Stabilin Receptors Clear LPS and Control Systemic Inflammation

NIH Image to ImageJ: 25 years of image analysis

Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638 · see citing works

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631 · see citing works

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374 · see citing works

Toll-like receptors in the induction of the innate immune response

Aderem, A. A., & Ulevitch, R. J. (2000) · Nature · doi:10.1038/35021228 · Cited by 3,047 · see citing works

LPS induction of gene expression in human monocytes.

Guha, M., & Mackman, N. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(00)00149-2 · Cited by 2,441 · see citing works

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 ( Tlr4 )

Qureshi, S. T., Larivière, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P., & Malo, D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.615 · Cited by 1,525 · see citing works

Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

Zarember, K. A., & Godowski, P. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.554 · Cited by 1,251 · see citing works

The indigenous gastrointestinal microflora

Berg, R. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10057-3 · Cited by 1,153 · see citing works

A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation.

Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776 · see citing works

Relationship between Plasma Levels of Lipopolysaccharide (LPS) and LPS‐Binding Protein in Patients with Severe Sepsis and Septic Shock

Opal, S. M., Scannon, P. J., Vincent, J., White, M., Carroll, S. F., Palardy, J. E., Parejo, N. A., Pribble, J. P., & Lemke, J. H. (1999) · The Journal of Infectious Diseases · doi:10.1086/315093 · Cited by 609 · see citing works

Recognition and plasma clearance of endotoxin by scavenger receptors

Hampton, R. Y., Golenbock, D. T., Penman, M., Krieger, M., & Raetz, C. R. H. (1991) · Nature · doi:10.1038/352342a0 · Cited by 524 · see citing works

Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity

Shetty, S., Lalor, P. F., & Adams, D. H. (2018) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-018-0020-y · Cited by 523 · see citing works

Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression

Stevens, B. R., Goel, R., Seungbum, K., Richards, E. M., Holbert, R. C., Pepine, C. J., & Raizada, M. K. (2018) · Gut · doi:10.1136/gutjnl-2017-314759 · Cited by 508 · see citing works

Association of endotoxemia with carotid atherosclerosis and cardiovascular disease

Wiedermann, C. J., Kiechl, S., Dunzendorfer, S., Schratzberger, P., Egger, G., Oberhollenzer, F., & Willeit, J. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00448-9 · Cited by 505 · see citing works

The Clearance, Tissue Distribution, and Cellular Localization of Intravenously Injected Lipopolysaccharide in Rabbits

Mathison, J. C., & Ulevitch, R. J. (1979) · The Journal of Immunology · doi:10.4049/jimmunol.123.5.2133 · Cited by 425 · see citing works

Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers

Larionova, I., Tuguzbaeva, G. M., Ponomaryova, A. A., Stakheyeva, M. N., Чердынцева, Н. В., Павлов, В. Н., Чойнзонов, Е. Л., & Kzhyshkowska, J. G. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.566511 · Cited by 396 · see citing works

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

Tulkens, J., Vergauwen, G., Deun, J. V., Geeurickx, E., Dhondt, B., Lippens, L., Scheerder, M. D., Miinalainen, I., Rappu, P., Geest, B. G. D., et al. (2018) · Gut · doi:10.1136/gutjnl-2018-317726 · Cited by 342 · see citing works

Metabolic endotoxemia and diabetes mellitus: A systematic review

Gomes, J. M. G., Costa, J. D. A., & Alfenas, R. D. C. G. (2016) · Metabolism · doi:10.1016/j.metabol.2016.12.009 · Cited by 334 · see citing works

Gut Microbiota, Intestinal Permeability, Obesity‐Induced Inflammation, and Liver Injury

Frazier, T. H., DiBaise, J. K., & McClain, C. J. (2011) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607111413772 · Cited by 306 · see citing works

Recent clinical trends in Toll‐like receptor targeting therapeutics

Anwar, M. A., Shah, M., Kim, J., & Choi, S. (2018) · Medicinal Research Reviews · doi:10.1002/med.21553 · Cited by 276 · see citing works

Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance

Caradonna, L., Amati, L., Magrone, T., Pellegrino, N. M., Jirillo, E., & Caccavo, D. (2000) · Journal of Endotoxin Research · doi:10.1177/09680519000060030101 · Cited by 247 · see citing works

Endotoxin, Toll-like receptor 4, and the afferent limb of innate immunity

Beutler, B. (2000) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)00046-6 · Cited by 238 · see citing works

Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease

Uhde, M., Ajamian, M., Caio, G., GIORGIO, R. D., Indart, A. C., Green, P. H., Verna, E. C., Volta, U., & Alaedini, A. (2016) · Gut · doi:10.1136/gutjnl-2016-311964 · Cited by 232 · see citing works

Endotoxemia—menace, marker, or mistake?

