Tsoy, A., Olzhayev, F., & Kushugulova, A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00104 · Cited by 208 · see citing works
Self-citationBana, B., & Cabreiro, F. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043650 · Cited by 207 · see citing works
Nagpal, R., Neth, B. J., Wang, S., Mishra, S. P., Craft, S., & Yadav, H. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102950 · Cited by 189 · see citing works
Self-citationThe human gut microbiome and aging
Bradley, E. S., & Haran, J. P. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2359677 · Cited by 186 · see citing works
The Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders
Anand, N., Gorantla, V. R., & Chidambaram, S. B. (2022) · Cells · doi:10.3390/cells12010054 · Cited by 185 · see citing works
Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases
de Almeida, A. J. P. O., Rezende, M. S. D. A., Dantas, S. H., Silva, S. D. L., de Oliveira, J. C. P. L., de Azevedo, F. D. L. A. A., Alves, R. M. F. R., de Menezes, G. M. S., dos Santos, P. F., Gonçalves, T. A. F., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1954398 · Cited by 167 · see citing works
Kandpal, M., Indari, O., Baral, B., Jakhmola, S., Tiwari, D., Bhandari, V., Pandey, R. K., Bala, K., Sonawane, A., & Jha, H. C. (2022) · Metabolites · doi:10.3390/metabo12111064 · Cited by 172 · see citing works
Age and the aging process significantly alter the small bowel microbiome
Leite, G., Pimentel, M., Barlow, G. M., Chang, C. Y.-Y., Hosseini, A., Wang, J., Parodi, G., Sedighi, R., Rezaie, A. R., & Mathur, R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109765 · Cited by 158 · see citing works
Pharmacological basis and new insights of resveratrol action in the cardiovascular system
Cheng, C. K., Luo, J., Lau, C. W., Chen, Z., Tian, X. Y., & Huang, Y. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14801 · Cited by 159 · see citing works
van Deuren, T., Blaak, E. E., & Canfora, E. E. (2022) · Obesity Reviews · doi:10.1111/obr.13498 · Cited by 162 · see citing works
Lee, J., Venna, V. R., Durgan, D. J., Shi, H., Hudobenko, J., Putluri, N., Petrosino, J. F., McCullough, L. D., & Bryan, R. M. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1814107 · Cited by 151 · see citing works
Evolution of the Human Diet and Its Impact on Gut Microbiota, Immune Responses, and Brain Health
Olmo, B. M. G., Butler, M. J., & Barrientos, R. M. (2021) · Nutrients · doi:10.3390/nu13010196 · Cited by 154 · see citing works
Wong, C. B., Odamaki, T., & Xiao, J. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.02.002 · Cited by 149 · see citing works
The microbiome: An emerging key player in aging and longevity
Kim, M., & Benayoun, B. A. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.07.004 · Cited by 142 · see citing works
The gut microbiome: what the oncologist ought to know
Lee, K. A., Luong, M., Shaw, H. M., Nathan, P., Bataille, V. A., & Spector, T. D. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01467-x · Cited by 151 · see citing works
Ahmadi, S., Razazan, A. P., Nagpal, R., Jain, S., Wang, B., Mishra, S. P., Wang, S., Justice, J. N., Ding, J., McClain, D. A., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa056 · Cited by 146 · see citing works
Self-citationLiu, A., Lv, H., Wang, H., Yang, H. B., Li, Y., & Qian, J. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz263 · Cited by 147 · see citing works
Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases
Rinninella, E., Cintoni, M., Raoul, P. C., Ianiro, G., Laterza, L., Lopetuso, L. R., Ponziani, F. R., Gasbarrini, A., & Mele, M. C. (2020) · Microorganisms · doi:10.3390/microorganisms8081140 · Cited by 151 · see citing works
Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice
Inokawa, H., Umemura, Y. M., Shimba, A., Kawakami, E., Koike, N., Tsuchiya, Y., Ohashi, M., Minami, Y., Cui, G., Asahi, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59541-y · Cited by 133 · see citing works
Metabolomic analysis in inflammatory bowel disease: A systematic review
Gallagher, K., Catesson, A., Griffin, J. L., Holmes, E., & Williams, H. R. T. (2021) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjaa227 · Cited by 133 · see citing works
Del Bo', C., Bernardi, S., Cherubini, A., Porrini, M., Gargari, G., Hidalgo-Liberona, N., González-Domínguez, R., Zamora-Ros, R., Peron, G., Marino, M., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.014 · Cited by 133 · see citing works
Widespread sex dimorphism in aging and age-related diseases
Sampathkumar, N. K., Bravo, J. I., Chen, Y., Danthi, P. S., Donahue, E. K., Lai, R. W., Lu, R. J., Randall, L. T., Vinson, N. M., & Benayoun, B. A. (2019) · Human Genetics · doi:10.1007/s00439-019-02082-w · Cited by 127 · see citing works
Ticinesi, A., Mancabelli, L., Tagliaferri, S., Nouvenne, A., Milani, C., Rio, D. D., Lauretani, F., Maggio, M. G., Ventura, M., & Meschi, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238946 · Cited by 133 · see citing works
Santus, W., Devlin, J. R., & Behnsen, J. (2021) · Infection and Immunity · doi:10.1128/iai.00648-20 · Cited by 132 · see citing works
Gut microbes in neurocognitive and mental health disorders
Halverson, T., & Alagiakrishnan, K. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1808239 · Cited by 125 · see citing works
Calder, P. C., Ortega, E. F., Meydani, S. N., Adkins, Y. C., Stephensen, C. B., Thompson, B., & Zwickey, H. L. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac052 · Cited by 136 · see citing works
Intestinal Flora as a Potential Strategy to Fight SARS-CoV-2 Infection
He, L., Ren, L., Li, J., Wu, Y.-N., Li, X., & Zhang, L. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01388 · Cited by 134 · see citing works
Kahleová, H., Rembert, E., Alwarith, J., Yonas, W., Tura, A., Holubkov, R., Agnello, M., Chutkan, R. K., & Barnard, N. D. (2020) · Nutrients · doi:10.3390/nu12102917 · Cited by 123 · see citing works
Immune aging in diabetes and its implications in wound healing
Moura, J., Madureira, P., Leal, E. C., Fonseca, A. C., & Carvalho, E. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.02.002 · Cited by 116 · see citing works
Gut microbiota and old age: Modulating factors and interventions for healthy longevity
Coman, V., & Vodnar, D. C. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111095 · Cited by 124 · see citing works
The Microbiota-Gut-Immune-Glia (MGIG) Axis in Major Depression
Rudzki, L., & Maes, M. H. J. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01961-y · Cited by 114 · see citing works
Sun, M., Ma, K., Wen, J., Wang, G., Zhang, C., Li, Q., Bao, X., & Wang, H. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-190872 · Cited by 113 · see citing works
Segregation of age-related skin microbiome characteristics by functionality
Kim, H.-J., Kim, J. J., Myeong, N. R., Kim, T., Kim, D., An, S., Kim, H., Park, T., Jang, S. I., Yeon, J. H., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-53266-3 · Cited by 113 · see citing works
García-Gutiérrez, E., Narbad, A., & Rodríguez, J. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.578666 · Cited by 115 · see citing works
Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis
Collins, A., Mitchell, C. A., & Passegué, E. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201545 · Cited by 111 · see citing works
Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors
Zsichla, L., & Müller, V. (2023) · Viruses · doi:10.3390/v15010175 · Cited by 113 · see citing works
Prokopidis, K., Chambers, E. S., Lochlainn, M. N., & Witard, O. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.770455 · Cited by 109 · see citing works
Settanni, C. R., Ianiro, G., Bibbò, S., Cammarota, G., & Gasbarrini, A. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110258 · Cited by 104 · see citing works
COPD and the gut-lung axis: the therapeutic potential of fibre
Vaughan, A., Frazer, Z. A., Hansbro, P. M., & Yang, I. A. (2019) · Journal of Thoracic Disease · doi:10.21037/jtd.2019.10.40 · Cited by 99 · see citing works
The Human Gut Phageome: Origins and Roles in the Human Gut Microbiome
Townsend, E. M., Kelly, L., Muscatt, G., Box, J. D., Hargraves, N., Lilley, D., & Jameson, E. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.643214 · Cited by 102 · see citing works
The Human Gut Microbiome as a Potential Factor in Autism Spectrum Disorder
Alharthi, A., Alhazmi, S., Alburae, N. A., & Bahieldin, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031363 · Cited by 121 · see citing works
The untwining of immunosenescence and aging
Xu, W., Wong, G. C. L., Hwang, Y. Y., & Larbi, A. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00824-x · Cited by 104 · see citing works
Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
Tarek, B., Soleti, R., Panaro, M. A., Torre, M. E. L., Monda, V., Messina, G., & Porro, C. (2021) · Molecules · doi:10.3390/molecules26164794 · Cited by 100 · see citing works
Luo, D., Chen, K., Li, J., Fang, Z., Pang, H., Yin, Y., Rong, X., & Guo, J. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109550 · Cited by 100 · see citing works
Han, M., Yang, K., Yang, P., Zhong, C., Chen, C., Wang, S., Lu, Q., & Ning, K. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1842991 · Cited by 100 · see citing works
Self-citationLarson, P. J., Zhou, W. L., Santiago, A., Driscoll, S., Fleming, E. S., Voigt, A. Y., Chun, O. K., Grady, J. J., Kuchel, G. A., Robison, J. T., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00287-9 · Cited by 100 · see citing works
Wu, L. H., Zeng, T., Deligios, M., Milanesi, L., Langille, M. G. I., Zinellu, A., Rubino, S., Carru, C., & Kelvin, D. J. (2020) · mSphere · doi:10.1128/msphere.00558-19 · Cited by 95 · see citing works
Wu, L., Xie, X., Li, Y., Liang, T., Zhong, H., Yang, L., Yu, X., Zhang, J., Ding, Y., & Wu, Q. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00366-0 · Cited by 102 · see citing works
Curcumin nanoformulations to combat aging-related diseases
Mahjoob, M., & Stochaj, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101364 · Cited by 92 · see citing works
Microbiome diurnal rhythmicity and its impact on host physiology and disease risk
Nobs, S. P., Tuganbaev, T., & Elinav, E. (2019) · EMBO Reports · doi:10.15252/embr.201847129 · Cited by 90 · see citing works
Microbial BMAA and the Pathway for Parkinson’s Disease Neurodegeneration
Nunes‐Costa, D., Magalhães, J. D., G-Fernandes, M., Cardoso, S. M., & Empadinhas, N. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00026 · Cited by 90 · see citing works
Functional microbiome deficits associated with ageing: Chronological age threshold
Ruiz‐Ruiz, S., Sánchez-Carrillo, S., Ciordia, S., Mena, M. C., Méndez–García, C., Rojo, D., Bargiela, R., Zubeldia‐Varela, E., Martínez‐Martínez, M., Barbas, C., et al. (2019) · Aging Cell · doi:10.1111/acel.13063 · Cited by 89 · see citing works
The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson’s disease?
