Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolism

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479 · see citing works

Ghrelin induces adiposity in rodents

Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949 · see citing works

A role for ghrelin in the central regulation of feeding

Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443 · cited 6× · see citing works

A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans

Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940 · see citing works

Ghrelin: Structure and Function

Kojima, M., & Kangawa, K. (2005) · Physiological Reviews · doi:10.1152/physrev.00012.2004 · Cited by 2,810 · see citing works

Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.

Cummings, D., Weigle, D., Frayo, R. S., Breen, P. A., Ma, M. K., Dellinger, E., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,499 · see citing works

Ghrelin enhances appetite and increases food intake in humans

Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494 · see citing works

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356 · see citing works

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

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Circulating Ghrelin Levels Are Decreased in Human Obesity

Tschöp, M. H., Weyer, C., Tataranni, P. A., Devanarayan, V., Ravussin, É., & Heiman, M. L. (2001) · Diabetes · doi:10.2337/diabetes.50.4.707 · Cited by 1,992 · see citing works

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881 · see citing works

The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion

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The role of neuropeptide Y in the antiobesity action of the obese gene product

Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498 · see citing works

Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion.

Shiiya, T., Nakazato, M., Mizuta, M., Date, Y., Mondal, M. S., Tanaka, M., Nozoe, S., Hosoda, H., Kangawa, K., & Matsukura, S. (2002) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.87.1.8129 · Cited by 1,390 · see citing works

Stomach Is a Major Source of Circulating Ghrelin, and Feeding State Determines Plasma Ghrelin-Like Immunoreactivity Levels in Humans

Ariyasu, H., Takaya, K., Tagami, T., Ogawa, Y., Hosoda, K., Akamizu, T., Suda, M., Koh, T., Natsui, K., Toyooka, S., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7885 · Cited by 1,282 · see citing works

Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human*

Giustina, A., & Veldhuis, J. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0353 · Cited by 1,253 · see citing works

Ghrelin causes hyperphagia and obesity in rats.

Wren, A., Small, C., Abbott, C., Dhillo, W., Seal, L., Cohen, M., Batterham, R., Taheri, S., Stanley, S., Ghatei, M., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2540 · Cited by 1,197 · see citing works

Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.

Guan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185 · see citing works

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in <i>ob/ob</i> Mice

Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Woods, S. C., Seeley, R. J., et al. (1996) · Diabetes · doi:10.2337/diab.45.4.531 · Cited by 904 · cited 1× · see citing works

Ghrelin Strongly Stimulates Growth Hormone Release in Humans

Takaya, K., Ariyasu, H., Kanamoto, N., Iwakura, H., Yoshimoto, A., Harada, M., Mori, K., Komatsu, Y., Usui, T., Shimatsu, A., et al. (2000) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.85.12.7167 · Cited by 864 · cited 1× · see citing works

Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

Shintani, M., Ogawa, Y., Ebihara, K., Aizawa‐Abe, M., Miyanaga, F., Takaya, K., Hayashi, T., Inoue, G., Hosoda, K., Kojima, M., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.2.227 · Cited by 849 · see citing works

Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor

Sun, Y., Wang, P., Zheng, H., & Smith, R. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305930101 · Cited by 743 · see citing works

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT

Baldanzi, G., Filigheddu, N., Cutrupi, S., Catapano, F., Bonissoni, S., Fubini, A., Malan, D., Baj, G., Granata, R., Broglio, F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200207165 · Cited by 724 · see citing works

Orexigenic Action of Peripheral Ghrelin Is Mediated by Neuropeptide Y and Agouti-Related Protein

Chen, H. Y., Trumbauer, M. E., Chen, A. S., Weingarth, D. T., Adams, J. R., Frazier, E. G., Shen, Z., Marsh, D. J., Feighner, S. D., Guan, X.-M., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1596 · Cited by 667 · see citing works

Mice lacking ghrelin receptors resist the development of diet-induced obesity

Zigman, J. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26002 · Cited by 654 · see citing works

Deletion of Ghrelin Impairs neither Growth nor Appetite

Sun, Y., Ahmed, S., & Smith, R. G. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.7973-7981.2003 · Cited by 644 · see citing works

