Cited by 1,037Tryptophan and brain disordersImmune cells in cancerAmino Acid Enzymes and Metabolism

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Indoleamine 2,3 dioxygenase and metabolic control of immune responses

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Munn, David H., Mellor, Andrew L.·2013·Trends in Immunology

DOI 10.1016/j.it.2012.10.001PMC PMC3594632

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Abstract

Sustained access to nutrients is a fundamental biological need, especially for proliferating cells, and controlling nutrient supply is an ancient strategy to regulate cellular responses to stimuli. By catabolizing the essential amino acid TRP, cells expressing the enzyme indoleamine 2,3 dioxygenase (IDO) can mediate potent local effects on innate and adaptive immune responses to inflammatory insults. Here, we discuss recent progress in elucidating how IDO activity promotes local metabolic changes that impact cellular and systemic responses to inflammatory and immunological signals. These recent developments identify potential new targets for therapy in a range of clinical settings, including cancer, chronic infections, autoimmune and allergic syndromes, and transplantation.

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Authors: Munn, D. H., & Mellor, A. L.
Affiliations: Augusta University Health (US)
Corresponding author: Mellor, Andrew L.
ORCID: Munn, David H.
Mellor, Andrew L.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2013-03
Volume: 34
Issue: 3
Pages: 137-143
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2012.10.001
PMC: PMC3594632
OpenAlex: W2012836981
Cited by: 1,037
References: 85
Citations by year: 2026: 69 · 2025: 64 · 2024: 54 · 2023: 80 · 2022: 72 · 2021: 109 · 2020: 105 · 2019: 89 · 2018: 94 · 2017: 86 · 2016: 72 · 2015: 78 · 2014: 34 · 2013: 27
FWCI: 2.83
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA096651, R01CA103320)
National Institute of Allergy and Infectious Diseases (R01AI103347, R01AI063402, U01AI083005, R01AI075165)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: indoleamine 2,3-dioxygenase, tryptophan catabolism, immune regulation, inflammation, innate immunity, adaptive immunity, kynurenine pathway, cancer immunotherapy, chronic infection, autoimmune disease, allergic diseases, transplantation
MeSH terms: Animals, Communicable Diseases, Humans, Immunity, Innate, Neoplasms, Tryptophan, Indoleamine-Pyrrole 2,3,-Dioxygenase, Adaptive Immunity

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Indoleamine 2,3 dioxygenase and metabolic control of immune responses

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