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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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RHO GTPASES: Biochemistry and Biology

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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mTOR signaling at a glance

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SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

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Phosphorylation and Functional Inactivation of TSC2 by Erk

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Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

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mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1

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mTORC1 Directly Phosphorylates and Regulates Human MAF1

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PIP3-Independent Activation of TorC2 and PKB at the Cell's Leading Edge Mediates Chemotaxis

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Moving towards a Better Understanding of Chemotaxis

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P-Rex1 Links Mammalian Target of Rapamycin Signaling to Rac Activation and Cell Migration

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HEAT Repeats Mediate Plasma Membrane Localization of Tor2p in Yeast*

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Rictor is a novel target of p70 S6 kinase-1

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A Ras Signaling Complex Controls the RasC-TORC2 Pathway and Directed Cell Migration

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Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

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mTOR Complex Component Rictor Interacts with PKCζ and Regulates Cancer Cell Metastasis

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The Pleckstrin Homology Domain Proteins Slm1 and Slm2 Are Required for Actin Cytoskeleton Organization in Yeast and Bind Phosphatidylinositol-4,5-Bisphosphate and TORC2

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Microtubule retraction into the uropod and its role in T cell polarization and motility

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Cellular responses to extracellular guidance cues

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The Rapamycin-Binding Domain Governs Substrate Selectivity by the Mammalian Target of Rapamycin

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CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1

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Rapamycin Inhibits the Growth and Metastatic Progression of Non-Small Cell Lung Cancer

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A Novel Ras-interacting Protein Required for Chemotaxis and Cyclic Adenosine Monophosphate Signal Relay inDictyostelium

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Rapamycin inhibits GM‐CSF‐induced neutrophil migration

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Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver

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Microtubule Asymmetry during Neutrophil Polarization and Migration

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Protein Kinase Activity and Identification of a Toxic Effector Domain of the Target of Rapamycin TOR Proteins in Yeast

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Carboxyl‐terminal region conserved among phosphoinositide‐kinase‐related kinases is indispensable for mTOR function in vivo and in vitro

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Prostaglandin E2 Activates and Utilizes mTORC2 as a Central Signaling Locus for the Regulation of Mast Cell Chemotaxis and Mediator Release

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The social lives of migrating cells in Drosophila

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mTORC2 regulates PGE2-mediated endothelial cell survival and migration

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Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs

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TOR signaling regulates microtubule structure and function

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Regulation of Microtubule-Dependent Protein Transport by the TSC2/Mammalian Target of Rapamycin Pathway

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Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation

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Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin.

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The Rapamycin derivative RAD inhibits mesangial cell migration through the CDK-inhibitor p27KIP1

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Actin-based forces driving embryonic morphogenesis in Caenorhabditis elegans

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Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

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Bone remodeling: an operational process ensuring survival and bone mechanical competence

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mTOR in Brain Physiology and Pathologies

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Signaling Networks that Regulate Cell MigrationPreprint

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Glutamate, Glutamate Receptors, and Downstream Signaling Pathways

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Rho GTPases in platelet function

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Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling

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Pituitary Diseases and Bone

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Mast Cell Chemotaxis – Chemoattractants and Signaling Pathways

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Homeostasis and the Importance for a Balance Between AKT/mTOR Activity and Intracellular Signaling

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The Golgi in Cell Migration: Regulation by Signal Transduction and Its Implications for Cancer Cell Metastasis

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Autophagy modulates cell migration and β1 integrin membrane recycling

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An Oncogenic Protein Golgi Phosphoprotein 3 Up-regulates Cell Migration via Sialylation

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G-Protein Coupled Receptors (GPCRs): Signaling Pathways, Characterization, and Functions in Insect Physiology and Toxicology

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Symbiotic Firmicutes establish mutualism with the host via innate tolerance and resistance to control systemic immunity

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Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth

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mTORC2 mediates CXCL12-induced angiogenesis

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Altered mTOR signalling in nephropathic cystinosis

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ASC amino acid transporter 2, defined by enzyme‐mediated activation of radical sources, enhances malignancy of GD2‐positive small‐cell lung cancer

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mTORC1 activity is supported by spatial association with focal adhesions

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mTOR: An attractive therapeutic target for osteosarcoma?

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The small GTPases Ras and Rap1 bind to and control TORC2 activity

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Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration

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Tension Monitoring during Epithelial-to-Mesenchymal Transition Links the Switch of Phenotype to Expression of Moesin and Cadherins in NMuMG Cells

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mTORC2 Is Required for Rit-Mediated Oxidative Stress Resistance

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A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum

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Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation

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Gene Expression Profiles of the NCI-60 Human Tumor Cell Lines Define Molecular Interaction Networks Governing Cell Migration Processes

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Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D

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Inhibition of PI3K Pathway Reduces Invasiveness and Epithelial-to-Mesenchymal Transition in Squamous Lung Cancer Cell Lines Harboring PIK3CA Gene Alterations

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Annexin A1 Preferentially Predicts Poor Prognosis of Basal-Like Breast Cancer Patients by Activating mTOR-S6 Signaling

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PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils

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Actuation of single downstream nodes in growth factor network steers immune cell migration

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Ras, PI3K and mTORC2 – three's a crowd?

