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Hydrogel Nanoparticles in Drug Delivery: A Review

Kianfar, Ehsan, Kadhum, Wesam R., Mahmoud, Zaid H.·2025·Intelligent Pharmacy
DOI 10.1016/j.ipha.2025.11.002
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Abstract

Hydrogel nanoparticles (HNPs) have emerged as a promising class of drug delivery systems due to their unique physicochemical properties, including high water content, biocompatibility, and tunable drug release capabilities. These nanoparticles, composed of cross-linked polymeric networks, can encapsulate a variety of therapeutic agents, including chemotherapeutic drugs, nucleic acids, and immunomodulators, and release them in a controlled and sustained manner. Hydrogel nanoparticles are particularly valuable in cancer therapy, as they can enhance drug solubility, improve bioavailability, and target tumor sites while minimizing off-target toxicity. Additionally, stimuli-responsive features, such as pH, temperature, and enzyme sensitivity, allow for the development of highly targeted drug delivery systems that release therapeutic agents in the tumor microenvironment. Despite their potential, the clinical translation of Hydrogel nanoparticles faces several challenges, including scalability, long-term stability, inconsistent drug release profiles, and the potential for resistance mechanisms in cancer cells. This review provides a comprehensive overview of hydrogel nanoparticles as an innovative drug delivery platform, with a particular focus on their applications in cancer therapy. We explore the mechanisms of drug loading and release, targeting strategies to enhance tumor specificity, and recent advances in the design and engineering of hydrogel nanoparticles. Hydrogels and nano…

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Research works printed but not linked: 289

  1. Cho, 2008, Therapeutic nanoparticles for drug delivery in cancer, Clinical cancer research, 14, 1310, 10.1158/1078-0432.CCR-07-1441 · DOI
  2. De Jong, 2008, Drug delivery and nanoparticles: applications and hazards, International journal of nanomedicine, 3, 133, 10.2147/IJN.S596 · DOI
  3. Couvreur, 2013, Nanoparticles in drug delivery: past, present and future, Advanced drug delivery reviews, 65, 21, 10.1016/j.addr.2012.04.010 · DOI
  4. Wilczewska, 2012, Nanoparticles as drug delivery systems, Pharmacological reports, 64, 1020, 10.1016/S1734-1140(12)70901-5 · DOI · Paper page
  5. Suri, 2007, Nanotechnology-based drug delivery systems, Journal of occupational medicine and toxicology, 2, 1, 10.1186/1745-6673-2-16 · DOI
  6. Yusuf, 2023, Nanoparticles as drug delivery systems: a review of the implication of nanoparticles’ physicochemical properties on responses in biological systems, Polymers, 15, 1596, 10.3390/polym15071596 · DOI
  7. Gonçalves, 2010, Self-assembled hydrogel nanoparticles for drug delivery applications, Materials, 3, 1420, 10.3390/ma3021420 · DOI
  8. Salatin, 2016, Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery, Archives of pharmacal research, 39, 1181, 10.1007/s12272-016-0782-0 · DOI
  9. Vinogradov, 2004, Nanogels for oligonucleotide delivery to the brain, Bioconjugate chemistry, 15, 50, 10.1021/bc034164r · DOI
  10. Shirakura, 2014, Hydrogel nanoparticles with thermally controlled drug release, ACS macro letters, 3, 602, 10.1021/mz500231e · DOI
  11. Huang, 2004, Controlled drug release from hydrogel nanoparticle networks, Journal of Controlled Release, 94, 303, 10.1016/j.jconrel.2003.10.007 · DOI
  12. Strong, 2014, Hydrogel-nanoparticle composites for optically modulated cancer therapeutic delivery, Journal of Controlled Release, 178, 63, 10.1016/j.jconrel.2014.01.014 · DOI
  13. Hamidi, 2008, Hydrogel nanoparticles in drug delivery, Advanced drug delivery reviews, 60, 1638, 10.1016/j.addr.2008.08.002 · DOI
  14. Xu, 2014, A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics, Biomaterials, 35, 3319, 10.1016/j.biomaterials.2013.12.080 · DOI
  15. Yallapu, 2011, Design and engineering of nanogels for cancer treatment, Drug discovery today, 16, 457, 10.1016/j.drudis.2011.03.004 · DOI
  16. Ma, 2022, Bioengineered nanogels for cancer immunotherapy, Chemical Society Reviews, 51, 5136, 10.1039/D2CS00247G · DOI
  17. Sepantafar, 2017, Engineered hydrogels in cancer therapy and diagnosis, Trends in biotechnology, 35, 1074, 10.1016/j.tibtech.2017.06.015 · DOI
  18. Zugazagoitia, 2016, Current challenges in cancer treatment, Clinical therapeutics, 38, 1551, 10.1016/j.clinthera.2016.03.026 · DOI
  19. Soni, 2016, Nanogels as potential nanomedicine carrier for treatment of cancer: A mini review of the state of the art, Saudi Pharmaceutical Journal, 24, 133, 10.1016/j.jsps.2014.04.001 · DOI
