The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Additionally, UNC93B1 stabilizes TLR proteins and prevents their degradation, functions that are independent of its endosomal trafficking activity (11).”
From UNC93B1 Is Widely Expressed in the Murine CNS and Is Required for Neuroinflammation and Neuronal Injury Induced by MicroRNA let-7b (2021) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cox, J., Hein, M. Y., Luber, C. A., Paron, I., Nagaraj, N., & Mann, M. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.031591 · Cited by 5,180
Roles of N-Linked Glycans in the Endoplasmic Reticulum
Helenius, A., & Aebi, M. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073752 · Cited by 2,037
Research works printed but not linked: 40
- Blasius, 2010, Intracellular toll-like receptors, Immunity, 32, 305, 10.1016/j.immuni.2010.03.012 · DOI
- Brinkmann, 2007, The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling, J. Cell Biol., 177, 265, 10.1083/jcb.200612056 · DOI · Paper page
- Carpenter, 2006, CellProfiler: image analysis software for identifying and quantifying cell phenotypes, Genome Biol., 7, R100, 10.1186/gb-2006-7-10-r100 · DOI
- Casrouge, 2006, Herpes simplex virus encephalitis in human UNC-93B deficiency, Science, 314, 308, 10.1126/science.1128346 · DOI · Paper page
- Cox, 2008, MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification, Nat. Biotechnol., 26, 1367, 10.1038/nbt.1511 · DOI · Paper page
- Cox, 2011, Andromeda: a peptide search engine integrated into the MaxQuant environment, J. Proteome Res., 10, 1794, 10.1021/pr101065j · DOI
- Davies, 2015, The future of CFTR modulating therapies for cystic fibrosis, Curr. Opin. Pulm. Med., 21, 579, 10.1097/MCP.0000000000000211 · DOI
- Fukui, 2009, Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing, J. Exp. Med., 206, 1339, 10.1084/jem.20082316 · DOI
- Fukui, 2011, Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking, Immunity, 35, 69, 10.1016/j.immuni.2011.05.010 · DOI
- Guo, 2015, SCARB2/LIMP-2 regulates IFN production of plasmacytoid dendritic cells by mediating endosomal translocation of TLR9 and nuclear translocation of IRF7, J. Immunol., 194, 4737, 10.4049/jimmunol.1402312 · DOI
- Hubner, 2010, Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions, J. Cell Biol., 189, 739, 10.1083/jcb.200911091 · DOI · Paper page
- Huh, 2014, UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5, Proc. Natl. Acad. Sci. USA, 111, 7072, 10.1073/pnas.1322838111 · DOI · Paper page
- Jo, 2013, Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes, Mol. Biol. Cell, 24, 169, 10.1091/mbc.e12-07-0564 · DOI
- Kanno, 2013, Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in an intramolecular disulfide bond, proteolytic cleavage and RNA sensing, Int. Immunol., 25, 413, 10.1093/intimm/dxt007 · DOI
- Kanno, 2015, Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases, Nat. Commun., 6, 6119, 10.1038/ncomms7119 · DOI
- Kim, 2008, UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes, Nature, 452, 234, 10.1038/nature06726 · DOI · Paper page
- Lafaille, 2012, Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells, Nature, 491, 769, 10.1038/nature11583 · DOI · Paper page
- Lee, 2013, UNC93B1 mediates differential trafficking of endosomal TLRs, eLife, 2, e00291, 10.7554/eLife.00291 · DOI · Paper page
- Lippincott-Schwartz, 2000, Secretory protein trafficking and organelle dynamics in living cells, Annu. Rev. Cell Dev. Biol., 16, 557, 10.1146/annurev.cellbio.16.1.557 · DOI
- Mancuso, 2009, Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells, Nat. Immunol., 10, 587, 10.1038/ni.1733 · DOI
- Meunier, 2015, Quantification of cytosolic vs. vacuolar salmonella in primary macrophages by differential permeabilization, J. Vis. Exp., e52960
- Murakami, 2014, Roles of the cleaved N-terminal TLR3 fragment and cell surface TLR3 in double-stranded RNA sensing, J. Immunol., 193, 5208, 10.4049/jimmunol.1400386 · DOI
- Nakano, 2010, Up-regulation of the endoplasmic reticulum transmembrane protein UNC93B in the B cells of patients with active systemic lupus erythematosus, Rheumatology (Oxford), 49, 876, 10.1093/rheumatology/keq001 · DOI
- Onji, 2013, An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing, Nat. Commun., 4, 1949, 10.1038/ncomms2949 · DOI