Munford, R. S. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ru0316-151r · Cited by 219 · see citing works

Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway.

Kzhyshkowska, J., Mamidi, S., Gratchev, A., Kremmer, E., Schmuttermaier, C., Krusell, L., Haus, G., Utikal, J., Schledzewski, K., Scholtze, J., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2843 · Cited by 216 · see citing works

Toll‐like receptor‐induced innate immune responses in non‐parenchymal liver cells are cell type‐specific

Wu, J., Meng, Z., Jiang, M., Zhang, E., Trippler, M., Broering, R., Bucchi, A., Krux, F., Dittmer, U., Yang, D., et al. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03179.x · Cited by 213 · see citing works

TLRs and chronic inflammation

Ospelt, C., & Gay, S. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.10.010 · Cited by 197 · see citing works

Lipopolysaccharide Clearance, Bacterial Clearance, and Systemic Inflammatory Responses Are Regulated by Cell Type–Specific Functions of TLR4 during Sepsis

Deng, M., Scott, M. J., Loughran, P., Gibson, G. A., Sodhi, C. P., Watkins, S. C., Hackam, D. J., & Billiar, T. R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300496 · Cited by 191 · see citing works

Gastrointestinal and hepatic mechanisms limiting entry and dissemination of lipopolysaccharide into the systemic circulation

Guerville, M., & Boudry, G. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2016 · Cited by 189 · see citing works

Uptake by liver cells of endotoxin following its intravenous injection.

Dj, R., van der Meulen, J., Brouwer, A., Mj, H., Mauw, B. J., Jc, V. D. P., & Wisse, E. (1981) · PubMed · Cited by 188 · see citing works

Clearance Capacity of Rat Liver Kupffer, Endothelial, and Parenchymal Cells

Dalen, D. P. P.-V., Brouwer, A., & Knook, D. L. (1981) · Gastroenterology · doi:10.1016/s0016-5085(81)80009-1 · Cited by 186 · see citing works

Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver

Uhrig, A., Banafsche, R., Kremer, M., Hegenbarth, S., Hamann, A., Neurath, M., Gerken, G., Limmer, A., & Knolle, P. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0604332 · Cited by 176 · see citing works

Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver

Miller, C. M., Donner, A. J., Blank, E. K., Egger, A. W., Kellar, B. M., Østergaard, M. E., Seth, P. P., & Harris, E. N. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw112 · Cited by 171 · see citing works

The Role of Toll-like Receptor 4 in Environmental Airway Injury in Mice

Hollingsworth, J. W., Cook, D. N., Brass, D. M., Walker, J. K. L., Morgan, D. L., Foster, W. M., & Schwartz, D. A. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200311-1499oc · Cited by 166 · see citing works

FcγRIIb on Liver Sinusoidal Endothelium Clears Small Immune Complexes

Ganesan, L. P., Kim, J., Wu, Y., Mohanty, S., Phillips, G. S., Birmingham, D. J., Robinson, J. M., & Anderson, C. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202017 · Cited by 166 · see citing works

Role of hepatocytes in direct clearance of lipopolysaccharide in rats

Mimura, Y., Sakisaka, S., Harada, M., Sata, M., & Tanikawa, K. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90765-3 · Cited by 163 · see citing works

Low TLR4 Expression by Liver Dendritic Cells Correlates with Reduced Capacity to Activate Allogeneic T Cells in Response to Endotoxin

Creus, A. D., Abe, M., Lau, A. H., Hackstein, H., Raimondi, G., & Thomson, A. W. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2037 · Cited by 162 · see citing works

The modification of biophysical and endotoxic properties of bacterial lipopolysaccharides by serum.