  20. Attama, 2022, Nanogels as target drug delivery systems in cancer therapy: A review of the last decade, Frontiers in Pharmacology, 13, 10.3389/fphar.2022.874510 · DOI
  21. Ma, 2022, Bioengineered nanogels for cancer immunotherapy, Chemical Society Reviews, 51, 5136, 10.1039/D2CS00247G · DOI
  22. Maya, 2013, Smart stimuli sensitive nanogels in cancer drug delivery and imaging: a review, Current pharmaceutical design, 19, 7203, 10.2174/138161281941131219124142 · DOI
  23. Sanapala, P., & Pola, S. (2023). Supramolecular hydrogels as drug delivery systems for nerve regeneration and wound healing. In Novel Platforms for Drug Delivery Applications (pp. 59-84). Woodhead Publishing. · DOI
  24. Peppas, N. A., & Mikos, A. G. (2019). Preparation methods and structure of hydrogels. In Hydrogels in medicine and pharmacy (pp. 1-26). CRC press. · DOI
  25. Brannon-Peppas, L. (1990). Preparation and characterization of crosslinked hydrophilic networks. In Studies in polymer science (Vol. 8, pp. 45-66). Elsevier. · DOI
  26. Flory, 1943, Statistical mechanics of cross‐linked polymer networks II. Swelling, The journal of chemical physics, 11, 521, 10.1063/1.1723792 · DOI
  27. Flory, 1950, Statistical mechanics of swelling of network structures, The Journal of Chemical Physics, 18, 108, 10.1063/1.1747424 · DOI
  28. Ratner, B. D., & Hoffman, A. S. (1976). Synthetic hydrogels for biomedical applications. · DOI
  29. Blanco, 1996, 5-Fluorouracil release from copolymeric hydrogels of itaconic acid monoester: I. Acrylamide-co-monomethyl itaconate, Biomaterials, 17, 1061, 10.1016/0142-9612(96)85906-0 · DOI
  30. Peppas, 1976, Poly (vinyl alcohol) hydrogels: reinforcement of radiation‐crosslinked networks by crystallization, Journal of Polymer Science: Polymer Chemistry Edition, 14, 441
  31. Soppimath, 2001, Biodegradable polymeric nanoparticles as drug delivery devices, Journal of controlled release, 70, 1, 10.1016/S0168-3659(00)00339-4 · DOI · Paper page
  32. Hoffman, 2012, Hydrogels for biomedical applications, Advanced drug delivery reviews, 64, 18, 10.1016/j.addr.2012.09.010 · DOI · Paper page
  33. Coviello, 2007, Polysaccharide hydrogels for modified release formulations, Journal of controlled release, 119, 5, 10.1016/j.jconrel.2007.01.004 · DOI
  34. Davis, 2002, Controlled release from crosslinked degradable networks, Critical Reviews™ in Therapeutic Drug Carrier Systems, 19
  35. da Silva, 2014, Nanotechnological strategies for vaginal administration of drugs—A review, Journal of Biomedical Nanotechnology, 10, 2218, 10.1166/jbn.2014.1890 · DOI
  36. Drotleff, 2004, Biomimetic polymers in pharmaceutical and biomedical sciences, European Journal of Pharmaceutics and Biopharmaceutics, 58, 385, 10.1016/j.ejpb.2004.03.018 · DOI
  37. Lin, 2006, Hydrogels in controlled release formulations: network design and mathematical modeling, Advanced drug delivery reviews, 58, 1379, 10.1016/j.addr.2006.09.004 · DOI
  38. Ganie, 2023, Recent innovations in the strategies for the functionalization of chitosan, pectin, alginate, hyaluronic acid, dextran and inulin biomaterials for anticancer applications-a review, Journal of Polymers and the Environment, 31, 13, 10.1007/s10924-022-02547-6 · DOI
  39. Ullah, 2015, Classification, processing and application of hydrogels: A review, Materials Science and Engineering: C, 57, 414
  40. Garg, 2016, Hydrogel: Classification, properties, preparation and technical features, Asian J. Biomater. Res, 2, 163
  41. Kasai, 2023, A review on hydrogels classification and recent developments in biomedical applications, International Journal of Polymeric Materials and Polymeric Biomaterials, 72, 1059, 10.1080/00914037.2022.2075872 · DOI
  42. Peppas, 1991, Physiologically responsive hydrogels, Journal of bioactive and compatible polymers, 6, 241, 10.1177/088391159100600303 · DOI
  43. Stauffer, 1992, Poly (vinyl alcohol) hydrogels prepared by freezing-thawing cyclic processing, Polymer, 33, 3932, 10.1016/0032-3861(92)90385-A · DOI
  44. Bell, C. L., & Peppas, N. A. (2005). Biomedical membranes from hydrogels and interpolymer complexes. In Biopolymers Ii (pp. 125-175). Berlin, Heidelberg: Springer Berlin Heidelberg. · DOI
  45. Laftah, 2011, Polymer hydrogels: A review, Polymer-Plastics Technology and Engineering, 50, 1475, 10.1080/03602559.2011.593082 · DOI
  46. Zhao, 2016, pH-and temperature-sensitive hydrogel nanoparticles with dual photoluminescence for bioprobes, ACS nano, 10, 5856, 10.1021/acsnano.6b00770 · DOI
  47. Memic, 2015, Hydrogels 2.0: improved properties with nanomaterial composites for biomedical applications, Biomedical materials, 11, 10.1088/1748-6041/11/1/014104 · DOI
  48. Biondi, 2015, Nanoparticle-integrated hydrogels as multifunctional composite materials for biomedical applications, Gels, 1, 162, 10.3390/gels1020162 · DOI
