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Hydrogel Nanoparticles in Drug Delivery: A Review

Kianfar, Ehsan, Kadhum, Wesam R., Mahmoud, Zaid H.·2025·Intelligent Pharmacy
DOI 10.1016/j.ipha.2025.11.002
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Abstract

Hydrogel nanoparticles (HNPs) have emerged as a promising class of drug delivery systems due to their unique physicochemical properties, including high water content, biocompatibility, and tunable drug release capabilities. These nanoparticles, composed of cross-linked polymeric networks, can encapsulate a variety of therapeutic agents, including chemotherapeutic drugs, nucleic acids, and immunomodulators, and release them in a controlled and sustained manner. Hydrogel nanoparticles are particularly valuable in cancer therapy, as they can enhance drug solubility, improve bioavailability, and target tumor sites while minimizing off-target toxicity. Additionally, stimuli-responsive features, such as pH, temperature, and enzyme sensitivity, allow for the development of highly targeted drug delivery systems that release therapeutic agents in the tumor microenvironment. Despite their potential, the clinical translation of Hydrogel nanoparticles faces several challenges, including scalability, long-term stability, inconsistent drug release profiles, and the potential for resistance mechanisms in cancer cells. This review provides a comprehensive overview of hydrogel nanoparticles as an innovative drug delivery platform, with a particular focus on their applications in cancer therapy. We explore the mechanisms of drug loading and release, targeting strategies to enhance tumor specificity, and recent advances in the design and engineering of hydrogel nanoparticles. Hydrogels and nano…

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Metadata

Authors
Kianfar, E., Kadhum, W. R., & Mahmoud, Z. H.
Venue
Intelligent Pharmacy
Publisher
Elsevier BV
Published
2025-11
ISSN
2949-866X
DOI
10.1016/j.ipha.2025.11.002
Cited by
8
References
1
Language
en
Licence

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