- Panchanathan, 2013, Expression of murine Unc93b1 is up-regulated by interferon and estrogen signaling: implications for sex bias in the development of autoimmunity, Int. Immunol., 25, 521, 10.1093/intimm/dxt015 · DOI
- Pelka, 2014, Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms, J. Immunol., 193, 3257, 10.4049/jimmunol.1301886 · DOI
- Pohar, 2013, The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists, J. Biol. Chem., 288, 442, 10.1074/jbc.M112.413922 · DOI
- Qi, 2012, Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization, J. Biol. Chem., 287, 32617, 10.1074/jbc.M112.387803 · DOI
- Rappsilber, 2007, Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips, Nat. Protoc., 2, 1896, 10.1038/nprot.2007.261 · DOI · Paper page
- Roberson, 1988, Immortalization of cloned mouse splenic macrophages with a retrovirus containing the v-raf/mil and v-myc oncogenes, Cell. Immunol., 116, 341, 10.1016/0008-8749(88)90236-5 · DOI
- Sasai, 2010, Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3, Science, 329, 1530, 10.1126/science.1187029 · DOI
- Scheltema, 2014, The Q Exactive HF, a Benchtop mass spectrometer with a pre-filter, high-performance quadrupole and an ultra-high-field Orbitrap analyzer, Mol. Cell. Proteomics, 13, 3698, 10.1074/mcp.M114.043489 · DOI
- Schmid-Burgk, 2014, OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines, Genome Res., 24, 1719, 10.1101/gr.176701.114 · DOI
- Schutze, 1994, An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum, EMBO J., 13, 1696, 10.1002/j.1460-2075.1994.tb06434.x · DOI
- Signorino, 2014, Role of Toll-like receptor 13 in innate immune recognition of group B streptococci, Infect. Immun., 82, 5013, 10.1128/IAI.02282-14 · DOI
- Tabeta, 2006, The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9, Nat. Immunol., 7, 156, 10.1038/ni1297 · DOI · Paper page
- Takahashi, 2007, A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses, J. Exp. Med., 204, 2963, 10.1084/jem.20071132 · DOI
- Tusher, 2001, Significance analysis of microarrays applied to the ionizing radiation response, Proc. Natl. Acad. Sci. USA, 98, 5116, 10.1073/pnas.091062498 · DOI · Paper page
- Valenzuela, 2003, High-throughput engineering of the mouse genome coupled with high-resolution expression analysis, Nat. Biotechnol., 21, 652, 10.1038/nbt822 · DOI
- Yang, 2007, Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages, Immunity, 26, 215, 10.1016/j.immuni.2006.12.005 · DOI · Paper page
Cited by
Sorted by citations
Toll-like Receptors and the Control of Immunity
Fitzgerald, K. A., & Kagan, J. C. (2020) · Cell · doi:10.1016/j.cell.2020.02.041 · Cited by 2,168
Inflammation and DNA damage: cause, effect or both
Pezone, A., Olivieri, F., Napoli, M. V., Procopio, A., Avvedimento, E. V., & Gabrielli, A. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00905-1 · Cited by 212
Klammer, M. G., Dzaye, O., Wallach, T., Krüger, C., Gaessler, D., Buonfiglioli, A., Derkow, K., Kettenmann, H., Brinkmann, M. M., & Lehnardt, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.715774 · Cited by 6
Self-citation
Metadata
- Authors
- Pelka, K., Bertheloot, D., Reimer, E., Phulphagar, K., Schmidt, S. V., Christ, A., Stahl, R., Watson, N., Miyake, K., Hacohen, N., Haas, A., Brinkmann, M. M., Marshak-Rothstein, A., Meissner, F., & Latz, E.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 48
- Issue
- 5
- Pages
- 911-922.e7
- ISSN
- 1074-7613
- PMC
- PMC6482051
- Cited by
- 145
- References
- 2
- Language
- en
- Licence
- Funders
- NIH (1R01AR066808-01A1)
- German Research Foundation (DFG) (SFB900, BR 3432/3-1)
- Excellence Cluster ImmunoSensation (SFB670, SFB1123, TRR83, TRR57, GRK21687, SPP1923)
- Initiative and Networking Fund of the Helmholtz Association
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport. https://app.cochat.ai/papers/10.1016/j.immuni.2018.04.011
- The paper
- Pelka, K., Bertheloot, D., Reimer, E., Phulphagar, K., Schmidt, S. V., Christ, A., Stahl, R., Watson, N., Miyake, K., Hacohen, N., Haas, A., Brinkmann, M. M., Marshak-Rothstein, A., Meissner, F., & Latz, E. (2018). The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport. Immunity. https://doi.org/10.1016/j.immuni.2018.04.011