  49. Kaith, 2021, Hydrogels: Synthesis, Classification, Properties and Potential Applications—A Brief Review, J Polym Environ, 29, 3827, 10.1007/s10924-021-02184-5 · DOI
  50. Yu, 2009, Surface modification of nanocarriers for cancer therapy, Current Nanoscience, 5, 123, 10.2174/157341309788185370 · DOI
  51. Sudhakar, 2020, Biodistribution and pharmacokinetics of thiolated chitosan nanoparticles for oral delivery of insulin in vivo, International journal of biological macromolecules, 150, 281, 10.1016/j.ijbiomac.2020.02.079 · DOI
  52. Mumuni, 2020, Insulin-loaded mucoadhesive nanoparticles based on mucin-chitosan complexes for oral delivery and diabetes treatment, Carbohydrate polymers, 229, 10.1016/j.carbpol.2019.115506 · DOI
  53. Tsai, 2019, Development of mutlifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin, International journal of biological macromolecules, 126, 141, 10.1016/j.ijbiomac.2018.12.182 · DOI
  54. Wong, 2020, Formulation and characterisation of insulin-loaded chitosan nanoparticles capable of inducing glucose uptake in skeletal muscle cells in vitro, Journal of Drug Delivery Science and Technology, 57, 10.1016/j.jddst.2020.101738 · DOI
  55. Nasir, 2021, Nanotechnology, a tool for diagnostics and treatment of cancer, Current topics in medicinal chemistry, 21, 1360, 10.2174/1568026621666210701144124 · DOI
  56. Suzuki, 1984, Protecting effect of chitin and chitosan on experimentally induced murine candidiasis, Microbiology and Immunology, 28, 903, 10.1111/j.1348-0421.1984.tb00746.x · DOI
  57. Solairaj, 2017, Anticancer activity of silver and copper embedded chitin nanocomposites against human breast cancer (MCF-7) cells, International journal of biological macromolecules, 105, 608, 10.1016/j.ijbiomac.2017.07.078 · DOI
  58. Mangalathillam, 2012, Curcumin loaded chitin nanogels for skin cancer treatment via the transdermal route, Nanoscale, 4, 239, 10.1039/C1NR11271F · DOI
  59. Zaharoff, 2010, Intratumoral immunotherapy of established solid tumors with chitosan/IL-12, Journal of immunotherapy, 33, 697, 10.1097/CJI.0b013e3181eb826d · DOI
  60. Coutinho, 2020, Mucoadhesive and pH responsive fucoidan-chitosan nanoparticles for the oral delivery of methotrexate, International journal of biological macromolecules, 158, 180, 10.1016/j.ijbiomac.2020.04.233 · DOI
  61. Sabra, 2019, Courier properties of modified citrus pectinate-chitosan nanoparticles in colon delivery of curcumin, Colloid and Interface Science Communications, 32, 10.1016/j.colcom.2019.100192 · DOI
  62. Xavier-Jr, 2019, Mucoadhesive paclitaxel-loaded chitosan-poly (isobutyl cyanoacrylate) core-shell nanocapsules containing copaiba oil designed for oral drug delivery, Journal of Drug Delivery Science and Technology, 53, 10.1016/j.jddst.2019.101194 · DOI
  63. Du, 2020, Polylysine and cysteine functionalized chitosan nanoparticle as an efficient platform for oral delivery of paclitaxel, Carbohydrate polymers, 229, 10.1016/j.carbpol.2019.115484 · DOI
  64. Tran, 2020, Development of conjugate-by-conjugate structured nanoparticles for oral delivery of docetaxel, Materials Science and Engineering: C, 107
  65. Ling, 2019, Alginate/chitosan microparticles for gastric passage and intestinal release of therapeutic protein nanoparticles, Journal of Controlled Release, 295, 174, 10.1016/j.jconrel.2018.12.017 · DOI
  66. Öztürk, 2020, Treatment of oxidative stress-induced pain and inflammation with dexketoprofen trometamol loaded different molecular weight chitosan nanoparticles: Formulation, characterization and anti-inflammatory activity by using in vivo HET-CAM assay, Microvascular Research, 128, 10.1016/j.mvr.2019.103961 · DOI
  67. Yu, 2020, Mucoadhesive dexamethasone-glycol chitosan nanoparticles for ophthalmic drug delivery, International Journal of Pharmaceutics, 575, 10.1016/j.ijpharm.2019.118943 · DOI
  68. Khalil, 2020, Chitosan coated liposomes (CCL) containing triamcinolone acetonide for sustained delivery: A potential topical treatment for posterior segment diseases, International Journal of Biological Macromolecules, 143, 483, 10.1016/j.ijbiomac.2019.10.256 · DOI
  69. Hosseinifar, 2018, Pressure responsive nanogel base on alginate‐cyclodextrin with enhanced apoptosis mechanism for colon cancer delivery, Journal of Biomedical Materials Research Part A, 106, 349, 10.1002/jbm.a.36242 · DOI
  70. Song, 2018, Magnetic alginate/chitosan nanoparticles for targeted delivery of curcumin into human breast cancer cells, Nanomaterials, 8, 907, 10.3390/nano8110907 · DOI
  71. Mirrahimi, 2019, A thermo-responsive alginate nanogel platform co-loaded with gold nanoparticles and cisplatin for combined cancer chemo-photothermal therapy, Pharmacological research, 143, 178, 10.1016/j.phrs.2019.01.005 · DOI
