The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells
Open accessAbstract
Summary Mucosal sites such as the intestine, oral cavity, nasopharynx, and vagina all have associated commensal flora. The surface of the eye is also a mucosal site, but proof of a living, resident ocular microbiome remains elusive. Here, we used a mouse model of ocular surface disease to reveal that commensals were present in the ocular mucosa and had functional immunological consequences. We isolated one such candidate commensal, Corynebacterium mastitidis, and showed that this organism elicited a commensal‐specific interleukin‐17 response from &ggr;&dgr; T cells in the ocular mucosa that was central to local immunity. The commensal‐specific response drove neutrophil recruitment and the release of antimicrobials into the tears and protected the eye from pathogenic Candida albicans or Pseudomonas aeruginosa infection. Our findings provide direct evidence that a resident commensal microbiome exists on the ocular surface and identify the cellular mechanisms underlying its effects on ocular immune homeostasis and host defense. Graphical Abstract Figure. No Caption available. HighlightsCorynebacterium mastitidis colonizes the mouse conjunctivaC. mastitidis induces interleukin‐17 production from mucosal &ggr;&dgr; T cellsIntroduction of the commensal to mice that lack it protects the eye from infectionTopical antibiotics cause the ocular surface to be more susceptible to infection &NA; Although the eye is a mucosal site, there has been a long‐standing controversy regarding whether a resident microbiome exists on the ocular surface. St. Leger et al. show that a microorganism that lives on the conjunctiva tunes local mucosal immunity and protects the eye from pathogenic infection.
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Cites
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Six-of-the-best: unique contributions of γδ T cells to immunology
Vantourout, P., & Hayday, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3384 · Cited by 1,232
Moran, A. E., Holzapfel, K. L., Xing, Y., Cunningham, N. R., Maltzman, J. S., Punt, J., & Hogquist, K. A. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110308 · Cited by 1,034
Ishigame, H., Kakuta, S., Nagai, T., Kadoki, M., Nambu, A., Komiyama, Y., Fujikado, N., Tanahashi, Y., Akitsu, A., Kotaki, H., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.009 · Cited by 1,004 · cited 6×
“Il17a / Il17f / mice were generated at The Institute of Medical Science, University of Tokyo, as previously described (Ishigame et al., 2009) and were bred in our facility.”
InfluentialBiogeography of a human oral microbiome at the micron scale
Mark Welch, J. L., Rossetti, B. J., Rieken, C. W., Dewhirst, F. E., & Borisy, G. G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522149113 · Cited by 968
Commensal–dendritic-cell interaction specifies a unique protective skin immune signature
Naik, S., Bouladoux, N., Linehan, J. L., Han, S.-J., Harrison, O. J., Wilhelm, C., Conlan, S., Himmelfarb, S., Byrd, A. L., Deming, C., et al. (2015) · Nature · doi:10.1038/nature14052 · Cited by 820
A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes
Scharschmidt, T. C., Vasquez, K. S., Truong, H.-A., Gearty, S. V., Pauli, M. L., Nosbaum, A., Gratz, I. K., Otto, M., Moon, J. J., Liese, J., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.016 · Cited by 586
Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis
Kobayashi, T., Glatz, M., Horiuchi, K., Kawasaki, H., Akiyama, H., Kaplan, D. H., Kong, H. H., Amagai, M., & Nagao, K. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.014 · Cited by 545
Mycotic keratitis: epidemiology, diagnosis and management
Thomas, P. A., & Kaliamurthy, J. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12126 · Cited by 495
Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization
Fan, D., Coughlin, L. A., Neubauer, M. M., Kim, J., Kim, M. S., Zhan, X., Simms-Waldrip, T. R., Xie, Y., Hooper, L. V., & Koh, A. Y. (2015) · Nature Medicine · doi:10.1038/nm.3871 · Cited by 426 · cited 2×
“Antibiotic-induced dysbiosis of the intestinal microbes, specifically in Bacteroides spp., is linked to a reduction in the cathelicidin antimicrobial peptide, CRAMP (LL-37 in humans), which results in the outgrowth of intestinal Candida spp. leading to other systemic pathologies (Fan et al., 2015).”
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Ribot, J. C., Lopes, N., & Silva-Santos, B. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00452-4 · Cited by 532
Control of Immunity by the Microbiota
Ansaldo, E., Farley, T. K., & Belkaid, Y. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-112348 · Cited by 298
A Critical Role of the IL-1β–IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis
Cai, Y., Xue, F., Quan, C., Qu, M., Liu, N., Zhang, Y., Fleming, C., Hu, X., Zhang, H.-G., Weichselbaum, R., et al. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.07.025 · Cited by 292
Mechanism of the Gut Microbiota Colonization Resistance and Enteric Pathogen Infection
Khan, I., Bai, Y., Zha, L., Ullah, N., Ullah, H., Shah, S. R. H., Sun, H., & Zhang, C. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.716299 · Cited by 291
Ma, Z., Zuo, T., Frey, N., & Rangrez, A. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01946-6 · Cited by 259
Metadata
- Authors
- St. Leger, A. J., Desai, J. V., Drummond, R. A., Kugadas, A., Almaghrabi, F., Silver, P., Raychaudhuri, K., Gadjeva, M., Iwakura, Y., Lionakis, M. S., & Caspi, R. R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 47
- Issue
- 1
- Pages
- 148-158.e5
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2736162768
- Cited by
- 288
- References
- 37
- FWCI
- 24.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- St. Leger, A. J., Desai, J. V., Drummond, R. A., Kugadas, A., Almaghrabi, F., Silver, P., Raychaudhuri, K., Gadjeva, M., Iwakura, Y., Lionakis, M. S., & Caspi, R. R. (2017). An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells. Immunity. https://doi.org/10.1016/j.immuni.2017.06.014
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