The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
ZBP1: Innate Sensor Regulating Cell Death and Inflammation
Open accessAbstract
Z-DNA binding protein 1 (ZBP1), initially reported as an IFN-inducible, tumor-associated protein, harbors nucleic acid binding domains for left handed helix (Z-form) and RHIM domains for protein homotypic interactions. Recent studies have identified ZBP1 as an innate sensor of viral infections and a target of viral evasion strategies, regulating cell death, inflammasome activation and proinflammatory responses. ZBP1 also functions during development and can trigger perinatal lethality when its RHIM-dependent interactions are not restricted. Here, we review the history and emergence of ZBP1 as a pathogen sensor and a central regulator of cell death and inflammatory responses. We also discuss the gaps in our knowledge regarding the regulation and functions of ZBP1 and highlight potential avenues for future research.
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Cites
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Cited by
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Galluzzi, L., Vitale, I., Warren, S., Adjemian, S., Agostinis, P., Martinez, A. B., Chan, T. A., Coukos, G., Demaria, S., Deutsch, E., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000337 · Cited by 1,119
An update on the regulatory mechanisms of NLRP3 inflammasome activation
Paik, S., Kim, J. K., Silwal, P., Sasakawa, C., & Jo, E.-K. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00670-3 · Cited by 892
Samir, P., Malireddi, R. K. S., & Kanneganti, T.-D. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00238 · Cited by 557
Self-citationToward targeting inflammasomes: insights into their regulation and activation
Christgen, S., Place, D. E., & Kanneganti, T.-D. (2020) · Cell Research · doi:10.1038/s41422-020-0295-8 · Cited by 281
Self-citationBarrera, M.-J., Aguilera, S., Castro, I., Carvajal, P., Jara, D., Molina, C., González, S., & González, M.-J. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102867 · Cited by 213
Metadata
- Authors
- Kuriakose, T., & Kanneganti, T.-D.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 39
- Issue
- 2
- Pages
- 123-134
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2768375143
- Cited by
- 299
- References
- 58
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- green
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