  72. Sun, 2017, Bio-responsive alginate-keratin composite nanogels with enhanced drug loading efficiency for cancer therapy, Carbohydrate Polymers, 175, 159, 10.1016/j.carbpol.2017.07.078 · DOI
  73. Selvam, 2018, Molecular encapsulator–appended poly (vinyl alcohol) shroud on ferrite nanoparticles. Augmented cancer–drug loading and anticancer property, Materials Science and Engineering: C, 93, 125
  74. Hu, 2008, Surfactant‐free, self‐assembled PVA‐iron oxide/silica core–shell nanocarriers for highly sensitive, magnetically controlled drug release and ultrahigh cancer cell uptake efficiency, Advanced Functional Materials, 18, 2946, 10.1002/adfm.200800428 · DOI
  75. Abdi, 2025, Biomechanical perspectives on traumatic brain injury in the elderly: A comprehensive review, Progress in Biomedical Engineering, 10.1088/2516-1091/ada654 · DOI
  76. Abdi, 2024, Quantitative assessment of traumatic brain injury risk in diverse age groups of females: Insights from computational biomechanics, Heliyon, 10, 10.1016/j.heliyon.2024.e31123 · DOI
  77. Abdi, 2024, Revealing the role of material properties in impact-related injuries: Investigating the influence of brain and skull density variations on head injury severity, Heliyon, 10, 10.1016/j.heliyon.2024.e29427 · DOI
  78. Kianfar, 2025, Gold nanoparticles in photothermal cancer therapy: Current trends and outlook, Trends in Sciences, 22, 10.48048/tis.2025.9433 · DOI
  79. Jiang, 2020, Nanoparticle–hydrogel superstructures for biomedical applications, Journal of Controlled Release, 324, 505, 10.1016/j.jconrel.2020.05.041 · DOI
  80. Lai, 2016, Design and fabrication of hydrogel-based nanoparticulate systems for in vivo drug delivery, Journal of Controlled Release, 243, 269, 10.1016/j.jconrel.2016.10.013 · DOI
  81. Kianfar, 2025, Biocompatibility study of silica-based magnesium composites: A review, Trends in Sciences, 22
  82. Gao, 2016, Nanoparticle-hydrogel: a hybrid biomaterial system for localized drug delivery, Annals of biomedical engineering, 44, 2049, 10.1007/s10439-016-1583-9 · DOI
  83. Narayanaswamy, R., & Torchilin, V. P. (2020). Hydrogels and their applications in targeted drug delivery. The road from nanomedicine to precision medicine, 1117-1150. · DOI
  84. Hameed, 2024, A comprehensive review of hydrogel-based drug delivery systems: classification, properties, recent trends, and applications, AAPS PharmSciTech, 25, 64, 10.1208/s12249-024-02786-x · DOI
  85. Mishra, B., & Singh, J. (2021). Hydrogel-based drug delivery systems for cancer therapy. In Advanced drug delivery systems in the management of cancer (pp. 63-74). Academic Press. · DOI
  86. Choi, 2024, Hybrid nanoparticle–hydrogel systems for drug delivery depots and other biomedical applications, ACS nano, 18, 22780, 10.1021/acsnano.4c06888 · DOI
  87. Hoare, 2008, Hydrogels in drug delivery: Progress and challenges, polymer, 49, 1993, 10.1016/j.polymer.2008.01.027 · DOI
  88. Branch, 2024, A Review Hydrogel nanoparticle in drug delivery: properties and applications, World
  89. Muringayil Joseph, 2025, Identifying gaps in practical use of epoxy foam/aerogels: review-solutions and prospects, Reviews in Chemical Engineering
  90. Mahmoud, 2025, Development of Vitex-derived polymer nanofibers using electrochemical sensors for the treatment of polycystic ovarian syndrome in rats as an animal model, Biosensors and Bioelectronics: X, 22
  91. Joseph, 2025, Adaptive and intelligent polyurethane shape-memory polymers enabling next-generation biomedical platforms, Case Studies in Chemical and Environmental Engineering, 10.1016/j.cscee.2025.101165 · DOI
  92. Mahmoud, 2025, Recent Advances in the Applications of smart nanomaterials in Biomedicine: A Review, Nano LIFE
  93. Al-Jamal, 2025, Photodynamic Therapy (PDT) in Drug Delivery: Nano-innovations enhancing treatment outcomes, Health Sciences Review, 10.1016/j.hsr.2025.100218 · DOI
  94. Mahmoud, 2025, Nano-Based Drug Delivery in Cancer: Tumor Tissue Characteristics and Targeting, Trends in Sciences, 22, 10.48048/tis.2025.9078 · DOI
  95. Ali, 2024, Role of CRISPR-Cas Systems in the Pathogenesis of Periodontal Disease and Precision Periodontal Therapy, Trends in Pharmaceutical Biotechnology, 2, 38, 10.57238/tpb.2024.153196.1022 · DOI
  96. Udeabor, 2024, Monoclonal Antibodies in Modern Medicine: Their Therapeutic Potential and Future Directions, Trends in Pharmaceutical Biotechnology, 2, 12, 10.57238/tpb.2024.153196.1019 · DOI
  97. Yousif, 2024, Development of Curcumin-Loaded Alginate Beads for Targeted Gastric Mucosa Delivery in Helicobacter Pylori-Associated Gastritis, Trends in Pharmaceutical Biotechnology, 2, 7, 10.57238/tpb.2024.153196.1018 · DOI
  98. Alhamadani, 2024, Biotechnology of the Diagnosis Urinary Tract Infections, Trends in Pharmaceutical Biotechnology, 2, 21, 10.57238/tpb.2024.153196.1017 · DOI
