Two unlike cousins: C andida albicans and C . glabrata infection strategies
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Candida albicans and C. glabrata are the two most common pathogenic yeasts of humans, yet they are phylogenetically, genetically and phenotypically very different. In this review, we compare and contrast the strategies of C. albicans and C. glabrata to attach to and invade into the host, obtain nutrients and evade the host immune response. Although their strategies share some basic concepts, they differ greatly in their outcome. While C. albicans follows an aggressive strategy to subvert the host response and to obtain nutrients for its survival, C. glabrata seems to have evolved a strategy which is based on stealth, evasion and persistence, without causing severe damage in murine models. However, both fungi are successful as commensals and as pathogens of humans. Understanding these strategies will help in finding novel ways to fight Candida, and fungal infections in general.
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Both C. albicans and C. glabrata can form biofilms on abiotic substrates, especially medical devices including catheters and implanted materials.
“Both C. albicans and C. glabrata can form biofilms on abiotic substrates, especially medical devices including catheters and implanted materials [26,27].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [27]
C. glabrata is not known to use hemoglobin or transferrin for iron acquisition, in contrast to C. albicans.
“Especially for C. glabrata, which (in contrast to C. albicans) is not known to use hemoglobin or transferrin for iron acquisition (8, 15)”
From A novel hybrid iron regulation network combines features from pathogenic and nonpathogenic yeasts (2016) · cites this paper as [8]
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“glabrata does not cause significant damage to the host cell and does not provoke a strong response by the host immune system [8].”
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“This shift highlights the urgent need for effective therapeutic strategies and a deeper understanding of the molecular mechanisms underlying drug tolerance and resistance (Brunke and Hube, 2013).”
- Authors
- Brunke, S., & Hube, B.
- Affiliations
- Jena University Hospital (DE)
- Corresponding author
- Hube, Bernhard
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2013-01-14
- Volume
- 15
- Issue
- 5
- Pages
- 701-708
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- PMC
- PMC3654559
- OpenAlex
- W1881372541
- Cited by
- 239
- References
- 83
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 22 · 2023: 11 · 2022: 12 · 2021: 24 · 2020: 19 · 2019: 23 · 2018: 19 · 2017: 19 · 2016: 20 · 2015: 26 · 2014: 12 · 2013: 9
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Cellular Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida albicans, Candida glabrata, fungal pathogenesis, nutrient acquisition, immune evasion, commensalism, comparative pathogenicity, antifungal drug targets
- MeSH terms
- Candida albicans, Candidiasis, Cell Adhesion, Humans, Phylogeny, Candida glabrata, Host-Pathogen Interactions
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