Mesenchymal stem cell-educated macrophages
Open accessAbstract
Mesenchymal stem cells (MSC) mediate their immunosuppressive effects via a variety of mechanisms. One of these mechanisms involves the induction of macrophages with immunomodulatory capacities. This effect of MSC may be exploited when MSC are used as a cell therapeutic product. Furthermore, MSC are resident in tissues where they may locally target infiltrating macrophages to adapt more regulatory properties. The present review discusses the interaction between MSC and macrophages, the induction of MSC-educated macrophages, how these cells position between other immune regulatory cells, and how they may be used in the clinic.
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MSC educated macrophages have a unique anti-inflammatory signature (IL-10 high, IL-12 low, IL-6 high, and TNF-a low) and are distinct from monocyte-derived M2 macrophages due to increased production of IL-6.
“These cells have a unique anti-inflammatory signature (IL-10 high, IL-12 low, IL-6 high, and TNF-a low) and are distinct from monocyte derived M2 macrophages, due to their increased production of IL-6 [85].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [85]
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Biomaterial based modulation of macrophage polarization: a review and suggested design principles
Sridharan, R., Cameron, A. R., Kelly, D. J., Kearney, C. J., & O’Brien, F. J. (2015) · Materials Today · doi:10.1016/j.mattod.2015.01.019 · Cited by 826 · see citing works
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- Authors
- Eggenhofer, E., & Hoogduijn, M. J.
- Affiliations
- University Hospital Regensburg (DE)
- Erasmus MC (NL)
- Corresponding author
- Eggenhofer, Elke
- Venue
- Transplantation Research
- Published
- 2012-09-28
- Volume
- 1
- Issue
- 1
- Pages
- 12-12
- ISSN
- 2047-1440 (ISSN-L)
- PMC
- PMC3560988
- OpenAlex
- W2112527416
- Cited by
- 169
- References
- 45
- Citations by year
- 2025: 2 · 2024: 10 · 2023: 7 · 2022: 16 · 2021: 14 · 2020: 20 · 2019: 18 · 2018: 21 · 2017: 15 · 2016: 16 · 2015: 12 · 2014: 13 · 2013: 5
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Transplantation Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- University of Regensburg Publication Server (University of Regensburg)
- Funders
- European Commission (EU-FP7, 260687)
- FP7 Health
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- mesenchymal stem cells, macrophages, immunomodulation, immunosuppression, macrophage polarization, regulatory macrophages, cell therapy, tissue-resident stem cells, infiltrating macrophages, regulatory immune cells
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