  99. Rheima, 2024, Nano biosensors: Classification, electrochemistry, nanostructures, and optical properties, Results in Engineering, 10.1016/j.rineng.2024.103428 · DOI
  100. Tahseen, 2024, Nanocellulose in Drug Delivery Systems: A Comprehensive Review, Trends in Pharmaceutical Biotechnology, 2, 1, 10.57238/tpb.2024.153196.1012 · DOI
  101. Mohammed, 2024, Biomedical Applications of Alginate Oligosaccharides: Exploring Their Therapeutic Potential and Modification Techniques, Trends in Pharmaceutical Biotechnology, 2, 22, 10.57238/tpb.2024.152722.1011 · DOI
  102. Hanan, 2023, Antimicrobial effects of three-types of Metronidazole Drug on Salmonella Enterica and Vibrio Fluvialis isolated from Thi-Qar Province, Trends in Pharmaceutical Biotechnology, 1, 11, 10.57238/tpb.2023.146833.1006 · DOI
  103. Alsaady, 2023, Biochemical Application of New Synthetic Compounds of Pyridine Derivatives Incorporating on Tetrazole Moieties, Trends in Pharmaceutical Biotechnology, 1, 17, 10.57238/tpb.2023.146842.1007 · DOI
  104. Dilfy, 2023, Optimizing Chrysin’s Anticancer Efficacy on MDA-MB-231 cells: synthesis and characterization of Chrysin-Loaded Gold/Chitosan Nanoparticles, Trends in Pharmaceutical Biotechnology, 1, 12, 10.57238/tpb.2023.144270.1001 · DOI
  105. Al-Hamadiny, 2023, Nanocarriers and Beyond: Innovations in Overcoming Barriers for Effective CNS Drug Delivery, Trends in Pharmaceutical Biotechnology, 1, 34, 10.57238/tpb.2023.144275.1003 · DOI
  106. Alalwani, 2023, Biomimetic Cell Membrane Vehicles: Navigating the BloodBrain Barrier for Enhanced CNS Drug Delivery, Trends in Pharmaceutical Biotechnology, 1, 48, 10.57238/tpb.2023.144292.1004 · DOI
  107. Omran, 2024, Boosted Removal of Sulfadiazine Drug Using Multiwall Carbon Nanotubes and Comparative with Other Adsorbents, Asian Journal of Green Chemistry, 8, 150
  108. Dourandish, 2024, Recent Advances in Electrochemical Sensing of Anticancer Drug Doxorubicin: A Mini-Review, Chemical Methodologies, 8, 293
  109. Bahmani, 2024, Folic Acid as an Exploiter of Natural Endocytosis Pathways in Drug Delivery, Chemical Methodologies, 8, 96
  110. Javadi, 2023, 'Investigation of enantiomeric separation of tiletamine drug using computational chemistry methods', Journal of Medicinal and Pharmaceutical Chemistry Research, 5, 661
  111. Abass, 2024, Synthesis, Characterization, and Applications of Metal Oxides of ZnO, CuO, and CeO2 Nanoparticles: A Review', Journal of Applied Organometallic Chemistry, 4, 349
  112. Amini, 2022, Medical Tourism Industry: A Systematic Review on Its Principles, Sequels, and Ethical Issues, Eurasian Journal of Science and Technology, 2, 143
  113. Asadullah, 2022, Investigation of a Low Cost, Stable and Efficient Adsorbent for the Fast Uptake of Cd (II) from Aqueous Media, Advanced Journal of Chemistry, Section A, 5, 345
  114. Asghari, 2023, PEGylated cationic nano-niosomes formulation containing herbal medicine curcumin for drug delivery to MCF-7 breast cancer cells, Journal of Medicinal and Pharmaceutical Chemistry Research, 5, 556
  115. Bahadorloo, 2023, The Effect of Low-Level Laser Therapy on Differentiation Ability of Human Adipocyte-Derived Stem Cells to Keratinocytes, International Journal of Advanced Biological and Biomedical Research, 11, 82
  116. Chandankar, 2022, 'Fundamental features of quantum dots and their diagnostic applications', Journal of Medicinal and Nanomaterials Chemistry, 4, 48
  117. Gumma, 2024, 'Eco-Friendly Phytochemical-Derived Co3O4@Ag Nanoparticles for Ethanol Oxidation and Antibacterial Activity', Asian Journal of Green Chemistry, 8, 560
  118. Hashim, 2023, A Novel Design for Gas Sensor of Zinc Oxide Nanostructure Prepared by Hydrothermal Annealing Technique, Chemical Methodologies, 7, 314
  119. Ibrahim, 2023, Studying the Structural and Optical Properties of Thin Compound Oxide Films Based on TiO2: NiO: In2O3 Nanostructure, Chemical Methodologies, 7, 871
  120. Islam, 2022, Investigation of Structural, Electronic, and Optical Properties of SrTiO3 and SrTi0.94Ag0.06O3 Quantum Dots Based Semiconductor Using First Principle Approach, Advanced Journal of Chemistry, Section A, 5, 164
  121. Kuraimid, Z, 2023, 'Static and Dynamic Study of Novel 4-Formyl-N-Hexadecyl-N,N-Dimethylbenzenaminium Bromide Synthesized as a Corrosion Inhibitor Use in Petroleum Wells Acidizing Process', Chemical Methodologies, 7, 552
  122. Kalvanagh, 2023, Investigating the Relationship Between A/T 251 Polymorphism of IL-8 Gene and Cancer Recurrence After Lumpectomy, Eurasian Journal of Science and Technology, 3, 172
  123. KamiL, 2024, 'Synthesis of Trimetallic Au:Ag:Zn Colloidal Nanoparticles Via Pulsed Laser Ablation in Liquid Method for Antibactial Activity', Journal of Applied Organometallic Chemistry, 4, 274
