Transgenic modeling of Ndr2 gene amplification reveals disturbance of hippocampus circuitry and function
Open accessAbstract
gene encodes a protein kinase important for neuronal development and is part of a microduplication region on chromosome 12 that is associated with intellectual disabilities, autism, and epilepsy. We developed a conditional transgenic mouse with increased Ndr2 expression in postmigratory forebrain neurons to study the consequences of an increased gene dosage of this Hippo pathway kinase on brain circuitry and cognitive functions. Our analysis reveals reduced terminal fields and synaptic transmission of hippocampal mossy fibers, altered hippocampal network activity, and deficits in mossy fiber-dependent behaviors. Reduced doublecortin expression and protein interactome analysis indicate that transgenic Ndr2 disturbs the maturation of granule cells in the dentate gyrus. Together, our data suggest that increased expression of Ndr2 may critically contribute to the development of intellectual disabilities upon gene amplification.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NDR2 is the only NDR kinase expressed in the adult mouse brain.
“Previously, we showed that from the mammalian NDR kinases, NDR2 is the only one expressed in the adult mouse brain.”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Madencioglu et al. 2021
The Results section (“TGNdr2 expression in the hippocampus”) says that both Ndr2 and its close homolog Ndr1 are endogenously expressed in wild-type dentate gyrus granule cells. The Methods specify that the expression measurements included mice at 3 months of age, contrary to the claim that NDR2 is the only NDR kinase expressed in the adult mouse brain. (LLM, conf=0.90)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredNDR1 expression remains completely absent in the mouse brain.
“NDR2 expression is low after birth and steadily increases during postnatal development, whereas NDR1 expression remains completely absent.”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Madencioglu et al. 2021
The Results section (‘TGNdr2 expression in the hippocampus’; page not provided) says Ndr1 is endogenously expressed in mouse dentate gyrus granule cells. That directly contradicts the claim that NDR1 expression is completely absent from the mouse brain. (LLM, conf=0.95)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredNDR2 expression is low after birth and steadily increases during postnatal development in the mouse brain.
“NDR2 expression is low after birth and steadily increases during postnatal development, whereas NDR1 expression remains completely absent.”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Madencioglu et al. 2021
The Results report that endogenous Ndr2 expression increases during postnatal development in mouse dentate gyrus granule cells. But the Discussion specifies that levels fell from P15 to P30 before rising in adulthood, so the measured trajectory was not steady; the paper also does not establish expression levels immediately after birth. (LLM, conf=0.88)
Experimental — accuracy not yet measuredNDR2 controls growth and plasticity of hippocampal mossy fibres.
“We showed that it controls the dendritic branching during the postnatal development of pyramidal neurons in hippocampal area CA3, growth, and plasticity of hippocampal mossy fibres (Demiray et al. 2018;”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Madencioglu et al. 2021
The Discussion says Ndr2-related signaling may alter mossy-fiber growth in adult-born granule cells. The Results report reduced late-phase mossy-fiber LTP in the ventral hippocampus of Ndr2-overexpressing mice, but no change in short-term plasticity or comparable change in dorsal mossy fibers. Thus, the unqualified claim that NDR2 controls mossy-fiber growth and plasticity is broader and more certain than the paper’s findings. (LLM, conf=0.85)
Experimental — accuracy not yet measuredNDR2 controls dendritic branching during the postnatal development of pyramidal neurons in hippocampal area CA3.
“We showed that it controls the dendritic branching during the postnatal development of pyramidal neurons in hippocampal area CA3, growth, and plasticity of hippocampal mossy fibres (Demiray et al. 2018;”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Madencioglu et al. 2021
The Introduction reports altered basal and apical dendrites in CA3 pyramidal neurons of Ndr2-knockout mice, supporting a role for Ndr2 in their dendritic growth. It describes those neurons in adulthood, however, and does not establish that Ndr2 controls their branching during postnatal development. (LLM, conf=0.84)
Experimental — accuracy not yet measured
The human NDR2 gene (STK38l) has been identified as a susceptibility gene for neurodevelopmental disorders, intellectual disability, and autism spectrum disorder.
