Cited by 46Memory and Neural MechanismsSpatial Cognition and NavigationNeurogenesis and neuroplasticity mechanisms

Hippocampus-dependent place learning enables spatial flexibility in C57BL6/N mice

Open access
Kleinknecht, Karl R., Bedenk, Benedikt T., Kaltwasser, Sebastian F., Grünecker, Barbara, Yen, Yi-Chun, Czisch, Michael, Wotjak, Carsten T.·2012·Frontiers in Behavioral Neuroscience

Abstract

Spatial navigation is a fundamental capability necessary in everyday life to locate food, social partners, and shelter. It results from two very different strategies: (1) place learning which enables for flexible way finding and (2) response learning that leads to a more rigid "route following." Despite the importance of knockout techniques that are only available in mice, little is known about mice' flexibility in spatial navigation tasks. Here we demonstrate for C57BL6/N mice in a water-cross maze (WCM) that only place learning enables spatial flexibility and relearning of a platform position, whereas response learning does not. This capability depends on an intact hippocampal formation, since hippocampus lesions by ibotenic acid (IA) disrupted relearning. In vivo manganese-enhanced magnetic resonance imaging revealed a volume loss of ≥60% of the hippocampus as a critical threshold for relearning impairments. In particular the changes in the left ventral hippocampus were indicative of relearning deficits. In summary, our findings establish the importance of hippocampus-dependent place learning for spatial flexibility and provide a first systematic analysis on spatial flexibility in mice.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fnbeh.2012.00087

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Spatial navigation paradigms are known to depend on normal synaptic function in the hippocampal CA1 region.

    “spatial navigation paradigms, which are known to be dependent on normal synaptic function in this region (Kleinknecht et al. 2012; Vorhees and Williams 2006).”

    From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Kleinknecht et al. 2012

    The Introduction describes place learning as a hippocampus-dependent navigation strategy, and the Abstract reports that hippocampal lesions disrupted spatial relearning in C57BL6/N mice. The paper does not establish that spatial navigation paradigms generally depend on normal synaptic function specifically in CA1; its experiment examined hippocampal lesions, not CA1 synaptic function. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 65 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Moser M. B. Moser E. I. (1998). Functional differentiation in the hippocampus. Hippocampus 8, 608– 619 9882018

Cited by

Sorted by citations

Authors
Kleinknecht, K. R., Bedenk, B. T., Kaltwasser, S. F., Grünecker, B., Yen, Y.-C., Czisch, M., & Wotjak, C. T.
Affiliations
Max Planck Institute of Psychiatry (DE)
Corresponding author
Wotjak, Carsten T.
Venue
Frontiers in Behavioral Neuroscience
Published
2012
Volume
6
Pages
87-87
ISSN
1662-5153 (ISSN-L)
OpenAlex
W2088181186
Cited by
46
References
65
Citations by year
2025: 3 · 2023: 1 · 2022: 2 · 2021: 9 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 2
FWCI
2.13
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
hippocampus, place learning, spatial flexibility, spatial navigation, response learning, ibotenic acid lesions, manganese-enhanced MRI, ventral hippocampus, C57BL/6 mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review