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Vascular Smooth Muscle Cell Apoptosis Promotes Transplant Arteriosclerosis Through Inducing the Production of SDF-1α

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Inhibition of 5‐Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β‐Arrestin2–Mammalian Target of Rapamycin/p70S6K Pathway

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The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II

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IGF-1 release kinetics from chitosan microparticles fabricated using environmentally benign conditions

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Front Signal-Dependent Accumulation of RHOA Inhibitor FAM65B at Leading Edges Polarizes Neutrophils

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Ecdysteroidogenesis and development in Heliothis virescens (Lepidoptera: Noctuidae): Focus on PTTH-stimulated pathways

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TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis

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The mTOR signalling in corneal diseases: A recent update

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Radil controls neutrophil adhesion and motility through β2-integrin activation

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Treating non-small cell lung cancer by targeting the PI3K signaling pathway

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Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory

Lana, D., Russo, J. D., Mello, T., Wenk, G. L., & Giovannini, M. G. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.11.006 · Cited by 21 · see citing works

DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization

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Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling

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Influence of digital hypothermia on lamellar events related to IL‐6/gp130 signalling in equine sepsis‐related laminitis

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The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function

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PI3Kβ links integrin activation and PI(3,4)P2 production during invadopodial maturation

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The role of c-Src in integrin (α6β4) dependent translational control

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F2-isoprostanes affect macrophage migration and CSF-1 signalling

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Emerging roles for angiomotin in the nervous system

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The Effect of Post-Resistance Exercise Amino Acids on Plasma MCP-1 and CCR2 Expression

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Emerging models for DNA repair: Dictyostelium discoideum as a model for nonhomologous end-joining

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Inhibition of CXCL12-mediated chemotaxis of Jurkat cells by direct immunotoxicants

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Inhibition of actin dynamics during epithelial-to-mesenchymal transition

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mRNA encoding WAVE–Arp2/3-associated proteins is co-localized with foci of active protein synthesis at the leading edge of MRC5 fibroblasts during cell migration

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Phospholipase D2 in prostate cancer: protein expression changes with Gleason score

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The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAMP/PKA/mTORC1/rpS6 Pathway

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Optimization of cell motility evaluation in scratch assay

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TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium

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mTORC2/Rictor is essential for coelomocyte endocytosis in Apostichopus japonicus

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Death associated protein kinase 2 suppresses T-B interactions and GC formation

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Recent Progress in Small-Molecule Agents Against Age-Related Macular Degeneration

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TOR kinase complexes and cell migration

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G-Protein-Coupled Receptors: Their Expression, Function and Regulation in Insecticide Resistance

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mTORC2 coordinates the leading and trailing edge cytoskeletal programs during neutrophil migrationPreprint

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Combined use of tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs) as target therapy in non-small cell lung cancer (NSCLC)

Cretella, D. (2015) · DSpaceUnipr (University of Parma)

TOR complex 2 regulates plasma membrane homeostasis

Berchtold, D. (2012) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.14648

Recrutamento de neutrófilos induzido por leptina em modelo murino de obesidade induzida por dieta

de Almeida, G. S. (2012) · Americanae (AECID Library)

Studies on Dictyostelium Discoideum Myosin-I and Myosin-II Heavy Chain Kinases

Yang, Y. (2013) · QSpace (Queen's University Library)

TORC2 dependent phosphorylation modulates calcium regulation of fission yeast myosinPreprint

Baker, K., Gyamfi, I. A., Mashanov, G. I., Molloy, J. E., Geeves, M. A., & Mulvihill, D. P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/498865

Application of omics to immunotoxicology : from mechanisms of action to alternative testing strategies

Shao, J. (2015) · doi:10.26481/dis.20150211js

Unveiling the potential of Cepharanthine from plant to patient- A comprehensive review of phytochemistry, pharmacology and clinical investigations

Dobhal, S., Nandave, M., Tiwari, V. K., & Singh, M. F. (2024) · Journal of Biologically Active Products from Nature · doi:10.1080/22311866.2024.2312835

Caffeine and Rapamycin Impair Growth and Morphogenesis by Affecting Both TOR-Dependent Pathways in DictyosteliumPreprint

Jaiswal, P. (2024) · Preprints.org · doi:10.20944/preprints202407.0276.v1

TOR signalling mediates the collective movement of border cells in Drosophila oogenesis

Halder, S., Sharma, A., Acharjee, S., Biju, N., Kunjumon, M., Khadilkar, R. J., & Prasad, M. (2025) · Development · doi:10.1242/dev.204612

Radiothérapie interne du mélanome métastatique pigmenté : mécanismes et associations

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Upregulated GluN2C-NMDARs in a model of focal cortical dysplasia type II drive neuronal hyperexcitability

Pineau, L. (2023) · theses.fr (ABES) · doi:10.70675/39c790cfzdf57z416bzb9cez06eca43d9cda

JCB: Review TOR kinase complexes and cell migration

Liu, L., & Parent, C. A. (2013)

Determining the role of the Ras family GTPase Rap1 in regulating mTORC2 activity and function in cell migration

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Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis

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Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR

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The Role of RAP1 in Regulating MTORC2 Activity and Function in Cell Migration

Cahigas, G. M., & Cahigas, G. M. (2024) · UA Campus Repository (The University of Arizona)