“The human NDR2 gene (STK38l) has been identified as a susceptibility gene for neurodevelopmental disorders, intellectual disability (Madencioglu et al. 2021; Firth et al. 2009), and autism spectrum disorder (Fromer et al. 2014).”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Madencioglu et al. 2021
The Introduction and Discussion identify human NDR2 as part of a chromosome 12p microduplication region associated with intellectual disability and autism, and the Introduction discusses rare neurodevelopmental disorders arising from such rearrangements. The paper does not establish NDR2 itself as a human susceptibility gene; its Discussion says that NDR2 multiplication *may contribute* to the associated phenotype. (LLM, conf=0.86)
Experimental — accuracy not yet measuredNDR2 is the principal NDR kinase in the mouse CNS.
“NDR2 is the principal NDR kinase in the mouse CNS, where it has been shown to regulate integrin‐dependent dendritic branching as well as growth and plasticity in hippocampal mossy fibers.”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Madencioglu et al. 2021
Sample size was estimated according to similar work published by the group previously.
“No power analysis was performed, but the sample size was estimated according to similar work published by our group previously (Madencioglu 2019; Rehberg et al. 2014; Madencioglu et al. 2021; Hayani et al. 2018).”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Madencioglu et al. 2021
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206 · see citing works
Pérez-Riverol, Y., Csordas, A., Bai, J.-W., Bernal-Llinares, M., Hewapathirana, S., Kundu, D. J., Inuganti, A., Griss, J., Mayer, G., Eisenacher, M., et al. (2018) · Nucleic Acids Res. · doi:10.1093/nar/gky1106 · Cited by 6,216 · see citing works
Efficient selection for high-expression transfectants with a novel eukaryotic vector
Niwa, H., Yamamura, K., & Miyazaki, J. (1991) · Gene · doi:10.1016/0378-1119(91)90434-d · Cited by 5,135 · see citing works
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
Ho, Y., Gruhler, A., Heilbut, A. M., Bader, G. D., Moore, L., Adams, S., Millar, A., Taylor, P. P., Bennett, K. L., Boutilier, K., et al. (2002) · Nature · doi:10.1038/415180a · Cited by 3,573 · see citing works
Reactivation of hippocampal ensemble memories during sleep
Wilson, M. A., & McNaughton, B. L. (1994) · Science · doi:10.1126/science.8036517 · Cited by 3,118 · see citing works
DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources
Firth, H. V., Richards, S. M., Bevan, A. P., Clayton, S., Corpas, M., Rajan, D., Vooren, S. V., Moreau, Y., Pettett, R. M., & Carter, N. P. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.03.010 · Cited by 1,990 · see citing works
von Mering, C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki005 · Cited by 1,768 · see citing works
Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning
Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759 · see citing works
Essential Role for TrkB Receptors in Hippocampus-Mediated Learning
Minichiello, L., Korte, M., Wolfer, D., Kühn, R., Unsicker, K., Cestari, V., Rossi-Arnaud, C., Lipp, H.-P., Bonhoeffer, T., & Klein, R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80853-3 · Cited by 799 · see citing works
GENECODIS: a web-based tool for finding significant concurrent annotations in gene lists
Carmona‐Sáez, P., Chagoyen, M., Tirado, F., Carazo, J. M., & Pascual-Montano, A. (2007) · Genome biology · doi:10.1186/gb-2007-8-1-r3 · Cited by 591 · see citing works
GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics
Tabas‐Madrid, D., Nogales‐Cadenas, R., & Pascual-Montano, A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks402 · Cited by 537 · see citing works
