Cited by 239Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

Two unlike cousins: C andida albicans and C . glabrata infection strategies

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Brunke, Sascha, Hube, Bernhard·2013·Cellular Microbiology

Abstract

Candida albicans and C. glabrata are the two most common pathogenic yeasts of humans, yet they are phylogenetically, genetically and phenotypically very different. In this review, we compare and contrast the strategies of C. albicans and C. glabrata to attach to and invade into the host, obtain nutrients and evade the host immune response. Although their strategies share some basic concepts, they differ greatly in their outcome. While C. albicans follows an aggressive strategy to subvert the host response and to obtain nutrients for its survival, C. glabrata seems to have evolved a strategy which is based on stealth, evasion and persistence, without causing severe damage in murine models. However, both fungi are successful as commensals and as pathogens of humans. Understanding these strategies will help in finding novel ways to fight Candida, and fungal infections in general.

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Authors
Brunke, S., & Hube, B.
Affiliations
Jena University Hospital (DE)
Corresponding author
Hube, Bernhard
Venue
Cellular Microbiology
Published
2013-01-14
Volume
15
Issue
5
Pages
701-708
ISSN
  • 1462-5814 (ISSN-L)
  • 1462-5822
OpenAlex
W1881372541
Cited by
239
References
83
Citations by year
2026: 6 · 2025: 17 · 2024: 22 · 2023: 11 · 2022: 12 · 2021: 24 · 2020: 19 · 2019: 23 · 2018: 19 · 2017: 19 · 2016: 20 · 2015: 26 · 2014: 12 · 2013: 9
FWCI
1.86
Type
journal article
Language
en
Open access
Locations
  • Cellular Microbiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Bundesministerium für Bildung und Forschung
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
Candida albicans, Candida glabrata, fungal pathogenesis, nutrient acquisition, immune evasion, commensalism, comparative pathogenicity, antifungal drug targets
MeSH terms
Candida albicans, Candidiasis, Cell Adhesion, Humans, Phylogeny, Candida glabrata, Host-Pathogen Interactions

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