Ulevitch, R. J., & Johnston, A. R. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109252 · Cited by 154 · see citing works

Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein

Yao, Z., Mates, J. M., Cheplowitz, A. M., Hammer, L. P., Maiseyeu, A., Phillips, G. S., Wewers, M. D., Rajaram, M. V. S., Robinson, J. M., Anderson, C. L., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600702 · Cited by 151 · see citing works

Elevated circulating levels of inflammatory cytokines and bacterial endotoxin in adults with congenital heart disease

Sharma, R., Bolger, A. P., Li, W., Davlouros, P. A., Volk, H., Poole-Wilson, P. A., Coats, A. J. S., Gatzoulis, M. Α., & Anker, S. D. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00536-8 · Cited by 149 · see citing works

Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding

HANSEN, B., Longati, P., Elvevold, K., Nedredal, G. I., Schledzewski, K., Olsen, R. E., Falkowski, M., Kzhyshkowska, J. G., CARLSSON, F., & JOHANSSON, S. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.09.017 · Cited by 144 · see citing works

Expression, Processing, and Glycosaminoglycan Binding Activity of the Recombinant Human 315-kDa Hyaluronic Acid Receptor for Endocytosis (HARE)

Harris, E. N., Kyosseva, S. V., Weigel, J. A., & Weigel, P. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607787200 · Cited by 137 · see citing works

Bacterial Lipopolysaccharides: Structure, Metabolism and Mechanisms of Action

Freudenberg, M. A., & Galanos, C. (1990) · International Reviews of Immunology · doi:10.3109/08830189009056632 · Cited by 133 · see citing works

LPS-induced down-regulation of signal regulatory protein α contributes to innate immune activation in macrophages

Kong, X., Yan, H., Chen, L., Dong, L., Yang, W., Liu, Q., Yu, L., Huang, D., Liu, S., Liu, H., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062611 · Cited by 131 · see citing works

Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor

Topchiy, E., Cirstea, M. S., Kong, H. J., Boyd, J. H., Wang, Y., Russell, J. A., & Walley, K. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155030 · Cited by 130 · see citing works

The Human Hyaluronan Receptor for Endocytosis (HARE/Stabilin-2) Is a Systemic Clearance Receptor for Heparin

Harris, E. N., Weigel, J. A., & Weigel, P. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710360200 · Cited by 126 · see citing works

Transport of Bacterial Lipopolysaccharide to the Golgi Apparatus

Thiéblemont, N., & Wright, S. D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.4.523 · Cited by 123 · see citing works

Enteric bacteria, lipopolysaccharides and related cytokines in inflammatory bowel disease: biological and clinical significance

Caradonna, L., Amati, L., Magrone, T., Pellegrino, N. M., Jirillo, E., & Caccavo, D. (2000) · Journal of Endotoxin Research · doi:10.1179/096805100101532063 · Cited by 120 · see citing works

Phase I trial of intravenously administered endotoxin (Salmonella abortus equi) in cancer patients.

Engelhardt, R., Mackensen, A., & Galanos, C. (1991) · PubMed · Cited by 114 · see citing works

Preoperative and Postoperative Endotoxemia in Children With Congenital Heart Disease

Lequier, L. L., Nikaidoh, H., Leonard, S. R., Bokovoy, J., White, M., Scannon, P. J., & Giroir, B. P. (2000) · CHEST Journal · doi:10.1378/chest.117.6.1706 · Cited by 108 · see citing works

A Host Lipase Detoxifies Bacterial Lipopolysaccharides in the Liver and Spleen

Shao, B., Lu, M., Katz, S. C., Varley, A. W., Hardwick, J., Rogers, T. E., Ojogun, N., Rockey, D. C., DeMatteo, R. P., & Munford, R. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609462200 · Cited by 106 · see citing works

Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis

Hirose, Y., Saijou, E., Sugano, Y., Takeshita, F., Nishimura, S., Nonaka, H., Chern, E., Sekine, K., Kido, T., Nakamura, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117560109 · Cited by 102 · see citing works

Examining Associations of Circulating Endotoxin With Nutritional Status, Inflammation, and Mortality in Hemodialysis Patients

Feroze, U., Kalantar‐Zadeh, K., Sterling, K. A., Molnar, M. Z., Noori, N., Benner, D., Shah, V. O., Dwivedi, R. S., Becker, K. L., Kovesdy, C. P., et al. (2011) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2011.05.004 · Cited by 99 · see citing works

Clever-1/Stabilin-1 Controls Cancer Growth and Metastasis

Karikoski, M., Marttila‐Ichihara, F., Elima, K., Rantakari, P., Hollmén, M., Kelkka, T., Gerke, H., Huovinen, V., Irjala, H., Holmdahl, R., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1236 · Cited by 99 · see citing works

Multifunctional Receptor Stabilin-1 in Homeostasis and Disease

Kzhyshkowska, J. G. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.189 · Cited by 96 · see citing works