Zeng, L.-H., Rensing, N., & Wong, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0066-09.2009 · Cited by 505 · see citing works
Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury
Koike, M., Shibata, M., Tadakoshi, M., Gotoh, K., Komatsu, M., Waguri, S., Kawahara, N., Kuida, K., Nagata, S., Kominami, E., et al. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070876 · Cited by 486 · see citing works
Couzens, A. L., Knight, J. D. R., Kean, M. J., Teo, G., Weiss, A., Dunham, W. H., Lin, Z., Bagshaw, R. D., Sicheri, F., Pawson, T. J., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004712 · Cited by 440 · see citing works
Gamma oscillations dynamically couple hippocampal CA3 and CA1 regions during memory task performance
Montgomery, S. M., & Buzsáki, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701826104 · Cited by 431 · see citing works
Vandecasteele, M., Varga, V., Berényi, A., Papp, E., Barthó, P., Venance, L., Freund, T. F., & Buzsáki, G. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411233111 · Cited by 409 · see citing works
Maier, N., Nimmrich, V., & Draguhn, A. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.044602 · Cited by 340 · see citing works
Girirajan, S., Dennis, M. Y., Baker, C. A., Malig, M., Coe, B. P., Campbell, C. D., Mark, K. M. K., Vu, T. H., Alkan, C., Cheng, Z., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.12.016 · Cited by 292 · see citing works
Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity
Berger, S., Wolfer, D. P., Selbach, O., Alter, H., Erdmann, G., Reichardt, H. M., Chepkova, A. N., Welzl, H., Haas, H. L., Lipp, H.-P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503878102 · Cited by 272 · see citing works
Huang, Y.-Y., Kandel, E. R., Varshavsky, L., Brandont, E. P., Qi, M., Idzerda, R. L., Stanley McKnight, G., & Bourtchouladz, R. (1995) · Cell · doi:10.1016/0092-8674(95)90146-9 · Cited by 267 · see citing works
Emoto, K., He, Y., Ye, B., Grueber, W. B., Adler, P. N., Jan, L. Y., & Jan, Y.-N. (2004) · Cell · doi:10.1016/j.cell.2004.09.036 · Cited by 235 · see citing works
Evers, M. R., Salmen, B., Bukalo, O., Rollenhagen, A., Bösl, M. R., Morellini, F., Bartsch, U., Dityatev, A., & Schachner, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07177.2002 · Cited by 172 · see citing works
Self-citationChan, C.-S., Weeber, E. J., Zong, L., Fuchs, E., Sweatt, J. D., & Davis, R. L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4110-05.2006 · Cited by 165 · see citing works
Serum response factor controls neuronal circuit assembly in the hippocampus
Knöll, B., Kretz, O., Fiedler, C., Alberti, S., Schütz, G., Frotscher, M., & Nordheim, A. (2006) · Nature Neuroscience · doi:10.1038/nn1627 · Cited by 162 · see citing works
Tetrasomy 12p (Pallister-Killian syndrome).
Schinzel, A. (1991) · Journal of Medical Genetics · doi:10.1136/jmg.28.2.122 · Cited by 157 · see citing works
Poland syndrome: a concept of pathogenesis based on limb bud embryology.
Pallister, P. D., Meisner, L. F., Elejalde, B. R., Francke, U., Herrmann, J., Spranger, J., Tiddy, W., Inhorn, S. L., & Opitz, J. M. (1977) · PubMed · Cited by 150 · see citing works
Crusio, W. E., Schwegler, H., & van Abeelen, J. H. F. (1989) · Behavioural Brain Research · doi:10.1016/s0166-4328(89)80075-0 · Cited by 143 · see citing works
Sasaki, T., Piatti, V. C., Hwaun, E., Ahmadi, S., Lisman, J. E., Leutgeb, S., & Leutgeb, J. K. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0061-5 · Cited by 134 · see citing works
Ultanir, S. K., Hertz, N. T., Li, G., Ge, W.-P., Burlingame, A. L., Pleasure, S. J., Shokat, K. M., Jan, L. Y., & Jan, Y.-N. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.019 · Cited by 131 · see citing works
Mechanosensory neurite termination and tiling depend on SAX-2 and the SAX-1 kinase.
