Reproducibility: Respect Your Cells!
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There is currently an absence of a culture of enhancing standards for environmental control, monitoring, and reporting in biomedical research.
“The task of enhancing standards for environmental control, monitoring, and reporting in biomedical research may initially seem overwhelming provided the current absence of a culture to this end (Collins and Tabak, 2014; Baker, 2016; Hunter, 2017).”
From Toward Best Practices for Controlling Mammalian Cell Culture Environments (2022) · cites this paper as Baker, 2016
Existing recommendations that aim to increase the relevance of in vitro cultures to in vivo physiology are available for many of these factors.
“For many of these factors, existing recommendations that aim to increase the relevance of in vitro cultures to in vivo physiology are available (Baker, 2016; Muelas et al., 2018; Hirsch and Schildknecht, 2019).”
From Toward Best Practices for Controlling Mammalian Cell Culture Environments (2022) · cites this paper as Baker, 2016
Increased batch-to-batch reproducibility may in the long term reduce the waste of resources associated with irreproducible experiments.
“Importantly however, even if the cost of a defined non‐animal derived ingredient is higher per purchase, one should consider that increased batch‐to‐batch reproducibility may in the long term reduce the waste of resources associated with irreproducible experiments [31].”
From A worldwide survey on the use of animal‐derived materials and reagents in scientific experimentation (2022) · cites this paper as [31]
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One score to rule them all: severity assessment in laboratory micePreprint
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- Authors
- Baker, M.
- Corresponding author
- Baker, Monya
- Venue
- Nature
- Published
- 2016-09-14
- Volume
- 537
- Issue
- 7620
- Pages
- 433-435
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2520227768
- Cited by
- 145
- References
- 7
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 11 · 2023: 22 · 2022: 21 · 2021: 13 · 2020: 13 · 2019: 6 · 2018: 10 · 2017: 10
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Social Sciences › Decision Sciences › Information Systems and Management › Scientific Computing and Data Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Keywords
- reproducibility, cell culture, experimental replication, batch-to-batch variation, serum, growth plate
- MeSH terms
- Animals, Cattle, Cell Line, Culture Media, Female, Humans, Pregnancy, Quality Control, Research Design, Reproducibility of Results, Artifacts, Culture Media, Serum-Free, Muscle Fibers, Skeletal, Cell Culture Techniques, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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