Principles and Practice of Pediatric Infectious Diseases

(2022) · Elsevier eBooks · doi:10.1016/c2019-0-00075-1 · Cited by 94 · see citing works

Design of a flow cytometric assay for the determination of natural killer and cytotoxic T-lymphocyte activity in human and in different animal species

Piriou, L., Chilmonczyk, S., Genetet, N., & Albina, E. (2000) · Cytometry · doi:10.1002/1097-0320(20001201)41:4 · Cited by 92 · see citing works

Lipopolysaccharide exposure is linked to activation of the acute phase response and growth failure in pediatric Crohnʼs disease and murine colitis

Pasternak, B. A., D’Mello, S., Jurickova, I., Han, X., Willson, T. A., Flick, L. M., Petiniot, L. K., Uozumi, N., Divanovic, S., Trauernicht, A. K., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21132 · Cited by 91 · see citing works

The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E

Harris, E. N., & Weigel, P. H. (2008) · Glycobiology · doi:10.1093/glycob/cwn045 · Cited by 90 · see citing works

Endocytic Function, Glycosaminoglycan Specificity, and Antibody Sensitivity of the Recombinant Human 190-kDa Hyaluronan Receptor for Endocytosis (HARE)

Harris, E. N., Weigel, J. A., & Weigel, P. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405322200 · Cited by 84 · see citing works

Metabolic endotoxaemia

Piya, M. K., Harte, A. L., & McTernan, P. G. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32835b4431 · Cited by 82 · see citing works

Purification of Hepatocytes and Sinusoidal Endothelial Cells from Mouse Liver Perfusion

Cabral, F., Miller, C. M., Kudrna, K. M., Hass, B. E., Daubendiek, J. G., Kellar, B. M., & Harris, E. N. (2018) · Journal of Visualized Experiments · doi:10.3791/56993 · Cited by 75 · see citing works

Serum Levels of Lipopolysaccharide and 1,3‐β‐D‐Glucan Refer to the Severity in Patients with Crohn’s Disease

Guo, Y., Zhou, G., He, C., Yang, W., He, Z., & Liu, Z. (2015) · Mediators of Inflammation · doi:10.1155/2015/843089 · Cited by 74 · see citing works

Antibiotic-Induced Lipopolysaccharide (LPS) Release fromSalmonella typhi: Delay between Killing by Ceftazidime and Imipenem and Release of LPS

van Langevelde, P., Kwappenberg, K. M. C., Groeneveld, P. H. P., Mattie, H., & van Dissel, J. T. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.4.739 · Cited by 69 · see citing works

Endotoxin, Toll-like Receptor-4, and Atherosclerotic Heart Disease

Bowman, J. D., Surani, S., & Horseman, M. A. (2016) · Current Cardiology Reviews · doi:10.2174/1573403x12666160901145313 · Cited by 67 · see citing works

Stabilin-2 is involved in lymphocyte adhesion to the hepatic sinusoidal endothelium via the interaction with αMβ2 integrin

Jung, M.-Y., Park, S., & Kim, I. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0107052 · Cited by 66 · see citing works

Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model

Riabov, V., Yin, S., Song, B., Avdic, A., Schledzewski, K., Ovsiy, I., Gratchev, A. N., Verdiell, M. L., Sticht, C., Schmuttermaier, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8857 · Cited by 57 · see citing works

Phosphatidylinositide 3-kinase activity is required for stabilin-1-mediated endosomal transport of acLDL

Kzhyshkowska, J. G., Gratchev, A. N., Brundiers, H., Mamidi, S., Krusell, L., & Goerdt, S. (2005) · Immunobiology · doi:10.1016/j.imbio.2005.05.022 · Cited by 53 · see citing works

Lipid Lateral Organization on Giant Unilamellar Vesicles Containing Lipopolysaccharides

Kubiak, J., Brewer, J. R., Hansen, S., & Bagatolli, L. A. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.01.012 · Cited by 53 · see citing works

A Gut Feeling on Endotoxemia: Causes and Consequences in Chronic Kidney Disease

Hauser, A. B., Stinghen, A. E. M., Gonçalves, S., Bucharles, S. G. E., & Pecoits‐Filho, R. (2010) · Nephron Clinical Practice · doi:10.1159/000321438 · Cited by 50 · see citing works

Probing Structural Selectivity of Synthetic Heparin Binding to Stabilin Protein Receptors

Pempe, E. H., Xu, Y., Gopalakrishnan, S., Liu, J., & Harris, E. N. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.320069 · Cited by 48 · see citing works

Blood volume in inbred strain BALB/c, CBA/J and C57BL/10 mice determined by means of 59Fe-labelled red cells and 59Fe bound to transferrin.