Gallegos, M. E., & Bargmann, C. I. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.021 · Cited by 124 · see citing works
Schuster, T., Krug, M., Stalder, M., Hackel, N., Gerardy‐Schahn, R., & Schachner, M. (2001) · Journal of Neurobiology · doi:10.1002/neu.1071 · Cited by 105 · see citing works
Pallister‐Killian syndrome: cytogenetic and molecular studies
Peltomäki, P., Knuutila, S., Ritvanen, A., Kaitila, I., & de la Chapelle, A. (1987) · Clinical Genetics · doi:10.1111/j.1399-0004.1987.tb02832.x · Cited by 102 · see citing works
Schwegler, H., Lipp, H. P., der Loos, H. V., & Buselmaier, W. (1981) · Science · doi:10.1126/science.7292015 · Cited by 97 · see citing works
The development of the dentate area and the hippocampal mossy fiber projection of the rat
Gaarskjaer, F. B. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902410204 · Cited by 88 · see citing works
Schmued, L., & Slikker, W. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01624-8 · Cited by 85 · see citing works
Hayani, H., Song, I., & Dityatev, A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00149 · Cited by 84 · see citing works
Self-citationAndres‐Alonso, M., Ammar, M. R., Butnaru, I., Gomes, G. M., Sanhueza, G. A., Raman, R., Yuanxiang, P., Borgmeyer, M., Lopez‐Rojas, J., Raza, S. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13224-z · Cited by 82 · see citing works
Self-citationCase report 72 : mental retardation, unusual facial appearance, abnormal hair
Killian, W. (1981) · Cited by 77 · see citing works
Zemankovics, R., Veres, J. M., Oren, I., & Hájos, N. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3680-12.2013 · Cited by 74 · see citing works
Hippocampal network oscillations at the interplay between innate anxiety and learned fear
Çalışkan, G., & Stork, O. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5109-z · Cited by 72 · see citing works
Self-citationIdentification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence
Çalışkan, G., Müller, I., Semtner, M., Winkelmann, A., Raza, A. S., Hollnagel, J., Rösler, A., Heinemann, U., Stork, O., & Meier, J. C. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw001 · Cited by 70 · see citing works
Self-citationMcNamara, R. K., Stumpo, D. J., Morel, L. M., Lewis, M. H., Wakeland, E. K., Blackshear, P. J., & Lenox, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14517 · Cited by 67 · see citing works
He, Y., Fang, X., Emoto, K., Jan, Y. N., & Adler, P. N. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-09-0828 · Cited by 64 · see citing works
Dumas, T. C., Powers, E. C., Tarapore, P. E., & Sapolsky, R. M. (2004) · Hippocampus · doi:10.1002/hipo.10210 · Cited by 62 · see citing works
Neuronal Functions of the Novel Serine/Threonine Kinase Ndr2
Stork, O., Zhdanov, A., Kudersky, A., Yoshikawa, T., Obata, K., & Pape, H.-C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403552200 · Cited by 55 · see citing works
Self-citationAlbrecht, A., Çalışkan, G., Oitzl, M. S., Heinemann, U., & Stork, O. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.192 · Cited by 55 · see citing works
Self-citationSchildt, S., Endres, T., Leßmann, V., & Edelmann, E. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.041 · Cited by 55 · see citing works
Çalışkan, G., & Stork, O. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.02.022 · Cited by 55 · see citing works
Self-citationThe Serine/Threonine Kinase Ndr2 Controls Integrin Trafficking and Integrin-Dependent Neurite Growth
Rehberg, K., Kliche, S., Madencioglu, D. A., Thiere, M., Müller, B., Meineke, B. M., Freund, C., Budinger, E., & Stork, O. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2728-13.2014 · Cited by 49 · see citing works
Self-citationPapatheodoropoulos, C., & Kostopoulos, G. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00738-9 · Cited by 48 · see citing works
Hippocampus-dependent place learning enables spatial flexibility in C57BL6/N mice
Kleinknecht, K. R., Bedenk, B. T., Kaltwasser, S. F., Grünecker, B., Yen, Y.-C., Czisch, M., & Wotjak, C. T. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00087 · Cited by 46 · see citing works
Rehberg, K., Bergado-Acosta, J. R., Koch, J. C., & Stork, O. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.04.007 · Cited by 46 · see citing works
Self-citationIdentification of SIN Pathway Targets Reveals Mechanisms of Crosstalk between NDR Kinase Pathways