  124. Khan, 2024, 'Nickel and Cobalt Magnetic Nanoparticles (MNPs): Synthesis, Characterization, and Applications', Journal of Chemical Reviews, 6, 94
  125. Mhaibes, 2023, ZnO Nanoparticles: A Highly Efficient and Recyclable Catalyst for Tandem Knoevenagel-Michael-Cyclocondensation Reaction, Asian Journal of Green Chemistry, 7, 1
  126. Moayeripour, 2023, Experimental investigation of the effect of titanium nano-particles on the properties of hydrophobic self-cleaning film, Journal of Medicinal and Pharmaceutical Chemistry Research, 5, 303
  127. Mohamed Sikkander, 2024, A Review of Advances in the Development of Bioresorbable Nano Stents: Part (II), Journal of Chemical Reviews, 6, 304
  128. Mohamed Sikkander, 2024, A Review of Diagnostic Nano Stents: Part (I), Journal of Chemical Reviews, 6, 138
  129. Mulyasuryani, 2024, 'Novel electrochemical sensor of Cu(II) prepared by carbon paste-magnetic ion imprinted materials on screen printed carbon electrode', Journal of Medicinal and Pharmaceutical Chemistry Research, 6, 502
  130. Patil, 2022, Copper Nanomaterials Derived Preventive Technologies for COVID-19 Pandemic: A Review, Advanced Journal of Chemistry, Section A, 5, 1
  131. Pourbahar, 2023, 'Phytofabrication, and Characterization of Ag/Fe3O4 Nanocomposite from Rosa Canina Plant Extracts Using a Green Method', Asian Journal of Green Chemistry, 7, 9
  132. Sajjadifar, 2024, Design and Characterization of Fe3O4@n-pr-NH2@Zn3(BTC)2 Magnetic MOF : A Catalyst for Dihydropyrimidine and 2-Amino-4H-Chromene Synthesis, Chemical Methodologies, 8, 550
  133. Shahoodh, 2023, 'Investigations on TiO2-NiO@In2O3 Nanocomposite Thin Films (NCTFs) for Gas Sensing: Synthesis, Physical Characterization, and Detection of NO2 and H2S Gas Sensors', Chemical Methodologies, 7, 994
  134. Sheikholeslami-Farahani, 2022, Amine functionalized SiO2@Fe3O4 as a green and reusable magnetic nanoparticles system for the synthesis of Knoevenagel condensation in water, Journal of Medicinal and Nanomaterials Chemistry, 4, 132
  135. Singh, 2024, 'Synthesis, Characterization, and Application of Nanoparticles: An Exhaustive Survey of Recent Advances and Future Directions', Journal of Applied Organometallic Chemistry, 4, 190
  136. Ukwubile, 2021, Nanoencapsulation of Phthalate from Melastomastrum Capitatum (Fern.) in Chitosan-Nps as a Target Mediated Drug Delivery for Multi-Drug Resistant Pathogen, International Journal of Advanced Biological and Biomedical Research, 9, 160
  137. aid Almarbd, 2022, Recycling of Plastic Waste Made of Polystyrene and Its Transformation into Nanocomposites by Green Methods, Chemical Methodologies, 6, 940
  138. Jasim, 2026, A Review Hydrogel nanoparticle in drug delivery: properties and applications, Nano LIFE, 16, 10.1142/S1793984424300085 · DOI
  139. Yoon, 2025, Dual-Drug Delivery Systems Using Hydrogel–Nanoparticle Composites: Recent Advances and Key Applications, Gels, 11, 520, 10.3390/gels11070520 · DOI
  140. Fan, 2025, Recent Developments in Nanoparticle‐Hydrogel Hybrid Materials for Controlled Release, Advanced Science, 12, 10.1002/advs.202507209 · DOI
  141. Graham, 2025, Magnetic nanoparticles and drug delivery systems for Anti-Cancer applications: A review, Nanomaterials, 15, 285, 10.3390/nano15040285 · DOI
  142. Stefanache, 2025, Chitosan Nanoparticle-Based Drug Delivery Systems: Advances, Challenges, and Future Perspectives, Polymers, 17, 1453, 10.3390/polym17111453 · DOI
  143. Yang, 2025, Advances in drug delivery systems based on liposome-composite hydrogel microspheres, Journal of Materials Chemistry B, 13, 11885, 10.1039/D5TB01369K · DOI
  144. Liu, 2025, Hydrogels in cancer treatment: mapping the future of precision drug delivery, Frontiers in Immunology, 16
  145. Zhao, 2025, Nanoformulation-Based Transdermal Drug Delivery: A Paradigm Shift in Antiparasitic Therapy for Zoonotic Diseases, Pharmaceutics, 17, 1216, 10.3390/pharmaceutics17091216 · DOI
  146. Mohammadzadeh, 2025, Hydrogels as advanced drug delivery platforms for cancer immunotherapy: promising innovations and future outlook, Journal of Nanobiotechnology, 23, 545, 10.1186/s12951-025-03613-6 · DOI
  147. Chang, 2025, Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers, Cell biology and toxicology, 41, 115, 10.1007/s10565-025-10064-0 · DOI
  148. Shadab, 2025, Hydrogel-based nanoparticles: revolutionizing brain tumor treatment and paving the way for future innovations, European Journal of Medical Research, 30, 71, 10.1186/s40001-025-02310-2 · DOI
  149. Shi, 2025, Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury, Frontiers in Bioengineering and Biotechnology, 12, 10.3389/fbioe.2024.1515164 · DOI
