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Cited by 126Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

The DOI matches its Crossref record; 41 of the 43 references it cites were found in a registry or an index.

Stimulatory effect of antidepressants on the production of IL-6

Kubera, Marta, Kenis, Gunter, Bosmans, Eugene, Kajta, Małgorzata, Basta-Kaim, Agnieszka, Scharpe, Simon, Budziszewska, Bogusława, Maes, Michael·2004·International Immunopharmacology
DOI 10.1016/j.intimp.2003.11.006
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Abstract

A body of evidence indicates that the therapeutic activity of antidepressants is connected with their modulatory effect on the inflammatory response system and cell-mediated immunity. The present study was carried out to examine the effects of antidepressant agents, such as imipramne, venlafaxine, l-5-hydroxytryptophan, fluoxetine and a combination of l-5-hydroxytryptophan and fluoxetine, on the production of the pleotrophic cytokines TNF-alpha and IL-6. Diluted whole blood from fluoxetine-treated patients with treatment-resistant depression (TRD) (mean age: 50.6+/-3.9 years), age-matched healthy controls (mean age: 51.6+/-1.7 years) and younger healthy volunteers (mean age: 35.4+/-1.7 years) was stimulated with phytohemagglutinin (PHA) and lipopolysaccharide (LPS) for 48 h with or without incubation with the antidepressants at 10(-6) and 10(-5) M. The major findings of this study are: (1). imipramine and venlafaxine (at the higher concentration), 5-HTP (at lower and higher concentrations) and a combination of 5-HTP and fluoxetine (both at the lower concentration) increased the production of IL-6; (2). all drugs used did not affect TNF-alpha production. IL-6 production was significantly higher in depressed patients than in age-matched volunteers, whereas TNF-alpha production was significantly higher in older volunteers than in younger ones. We speculate that the therapeutic activity of these antidepressants is at least partly connected with their effect on the cytokine network and IL-6 production.

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  1. Służewska, 1996, Increased levels of alpha-1-acid glycoprotein and interleukin-6 in refractory depression, Depression, 39, 149
  2. Kubera M, Maes M, Kim Y-K, Lasoń W. Effect of serotonin and serotonergic agonists and antagonists on the production of TNF-α and IL-6 in human whole blood. Psychiatry Res [in press].

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Metadata

Authors
Kubera, M., Kenis, G., Bosmans, E., Kajta, M., Basta-Kaim, A., Scharpe, S., Budziszewska, B., & Maes, M.
Affiliations
  • Maj Institute of Pharmacology (PL)
  • Vanderbilt University (US)
Corresponding author
Kubera, Marta
ORCID
Venue
International Immunopharmacology
Publisher
Elsevier BV
Published
2004-02
Volume
4
Issue
2
Pages
185-192
ISSN
1567-5769 (ISSN-L)
DOI
10.1016/j.intimp.2003.11.006
OpenAlex
W2040924241
Cited by
126
References
43
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2022: 2 · 2021: 8 · 2020: 2 · 2019: 5 · 2017: 15 · 2016: 11 · 2015: 7 · 2014: 7 · 2013: 9 · 2012: 12
FWCI
1.17
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Immunopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
antidepressants, interleukin-6, TNF-α, imipramine, venlafaxine, 5-hydroxytryptophan, fluoxetine, treatment-resistant depression, cytokine production, inflammation, cell-mediated immunity, phytohemagglutinin, lipopolysaccharide
MeSH terms
Venlafaxine Hydrochloride, Adult, Age Factors, Aging, Antidepressive Agents, Blood Cells, Cyclohexanols, Depressive Disorder, Drug Combinations, Female, Fluoxetine, Humans, 5-Hydroxytryptophan, Imipramine, Inflammation, Male, Middle Aged, Tumor Necrosis Factor-alpha, Interleukin-6, In Vitro Techniques

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