Immune Signaling in Neurodegeneration

Cites (268)

Items 201–268 of 268

1. Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models
   Andreas Weihofen, Yuting Liu, Joseph W. Arndt, Christian Huy, Chao Quan, Benjamin A. Smith, Jean‐Luc Baeriswyl, Nicole Cavegn, Luzia Senn, Lihe Su et al. · 2018 · Neurobiology of Disease
2. Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease: A Genome-Wide Association Study
   Naj, Adam C., Jun, Gyungah, Reitz, Christiane, Kunkle, Brian W., Perry, William, Park, Yo Son, Beecham, Gary W., Rajbhandary, Ruchita A., Hamilton-Nelson, Kara L., Wang, Li-San et al. · 2014 · JAMA Neurology
3. Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
   Iris Broce, Celeste M M. Karch, Natalie Wen, Chun Chieh Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A. Ross, Günter U. Höglinger, Ulrich Müller et al. · 2018 · PLoS Medicine
4. TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
   Xiang, Xianyuan, Werner, Georg, Bohrmann, Bernd, Liesz, Arthur, Mazaheri, Fargol, Capell, Anja, Feederle, Regina, Knuesel, Irene, Kleinberger, Gernot, Haass, Christian · 2016 · EMBO Molecular Medicine
5. A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System
   Qin, Yan, Garrison, Brian S., Ma, Wenjiang, Wang, Rui, Jiang, Aiping, Li, Jing, Mistry, Meeta, Bronson, Roderick T., Santoro, Daria, Franco, Charlotte et al. · 2018 · Cell
6. Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation
   Liao, Fan, Li, Aimin, Xiong, Monica, Bien-Ly, Nga, Jiang, Hong, Zhang, Yin, Finn, Mary Beth, Hoyle, Rosa, Keyser, Jennifer, Lefton, Katheryn B. et al. · 2018 · Journal of Clinical Investigation
7. Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model
   Pereira Diniz, Luan, Tortelli, Vanessa, Matias, Isadora, Morgado, Juliana, Bérgamo Araujo, Ana Paula, Melo, Helen M., Seixas da Silva, Gisele S., Alves-Leon, Soniza V., de Souza, Jorge M., Ferreira, Sergio T. et al. · 2017 · The Journal of Neuroscience
8. Transforming growth factor-β1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson's disease
   Makio Mogi, Minoru Harada, Tomoyoshi Kondo, Hirotaro Narabayashi, Peter Franz Riederer, Toshiharu Nagatsu · 1995 · Neuroscience Letters
9. Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease
   Milber, Joshua M., Noorigian, Joseph V., Morley, James F., Petrovitch, Helen, White, Lon, Ross, G. Webster, Duda, John E. · 2012 · Neurology
10. Regulation of Microglial Phagocytosis and Inflammatory Gene Expression by Gas6 Acting on the Axl/Mer Family of Tyrosine Kinases
    Grommes, Christian, Lee, C. Y. Daniel, Wilkinson, Brandy L., Jiang, Qingguang, Koenigsknecht-Talboo, Jessica L., Varnum, Brian, Landreth, Gary E. · 2008 · Journal of Neuroimmune Pharmacology
11. Specific lipid recognition is a general feature of CD300 and TREM molecules
    John P. Cannon, Marci O’Driscoll, Gary W. Litman · 2011 · Immunogenetics
12. α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era
    Naomi P. Visanji, Jonathan M. Brotchie, Lorraine V. Kalia, James B. Koprich, Anurag Tandon, Joel C. Watts, Anthony Edward Lang · 2016 · Trends in Neurosciences
13. Amyloid-β ¹¹ C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials
    Liu, Enchi, Schmidt, Mark E., Margolin, Richard, Sperling, Reisa, Koeppe, Robert, Mason, Neale S., Klunk, William E., Mathis, Chester A., Salloway, Stephen, Fox, Nick C. et al. · 2015 · Neurology
14. Protection of TGF-β1 against Neuroinflammation and Neurodegeneration in Aβ1–42-Induced Alzheimer’s Disease Model Rats
    Chen, Jia-Hui, Ke, Kai-Fu, Lu, Jian-Hua, Qiu, Yi-Hua, Peng, Yu-Ping · 2015 · PLOS ONE
15. Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-Aβ Antibody Administration in PDAPP Mice
    Koenigsknecht-Talboo, Jessica, Meyer-Luehmann, Melanie, Parsadanian, Maia, Garcia-Alloza, Monica, Finn, Mary Beth, Hyman, Bradley T., Bacskai, Brian J., Holtzman, David M. · 2008 · The Journal of Neuroscience
16. Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease
    Giraldo, Margarita, Lopera, Francisco, Siniard, Ashley L., Corneveaux, Jason J., Schrauwen, Isabelle, Carvajal, Julian, Muñoz, Claudia, Ramirez-Restrepo, Manuel, Gaiteri, Chris, Myers, Amanda J. et al. · 2013 · Neurobiology of Aging
