In vitro anti-Candida activity of Glycyrrhiza glabra L.
Open accessAbstract
The severity and frequency of opportunistic fungal infections still growing, concomitantly to the increasing rates of antimicrobial drug’s resistance. Natural matrices have been used over years due to its multitude of health benefits, including antifungal potential. Thus, the present work aims to evaluate the anti-Candida potential of the phenolic extract and individual phenolic compounds of Glycyrrhiza glabra L. (licorice), by disc diffusion assay, followed by determination of the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) for both planktonic cells and biofilms.Licorice extract evidenced inhibitory potential against the nineteen tested Candida strains, but no pronounced effect was observed by testing the most abundant individual phenolic compounds. Candida tropicalis strains were the most sensible, followed by Candida glabrata, Candida parapsilosis and, then, Candida albicans. Lower MIC and MFC values were achieved to C. glabrata and C. tropicalis, which confirms its susceptibility to licorice extract; however, for C. tropicalis strains a higher variability was observed. Anti-biofilm potential was also achieved, being most evident in some C. glabrata and C. tropicalis strains. In general, a twice concentration of the MIC was necessary for planktonic cells to obtain a similar potential to that one observed for biofilms. Thus, an upcoming approach for new antifungal agents, more effective and safer than the current ones, is established; notwithstanding, further studies are necessary in order to understand its mechanism of action, as also to assess kinetic parameters.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Glycyrrhiza glabra extracts have shown promising inhibitory results against several Candida strains, especially C. tropicalis and C. glabrata.
“Glycyrrhiza glabra extracts have shown promising inhibitory results against several Candida strains, especially C. tropicalis and C. glabrata.”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [241]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Wiegand, I., Hilpert, K., & Hancock, R. E. W. (2008) · Nature Protocols · doi:10.1038/nprot.2007.521 · Cited by 6,156 · see citing works
<i>Candida albicans</i> pathogenicity mechanisms
Mayer, F. L., Wilson, D., & Hube, B. (2013) · Virulence · doi:10.4161/viru.22913 · Cited by 1,848 · see citing works
Sardi, J. C. O., Scorzoni, L., Bernardi, T., Fusco-Almeida, A. M., & Mendes Giannini, M. J. S. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.045054-0 · Cited by 1,184 · see citing works
Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences
Sanglard, D., & Odds, F. C. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00181-0 · Cited by 784 · see citing works
Resistance to Antifungal Agents: Mechanisms and Clinical Impact
Kanafani, Z. A., & Perfect, J. R. (2008) · Clinical Infectious Diseases · doi:10.1086/524071 · Cited by 619 · see citing works
Candidiasis: Predisposing Factors, Prevention, Diagnosis and Alternative Treatment
Martins, N. A., Ferreira, I. C. F. R., Barros, L., Silva, S. M., & Henriques, M. (2014) · Mycopathologia · doi:10.1007/s11046-014-9749-1 · Cited by 285 · see citing works
Self-citationWächtler, B., Citiulo, F., Jablonowski, N., Förster, S., Dalle, F., Schaller, M., Wilson, D., & Hube, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036952 · Cited by 250 · see citing works
Activity of phenolic compounds from plant origin against Candida species
Martins, N. A., Barros, L., Henriques, M., Silva, S. M., & Ferreira, I. C. F. R. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.05.067 · Cited by 138 · see citing works
Self-citationAntifungal activity of Glycyrrhiza glabra extracts and its active constituent glabridin
Fatima, A., Gupta, V. K., Luqman, S., et al. (2009) · Phytotherapy Research · doi:10.1002/ptr.2726 · Cited by 97 · see citing works
Martins, N., Barros, L., Dueñas, M., Santos-Buelga, C., & Ferreira, I. C. F. R. (2015) · RSC Advances · doi:10.1039/c5ra03963k · Cited by 87 · see citing works
Self-citationGallucci, M. N., Carezzano, M. E., Oliva, M. M., Demo, M. S., Pizzolitto, R. P., Zunino, M. P., Zygadlo, J. A., & Dambolena, J. S. (2014) · Journal of Applied Microbiology · doi:10.1111/jam.12432 · Cited by 81 · see citing works
Opportunistic yeast infections: candidiasis, cryptococcosis, trichosporonosis and geotrichosis
Vázquez‐González, D., Perusquía‐Ortiz, A. M., Hundeiker, M., et al. (2013) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.12097 · Cited by 68 · see citing works
Leaves Antimicrobial Activity of Glycyrrhiza glabra L.
Irani, M., Sarmadi, M., Bernard, F., et al. (2010) · PubMed · Cited by 56 · see citing works
Martins, N., Ferreira, I. C. F. R., Barros, L., Carvalho, A. M., Henriques, M., & Silva, S. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.12.033 · Cited by 48 · see citing works
Self-citationThe Biological Origin of Linguistic Diversity
Baronchelli, A., Nick Chater, A., Pastor‐Satorras, R., & Christiansen, M. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048029 · Cited by 41 · see citing works
Barros, F., Pippi, B., Dresch, R. R., et al. (2012) · Industrial Crops and Products · doi:10.1016/j.indcrop.2012.11.017 · Cited by 30 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Candida glabrata Biofilms: How Far Have We Come?
Rodrigues, C., Rodrigues, M., Silva, S., & Henriques, M. (2017) · Journal of Fungi · doi:10.3390/jof3010011 · Cited by 129 · see citing works
Self-citation
- Authors
- Martins, N., Ferreira, I. C. F. R., Henriques, M., & Silva, S.
- Affiliations
- Universidade Politécnica de Bragança (PT)
- University of Minho (PT)
- Corresponding author
- Ferreira, Isabel C.F.R.
- Silva, Sónia
- Venue
- Industrial Crops and Products
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 83
- Pages
- 81-85
- ISSN
- 0926-6690 (ISSN-L)
- OpenAlex
- W2205528519
- Cited by
- 36
- References
- 16
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 2
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Industrial Crops and Products (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Funders
- Fundação para a Ciência e a Tecnologia (PEst-OE/AGR/UI0690/2014, SFRH/BD/87658/2012)
- Programa Operacional Temático Factores de Competitividade (PEst-OE/EQB/LA0023/2013, PTDC/SAU-MIC/119069/2010, RECI/EBB-EBI/0179/2012)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- licorice, anti-Candida activity, antifungal activity, Candida biofilms, Candida albicans, Candida tropicalis, Candida glabrata, Candida parapsilosis, phenolic compounds, phenolic extracts, minimum inhibitory concentration, minimum fungicidal concentration, opportunistic fungal infection, natural products
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