Gupta, S. V., Mana‐Capelli, S., McLean, J. R., Chen, C., Ray, S., Gould, K. L., & McCollum, D. (2013) · Current Biology · doi:10.1016/j.cub.2013.01.014 · Cited by 46 · see citing works
Arruda-Carvalho, M., Restivo, L., Guskjolen, A. J., Epp, J. R., Elgersma, Y., Josselyn, S. A., & Frankland, P. W. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0652-14.2014 · Cited by 44 · see citing works
The growing role of the Hippo-NDR kinase signalling in neuronal development and disease
Emoto, K. (2011) · The Journal of Biochemistry · doi:10.1093/jb/mvr080 · Cited by 44 · see citing works
Lu, C. B., Jefferys, J. G. R., Toescu, E. C., & Vreugdenhil, M. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.11.008 · Cited by 43 · see citing works
Sakuma, C., Saito, Y., Umehara, T., Kamimura, K., Maeda, N., Mosca, T. J., Miura, M., & Chihara, T. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.066 · Cited by 41 · see citing works
GAD65 haplodeficiency conveys resilience in animal models of stress-induced psychopathology
ller, I. M. ⁄., Obata, K., Richter‐Levin, G., & Stork, O. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00265 · Cited by 40 · see citing works
Self-citationHelme-Guizon, A., Davis, S., Israel, M., Lesbats, B., Mallet, J., Laroche, S., & Hicks, A. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00232.x · Cited by 39 · see citing works
Structural plasticity of spines at giant mossy fiber synapses
Zhao, S., Studer, D., Chai, X., Graber, W. A., Brose, N., Nestel, S., Young, C. C., Rodriguez, E., Saetzler, K., & Frotscher, M. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00103 · Cited by 37 · see citing works
Segev, A., Yanagi, M., Scott, D. E., Southcott, S. A., Lister, J. M., Tan, C., Li, W., Birnbaum, S. G., Kourrich, S., & Tamminga, C. A. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0124-3 · Cited by 33 · see citing works
Hiroi, N., & Yamauchi, T. (2019) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz026 · Cited by 31 · see citing works
Enhanced dendritogenesis and axogenesis in hippocampal neuroblasts of LRRK2 knockout mice
Paus, M., Kohl, Z., Abdallah, N. M. ‐. B., Galter, D., Gillardon, F., & Winkler, J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.12.024 · Cited by 31 · see citing works
Çalışkan, G., Schulz, S., Gruber, D., Behr, J., Heinemann, U., & Gerevich, Z. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12750 · Cited by 29 · see citing works
Self-citationCircadian Modulation of Anxiety: A Role for Somatostatin in the Amygdala
Albrecht, A., Thiere, M., Bergado-Acosta, J. R., Poranzke, J., Müller, B., & Stork, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084668 · Cited by 26 · see citing works
Self-citationSynapsin- and Actin-Dependent Frequency Enhancement in Mouse Hippocampal Mossy Fiber Synapses
Owe, S. G., Jensen, V., Evergren, E., Ruiz, A. J., Shupliakov, O., Kullmann, D. M., Storm‐Mathisen, J., Walaas, S. I., Hvalby, Ø., & Bergersen, L. H. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn101 · Cited by 24 · see citing works
Are NCAM deficient mice an animal model for schizophrenia?
Albrecht, A., & Stork, O. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00043 · Cited by 23 · see citing works
Self-citationYan, H., Ge, W., Chew, T. G., Chow, J. Y., McCollum, D., Neiman, A. M., & Balasubramanian, M. K. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1060 · Cited by 21 · see citing works
A review of structural brain abnormalities in Pallister‐Killian syndrome
Poulton, C., Baynam, G. S., Yates, C. G., Alinejad‐Rokny, H., Williams, S., Wright, H., Woodward, K. J., Sivamoorthy, S., Peverall, J., Shipman, P. J., et al. (2017) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.351 · Cited by 20 · see citing works
Origins of an Intrinsic Hippocampal EEG Pattern
Rex, C. S., Colgin, L. L., Jia, Y., Casale, M., Yanagihara, T. K., Debenedetti, M., Gall, C. M., Kramár, E. A., & LYNCH, G. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007761 · Cited by 17 · see citing works
Seizures and EEG patterns in Pallister–Killian syndrome: 13 New Italian patients
Giordano, L., Viri, M., Borgatti, R., Lodi, M. A. M., Accorsi, P., Faravelli, F., Ferretti, M. C., Grasso, R., Memo, L., Prola, S., et al. (2012) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2012.03.003 · Cited by 15 · see citing works
