Cited by 142Cytokine Signaling Pathways and InteractionsPI3K/AKT/mTOR signaling in cancerT-cell and B-cell Immunology

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Intersection of mTOR and STAT signaling in immunity

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Saleiro, Diana, Platanias, Leonidas C.·2015·Trends in Immunology

DOI 10.1016/j.it.2014.10.006PMC PMC4297313

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Abstract

Optimal regulation of immune networks is essential for the generation of effective immune responses, and defects in such networks can lead to immunodeficiency while uncontrolled responses can result in autoimmune disorders. mTOR and STAT signaling cascades are key regulators of the differentiation and function of cells of the immune system. Both pathways act as sensors and transducers of environmental stimuli, and recent evidence has revealed points of crosstalk between these pathways, highlighting synergistic regulation of immune cell differentiation and function. We review here the current understanding of mTOR and STAT interactions in T cells and innate immune cells, and discuss potential mechanisms underlying these events. We further outline models for the intersection of these pathways in the regulation of immunity and highlight important areas for future research.

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Authors: Saleiro, D., & Platanias, L. C.
Affiliations: Northwestern University (US)
Corresponding author: Platanias, Leonidas C.
ORCID: Saleiro, Diana
Platanias, Leonidas C.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2015-01
Volume: 36
Issue: 1
Pages: 21-29
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2014.10.006
PMC: PMC4297313
OpenAlex: W2028684481
Cited by: 142
References: 84
Citations by year: 2026: 9 · 2025: 10 · 2024: 10 · 2023: 9 · 2022: 12 · 2021: 17 · 2020: 14 · 2019: 13 · 2018: 12 · 2017: 12 · 2016: 16 · 2015: 7
FWCI: 1.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA161796, CA-77816, CA121192, R01CA121192, R01CA155566, CA161196, R01CA077816, CA155566, P30CA060553)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: mTOR signaling, STAT signaling, pathway crosstalk, immune cell differentiation, T cells, innate immune cells, immune regulation, immunodeficiency, autoimmunity, signal transduction
MeSH terms: Mechanistic Target of Rapamycin Complex 2, Animals, Dendritic Cells, Humans, Immune System, Immunity, Macrophages, Protein Binding, T-Lymphocytes, Signal Transduction, Multiprotein Complexes, STAT Transcription Factors, Receptor, Interferon alpha-beta, TOR Serine-Threonine Kinases

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Intersection of mTOR and STAT signaling in immunity

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