17. Complement activation in the Parkinson's disease substantia nigra: an immunocytochemical study.
    David A. Loeffler, Dianne M. Camp, Stephanie B. Conant · 2006 · Journal of Neuroinflammation
18. Regulation of Innate and Adaptive Immunity by TGFβ
    Aoife Kelly, Stephanie A. Houston, Eleanor Sherwood, Joshua Casulli, Mark A. Travis · 2017 · Advances in immunology
19. A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease
    Peter Holmans, Valentina Moskvina, Lesley Jones, Manu Sharma, Alexey Vedernikov, Finja Büchel, Mohamad Sadd, José Brás, Francesco Bettella, Nayia Nicolaou et al. · 2012 · Human Molecular Genetics
20. Examining the mechanisms that link β-amyloid and α-synuclein pathologies
    Samuel E. Marsh, Mathew M. Blurton-Jones · 2012 · Alzheimer s Research & Therapy
21. In Vivo Effects of ApoE and Clusterin on Amyloid-β Metabolism and Neuropathology
    David M. Holtzman · 2004 · Journal of Molecular Neuroscience
22. DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response
    Zhong, Li, Chen, Xiao-Fen, Zhang, Zhen-Lian, Wang, Zhe, Shi, Xin-Zhen, Xu, Kai, Zhang, Yun-Wu, Xu, Huaxi, Bu, Guojun · 2015 · Journal of Biological Chemistry
23. CD33/Siglec-3 Binding Specificity, Expression Pattern, and Consequences of Gene Deletion in Mice
    Els C.M. Brinkman-Van der Linden, Takashi Angata, Shirley A. Reynolds, Leland D. Powell, Stephen Μ. Hedrick, Ajit P Varki · 2003 · Molecular and Cellular Biology
24. Detection and interpretation of expression quantitative trait loci (eQTL)
    Jacob J. Michaelson, Salvatore Loguercio, Andreas Beyer · 2009 · Methods
25. Animal Models of Parkinson's Disease: Vertebrate Genetics
    Yunjong Lee, Valina Lynn Dawson, Ted M. Dawson · 2012 · Cold Spring Harbor Perspectives in Medicine
26. The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells
    Jessica A. Hamerman, Minjian Ni, Justin R Killebrew, Ching‐Liang Chu, Clifford A. Lowell · 2009 · Immunological Reviews
27. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement
    Lee, Seung-Hye, Le Pichon, Claire E., Adolfsson, Oskar, Gafner, Valérie, Pihlgren, Maria, Lin, Han, Solanoy, Hilda, Brendza, Robert, Ngu, Hai, Foreman, Oded et al. · 2016 · Cell Reports
28. Expression of complement system components during aging and amyloid deposition in APP transgenic mice
    Julia Reichwald, Simone Danner, Karl‐Heinz Wiederhold, Matthias Staufenbiel · 2009 · Journal of Neuroinflammation
29. Mutations inTREM2lead to pure early-onset dementia without bone cysts
    Éliane Chouery, Valérie Delague, Anne Bergougnoux, Salam Koussa, Jean‐Louis Serre, André Mégarbané · 2008 · Human Mutation
30. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD
    Cyril P. Pottier, Yingxue Ren, Ralph B. Perkerson, Matt C. Baker, Gregory D. Jenkins, Marka van Blitterswijk, Mariely DeJesus‐Hernandez, Jeroen van Rooij, Melissa Erin Murray, Elizabeth A. Christopher et al. · 2019 · Acta Neuropathologica
31. Complement activation in very early Alzheimer disease
    Zanjani, H, Finch, C E, Kemper, C, Atkinson, J, McKeel, D, Morris, J C, Price, J L · 2005 · Alzheimer Disease & Associated Disorders
32. TGF Signaling Regulates the Timing of CNS Myelination by Modulating Oligodendrocyte Progenitor Cell Cycle Exit through SMAD3/4/FoxO1/Sp1
    Javier Palazuelos, Michael Klingener, Adan A. Aguirre · 2014 · Journal of Neuroscience
33. Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo
    DeVos, Sarah L, Corjuc, Bianca T, Commins, Caitlin, Dujardin, Simon, Bannon, Riley N, Corjuc, Diana, Moore, Benjamin D, Bennett, Rachel E, Jorfi, Mehdi, Gonzales, Jose A et al. · 2018 · Brain
34. The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions
    Tatiana Orme, Rita João Guerreiro, José Brás · 2018 · Current Neurology and Neuroscience Reports