Elevated plasma ghrelin levels in Prader–Willi syndrome

Cummings, D. E., Clément, K., Purnell, J., Vaisse, C., Foster, K. E., Frayo, R. S., Schwartz, M., Basdevant, A., & Weigle, D. (2002) · Nature Medicine · doi:10.1038/nm0702-643 · Cited by 622 · see citing works

Chronic Central Infusion of Ghrelin Increases Hypothalamic Neuropeptide Y and Agouti-Related Protein mRNA Levels and Body Weight in Rats

Kamegai, J., Tamura, H., Shimizu, T., Ishii, S., Sugihara, H., & Wakabayashi, I. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2438 · Cited by 609 · see citing works

Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat

Willesen, M. G., Kristensen, P., & Rømer, J. (1999) · Neuroendocrinology · doi:10.1159/000054491 · Cited by 605 · see citing works

Ghrelin?a hormone with multiple functions

Korbonits, M. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.03.002 · Cited by 593 · see citing works

Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues

Cummings, D. E., Frayo, R. S., Marmonier, C., Aubert, R., & Chapelot, D. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00582.2003 · Cited by 528 · see citing works

Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects.

Faraj, M., Havel, P., Phélis, S., Blank, D., Sniderman, A., & Cianflone, K. (2003) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2002-021309 · Cited by 520 · see citing works

High constitutive signaling of the ghrelin receptor–identification of a potent inverse agonist

Holst, B., Cygankiewicz, A., Jensen, T. H., Ankersen, M., & Schwartz, T. W. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0069 · Cited by 515 · see citing works

Effects of Ghrelin Administration on Left Ventricular Function, Exercise Capacity, and Muscle Wasting in Patients With Chronic Heart Failure

Nagaya, N., Moriya, J., Yasumura, Y., Uematsu, M., Ono, F., Shimizu, W., Ueno, K., Kitakaze, M., Miyatake, K., & Kangawa, K. (2004) · Circulation · doi:10.1161/01.cir.0000149746.62908.bb · Cited by 488 · see citing works

Antagonism of ghrelin receptor reduces food intake and body weight gain in mice

Asakawa, A., Inui, A., Kaga, T., Katsuura, G., Fujimiya, M., Fujino, M. A., & Kasuga, M. (2003) · Gut · doi:10.1136/gut.52.7.947 · Cited by 473 · see citing works

Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference

Wortley, K. E., Anderson, K. D., García, K., Murray, J. D., Malinova, L., Liu, R., Moncrieffe, M., Thabet, K., Cox, H. J., Yancopoulos, G. D., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402763101 · Cited by 471 · see citing works

Ghrelin action in the brain controls adipocyte metabolism

Theander-Carrillo, C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25811 · Cited by 465 · see citing works

Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway

Toshinai, K., Date, Y., Murakami, N., Shimada, M., Mondal, M. S., Shimbara, T., Guan, J., Wang, Q., Funahashi, H., Sakurai, T., et al. (2003) · Endocrinology · doi:10.1210/en.2002-220788 · Cited by 462 · see citing works

Ghrelin Increases Energy Intake in Cancer Patients with Impaired Appetite: Acute, Randomized, Placebo-Controlled Trial

Neary, N. M., Small, C. J., Wren, A., Lee, J. L., Druce, M. R., Palmieri, C., Frost, G. S., Ghatei, M. A., Coombes, R. C., & Bloom, S. R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031768 · Cited by 456 · see citing works

Acute Central Ghrelin and GH Secretagogues Induce Feeding and Activate Brain Appetite Centers

Lawrence, C. B., Snape, A. C., Baudoin, F., & Luckman, S. M. (2002) · Endocrinology · doi:10.1210/endo.143.1.8561 · Cited by 436 · see citing works

Effects of Roux-en-Y Gastric Bypass Surgery on Fasting and Postprandial Concentrations of Plasma Ghrelin, Peptide YY, and Insulin

Korner, J., Bessler, M., Cirilo, L. J., Conwell, I. M., Daud, A., Restuccia, N. L., & Wardlaw, S. L. (2005) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-1076 · Cited by 417 · see citing works

