DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response

Inflammation and Alzheimer’s disease

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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<i>TREM2</i> Variants in Alzheimer's Disease

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Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

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Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

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Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2

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TREM-1 amplifies inflammation and is a crucial mediator of septic shock

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Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

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TREMs in the immune system and beyond

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Cutting Edge: TREM-2 Attenuates Macrophage Activation

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Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype

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Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

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A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

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Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

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Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12

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TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue Debris Clearance and Facilitate Recovery in an Animal Model of Multiple Sclerosis

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TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

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Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

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An immortalized cell line expresses properties of activated microglial cells

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Heterogeneous expression of the triggering receptor expressed on myeloid cells‐2 on adult murine microglia

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DAP10‐ and DAP12‐associated receptors in innate immunity

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Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12

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Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage

Wunderlich, P., Glebov, K., Kemmerling, N., Tien, N. T., Neumann, H., & Walter, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.517540 · Cited by 296 · see citing works

<i>TREM2</i>Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

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Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease

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The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

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CNS manifestations of Nasu–Hakola disease

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The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function

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Immunotherapy for Alzheimer’s disease: hoops and hurdles

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Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

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Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

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TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

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Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia

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TREM2 is associated with the risk of Alzheimer's disease in Spanish population

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TREM2 R47H Variant as a Risk Factor for Early-Onset Alzheimer's Disease

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Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression

Zhang, Y., Wang, R., Liu, Q., Zhang, H., Liao, F., & Xu, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703903104 · Cited by 150 · see citing works

DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis

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SQSTM1 mutations in Han Chinese populations with sporadic amyotrophic lateral sclerosis

Chen, Y., Zheng, Z., Chen, X., Huang, R., Yang, Y., Yuan, L., Pan, L., Hadano, S., & Shang, H. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.008 · Cited by 60 · see citing works

Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: Continuous shuttling to and from the plasma membrane regulated by cell stimulation

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Presenilins and γ-Secretase Inhibitors Affect Intracellular Trafficking and Cell Surface Localization of the γ-Secretase Complex Components

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γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer’s Disease

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TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

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TREM2 — a key player in microglial biology and Alzheimer disease

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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

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New insights into the role of TREM2 in Alzheimer’s disease

Gratuze, M., Leyns, C. E. G., & Holtzman, D. M. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0298-9 · Cited by 489 · see citing works

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model

Zhong, L., Xu, Y., Zhuo, R., Wang, T., Wang, K., Huang, R., Wang, D., Gao, Y., Zhu, Y., Sheng, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09118-9 · Cited by 371 · see citing works

Immune Signaling in Neurodegeneration

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The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

Bailey, C. C., DeVaux, L. B., & Farzan, M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.677286 · Cited by 303 · see citing works

TREM2-Ligand Interactions in Health and Disease

Kober, D. L., & Brett, T. J. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.04.004 · Cited by 284 · see citing works

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

Sayed, F. A., Telpoukhovskaia, M., Kodama, L., Li, Y., Zhou, Y., Le, D., Hauduc, A., Ludwig, C., Gao, F., Clelland, C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811411115 · Cited by 229 · see citing works

Alzheimer’s disease as an inflammatory disease

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<i>Trem2</i> promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

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TREM2 dependent and independent functions of microglia in Alzheimer’s disease

Hou, J., Chen, Y., Grajales-Reyes, G., & Colonna, M. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00588-y · Cited by 191 · see citing works

TREM2 in CNS homeostasis and neurodegenerative disease

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TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

Jiang, T., Zhang, Y.-D., Chen, Q., Gao, Q., Zhu, X.-C., Zhou, J.-S., Shi, J.-Q., Lu, H., Tan, L., & Yu, J.-T. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.01.028 · Cited by 176 · see citing works

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

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Imbalance of microglial TLR4/TREM2 in LPS-treated APP/PS1 transgenic mice: a potential Link between Alzheimer's disease and systemic inflammation

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Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

Yao, H., Coppola, K., Schweig, J. E., Crawford, F., Mullan, M., & Paris, D. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00457 · Cited by 110 · see citing works

G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer’s disease

Desale, S. E., Chidambaram, H., & Chinnathambi, S. (2021) · Molecular Biomedicine · doi:10.1186/s43556-021-00036-1 · Cited by 99 · see citing works

Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

Terzioglu, G., & Young-Pearse, T. L. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00674-9 · Cited by 95 · see citing works

Vps35-dependent recycling of Trem2 regulates microglial function

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Microglia communication: parallels between aging and Alzheimer's disease

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A 25-gene classifier predicts overall survival in resectable pancreatic cancer

Birnbaum, D. J., Finetti, P., Lopresti, A., Gilabert, M., Poizat, F., Raoul, J.-L., Delpero, J.-R., Moutardier, V., Birnbaum, D., Mamessier, E., et al. (2017) · BMC Medicine · doi:10.1186/s12916-017-0936-z · Cited by 51 · see citing works

A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells

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TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function

Cheng, Q., Danao, J., Talreja, S., Wen, P. H., Yin, J., Sun, N., Li, C.-M., Chui, D., Tran, D. T., Koirala, S., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.001848 · Cited by 129 · see citing works

TREM2 enables amyloid β clearance by microglia.

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Decision letter for "Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age- and Sex-Dependent Musculoskeletal Alterations in Mice"

(2022) · doi:10.1002/jbmr.4572/v1/decision1

Decision letter for "Role of Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) in Neurodegenerative Dementias"

(2021) · doi:10.1111/ejn.15215/v2/decision1

Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma

Peshoff, M., Gupta, P., Oberai, S., Trivedi, R., Katayama, H. G., Chakrapani, P., Dang, M., Migliozzi, S., Gumin, J., Kadri, D. B., et al. (2024) · Neuro-Oncology · doi:10.1093/neuonc/noad257 · Cited by 57 · see citing works