The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
B cells and autoantibodies: complex roles in CNS injury
Open accessAbstract
Emerging data indicate that traumatic injury to the brain or spinal cord activates B lymphocytes, culminating in the production of antibodies specific for antigens found within and outside the central nervous system (CNS). Here, we summarize what is known about the effects of CNS injury on B cells. We outline the potential mechanisms for CNS trauma-induced B cell activation and discuss the potential consequences of these injury-induced B cell responses. On the basis of recent data, we hypothesize that a subset of autoimmune B cell responses initiated by CNS injury are pathogenic and that targeted inhibition of B cells could improve recovery in cases of brain and spinal cord injury.
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“However, the idea that the CNS is an immune privileged organ has been reconsidered, as the functional immune cells can enter the CNS through the BBB, the choroid plexus, and the lymphatic vessels and have been described beyond neuropathological conditions (26, 35–47).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [38]
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“Among the molecules that can pass the BBB are also bacterial products and metabolites shaping not only the CNS development and functions (6, 15) but also the genesis of certain diseases (33–42).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [38]
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Аутоімунна реакція проти нейроспецифічних білків та якість життя пацієнтів з уродженою вадою серця
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Metadata
- Authors
- Ankeny, D. P., & Popovich, P. G.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- Corresponding author
- Popovich, Phillip G.
- ORCID
- Popovich, Phillip G.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 31
- Issue
- 9
- Pages
- 332-338
- ISSN
- 1471-4906 (ISSN-L)
- PMC
- PMC2933277
- OpenAlex
- W2148945613
- Cited by
- 116
- References
- 63
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 14 · 2022: 9 · 2021: 3 · 2020: 7 · 2019: 14 · 2018: 4 · 2017: 1 · 2016: 8 · 2015: 6 · 2014: 17 · 2013: 9 · 2012: 6
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS047175)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Keywords
- B cells, autoantibodies, central nervous system injury, traumatic brain injury, spinal cord injury, B cell activation, autoimmunity, B cell inhibition, injury recovery
- MeSH terms
- Animals, Autoantibodies, B-Lymphocytes, Central Nervous System, Humans, Lymphocyte Activation, Autoimmunity
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