Vácha, J. (1975) · PubMed · Cited by 35 · see citing works

Stabilin-1 is required for the endothelial clearance of small anionic nanoparticles

Arias‐Alpizar, G., Koch, B. E. V., Hamelmann, N. M., Neustrup, M. A., Paulusse, J. M. J., Jiskoot, W., Kros, A., & Bussmann, J. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102395 · Cited by 34 · see citing works

Purification of Hepatocytes and Sinusoidal Endothelial Cells from Mouse Liver Perfusion

Cabral, F., Miller, C. M., Kudrna, K. M., Hass, B. E., Daubendiek, J. G., Kellar, B. M., & Harris, E. N. (2018) · Journal of Visualized Experiments · doi:10.3791/56993-v · Cited by 34 · see citing works

Ligand Binding and Signaling of HARE/Stabilin-2

Harris, E. N., & Cabral, F. (2019) · Biomolecules · doi:10.3390/biom9070273 · Cited by 33 · see citing works

Chronic Endotoxemia in Subjects with Type-1 Diabetes Is Seen Much before the Onset of Microvascular Complications

Aravindhan, V., Mohan, V., Arunkumar, N., Sreedharan, S., & Babu, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137618 · Cited by 31 · see citing works

LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4

Bihl, F., Larivière, L., Qureshi, S. T., Flaherty, L., & Malo, D. (2001) · Genes and Immunity · doi:10.1038/sj.gene.6363732 · Cited by 29 · see citing works

Endocytosis of Advanced Glycation End-Products in Bovine Choriocapillaris Endothelial Cells

Li, R., McCourt, P., Schledzewski, K., Goerdt, S., Moldenhauer, G., Liu, X., Smedsrød, B. H., & Sørensen, K. K. (2009) · Microcirculation · doi:10.1080/10739680903133185 · Cited by 25 · see citing works

Systemic Glycosaminoglycan Clearance by HARE/Stabilin-2 Activates Intracellular Signaling

Weigel, P. H. (2020) · Cells · doi:10.3390/cells9112366 · Cited by 24 · see citing works

The role of immune activation in endotoxin-induced atherogenesis

Wiedermann, C. J., Kiechl, S. J., Schratzberger, P., Dunzendorfer, S., Weiss, G., & Willeit, J. (2001) · Journal of Endotoxin Research · doi:10.1177/09680519010070040401 · Cited by 21 · see citing works

Strategies for the Treatment of Endotoxemia: Significance of the Acute-Phase Response

Warren, H. S., & CHEDID, L. A. (1987) · Clinical Infectious Diseases · doi:10.1093/clinids/9.supplement_5.s630 · Cited by 21 · see citing works

Not CD68 but stabilin‐1 expression is associated with the risk of recurrence in patients with oral cavity squamous cell carcinoma

Kwon, M., Yeo, S. C., Lee, J. S., & Park, J. J. (2019) · Head & Neck · doi:10.1002/hed.25654 · Cited by 12 · see citing works

No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function

Maiseyeu, A., Yang, H.-Y., Ramanathan, G., Yin, F., Bard, R. L., Morishita, M., Dvonch, J. T., Wang, L., Spino, C., Mukherjee, B., et al. (2014) · Inhalation Toxicology · doi:10.3109/08958378.2013.850761 · Cited by 12 · see citing works

3- O sulfation of heparin leads to hepatotropism and longer circulatory half-life

Miller, C. M., Xu, Y., Kudrna, K. M., Hass, B. E., Kellar, B. M., Egger, A. W., Liu, J., & Harris, E. N. (2018) · Thrombosis Research · doi:10.1016/j.thromres.2018.05.018 · Cited by 9 · see citing works

Accumulation of stabilin‑1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival

Yin, S., Gao, Y., Xie, X., Xu, D., Riabov, V., & Du, W. (2020) · Oncology Letters · doi:10.3892/ol.2020.11310 · Cited by 9 · see citing works

Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via FcγRIIb on Liver Sinusoidal Endothelial Cells by Endocytosis

Turman, J. M., Cheplowitz, A. M., Tiwari, C., Thomas, T., Joshi, D. K., Bhat, M., Wu, Q., Pong, E., Chu, S. Y., Szymkowski, D. E., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2000772 · Cited by 8 · see citing works

