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Cited by 339

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

The role of chalcones in suppression of NF-κB-mediated inflammation and cancer

Open access
Yadav, Vivek R., Prasad, Sahdeo, Sung, Bokyung, Aggarwal, Bharat B.·2011·International Immunopharmacology
DOI 10.1016/j.intimp.2010.12.006
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Abstract

Although consumption of fruits, vegetables, spices, cereals and pulses has been associated with lower incidence of cancer and other chronic diseases, how these dietary agents and their active ingredients minimize these diseases, is not fully understood. Whether it is oranges, kawa, hops, water-lilly, locorice, wax apple or mulberry, they are all connected by a group of aromatic ketones, called chalcones (1,3-diaryl-2-propen-1-ones). Some of the most significant chalcones identified from these plants include flavokawin, butein, xanthoangelol, 4-hydroxyderricin, cardamonin, 2′,4′-dihydroxychalcone, isoliquiritigenin, isosalipurposide, and naringenin. These chalcones have been linked with immunomodulation, antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, anticancer, and antidiabetic activities. The current review, however, deals with the role of various chalcones in inflammation that controls both the immune system and tumorigenesis. Inflammatory pathways have been shown to mediate the survival, proliferation, invasion, angiogenesis and metastasis of tumors. How these chalcones modulate inflammatory pathways, tumorigenesis and immune system is the focus of this review.

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Metadata

Authors
Yadav, V. R., Prasad, S., Sung, B., & Aggarwal, B. B.
Venue
International Immunopharmacology
Publisher
Elsevier BV
Published
2011-03
Volume
11
Issue
3
Pages
295-309
ISSN
1567-5769 (ISSN-L)
DOI
10.1016/j.intimp.2010.12.006
OpenAlex
W1997362033
Cited by
339
References
11
FWCI
9.84
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The role of chalcones in suppression of NF-κB-mediated inflammation and cancer. https://app.cochat.ai/papers/10.1016/j.intimp.2010.12.006
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Yadav, V. R., Prasad, S., Sung, B., & Aggarwal, B. B. (2011). The role of chalcones in suppression of NF-κB-mediated inflammation and cancer. International Immunopharmacology. https://doi.org/10.1016/j.intimp.2010.12.006

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.