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In vivo effects: Methodologies and biokinetics of inhaled nanomaterials

Oberdörster, Günter, Kuhlbusch, Thomas A.J.·2018·NanoImpact
DOI 10.1016/j.impact.2017.10.007
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Fig. 3 Estimation of chronic NOAEC from subchronic rodent study using MPPD modelling of experimentally determined subchronic NOAEC and associated NOAEL. (Modi fi ed from Oberdörster, 2002.)
Fig. 3 Estimation of chronic NOAEC from subchronic rodent study using MPPD modelling of experimentally determined subchronic NOAEC and associated NOAEL. (Modi fi ed from Oberdörster, 2002.)CC-BY-NC-ND · From the PDF
Fig. 4 Examples of cell-free (acellular) assays determining ROS activity.
Fig. 4 Examples of cell-free (acellular) assays determining ROS activity.CC-BY-NC-ND · From the PDF
Image 6
CC-BY-NC-ND · From the PDF
Fig. 6 Correlation of in vivo pulmonary in fl ammation and cell-free in vitro ROS activity expressed per unit particle surface.
Fig. 6 Correlation of in vivo pulmonary in fl ammation and cell-free in vitro ROS activity expressed per unit particle surface.CC-BY-NC-ND · From the PDF
Fig. 7 ROS/cm 2 response of anatase TiO2 in cell free assay as function of particle size showing that the surface reactivity can be size-dependent.
Fig. 7 ROS/cm 2 response of anatase TiO2 in cell free assay as function of particle size showing that the surface reactivity can be size-dependent.CC-BY-NC-ND · From the PDF
Image 9
CC-BY-NC-ND · From the PDF
Fig. 9 Determinants of pulmonary biopersistence of inhaled particles.
Fig. 9 Determinants of pulmonary biopersistence of inhaled particles.CC-BY-NC-ND · From the PDF
Image 11
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Concept: The same normalized retained lung dose in rats after acute, subchronic or chronic inhalation of poorly soluble particles is reached by humans exposed to the HEC. Effects may be different for both species.
Concept: The same normalized retained lung dose in rats after acute, subchronic or chronic inhalation of poorly soluble particles is reached by humans exposed to the HEC. Effects may be different for both species.CC-BY-NC-ND · From the PDF
Fig. 12 Approach for deriving ρ e ff in vivo using a 4-h rat inhalation study with aerosols of agglomerated/aggregated nanoparticles.
Fig. 12 Approach for deriving ρ e ff in vivo using a 4-h rat inhalation study with aerosols of agglomerated/aggregated nanoparticles.CC-BY-NC-ND · From the PDF
Fig. 13 Concept of estimating in vivo dissolution of NPs: Accumulation in rat lungs of inhaled SiO2 NPs established in 4-week inhalation study; (4 h/day; 5 days/week; 4 weeks; conc 4.6 mg/m 3 ; MMAD = 0.49 μ m; GSD = 1.91); comparison to modelled accumulation of inhaled PSP with same aerosol and exposure characteristics. The di ff erence in clearance rates between SiO2 and PSP is due to dissolution of SiO2 NPs.
Fig. 13 Concept of estimating in vivo dissolution of NPs: Accumulation in rat lungs of inhaled SiO2 NPs established in 4-week inhalation study; (4 h/day; 5 days/week; 4 weeks; conc 4.6 mg/m 3 ; MMAD = 0.49 μ m; GSD = 1.91); comparison to modelled accumulation of inhaled PSP with same aerosol and exposure characteristics. The di ff erence in clearance rates between SiO2 and PSP is due to dissolution of SiO2 NPs.CC-BY-NC-ND · From the PDF
Fig. 14 Approach for comparative hazard and risk characterization of inhaled nanoparticles based on subchronic (3 months) rat inhalation studies. NOAEL : no observed adverse effect level ; BMD : benchmark dose ; OEL : occupational exposure level ; ATS : alternative testing strategy .
Fig. 14 Approach for comparative hazard and risk characterization of inhaled nanoparticles based on subchronic (3 months) rat inhalation studies. NOAEL : no observed adverse effect level ; BMD : benchmark dose ; OEL : occupational exposure level ; ATS : alternative testing strategy .CC-BY-NC-ND · From the PDF
Fig. 15 In vitro -in vivo dosimetric extrapolation in nanotoxicology for respiratory tract exposures (modi fi ed from Oberdörster et al., 2015). VCM: Volumetric Centrifugation Method (DeLoid et al., 2014). ISDD: In vitro Sedimentation, Di ff usion, Dosimetry: (Hinderliter et al., 2010), DG: Distorted Grid (soluble): (DeLoid et al., 2015), MPPD: Multiple Path Particle Dosimetry: (Miller et al., 2016).
Fig. 15 In vitro -in vivo dosimetric extrapolation in nanotoxicology for respiratory tract exposures (modi fi ed from Oberdörster et al., 2015). VCM: Volumetric Centrifugation Method (DeLoid et al., 2014). ISDD: In vitro Sedimentation, Di ff usion, Dosimetry: (Hinderliter et al., 2010), DG: Distorted Grid (soluble): (DeLoid et al., 2015), MPPD: Multiple Path Particle Dosimetry: (Miller et al., 2016).CC-BY-NC-ND · From the PDF
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Metadata

Authors
Oberdörster, G., & Kuhlbusch, T. A. J.
Venue
NanoImpact
Publisher
Elsevier BV
Published
2018-04
Volume
10
Pages
38-60
ISSN
2452-0748
DOI
10.1016/j.impact.2017.10.007
Cited by
88
References
6
Language
en
Licence
Funders
EU H2020 (646325)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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