The Systemic Inflammatory Response Syndrome (SIRS), Sepsis, and Septic Shock

Guzman‐Cottrill, J. A., Cheesebrough, B., Nadel, S., & Goldstein, B. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-2702-9.00011-8 · Cited by 3 · see citing works

Integrated multimodal cell atlas of Alzheimer’s disease

Gabitto, M. I., Travaglini, K. J., Rachleff, V. M., Kaplan, E. S., Long, B., Ariza, J., Ding, Y., Mahoney, J. T., Dee, N., Goldy, J., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01774-5 · Cited by 397 · see citing works

Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases

Rodrigues, S. G., der Merwe, V., Krag, A. A., & Wiest, R. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2023.101859 · Cited by 51 · see citing works

The Battle of LPS Clearance in Host Defense vs. Inflammatory Signaling

Kumar, P., Schroder, E. A., Rajaram, M. V. S., Harris, E. N., & Ganesan, L. P. (2024) · Cells · doi:10.3390/cells13181590 · Cited by 52 · see citing works

Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury

Papaioannou, S., See, J., Jeong, M., Torre, C. D. L., Ast, V., Reiners-Koch, P.-S., Sati, A., Mogler, C., Platten, M., Cerwenka, A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112836 · Cited by 40 · see citing works

Lipopolysaccharide, arbiter of the gut–liver axis, modulates hepatic cell pathophysiology in alcoholism

Mak, K. M., & Shekhar, A. C. (2024) · The Anatomical Record · doi:10.1002/ar.25562 · Cited by 38 · see citing works

Scavenger Receptors: Novel Roles in the Pathogenesis of Liver Inflammation and Cancer

Patten, D. A., Wilkinson, A. L., O'Keeffe, A., & Shetty, S. (2021) · Seminars in Liver Disease · doi:10.1055/s-0041-1733876 · Cited by 26 · see citing works

Liver Cell Type-Specific Targeting by Nanoformulations for Therapeutic Applications

Kaps, L., Limeres, M. J., Schneider, P. M., Svensson, M., Zeyn, Y., Ghazi, S. F.-E., Cacicedo, M. L., Galle, P. R., Gehring, S., & Bros, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411869 · Cited by 18 · see citing works

Fucoidan reduces NET accumulation and alleviates chemotherapy-induced peripheral neuropathy via the gut–blood–DRG axis

Jia, R., Wan, L., Jin, L., Tian, Q., Chen, Y., Zhu, X., Zhang, M., Zhang, Y., Zong, L., Wu, X., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03431-5 · Cited by 18 · see citing works

Tumor-associated macrophages respond to chemotherapy by detrimental transcriptional reprogramming and suppressing stabilin-1 mediated clearance of EGF

Larionova, I., Kiselev, A. M., Kazakova, E., Liu, T., Patysheva, M. R., Iamshchikov, P. S., Liu, Q., Mossel, D. M., Riabov, V., Rakina, M. A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1000497 · Cited by 15 · see citing works

HNF4A mitigates sepsis-associated lung injury by upregulating NCOA2/GR/STAB1 axis and promoting macrophage polarization towards M2 phenotype

Yang, Y., Wen, R., Huang, X., Zhang, H., Yang, N., Liu, C., & Zhang, T. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07452-z · Cited by 12 · see citing works

Highly oxidized albumin is cleared by liver sinusoidal endothelial cells via the receptors stabilin-1 and -2

Holte, C. F., Szafranska, K., Kruse, L. D., Simón-Santamaría, J., Li, R., Svistounov, D., & McCourt, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-46462-9 · Cited by 13 · see citing works

Research Progress on the Immune Function of Liver Sinusoidal Endothelial Cells in Sepsis

Wang, X.-R., Guo, Z., Xia, Y., Wang, X., & Wang, Z. (2025) · Cells · doi:10.3390/cells14050373 · Cited by 13 · see citing works

Liver as a key organ for systemic antimicrobial defense

Yao, T., Maccioni, L., Guan, Y., Rodrigues, R. M., & Gao, B. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000814 · Cited by 6 · see citing works

Stabilin-1 in Tumor-Associated Macrophages: A Potential Therapeutic Target in Cancer Immunotherapy

Gurung, J. L., Tamang, R. L., Madduri, L. S. V., Bennett, R. G., Harris, E. N., Denton, P. W., & McVicker, B. L. (2025) · Biology · doi:10.3390/biology14091198 · Cited by 4 · see citing works