Ghrelin and Des-Octanoyl Ghrelin Promote Adipogenesis Directly in Vivo by a Mechanism Independent of the Type 1a Growth Hormone Secretagogue Receptor

Thompson, N. M., Gill, D. A. S., Davies, R., Loveridge, N., Houston, P. A., Robinson, I. C. A. F., & Wells, T. (2003) · Endocrinology · doi:10.1210/en.2003-0899 · Cited by 415 · see citing works

Ghrelin increases food intake in obese as well as lean subjects

Druce, M. R., Wren, A., Park, A. J., Milton, J. E., Patterson, M., Frost, G. S., Ghatei, M. A., Small, C. J., & Bloom, S. R. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803001 · Cited by 393 · see citing works

Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity

Yıldız, B. O., Suchard, M. A., Wong, M., McCann, S. M., & Licinio, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403465101 · Cited by 385 · see citing works

Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans

Arvat, E., Vito, L. D., Broglio, F., Papotti, M. G., Muccioli, G., Diéguez, C., Casanueva, F. F., Deghenghi, R., Camanni, F., & Ghigo, E. (2000) · Journal of Endocrinological Investigation · doi:10.1007/bf03343763 · Cited by 384 · see citing works

Minireview: From Anorexia to Obesity—The Yin and Yang of Body Weight Control

Zigman, J. M., & Elmquist, J. K. (2003) · Endocrinology · doi:10.1210/en.2003-0241 · Cited by 375 · see citing works

Des-Acyl Ghrelin Induces Food Intake by a Mechanism Independent of the Growth Hormone Secretagogue Receptor

Toshinai, K., Yamaguchi, H., Sun, Y., Smith, R. G., Yamanaka, A., Sakurai, T., Date, Y., Mondal, M. S., Shimbara, T., Kawagoe, T., et al. (2006) · Endocrinology · doi:10.1210/en.2005-1357 · Cited by 375 · see citing works

Absence of ghrelin protects against early-onset obesity

Wortley, K. E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26003 · Cited by 375 · see citing works

Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice.

Sun, Y.-X., Asnicar, M., Saha, P., Chan, L., & Smith, R. G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.004 · Cited by 368 · see citing works

Purification and Characterization of Rat des-Gln14-Ghrelin, a Second Endogenous Ligand for the Growth Hormone Secretagogue Receptor

Hosoda, H., Kojima, M., Matsuo, H., & Kangawa, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002784200 · Cited by 362 · see citing works

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

Pantel, J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25303 · Cited by 358 · see citing works

Systemic Administration of Ghrelin Induces Fos and Egr‐1 Proteins in the Hypothalamic Arcuate Nucleus of Fasted and Fed Rats

Hewson, A. K., & Dickson, S. L. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00584.x · Cited by 357 · see citing works

Balance in Ghrelin and Leptin Plasma Levels in Anorexia Nervosa Patients and Constitutionally Thin Women

Tolle, V., Kadem, M., Bluet‐Pajot, M., Frère, D., Foulon, C., Bossu, C., Dardennes, R. M., Mounier, C., Zizzari, P., Lang, F., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020645 · Cited by 355 · see citing works

High Circulating Ghrelin: A Potential Cause for Hyperphagia and Obesity in Prader-Willi Syndrome

DelParigi, A., Tschöp, M. H., Heiman, M. L., Salbe, A. D., de Courten, B. V., Sell, S. M., Bunt, J. C., & Tataranni, P. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020871 · Cited by 348 · see citing works

A Nonpeptidyl Growth Hormone Secretagogue

Smith, R. G., Cheng, K., Schoen, W. R., Pong, S., Hickey, G. J., Jacks, T., Butler, B., CHAN, W. W.-S., Chaung, L. Y., Judith, F. R., et al. (1993) · Science · doi:10.1126/science.8503009 · Cited by 341 · see citing works

Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites.

