The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
New insights into NF-κB regulation and function
Open accessAbstract
NF-κB (nuclear factor-κB) transcription factors have multiple critical roles in the regulation of immune responses. In unstimulated cells, NF-κB proteins are sequestered in the cytoplasm by IκB inhibitory proteins. Various immune stimuli induce the IκB kinase (IKK) to phosphorylate IκBs, triggering their ubiquitination and proteasomal degradation, which permits nuclear translocation of associated NF-κB subunits and activation of NF-κB target genes. Recent studies have highlighted the importance of dynamic ubiquitination-deubiquitination events in regulating this canonical NF-κB signaling pathway. Ubiquitination additionally plays critical roles in activation of the noncanonical pathway that regulates NF-κB via signal-induced processing of NF-κB2 p100. New research has also identified several novel regulatory proteins that control the transcriptional activity of nuclear NF-κB.
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Cites
Integrating cell-signalling pathways with NF-κB and IKK function
Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350
The immune response of Drosophila
Hoffmann, J. A. (2003) · Nature · doi:10.1038/nature02021 · Cited by 1,553
Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A. (2000) · Science · doi:10.1126/science.289.5488.2350 · Cited by 1,409
IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis
Varfolomeev, E., Blankenship, J. W., Wayson, S. M., Fedorova, A. V., Kayagaki, N., Garg, P., Zobel, K., Dynek, J. N., Elliott, L. O., Wallweber, H. J. A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.030 · Cited by 1,218
Ubiquitin signalling in the NF-κB pathway
Chen, Z. J. (2005) · Nature Cell Biology · doi:10.1038/ncb0805-758 · Cited by 1,184
NF-κB RelA Phosphorylation Regulates RelA Acetylation
Chen, L.-F., Williams, S. A., Mu, Y., Nakano, H., Duerr, J. M., Buckbinder, L., & Greene, W. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.7966-7975.2005 · Cited by 438
Cited by
NF-κB signaling in inflammation
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791
Self-citationNF-κB in inflammation and renal diseases
Zhang, H., & Sun, S.-C. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0056-4 · Cited by 383
Self-citationGan, P., Gao, Z., Zhao, X., & Qi, G. (2016) · Scientific Reports · doi:10.1038/srep39303 · Cited by 74
Controlling the Fate of NIK: A Central Stage in Noncanonical NF-κB Signaling
Sun, S.-C. (2010) · Science Signaling · doi:10.1126/scisignal.3123pe18 · Cited by 61
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Metadata
- Authors
- Sun, S.-C., & Ley, S. C.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 29
- Issue
- 10
- Pages
- 469-478
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2024991882
- Cited by
- 318
- References
- 6
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
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