Is macrophage polarization important in rheumatoid arthritis?

Wang, Yang; Han, Chen-chen; Cui, Dongqian; Li, Yifan; Ma, Yang; Wei, Wei

doi:10.1016/j.intimp.2017.07.019

Cited by 111Rheumatoid Arthritis Research and TherapiesImmune cells in cancerAutoimmune and Inflammatory Disorders Research

Is macrophage polarization important in rheumatoid arthritis?

Wang, Yang, Han, Chen-chen, Cui, Dongqian, Li, Yifan, Ma, Yang, Wei, Wei·2017·International Immunopharmacology

DOI 10.1016/j.intimp.2017.07.019

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Abstract

Macrophages are myeloid immune cells which are strategically positioned throughout the body, where they engulf and degrade debris, dead cells, and foreign substances, and coordinating the inflammatory processes. Macrophages can be divided into two extreme subsets, classical activation (M1), and alternatively activation (M2). The symptoms and signs of rheumatoid arthritis (RA) would exacerbate with the increase in pro-inflammatory cytokines, whereas anti-inflammatory cytokines will alleviate the symptoms and signs of RA. This review, mainly discusses the effects of Notch, JNK and ERK signaling pathways on the regulation of macrophage polarization, and the effects of pro-inflammatory factors and/or anti-inflammatory cytokines produced by polarized macrophages in RA. Also, we will make an attempt to find out the importance of macrophage polarization in RA treatment as a drug target.

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Expression of the M1 phenotype is regulated by transcription factors such as NF-κB, IRF-3, and IRF-5.
“Expression of the M1 phenotype is regulated by transcription factors such as NF-κB, IRF-3, and IRF-5 [189,190,191].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [190]

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Authors: Wang, Y., Han, C.-C., Cui, D., Li, Y., Ma, Y., & Wei, W.
Affiliations: Anhui Medical University (CN)
Corresponding author: Ma, Yang
Wei, Wei
ORCID: Wang, Yang
Li, Yifan
Ma, Yang
Wei, Wei
Venue: International Immunopharmacology
Publisher: Elsevier BV
Published: 2017-09
Volume: 50
Pages: 345-352
ISSN: 1567-5769 (ISSN-L)
DOI: 10.1016/j.intimp.2017.07.019
OpenAlex: W2737504626
Cited by: 111
References: 117
Citations by year: 2026: 2 · 2025: 10 · 2024: 14 · 2023: 13 · 2022: 21 · 2021: 19 · 2020: 11 · 2019: 11 · 2018: 9 · 2017: 1
FWCI: 1.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: International Immunopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords: macrophage polarization, rheumatoid arthritis, M1/M2 macrophages, Notch signaling, JNK signaling, ERK signaling, inflammatory cytokines, anti-inflammatory cytokines, therapeutic target
MeSH terms: Animals, Arthritis, Rheumatoid, Cell Differentiation, Humans, Immunotherapy, Macrophages, Cytokines, Th1 Cells, Th2 Cells, MAP Kinase Signaling System, Extracellular Signal-Regulated MAP Kinases, Receptors, Notch

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Is macrophage polarization important in rheumatoid arthritis?

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