d’Angelo, M., Cimini, A., Castelli, V., Quintiliani, M., Benedetti, E., & Cifone, M. G. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.295270 · Cited by 89 · see citing works
Interventions on Gut Microbiota for Healthy Aging
Zeppa, S. D., Agostini, D., Ferrini, F., Gervasi, M., Barbieri, E., Bartolacci, A., Piccoli, G., Saltarelli, R., Sestili, P., & Stocchi, V. (2022) · Cells · doi:10.3390/cells12010034 · Cited by 91 · see citing works
The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease
Jennison, E., & Byrne, C. D. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0129 · Cited by 89 · see citing works
Navarro‐Tapia, E., Sebastiani, G., Sailer, S., Almeida-Toledano, L., Serra-Delgado, M., García‐Algar, Ó., & Andreu-Férnández, V. (2020) · Nutrients · doi:10.3390/nu12082243 · Cited by 86 · see citing works
The gut microbiome and Alzheimer’s disease: Complex and bidirectional interactions
Tarawneh, R. M., & Penhos, E. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104814 · Cited by 88 · see citing works
Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects
Kurian, S. J., Unnikrishnan, M. K., Miraj, S. S., Bagchi, D., Banerjee, M., Reddy, B. S., Rodrigues, G. S., Manu, M. K., Saravu, K., Mukhopadhyay, C., et al. (2021) · Archives of Medical Research · doi:10.1016/j.arcmed.2021.03.002 · Cited by 87 · see citing works
Metabolomics Signatures of Aging: Recent Advances
Adav, S. S., & Wang, Y. (2021) · Aging and Disease · doi:10.14336/ad.2020.0909 · Cited by 85 · see citing works
Bellucci, A., Bubacco, L., Longhena, F., Parrella, E., Faustini, G., Porrini, V., Bono, F., Missale, C., & Pizzi, M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00068 · Cited by 82 · see citing works
Influence of the Mediterranean Diet on Healthy Aging
Andreo-López, M. C., Contreras-Bolívar, V., Muñoz‐Torres, M., García-Fontana, B., & García‐Fontana, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054491 · Cited by 87 · see citing works
Munteanu, C., & Schwartz, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158250 · Cited by 86 · see citing works
Gut, oral and skin microbiome of Indian patrilineal families reveal perceptible association with age
Chaudhari, D. S., Dhotre, D. P., Agarwal, D. M., Gaike, A. H., Bhalerao, D., Jadhav, P., Mongad, D., Lubree, H., Sinkar, V. P., Patil, U. K., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62195-5 · Cited by 81 · see citing works
Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function
Mishra, S. P., Jain, S., Wang, B., Wang, S., Miller, B. C., Lee, J.-Y., Borlongan, C. V., Jiang, L., Pollak, J., Taraphder, S., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.168443 · Cited by 89 · see citing works
Self-citationHolmes, A., Finger, C. E., Morales‐Scheihing, D., Lee, J., & McCullough, L. D. (2020) · Translational research · doi:10.1016/j.trsl.2020.07.012 · Cited by 87 · see citing works
Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
Du, Y., Zhu, Y., Zhou, Y., Ding, J., & Liu, J. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00108-w · Cited by 82 · see citing works
- Authors
- Nagpal, R., Mainali, R., Ahmadi, S., Wang, S., Singh, R., Kavanagh, K., Kitzman, D. W., Kushugulova, A., Marotta, F., & Yadav, H.
- Affiliations
- Atrium Health Wake Forest Baptist (US)
- Wake Forest University Health Sciences (US)
- Nazarbayev University (KZ)
- ReGenera Research and Development for Aging Interventions, and San Babila Clinic, Corso Matteotti 1/A, Milano, Italy
- Corresponding author
- Yadav, Hariom
- ORCID
- Venue
- Nutrition and Healthy Aging
- Publisher
- SAGE Publications
- Published
- 2017-11-06
- Volume
- 4
- Issue
- 4
- Pages
- 267-285
- ISSN
- 2451-9480 (ISSN-L)
- 2451-9502
- PMC
- PMC6004897
- OpenAlex
- W2767624273
- Cited by
- 670
- References
- 200
- Citations by year
- 2026: 44 · 2025: 69 · 2024: 93 · 2023: 73 · 2022: 103 · 2021: 118 · 2020: 116 · 2019: 48 · 2018: 6
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nutrition and Healthy Aging (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Nazarbayev University Repository (Nazarbayev University) (submittedVersion)
- Funders
- National Institutes of Health (P30AG12232, R01AG18915)
- Wake Forest School of Medicine
- National Institute on Aging (R01AG018915, R37AG018915, P30AG021332)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, aging, microbiota-immune interactions, immune system development, infancy, probiotics, microbiota-targeted interventions, healthy aging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
