Cutting Edge: Skin CCR10+ CD8+ T Cells Support Resident Regulatory T Cells through the B7.2/Receptor Axis To Regulate Local Immune Homeostasis and Response
Open accessAbstract
Resident T cells in barrier tissues are important in protecting against foreign agents but can also contribute to inflammatory diseases if dysregulated. How T cell homeostasis is maintained in barrier tissues is still poorly understood. We report that resident CD8+ T cells directly support maintenance of regulatory T cells (Tregs) in the skin to promote immune homeostasis. Impaired establishment of resident CD8+ T cells caused by knockout of the skin-homing chemokine receptor CCR10 resulted in an altered balance of resident Tregs and CD4+ effector T cells in the skin and overreactive inflammatory responses to cutaneous stimulations. Furthermore, B7.2 expressed on skin CD8+ T cells supports the survival of Tregs, likely through interaction with its receptor CTLA-4, which is highly expressed on skin Tregs. Our findings provide novel insights into T cell homeostatic regulation in the skin and may improve our understanding of the pathobiology of tissue inflammatory diseases.
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All skin-resident T cells are pre-activated T cells with effector/memory-like phenotypes, which could be activated in an innate fashion by alterations of molecular cues of the local tissue they reside in.
“All skin-resident T cells are pre-activated T cells with effector/memory-like phenotypes, which could be activated in an innate fashion by alterations of molecular cues of the local tissue they reside in.26,27,28,29,30,31,32”
From Skin-resident T cells play an important role in controlling skin colonization of Candidozyma (Candida) auris (2026) · cites this paper as [27]
The Results and Discussion section (page unavailable) reports that most EGFP+ OT-I CD8+ cells in skin after immunization had markers typical of resident memory T cells. This supports a memory-like phenotype for the studied cells, but not the claim that all skin-resident T cells are pre-activated. The paper also does not establish that local molecular cues activate them in an innate fashion; its described OT-I activation followed Ova immunization. (LLM, conf=0.86)
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- Authors
- Fu, Y., Yang, J., & Xiong, N.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Xiong, Na
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-06
- Volume
- 196
- Issue
- 12
- Pages
- 4859-4864
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC4893913
- OpenAlex
- W2371771084
- Cited by
- 14
- References
- 18
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR064831)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- CCR10, CD8+ T cells, regulatory T cells, CD86, CTLA-4, skin, T cell homeostasis, barrier tissues, skin inflammation, chemokine receptors, CD4+ effector T cells, skin-homing T cells
- MeSH terms
- Animals, Gene Expression Regulation, Homeostasis, Inflammation, Skin, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, Mice, B7-2 Antigen, Receptors, CCR10, CTLA-4 Antigen
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