  150. Nunziata, 2025, Smart pH-Responsive polymers in biomedical Applications: Nanoparticles, hydrogels, and emerging hybrid platforms, Materials Today Chemistry, 49, 10.1016/j.mtchem.2025.103063 · DOI
  151. Sodimanage, 2025, The Role of Nanoparticle Elasticity on Biological Hydrogel Penetration, Pharmaceutics, 17, 760, 10.3390/pharmaceutics17060760 · DOI
  152. Xu, 2025, Nanoparticles-incorporated hydrogel microneedle for biomedical applications: fabrication strategies, emerging trends and future prospects, Asian Journal of Pharmaceutical Sciences, 10.1016/j.ajps.2025.101069 · DOI
  153. Song, 2025, Nanoparticle-integrated hydrogels as versatile colorimetric sensors, Coordination Chemistry Reviews, 541, 10.1016/j.ccr.2025.216835 · DOI
  154. Fu, 2025, A review of synergistic strategies in cancer therapy: resveratrol-loaded hydrogels for targeted and multimodal treatment, Discover Oncology, 16, 1382, 10.1007/s12672-025-03079-w · DOI
  155. Moreno, 2025, Intraocular injectable hydrogels for the delivery of cells and nanoparticles, Materials Today Bio
  156. Yang, 2025, Hydrogel Microspheres as Versatile Platforms for Biomedical Research: Design, Properties, and Applications, MedComm, 6, 10.1002/mco2.70423 · DOI
  157. Chen, 2025, Innovative Gastrointestinal Drug Delivery Systems: Nanoparticles, Hydrogels, and Microgrippers, Frontiers in Bioscience-Landmark, 30, 10.31083/FBL25281 · DOI
  158. Das, 2025, Classification and bibliometric analysis of hydrogels in periodontitis treatment: Trends, mechanisms, advantages, and future research directions, Dental Materials, 41, 81, 10.1016/j.dental.2024.10.017 · DOI
  159. Praveen, 2025, Engineering Biomaterial Scaffolds for Melanoma: Innovations in 3D Printing and Nanoparticle–Hydrogel Scaffolds for Enhanced Drug Delivery, Biomedical Materials & Devices, 1
  160. Mamidi, 2025, Advances in three-dimensional hydrogel networks for cancer immunotherapy, Journal of Materials Chemistry B, 13, 10440, 10.1039/D5TB01133G · DOI
  161. Visan, 2025, Environmental and wastewater treatment applications of stimulus-responsive hydrogels, Gels, 11, 72, 10.3390/gels11010072 · DOI
  162. Kim, 2025, Hybrid Systems of Gels and Nanoparticles for Cancer Therapy: advances in Multifunctional Therapeutic Platforms, Gels, 11, 170, 10.3390/gels11030170 · DOI
  163. Hinojosa-Ventura, 2025, From Basic to Breakthroughs: The Journey of Microfluidic Devices in Hydrogel Droplet Generation, Gels, 11, 309, 10.3390/gels11050309 · DOI
  164. Machado, 2025, Applicability of Hydrogels as Platforms for Bone Regeneration: A Mini‐Review, Polymers for Advanced Technologies, 36, 10.1002/pat.70336 · DOI
  165. Sun, 2019, Hydrogel-based controlled drug delivery for cancer treatment: a review, Molecular pharmaceutics, 17, 373
  166. Dattilo, 2023, Polysaccharide-based hydrogels and their application as drug delivery systems in cancer treatment: a review, Journal of Functional Biomaterials, 14, 55, 10.3390/jfb14020055 · DOI
  167. Norouzi, 2016, Injectable hydrogel-based drug delivery systems for local cancer therapy, Drug discovery today, 21, 1835, 10.1016/j.drudis.2016.07.006 · DOI
  168. Wang, 2023, Poly ethylene glycol (PEG)‐based hydrogels for drug delivery in cancer therapy: a comprehensive review, Advanced healthcare materials, 12
  169. Schmidt, 2008, Hydrogels used for cell‐based drug delivery, Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 87, 1113, 10.1002/jbm.a.32287 · DOI
  170. Thang, 2023, Polymer-based hydrogels applied in drug delivery: An overview, Gels, 9, 523, 10.3390/gels9070523 · DOI
  171. Peppas, 1997, Hydrogels and drug delivery, Current opinion in colloid & interface science, 2, 531, 10.1016/S1359-0294(97)80103-3 · DOI · Paper page
  172. Virmani, 2023, Amelioration of cancer employing chitosan, its derivatives, and chitosan-based nanoparticles: Recent updates, Polymers, 15, 2928, 10.3390/polym15132928 · DOI
  173. Rao Bommi, 2023, Recent trends in biosensing and diagnostic methods for novel cancer biomarkers, Biosensors, 13, 398, 10.3390/bios13030398 · DOI
  174. Zheng, 2025, Antimicrobial peptide biological activity, delivery systems and clinical translation status and challenges, Journal of Translational Medicine, 23, 292, 10.1186/s12967-025-06321-9 · DOI
  175. Zhang, 2025, From macrophage polarization to clinical translation: immunomodulatory hydrogels for infection-associated bone regeneration, Frontiers in Cell and Developmental Biology, 13, 10.3389/fcell.2025.1684357 · DOI
  176. Song, 2025, Clinical Translation Challenges and Strategies for Tumour Vaccines Considering Multiple Delivery Routes, Vaccines, 13, 469, 10.3390/vaccines13050469 · DOI
  177. Mubassir, 2025, Exploring the Versatile Pharmacological Potential of Indole Derivatives: A Comprehensive Review, Progress in Chemical and Biochemical Research, 8, 257