Vriese, C. D., Grégoire, F., Lema-Kisoka, R., Waelbroeck, M., Robberecht, P., & Delporte, C. (2004) · Endocrinology · doi:10.1210/en.2004-0569 · Cited by 322 · see citing works

Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety

Borg, C.-M., le Roux, C. W., Ghatei, M. A., Bloom, S. R., Patel, A. G., & Aylwin, S. J. B. (2006) · British journal of surgery · doi:10.1002/bjs.5227 · Cited by 318 · see citing works

Postprandial Suppression of Plasma Ghrelin Level Is Proportional to Ingested Caloric Load but Does Not Predict Intermeal Interval in Humans

Callahan, H. S., Cummings, D. E., PEPE, M. S., Breen, P. A., Matthys, C. C., & Weigle, D. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031267 · Cited by 317 · see citing works

Ghrelin and Adipose Tissue Regulatory Peptides: Effect of Gastric Bypass Surgery in Obese Humans

Holdstock, C., Engström, B. E., Öhrvall, M., Lind, L., Sundbom, M., & Karlsson, F. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021734 · Cited by 315 · see citing works

Ultradian Rhythmicity of Ghrelin Secretion in Relation with GH, Feeding Behavior, and Sleep-Wake Patterns in Rats

Tolle, V., Bassant, M., Zizzari, P., Poindessous‐Jazat, F., Tomasetto, C., Epelbaum, J., & Bluet‐Pajot, M. (2002) · Endocrinology · doi:10.1210/endo.143.4.8712 · Cited by 305 · see citing works

Induction of c-fos Messenger Ribonucleic Acid in Neuropeptide Y and Growth Hormone (GH)-Releasing Factor Neurons in the Rat Arcuate Nucleus Following Systemic Injection of the GH Secretagogue, GH-Releasing Peptide-6

Dickson, S. L., & Luckman, S. M. (1997) · Endocrinology · doi:10.1210/endo.138.2.4907 · Cited by 301 · see citing works

The Synergistic Effects of His-D-Trp-Ala-Trp-D-Phe- Lys-NH2on Growth Hormone (GH)-Releasing Factor- Stimulated GH Release and Intracellular Adenosine 3',5'-Monophosphate Accumulation in Rat Primary Pituitary Cell Culture

CHENG, R., CHAN, W. W.-S., BARRETO, A., Convey, E. Μ., & Smith, R. G. (1989) · Endocrinology · doi:10.1210/endo-124-6-2791 · Cited by 297 · see citing works

Treatment of Cachexia With Ghrelin in Patients With COPD

Nagaya, N., Itoh, T., Murakami, S., Oya, H., Uematsu, M., Miyatake, K., & Kangawa, K. (2005) · CHEST Journal · doi:10.1378/chest.128.3.1187 · Cited by 295 · see citing works

A Low Dose of Ghrelin Stimulates Growth Hormone (GH) Release Synergistically with GH-Releasing Hormone in Humans

Hataya, Y., Akamizu, T., Takaya, K., Kanamoto, N., Ariyasu, H., Saijo, M., Moriyama, K., Shimatsu, A., Kojima, M., Kangawa, K., et al. (2001) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.86.9.8002 · Cited by 293 · cited 1× · see citing works

Plasma Ghrelin Concentrations Are Decreased in Insulin-Resistant Obese Adults Relative to Equally Obese Insulin-Sensitive Controls

McLaughlin, T., Abbasi, F., Lamendola, C. A., Frayo, R. S., & Cummings, D. E. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031572 · Cited by 274 · see citing works

Ghrelin Levels Correlate with Insulin Levels, Insulin Resistance, and High-Density Lipoprotein Cholesterol, But Not with Gender, Menopausal Status, or Cortisol Levels in Humans

Purnell, J. Q., Weigle, D. S., Breen, P. A., & Cummings, D. E. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030513 · Cited by 274 · see citing works

Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus

Muroya, S., Funahashi, H., Yamanaka, A., Kohno, D., Uramura, K., Nambu, T., Shibahara, M., Kuramochi, M., Takigawa, M., Yanagisawa, M., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03255.x · Cited by 241 · see citing works

Circulating Ghrelin Is Sensitive to Changes in Body Weight during a Diet and Exercise Program in Normal-Weight Young Women

Leidy, H. J., Gardner, J. K., Frye, B. R., Snook, M. L., Schuchert, M. K., Richard, E. L., & Williams, N. I. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031471 · Cited by 235 · see citing works