Mechanistic insights into hepatic cell type-specific contributions to acetaminophen-induced acute liver injury

Yang, D., Kim, B., & Kim, J.-W. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i45.112720 · Cited by 4 · see citing works

Bidirectional regulation of liver sinusoidal clearance by amino acid nanofibers and IGFBP4 complex: effects on HbA1c

Lee, A., Castellví, S. D. L., Sellers, P. R., Taneja, S., Ortiz, M. R., Kowdley, D., Leung, J. H., Pokharel, B., Ganesan, L. P., NEEDLEMAN, B. J., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03943-5 · Cited by 2 · see citing works

Liver Sinusoidal Endothelium: The Hidden Interface in the Gut–Liver Axis in Metabolic Dysfunction-Associated Steatotic Liver Disease?

Chen, T., Grefhorst, A., & Holleboom, A. G. (2025) · Lipidology · doi:10.3390/lipidology2020010 · Cited by 2 · see citing works

Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock

Posor, Y., Conduit, S. E., Pearce, W. P., Morelli, D., Constantinou, G., Whitehead, M. A., Sebire, N. J., Scudamore, C. L., Peltzer, N., Walczak, H., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2423358122 · Cited by 2 · see citing works

Identification by Exome Sequencing of Predisposing Variants in Familial Cases of Autoinflammatory Recurrent Fevers

Sangiorgi, E., Azzarà, A., Rumore, R., Cassano, I., Verrecchia, E., Giacò, L., Tullio, M. A., Gurrieri, F., & Manna, R. (2023) · Genes · doi:10.3390/genes14071310 · Cited by 1 · see citing works

Gastrointestinal Permeability After Bariatric Surgery: A Systematic Review

O’Brien, J., Merali, N., Pring, C. M., Rockall, T. A., Robertson, D., Bartlett, D. B., & Frampton, A. E. (2024) · Cureus · doi:10.7759/cureus.60480 · Cited by 1 · see citing works

Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis–induced cytokine transcriptional responses

Ivie, J., Dill‐McFarland, K. A., Simmons, J. D., Peterson, G. J., Benchek, P. H., Mayanja‐Kizza, H., Veith, L. E., Agata, M., Ha, D. T. M., Nghia, H. D. T., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci179822 · Cited by 1 · see citing works

Peptide hormones and bile acids shaping immune tolerance of the liver: implications and applications

van Niekerk, G., Kumpanenko, Y., Degryse, J., Fevery, J., & Dallmeier, K. (2025) · Protein & Cell · doi:10.1093/procel/pwaf096 · Cited by 1 · see citing works

Pseudomonas aeruginosa- mediated cardiac dysfunction is driven by extracellular vesicles released during infection

Kumar, N., Matoo, S. S., Sanghvi, S. K., Ellendula, M., Mahajan, S., Planner, C., Bednash, J. S., Khan, M., Ganesan, L. P., Singh, H., et al. (2026) · mBio · doi:10.1128/mbio.03091-25 · Cited by 1 · see citing works

Intestinal decontamination with rifaximin attenuates LSEC dysfunction and liver fibrosis in mice

Su, T., Lai, S., & Chen, H. (2026) · PLoS ONE · doi:10.1371/journal.pone.0340664 · Cited by 1 · see citing works

Spatially Resolved Heterogeneity of Lymphatic Vasculature in the Adult Lung—Brief Report

Crossey, E., Carty, S., Garza, I., Perez, M., Shao, F., Abdullatif, S. A., Campbell, J. D., Mizgerd, J. P., Fine, A., & Jones, M. R. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.126.324437 · Cited by 1 · see citing works

Nuclear receptors shape sepsis pathophysiology

Jelinek, M., Bosscher, K. D., Libert, C., & Vandewalle, J. (2026) · Endocrine Reviews · doi:10.1210/endrev/bnag017 · Cited by 1 · see citing works

Effects of grape seed proanthocyanidin extract on lipopolysaccharide translocation and trafficking from the gut to tissues

Sierra‐Cruz, M., Miguéns‐Gómez, A., Rodríguez‐Gallego, E., D’Addario, C., Bartolomeo, M. D., Blay, M., Pinent, M., Beltrán‐Debón, R., & Terra, X. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105566 · Cited by 1 · see citing works

Scavenger endothelial cells alleviate tissue damage by engulfing toxic molecules derived from hemolysis

