Review: Fluid biomarkers for frontotemporal dementias
Abstract
Frontotemporal dementias (FTDs) are clinically, genetically and pathologically heterogeneous neurodegenerative disorders that affect the frontal and anterior temporal lobes of the brain. They are relatively common causes of young-onset dementia and usually present with behavioural disturbance (behavioural variant FTD) or language impairment (primary progressive aphasia), but there is also overlap with motor neurone disease and the atypical parkinsonian disorders, corticobasal syndrome and progressive supranuclear palsy. At post mortem, neuronal inclusions containing tau, TDP-43 or infrequently FUS protein are seen in most cases. However, a poor correlation between clinical syndrome and underlying pathology means that it is difficult to diagnose the underlying molecular basis using clinical criteria. At this point, biomarkers for the underlying pathology come into play. This paper provides a brief update on fluid biomarkers for FTDs that may be useful to dissect the underlying molecular changes in patients presenting with signs of frontal and/or temporal lobe dysfunction. The hope is that such biomarkers, together with genetics and imaging, would be useful in clinical trials of novel drug candidates directed against specific pathologies and, in the long run, helpful in clinical practice to select the most appropriate treatment at the right dose for individual patients.
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Clinical diagnosis of each FTD variant requires high levels of expertise and multidisciplinary teams to distinguish among subtle phenotypes with similar underlying physiopathological processes.
“In particular, the clinical diagnosis of each frontotemporal dementia (FTD) variant requires high levels of expertise and multidisciplinary teams to distinguish among subtle phenotypes with similar underlying physiopathological processes (Bejanin et al., 2020; Staffaroni et al., 2019; Zetterberg et al., 2019).”
From Multiclass characterization of frontotemporal dementia variants via multimodal brain network computational inference (2023) · cites this paper as Zetterberg et al., 2019
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- Authors
- Zetterberg, H., van Swieten, J. C., Boxer, A. L., & Rohrer, J. D.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Department of Neurology Erasmus Medical Center Rotterdam The Netherlands
- University of California, San Francisco (US)
- UCL Queen Square Institute of Neurology (GB)
- Corresponding author
- Zetterberg, H.
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 2018-12-03
- Volume
- 45
- Issue
- 1
- Pages
- 81-87
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W2901302121
- Cited by
- 48
- References
- 54
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 9
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropathology and Applied Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Vetenskapsrådet
- H2020 European Research Council
- Knut och Alice Wallenbergs Stiftelse
- Wellcome Trust
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (733050811, 733050813)
- Alzheimer Nederland
- National Institutes of Health (R01AG038791, U54NS092089)
- University of California
- Bristol-Myers Squibb
- Eli Lilly and Company
- Genentech
- Medical Research Council (MR/M008525/1)
- National Institute on Handicapped Research (BRC149/NS/MH)
- Alzheimer’s Research UK
- Brain Research Trust
- Wolfson Foundation
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- frontotemporal dementia, fluid biomarkers, tau protein, TDP-43, FUS, behavioral variant frontotemporal dementia, primary progressive aphasia, corticobasal syndrome, progressive supranuclear palsy, motor neuron disease, neurodegeneration, clinical trials, personalized treatment
- MeSH terms
- Humans, Biomarkers, Frontotemporal Dementia
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