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Immunological Functions of the Omentum

Open access
Meza-Perez, Selene, Randall, Troy D.·2017·Trends in Immunology

Abstract

The omentum is a visceral adipose tissue with unique immune functions. Although it is primarily an adipose tissue, the omentum also contains lymphoid aggregates, called milky spots (MS), that contribute to peritoneal immunity by collecting antigens, particulates and pathogens from the peritoneal cavity and, depending on the stimuli, promoting a variety of immune responses, including inflammation, tolerance or even fibrosis. Reciprocal interactions between cells in the MS and adipocytes regulate their immune and metabolic functions. Importantly, the omentum collects metastasizing tumor cells and supports tumor growth by immunological and metabolic mechanisms. Here we summarize our current knowledge about the development, organization and function of the omentum in peritoneal immunity.

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Metadata

Authors
Meza-Perez, S., & Randall, T. D.
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2017-07
Volume
38
Issue
7
Pages
526-536
ISSN
1471-4906 (ISSN-L)
OpenAlex
W2620731633
Cited by
326
References
8
FWCI
4.29
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Immunological Functions of the Omentum. https://app.cochat.ai/papers/10.1016/j.it.2017.03.002
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Meza-Perez, S., & Randall, T. D. (2017). Immunological Functions of the Omentum. Trends in Immunology. https://doi.org/10.1016/j.it.2017.03.002

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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