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Cited by 37Chemokine receptors and signalingDermatology and Skin DiseasesPsoriasis: Treatment and Pathogenesis

CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues

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Davila, Micha L., Xu, Ming, Huang, Chengyu, Gaddes, Erin R., Winter, Levi, Cantorna, Margherita T., Wang, Yong, Xiong, Na·2022·iScience
DOI 10.1016/j.isci.2022.104426PMC PMC9157018
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Abstract

Abundant immune cells reside in barrier tissues. Understanding the regulation of these cells can yield insights on their roles in tissue homeostasis and inflammation. Here, we report that the chemokine CCL27 is critical for establishment of resident lymphocytes and immune homeostasis in barrier tissues. CCL27 expression is associated with normal skin and hair follicle development independent of commensal bacterial stimulation, indicative of a homeostatic role for the chemokine. Accordingly, in the skin of CCL27-knockout mice, there is a reduced presence and dysregulated localization of T cells that express CCR10, the cognate receptor to CCL27. Besides, CCL27-knockout mice have overreactive skin inflammatory responses in an imiquimod-induced model of psoriasis. Beyond the skin, CCL27-knockout mice have increased infiltration of CCR10 + T cells into lungs and reproductive tracts, the latter of which also exhibit spontaneous inflammation. Our findings demonstrate that CCL27 is critical for immune homeostasis across barrier tissues.

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  • CCR10 is a chemokine receptor expressed by most skin-resident T cells and is critical for their homeostatic establishment through interaction with CCL27 expressed by keratinocytes.

    “CCR10 is a chemokine receptor expressed by most skin-resident T cells and is critical for their homeostatic establishment through interaction with its ligand CCL27, expressed by keratinocytes.20,21”

    From Skin-resident T cells play an important role in controlling skin colonization of Candidozyma (Candida) auris (2026) · cites this paper as [21]

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Authors
Davila, M. L., Xu, M., Huang, C., Gaddes, E. R., Winter, L., Cantorna, M. T., Wang, Y., & Xiong, N.
Affiliations
  • Pennsylvania State University (US)
  • The University of Texas at San Antonio Health Science Center (US)
Corresponding author
Xiong, Na
ORCID
Venue
iScience
Publisher
Elsevier BV
Published
2022-06
Volume
25
Issue
6
Pages
104426
ISSN
2589-0042 (ISSN-L)
DOI
10.1016/j.isci.2022.104426
PMC
PMC9157018
OpenAlex
W4280518982
Cited by
37
References
4
Citations by year
2026: 12 · 2025: 9 · 2024: 11 · 2023: 4 · 2022: 1
FWCI
2.72
Type
journal article
Language
en
Open access
Licence
Locations
  • iScience (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR064831, R01AR070887, R01AR073364)
  • University of Texas Health Science Center at San Antonio (10,588,941)
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
CCL27, CCR10, chemokines, immune homeostasis, barrier tissues, skin, mucosal tissues, hair follicle development, T cell localization, psoriasis, imiquimod, skin inflammation, lung, reproductive tract, commensal bacteria

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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