  178. Ukwubile, 2025, Analgesic, Anti-inflammatory, and Anti-Brain Tumor Activities of Melastomastrum capitatum A. and R. Fern. Leaf Methanol Extract in Wistar Rats, Progress in Chemical and Biochemical Research, 8, 171
  179. Mahmoodiyan, 2025, Recent Progress in Biomaterial – Enhanced Transarterial Embolization for Primary Liver Cancer Therapy: A short Review, Progress in Chemical and Biochemical Research, 8, 191
  180. Sadiq, 2024, 'Preliminary Anticancer Activity, Antimicrobial Activity, and Brine Shrimp Lethality Bioassay Fractions of Ficus platyphylla del, Stem Bark', Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry, 6, 182
  181. Gadhave, 2025, Design, Synthesis and Evaluation of Novel Phenyl-(1-morpholine-4-dimethyl/piperazin-1-ylmethyl)-1H-indol-3-ylmethylene Amine Derivatives Against Breast Cancer Cells, Chemical Methodologies, 9, 851
  182. Safaei, 2025, A Systematic Review on the Role of Silver Nanoparticles in Treatment of Oral Cancer, Chemical Methodologies, 9, 938
  183. Nouri Mollalar, 2025, 'Synthesis, Characterization, and Adsorption Studies of Functionalized Graphene Oxide via Covalent Interactions', Chemical Methodologies, 9, 771
  184. Mubassir, 2025, Comprehensive Review of Schiff Base Sulphonamides: Synthesis, Biological Activity, and Marketed Applications, Eurasian Journal of Science and Technology, 5, 366
  185. Adress. Hassan, 2025, 'Synthesis, Characterization of Silver Nanoparticles of Zizipℎus Plant Extracts and Investigation of Their Biological Activities: Antibacterial and Anticancer', Journal of Applied Organometallic Chemistry, 5, 304
  186. Balaji, 2025, Extraction, Phytochemical Screening, Green Synthesis of Silver Nanoparticles (Ag-NPs), and Antioxidant Potential of Apℎanamixis polystacℎya, Journal of Applied Organometallic Chemistry, 5, 343
  187. Ali, 2025, 'Synthesis of Tetrahydrobenzo[b]pyran Derivatives Using Reusable CoFe2O4@SiO2-CPTES-Melamine-Cu Nanocatalyst', Journal of Applied Organometallic Chemistry, 5, 97
  188. Dhaka, 2024, Exploring the Diverse Ethnopharmacological Applications of Urtica dioica L.: An Extensive Review, Journal of Agricultural Sciences and Engineering, 6, 60
  189. Mubassir, 2025, Schiff base indole derivatives: Synthesis and biological activities- a comprehensive review, Journal of Medicinal and Nanomaterials Chemistry, 7, 267
  190. Sawant, 2025, 'Biogenic synthesis of hexagonal silver nanoparticles in Cannonball flower extract exhibits antibacterial, antioxidant and anticancer effective trio bioactivities', Journal of Medicinal and Nanomaterials Chemistry, 7, 130
  191. Ahmad, 2025, 'Synthesis, characterization and pharmacological evaluation some newly Schiff base sulphonamide derivative', Journal of Medicinal and Nanomaterials Chemistry, 7, 148
  192. Shaikh, 2025, Molecular Docking and Network Pharmacology: Investigating Vitis vinifera Phytoconstituents as Multi-Target Therapeutic Agents against Breast Cancer, Journal of Pharmaceutical Sciences and Computational Chemistry, 1, 116
  193. Makong Ekpan, 2024, Emerging Technologies for Eco-Friendly Production of Bioethanol from Lignocellulosic Waste Materials, Eurasian Journal of Science and Technology, 4, 179
  194. Ndung’u, 2024, Efficacy of Adsorption of Congo Red Dyes from an Aqueous Media using Silicon Nitride (Si3N4) Adsorbent Derived from Sand and Coffee Husk Wastes, Eurasian Journal of Science and Technology, 4, 253
  195. vojood, 2024, Origin of Life on the Planet Earth: A Brief Review, Eurasian Journal of Science and Technology, 4, 11
  196. Kalvanagh, 2023, Investigating the Relationship Between A/T 251 Polymorphism of IL-8 Gene and Cancer Recurrence After Lumpectomy, Eurasian Journal of Science and Technology, 3, 172
  197. Esan, 2023, Physicochemical Properties and Solubilization of Acid Red-27 Dye in CTABr Micellar Media: Enhanced Trapping and Interactional Investigation, International Journal of Advanced Biological and Biomedical Research, 11, 232
  198. Singh, 2024, 'Synthesis, Characterization, and Application of Nanoparticles: An Exhaustive Survey of Recent Advances and Future Directions', Journal of Applied Organometallic Chemistry, 4, 190
  199. El Baakili, 2023, Synthesis Method Effect on Acellular Bioactivity of Bioglasses: Structural Analysis and Solid-State NMR, Journal of Applied Organometallic Chemistry, 3, 268
  200. Ali, 2023, Improved Morphological, Structural, and Optical Features of ErxCuNiO3 {x= 0, 0.5, 0.7, 0.9, Journal of Applied Organometallic Chemistry, 3, 308

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Metadata

Authors
Kianfar, E., Kadhum, W. R., & Mahmoud, Z. H.
Venue
Intelligent Pharmacy
Publisher
Elsevier BV
Published
2025-11
ISSN
2949-866X
DOI
10.1016/j.ipha.2025.11.002
Cited by
8
References
1
Language
en
Licence

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