Plants used in folk medicine: The potential of their hydromethanolic extracts against Candida species
Open accessAbstract
Currently, opportunistic fungal infections are considered a serious problem regarding public health. Despite the advances towards the synthesis of new antifungal agents, an increasing incidence of drug-resistant microorganisms has been observed. In this sense, other alternatives are necessary. In the present work, the antifungal activity of extracts from ten different plants, commonly used in folk medicine, were evaluated against nineteen Candida strains, including C. albicans, C. glabrata, C. parapsilosis and C. tropicalis species. Although the majority of the extracts had no antimicrobial effect, Juglans regia extract was very effective, exerting an inhibitory effect against all the tested Candida strains, while Eucalyptus globulus was effective against seventeen of them. Pterospartum tridentatum and Rubus ulmifolius presented similar antifungal effects, being effective against six Candida strains. The diameter of halo ranged, respectively, between 9–14mm and 9–21mm to the mentioned plant extracts, and the MIC50 values evidenced mainly a fungistatic activity. Both extracts showed similar MIC50 values for C. albicans strains, while C. parapsilosis and C. glabrata were more sensible to E. globulus. Otherwise, all the C. tropicalis strains were more sensible to J. regia. Overall, hydromethanolic plant extracts could constitute promissory alternatives to the traditional antifungal agents.
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The effects of Juglans regia and Eucalyptus globulus were assessed in more detail revealing a fungistatic and not fungicidal activity.
“The effects of Juglans regia and Eucalyptus globulus were assessed in more detail revealing a fungistatic and not fungicidal activity [240].”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [240]
Extracts from Juglans regia, Eucalyptus globulus, Pterospartum tridentatum, and Rubus ulmifolius were effective against several Candida species, especially C. glabrata, followed by C. albicans, C. parapsilosis, and C. tropicalis.
“Extracts from Juglans regia, Eucalyptus globulus, Pterospartum tridentatum, and Rubus ulmifolius were also effective against several Candida species, especially C. glabrata, followed by C. albicans, C. parapsilosis, and C. tropicalis.”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [240]
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Candida glabrata Biofilms: How Far Have We Come?
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Self-citation
- Authors
- Martins, N., Ferreira, I. C. F. R., Barros, L., Carvalho, A. M., Henriques, M., & Silva, S.
- Affiliations
- Universidade Politécnica de Bragança (PT)
- University of Minho (PT)
- Corresponding author
- Ferreira, Isabel C.F.R.
- Silva, Sónia
- ORCID
- Venue
- Industrial Crops and Products
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 66
- Pages
- 62-67
- ISSN
- 0926-6690 (ISSN-L)
- OpenAlex
- W1983793251
- Cited by
- 48
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 10 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 3
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Industrial Crops and Products (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Funders
- Programa Operacional Temático Factores de Competitividade
- Fundação para a Ciência e a Tecnologia (PEst-OE/EQB/LA0023/2013, RECI/EBB-EBI/0179/2012, PTDC/SAU-MIC/119069/2010, PEst-OE/AGR/UI0690/2011, SFRH/BD/87658/2012)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Keywords
- antifungal activity, Candida, Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, plant extracts, folk medicine, Juglans regia, Eucalyptus globulus, Pterospartum tridentatum, Rubus ulmifolius, hydromethanolic extract, fungistatic activity, minimum inhibitory concentration, opportunistic fungal infection, drug-resistant fungi
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