Central Administration of Ghrelin and Agouti-Related Protein (83–132) Increases Food Intake and Decreases Spontaneous Locomotor Activity in Rats

Tang-Christensen, M., Vrang, N., Ortmann, S., Bidlingmaier, M., Horvath, T. L., & Tschöp, M. (2004) · Endocrinology · doi:10.1210/en.2004-0529 · Cited by 226 · see citing works

Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents

Misra, M., Miller, K. K., Kuo, K., Griffin, K. J., Stewart, V., Hunter, E., Herzog, D. B., & Klibanski, A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00041.2005 · Cited by 221 · see citing works

Postprandial Response of Plasma Ghrelin Levels to Various Test Meals in Relation to Food Intake, Plasma Insulin, and Glucose

Erdmann, J., Töpsch, R., Lippl, F., Gussmann, P., & SCHUSDZIARRA, V. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031610 · Cited by 220 · see citing works

Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity.

Shuto, Y., Shibasaki, T., Otagiri, A., Kuriyama, H., Ohata, H., Tamura, H., Kamegai, J., Sugihara, H., Oikawa, S., & Wakabayashi, I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213300 · Cited by 220 · see citing works

Ghrelin Secretion in Humans Is Sexually Dimorphic, Suppressed by Somatostatin, and Not Affected by the Ambient Growth Hormone Levels

Barkan, A. L., Dimaraki, E. V., Jessup, S. K., Symons, K. V., Mn, E., & Jaffe, C. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021169 · Cited by 214 · see citing works

Subcutaneous Ghrelin Enhances Acute Food Intake in Malnourished Patients Who Receive Maintenance Peritoneal Dialysis

Wynne, K., Giannitsopoulou, K., Small, C. J., Patterson, M., Frost, G. S., Ghatei, M. A., Brown, E. A., Bloom, S. R., & Choi, P. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010039 · Cited by 208 · see citing works

Plasma Ghrelin, Obesity, and the Polycystic Ovary Syndrome: Correlation with Insulin Resistance and Androgen Levels

Pagotto, U., Gambineri, A., Vicennati, V., Heiman, M. L., Tschöp, M. H., & Pasquali, R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020776 · Cited by 204 · see citing works

Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP- 6 main action is exerted at the hypothalamic level

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Differential effect of protein and fat on plasma ghrelin levels in man

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Ghrelin Can Bind to a Species of High Density Lipoprotein Associated with Paraoxonase

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Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus

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Ghrelin Neutralization by a Ribonucleic Acid-SPM Ameliorates Obesity in Diet-Induced Obese Mice

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Acetylcholine Regulates Ghrelin Secretion in Humans

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The Cholinergic System Controls Ghrelin Release and Ghrelin-Induced Growth Hormone Release in Humans

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Agonist-Specific Coupling of Growth Hormone Secretagogue Receptor Type 1a to Different Intracellular Signaling Systems

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Growth Hormone-Releasing Peptide-2 Stimulates GH Secretion in GH-Deficient Patients with Mutated GH-Releasing Hormone Receptor

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Chronic central administration of ghrelin reverses the effects of leptin

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Effects of Eight Months Treatment with Graded Doses of a Growth Hormone (GH)-Releasing Peptide in GH-Deficient Children1

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Ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erection

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Update on the diagnosis of GH deficiency in adults

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GHRP‐6‐Induced Changes in Electrical Activity of Single Cells in the Arcuate, Ventromedial and periventricular nucleusriventricular Nuclei of a Hypothalamic Slice Preparation in Vitro

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Standard light breakfast inhibits circulating ghrelin level to the same extent of oral glucose load in humans, despite different impact on glucose and insulin levels

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Effects of Combined Long-Term Treatment with a Growth Hormone-Releasing Hormone Analogue and a Growth Hormone Secretagogue in the Growth Hormone-Releasing Hormone Knock Out Mouse

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Administration of a Nonpeptidyl Growth Hormone Secretagogue, L-163,255, Changes Somatostatin Pattern, But Has No Effect on Patterns of Growth Hormone-Releasing Factor in the Hypophyseal-Portal Circulation of the Conscious Pig

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