Dai, Y., Jiang, Y., Cao, C., Xu, Y., Lai, S., Zhu, W., Gao, M., Li, F., He, S., & Xu, J. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2406794122 · Cited by 1 · see citing works

Highly oxidized albumin is mainly cleared by mouse liver sinusoidal endothelial cells via the receptors stabilin-1 and -2Preprint

Holte, C. F., Szafranska, K., Kruse, L. D., Simón-Santamaría, J., Li, R., Svistounov, D., & McCourt, P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.20.549630

The liver sinusoid in acute-on-chronic liver failure

Schierwagen, R., Brol, M. J., Klein, S., Uschner, F. E., & Trebicka, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95262-0.00016-4

Identification of Novel Genes Implicated in Acute Myeloid Leukemia Progression using Bioinformatics Analysis of Microarray DataPreprint

Al-Sayegh, H. A. H., & Safaralizadeh, R. (2024) · Research Square · doi:10.21203/rs.3.rs-4916069/v1

Rôle des cellules de Kupffer dans la physiopathologie des hépatites aiguës

Chabat-Courrède, C. (2024) · theses.fr (ABES) · doi:10.70675/68752933z5f36z44e9z866az70f7363a7e98

Hyaluronan (HA) Receptors: Discovery, Function & Pathology

Bopp, A. E., Pratt, L. B., Schroder, C. J., Staab, J. D., Hatcher, G. D., McWilliams, J. T., Wilhelm, M. C., Texel, A. C., & Harris, E. N. (2026) · Proteoglycan Research · doi:10.1002/pgr2.70049

The Scavenger Function of LSECs, a Regulator of Liver Diseases

Zhou, J., Zhang, L., Wang, J., Zhang, C., & Tian, C. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48080802

Dietary, Nutrient, and Supramolecular Nanofiber Modulation of the Liver Sinusoidal Clearance System in Metabolic Diseases and Aging

Pokharel, B., Kulkarni, A., Drager, R., Muhammad, F. A., & Ziouzenkova, O. (2026) · Biomedicines · doi:10.3390/biomedicines14081834

Development and In Vitro Efficacy of Macrophage-Targeted Nanoparticles Encapsulating Vitamin E Derivatives Garcinoic Acid and α-13′-Carboxychromanol

Göl, D., Talaz, E. İ., Mese-tayfur, S., Elmas, M. A., Gioiello, A., Galli, F., Özer, N. K., Sözen, E., & Gök, Ö. (2026) · ACS Omega · doi:10.1021/acsomega.6c01032

Adaptive resilience: agarikon mycelium modulates immune responses and provides oxidative stress buffering in human immune cells

Doar, E., Kishiyama, J., Bair, Z. J., Stamets, P. E., & Beathard, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1946950

The hepatic sinusoid as a regulatory niche: From cellular specialization to precision hepatology

Fernández‐Iglesias, A., Harris, E. N., Jalan‐Sakrikar, N., Kaur, S., Zapotoczny, B., Ikejima, K., & Gracia‐Sancho, J. (2026) · Hepatology · doi:10.1097/hep.0000000000001870

A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression

Macagno, A., Molteni, M., Rinaldi, A., Bertoni, F., Lanzavecchia, A., Rossetti, C., & Sallusto, F. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060136 · Cited by 79 · see citing works

Slit2–Robo4 Pathway Modulates Lipopolysaccharide-Induced Endothelial Inflammation and Its Expression Is Dysregulated during Endotoxemia

Zhao, H., Anand, A. R., & Ganju, R. K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302021 · Cited by 90 · see citing works

Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production

Metwally, H., Tanaka, T., Li, S., Parajuli, G., Kang, S., Hanieh, H., Hashimoto, S., Chalise, J. P., Gemechu, Y., Standley, D. M., et al. (2020) · Science Signaling · doi:10.1126/scisignal.aay0574 · Cited by 50 · see citing works

A Novel Pathway Regulating Lipopolysaccharide-Induced Shock by ST2/T1 Via Inhibition of Toll-Like Receptor 4 Expression

Sweet, M. J., Leung, B. P. L., Kang, D., Søgaard, M., Schulz, K., Trajković, V., Campbell, C., Xu, D., & Liew, F. Y. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6633 · Cited by 248 · see citing works

Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1–dependent mechanism #

Scott, M. J., Liu, S., Shapiro, R. A., Yoram Vodovotz, B., & Billiar, T. R. (2009) · Hepatology · doi:10.1002/hep.22839 · Cited by 82 · see citing works