35. Transforming growth factor beta in Alzheimer's disease
    C C Chao, Sung Hu, William H. Frey, T A, W. W. Tourtellotte, Phillip K. Peterson · 1994 · Clinical and Diagnostic Laboratory Immunology
36. Increased cerebrospinal fluid levels of transforming growth factor-β1 in Alzheimer’s disease
    Henrik Zetterberg, Niels Andreasen, Kaj Blennow · 2004 · Neuroscience Letters
37. Tgfβ signaling regulates temporal neurogenesis and potency of neural stem cells in the CNS
    Dias, José M., Alekseenko, Zhanna, Applequist, Joanna M., Ericson, Johan · 2014 · Neuron
38. Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions
    Nadia K. Magdalinou, Andrew John Lees, Henrik Zetterberg · 2014 · Journal of Neurology Neurosurgery & Psychiatry
39. A randomized, single ascending dose study of intravenous BIIB092 in healthy participants
    Irfan Qureshi, Giridhar Tirucherai, Michael K. Ahlijanian, Gerry Kolaitis, Clifford M. Bechtold, Michael Grundman · 2018 · Alzheimer s & Dementia Translational Research & Clinical Interventions
40. Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice
    Ina C. Tesseur, Andy Nguyen, Betty Chang, Lulin Li, Nathaniel S. Woodling, Tony Wyss‐Coray, Jian Luo · 2017 · Journal of Neuroscience
41. Microglial Immunoreceptor Tyrosine-Based Activation and Inhibition Motif Signaling in Neuroinflammation
    Linnartz, Bettina, Wang, Yiner, Neumann, Harald · 2010 · International Journal of Alzheimer's Disease
42. Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s diseases
    Gagliano, Sarah A., Pouget, Jennie G., Hardy, John, Knight, Jo, Barnes, Michael R., Ryten, Mina, Weale, Michael E. · 2016 · Annals of Clinical and Translational Neurology
43. All (animal) models (of neurodegeneration) are wrong. Are they also useful?
    Richard M. Ransohoff · 2018 · The Journal of Experimental Medicine
44. TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway
    Caraci, Filippo, Battaglia, Giuseppe, Busceti, Carla, Biagioni, Francesca, Mastroiacovo, Federica, Bosco, Paolo, Drago, Filippo, Nicoletti, Ferdinando, Sortino, Maria Angela, Copani, Agata · 2008 · Neurobiology of Disease
45. Molecular Genetics of Neurodegenerative Dementias
    Flora I. Hinz, Daniel H. Geschwind · 2016 · Cold Spring Harbor Perspectives in Biology
46. Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease
    Lalli, M A, Bettcher, B M, Arcila, M L, Garcia, G, Guzman, C, Madrigal, L, Ramirez, L, Acosta-Uribe, J, Baena, A, Wojta, K J et al. · 2015 · Molecular Psychiatry
47. Mice deficient in NRROS show abnormal microglial development and neurological disorders
    Wong, Kit, Noubade, Rajkumar, Manzanillo, Paolo, Ota, Naruhisa, Foreman, Oded, Hackney, Jason A, Friedman, Brad A, Pappu, Rajita, Scearce-Levie, Kimberly, Ouyang, Wenjun · 2017 · Nature Immunology
48. The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer’s disease
    Alzheimer’s Disease Neuroimaging Initiative, Luke W. Bonham, Rahul S. Desikan, Jennifer S. Yokoyama · 2016 · Acta Neuropathologica Communications
49. A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease
    AESG, Daniela Hartl, Patrick May, Wei Gu, Manuel Mayhaus, Sabrina Pichler, Christian Spaniol, Enrico Glaab, Dheeraj Reddy Bobbili, Paul M. A. Antony et al. · 2018 · Molecular Psychiatry
50. Relation of genomic variants for Alzheimer disease dementia to common neuropathologies
    Farfel, Jose M., Yu, Lei, Buchman, Aron S., Schneider, Julie A., De Jager, Philip L., Bennett, David A. · 2016 · Neurology
51. Gene-based association studies report genetic links for clinical subtypes of frontotemporal dementia
    Aniket Mishra, Raffaele Ferrari, Peter Heutink, John Hardy, Yolande A.L. Pijnenburg, Daniëlle Posthuma · 2017 · Brain
52. Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup
    Woollacott, Ione O. C., Nicholas, Jennifer M., Heslegrave, Amanda, Heller, Carolin, Foiani, Martha S., Dick, Katrina M., Russell, Lucy L., Paterson, Ross W., Keshavan, Ashvini, Fox, Nick C. et al. · 2018 · Alzheimer's Research & Therapy
53. TGF-β1 promotes cerebral cortex radial glia-astrocyte differentiation in vivo
    Joice Stipursky, Daniel Francis, Rômulo Sperduto Dezonne, Ana Paula Bérgamo de AraÃojo, Lays Souza, Carolina A. Moraes, Flávia Carvalho Alcântara Gomes · 2014 · Frontiers in Cellular Neuroscience
54. The key role of T cells in Parkinson's disease pathogenesis and therapy
    Jill K. Baird, DENNIS N. BOURDETTE, Charles K. Meshul, Joseph F. Quinn · 2018 · Parkinsonism & Related Disorders
55. The AXL Receptor Is a Sensor of Ligand Spatial Heterogeneity
    Aaron S. Meyer, Annelien J.M. Zweemer, Douglas A. Lauffenburger · 2015 · Cell Systems
56. Review: Fluid biomarkers for frontotemporal dementias
    Zetterberg, H., van Swieten, J. C., Boxer, A. L., Rohrer, J. D. · 2019 · Neuropathology and Applied Neurobiology
57. The FAM3 superfamily member ILEI ameliorates Alzheimer’s disease-like pathology by destabilizing the penultimate amyloid-β precursor
    Hiroshi Hasegawa, Lei Liu, Ikuo Tooyama, Shigeo Murayama, Masaki Nishimura · 2014 · Nature Communications
58. Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease
    Candan Depboylu, Kathrin Schorlemmer, Martin Klietz, Wolfgang Hermann Oertel, Eberhard Weihe, Günter U. Höglinger, Martin K.-H. Schäfer · 2011 · Journal of Neuroimmunology
59. Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)
    Konstantin Glebov, Patrick Wunderlich, Ilker Karaca, Jochen Walter · 2016 · Journal of Neuroinflammation
60. Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1
    Jenny U. Johansson, William D. Brubaker, Harold S. Javitz, Andrew W. Bergen, Denise Nishita, Abhishek Trigunaite, Andrés Crane, Justine Ceballos, Diego Mastroeni, Andrea J. Tenner et al. · 2018 · Alzheimer s & Dementia
61. APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice
    Pankiewicz, Joanna E, Baquero-Buitrago, Jairo, Sanchez, Sandrine, Lopez-Contreras, Jennifer, Kim, Jungsu, Sullivan, Patrick M., Holtzman, David M., Sadowski, Martin J. · 2017 · Molecular Neurodegeneration
62. The Microglial Response to Neurodegenerative Disease
    Wilbur M. Song, Marco Colonna · 2018 · Advances in immunology
63. Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer’s Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ 42 Load
    Joyce R. Chong, Yuek Ling Chai, Jasinda H. Lee, David Howlett, Johannes Attems, Clive G. Ballard, Dag Aarsland, Paul T. Francis, Christopher P. Chen, Mitchell K.P. Lai · 2016 · Journal of Alzheimer s Disease
64. Trans -pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci
    Gail Chan, Charles C. White, Phoebe A. Winn, Maria Cimpean, Joseph M. Replogle, Laura R. Glick, Nicole Cuerdon, Katie J. Ryan, Keith A. Johnson, Julie A. Schneider et al. · 2016 · Neurology Genetics
65. Complement 3-deficient mice are not protected against MPTP-induced dopaminergic neurotoxicity
    Yajie Liang, Shurong Li, Qiang Guo, Yanliang Zhang, Can Wen, Qiang Zou, Bingyin Su · 2007 · Brain Research
66. CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson’s disease
    Rudy J. Castellani, Summer L. Nugent, Alan L. Morrison, Xiongwei Zhu, Hyoung‐gon Lee, Peggy L.R. Harris, Vladan Bajić, Hari Shanker Sharma, Shu G. Chen, Peter Oettgen et al. · 2010 · Journal of Neural Transmission
67. Overview of Mouse Models of Parkinson's Disease
    Wojciech Bobela, Lu Zheng, Bernard Laurent Schneider · 2014 · Current Protocols in Mouse Biology
68. Untitled work
    Cole · 2000 · 10.1002/1097-0029(20000815)50:4