The c-Jun N-terminal kinase signaling pathway in epilepsy: activation, regulation, and therapeutics
Zhang, W., Wang, X. B., Yu, M., Li, J., & Meng, H. (2018) · Journal of Receptors and Signal Transduction · doi:10.1080/10799893.2019.1590410 · Cited by 14 · see citing works
Ndr2 Kinase Controls Neurite Outgrowth and Dendritic Branching Through α1 Integrin Expression
Demiray, Y. E., Rehberg, K., Kliche, S., & Stork, O. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00066 · Cited by 12 · see citing works
Self-citationKolodziej, A., Smalla, K., Richter, S., Engler, A., Pielot, R., Dieterich, D. C., Tischmeyer, W., Naumann, M., & Kähne, T. (2016) · Journal of Visualized Experiments · doi:10.3791/54992 · Cited by 9 · see citing works
Self-citationZhang, Y.-F., Li, S.-L., Xiong, T., Yang, L., Li, Y., Tan, B., li, Y.-C., & li, Y.-C. (2013) · Epilepsy Research · doi:10.1016/j.eplepsyres.2013.10.019 · Cited by 8 · see citing works
Long-term changes in the CA3 associative network of fear-conditioned mice
Çalışkan, G., Albrecht, A., Hollnagel, J., Rösler, A., Richter‐Levin, G., Heinemann, U., & Stork, O. (2015) · Stress · doi:10.3109/10253890.2015.1004628 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Pallister P.D. Meisner L.F. Elejalde B.R. Francke U. Herrmann J. Spranger J. Tiddy W. Inhorn S.L. Opitz J.M. The pallister mosaic syndrome. Birth Defects Orig Artic. Ser. 13 1977 103 110 890087
Cited by
Sorted by citations
The NDR family of kinases: essential regulators of aging
Jonischkies, K., del Ángel, M., Demiray, Y. E., Zambrano, A. L., & Stork, O. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1371086 · Cited by 9 · see citing works
Self-citationÇalışkan, G., Demiray, Y. E., & Stork, O. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16112 · Cited by 7 · see citing works
Self-citationZhang, C., He, Z., Tan, Z., & Tian, F. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284359 · Cited by 4 · see citing works
del Ángel, M., Tsutiya, A., Hayani, H., Madencioglu, D., Kul, E., Caliskan, G., Demiray, Y. E., Dityatev, A., & Stork, O. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70094 · Cited by 1 · see citing works
Self-citationCui, Y., Wang, Q., Zhai, H., Yan, G., & Li, J. (2023) · Journal of Mechanics in Medicine and Biology · doi:10.1142/s021951942340078x · Cited by 1 · see citing works
NDR2 kinase: A review of its physiological role and involvement in carcinogenesis
Biojout, T., Bergot, E., Bernay, B., Levallet, G., & Levallet, J. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143656 · Cited by 1 · see citing works
Gu, J., Marjanović, J., Tomic‐Canic, M., Zhang, F., & Verde, F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.30.685405
- Authors
- Madencioglu, D. A., Çalışkan, G., Yuanxiang, P., Rehberg, K., Demiray, Y. E., Kul, E., Engler, A., Hayani, H., Bergado-Acosta, J. R., Kummer, A., Müller, I., Song, I., Dityatev, A., Kähne, T., Kreutz, M. R., & Stork, O.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- Center for Behavioral Brain Sciences (DE)
- Leibniz Institute for Neurobiology (DE)
- German Center for Neurodegenerative Diseases (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Stork, Oliver
- ORCID
- Venue
- iScience
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 24
- Issue
- 8
- Pages
- 102868
- ISSN
- 2589-0042 (ISSN-L)
- PMC
- PMC8340122
- OpenAlex
- W3186221385
- Cited by
- 8
- References
- 76
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 3 · 2022: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- iScience (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by-nc-nd)
- DZNE Pub (submittedVersion, cc-by-nc-nd)
- Digitalen Hochschulbibliothek Sachsen-Anhalt (Universitäts- und Landesbibliothek Sachsen-Anhalt)
- Funders
- European Regional Development Fund (ZS/2016/04/78113)
- Deutsche Forschungsgemeinschaft (CRC779, 362321501/RTG 2413 SynAGE, STO448/4-1, DI 702/8-1)
- Wellcome Trust
- Leibniz-Gemeinschaft
- Center for Behavioral Brain Sciences (SAS-2015-LIN-LWC)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Keywords
- NDR2, gene amplification, Hippo signaling pathway, hippocampus, mossy fibers, synaptic transmission, dentate gyrus, granule cell maturation, doublecortin, intellectual disability, autism spectrum disorder, epilepsy, cognitive impairment, neuronal development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
