Cited by 116T-cell and B-cell ImmunologyTraumatic Brain Injury and Neurovascular DisturbancesSpinal Cord Injury Research

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B cells and autoantibodies: complex roles in CNS injury

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Ankeny, Daniel P., Popovich, Phillip G.·2010·Trends in Immunology

DOI 10.1016/j.it.2010.06.006PMC PMC2933277

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Abstract

Emerging data indicate that traumatic injury to the brain or spinal cord activates B lymphocytes, culminating in the production of antibodies specific for antigens found within and outside the central nervous system (CNS). Here, we summarize what is known about the effects of CNS injury on B cells. We outline the potential mechanisms for CNS trauma-induced B cell activation and discuss the potential consequences of these injury-induced B cell responses. On the basis of recent data, we hypothesize that a subset of autoimmune B cell responses initiated by CNS injury are pathogenic and that targeted inhibition of B cells could improve recovery in cases of brain and spinal cord injury.

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Authors: Ankeny, D. P., & Popovich, P. G.
Affiliations: The Ohio State University Wexner Medical Center (US)
Corresponding author: Popovich, Phillip G.
ORCID: Popovich, Phillip G.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2010-09
Volume: 31
Issue: 9
Pages: 332-338
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2010.06.006
PMC: PMC2933277
OpenAlex: W2148945613
Cited by: 116
References: 63
Citations by year: 2026: 3 · 2025: 5 · 2024: 5 · 2023: 14 · 2022: 9 · 2021: 3 · 2020: 7 · 2019: 14 · 2018: 4 · 2017: 1 · 2016: 8 · 2015: 6 · 2014: 17 · 2013: 9 · 2012: 6
FWCI: 0.48
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS047175)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Keywords: B cells, autoantibodies, central nervous system injury, traumatic brain injury, spinal cord injury, B cell activation, autoimmunity, B cell inhibition, injury recovery
MeSH terms: Animals, Autoantibodies, B-Lymphocytes, Central Nervous System, Humans, Lymphocyte Activation, Autoimmunity

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B cells and autoantibodies: complex roles in CNS injury

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