Control of Dendritic Branching and Tiling by the Tricornered-Kinase/Furry Signaling Pathway in Drosophila Sensory Neurons
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To cover the receptive field completely but without redundancy, neurons of certain functional groups exhibit tiling of their dendrites via dendritic repulsion. Here we show that two evolutionarily conserved proteins, the Tricornered (Trc) kinase and Furry (Fry), are essential for tiling and branching control of Drosophila sensory neuron dendrites. Dendrites of fry and trc mutants display excessive terminal branching and fail to avoid homologous dendritic branches, resulting in significant overlap of the dendritic fields. Trc control of dendritic branching involves regulation of RacGTPase, a pathway distinct from the action of Trc in tiling. Timelapse analysis further reveals a specific loss of the ability of growing dendrites to turn away from nearby dendritic branches in fry mutants, suggestive of a defect in like-repels-like avoidance. Thus, the Trc/Fry signaling pathway plays a key role in patterning dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching.
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Loss of the NDR2 homolog Trc or its regulator Fry in Drosophila disrupts both dendritic tiling and branching.
“Previous studies have shown that the loss of the NDR2 homolog Trc or its regulator Fry in Drosophila disrupts both dendritic tiling and branching (Emoto et al. 2004)”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Emoto et al. 2004
Drosophila and C. elegans Ndr homologs Tricornered and SAX-1 are involved in patterning dendrites.
“The Drosophila and Caenorhabditis elegans Ndr homologs Tricornered and SAX-1 are involved in patterning dendrites (Emoto et al., 2004; Emoto et al., 2006; Gallegos and Bargmann, 2004; He et al., 2005).”
From Rassf5 and Ndr kinases act in a novel pathway regulating neuronal polarity through Par3 phosphorylation (2014) · cites this paper as Emoto et al., 2004
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Dendritic arbor development and synaptogenesis
Cline, H. T. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00182-3 · Cited by 499 · see citing works
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Branching out: mechanisms of dendritic arborization
Jan, Y.-N., & Jan, L. Y. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2836 · Cited by 693 · see citing works
Self-citationGulsuner, S., Walsh, T., Watts, A. C., Lee, M. K., Thornton, A. M., Casadei, S., Rippey, C., Shahin, H., Braff, D., Cadenhead, K. S., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.049 · Cited by 536 · see citing works
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Genetic modifiers of MeCP2 function in Drosophila
Cukier, H. N., Perez, A. M., Collins, A. L., Zhou, Z., Zoghbi, H. Y., & Botas, J. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000179 · Cited by 73 · see citing works
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“Notably, the NDR kinase homologs in D. melanogaster (Emoto et al. 2004) and C. elegans (Gallegos et al. 2004) have been shown to play critical roles in regulating dendritic tiling and branching.”
- Authors
- Emoto, K., He, Y., Ye, B., Grueber, W. B., Adler, P. N., Jan, L. Y., & Jan, Y.-N.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Virginia Cancer Center (US)
- Corresponding author
- Jan, Yuh-Nung
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 119
- Issue
- 2
- Pages
- 245-256
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2106013763
- Cited by
- 235
- References
- 2
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 5 · 2021: 13 · 2020: 9 · 2019: 7 · 2018: 12 · 2017: 3 · 2016: 8 · 2015: 10 · 2014: 11 · 2013: 15 · 2012: 17
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3211 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (R0153498)
- National Institute of General Medical Sciences (R01GM053498)
- National Institute of Neurological Disorders and Stroke (R01NS40929, F32NS046847, R01NS040929)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- dendritic branching, sensory neurons, Drosophila, Rac GTPase, dendritic growth
- MeSH terms
- Amino Acid Sequence, Animals, Dendrites, Drosophila melanogaster, Humans, Molecular Sequence Data, Neurons, Afferent, Phenotype, Signal Transduction, Sequence Alignment, Protein Serine-Threonine Kinases, Genes, Reporter, rac GTP-Binding Proteins, Drosophila Proteins, Cell Shape
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