The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism
Open accessAbstract
T cells are a central component of defenses against pathogens and tumors. Their effector functions are sustained by specific metabolic changes that occur upon activation, and these have been the focus of renewed interest. Energy production inevitably generates unwanted products, namely reactive oxygen species (ROS), which have long been known to trigger cell death. However, there is now evidence that ROS also act as intracellular signaling molecules both in steady-state and upon antigen recognition. The levels and localization of ROS contribute to the redox modeling of effector proteins and transcription factors, influencing the outcome of the T cell response. We discuss here how ROS can directly fine-tune metabolism and effector functions of T cells.
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Cites
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ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
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Modulation of oxidative stress as an anticancer strategy
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Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases
Phaniendra, A., Jestadi, D. B., & Periyasamy, L. (2015) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-014-0446-0 · Cited by 2,886
Physiological Roles of Mitochondrial Reactive Oxygen Species
Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.025 · Cited by 2,632
Social controls on cell survival and cell death
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Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chang, C.-H., Curtis, J. D., Maggi, L. B., Faubert, B., Villarino, A. V., O’Sullivan, D., Huang, S. C.-C., van der Windt, G. J. W., Blagih, J., Qiu, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.016 · Cited by 2,204
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An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
Vinogradova, E. V., Zhang, X., Remillard, D., Lazar, D. C., Suciu, R. M., Wang, Y., Bianco, G., Yamashita, Y., Crowley, V. M., Schafroth, M. A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.07.001 · Cited by 351
Biochemical basis and metabolic interplay of redox regulation
Zhang, L., Wang, X., Cueto, R., Effi, C., Zhang, Y., Tan, H., Qin, X., Ji, Y., Yang, X., & Wang, H. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101284 · Cited by 308
Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?
Ohl, K., & Tenbrock, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.633845 · Cited by 31
Defining the Cell Surface Cysteinome Using Two-Step Enrichment Proteomics
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Metadata
- Authors
- Franchina, D. G., Dostert, C., & Brenner, D.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 39
- Issue
- 6
- Pages
- 489-502
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2787794728
- Cited by
- 322
- References
- 97
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Franchina, D. G., Dostert, C., & Brenner, D. (2018). Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism. Trends in Immunology. https://doi.org/10.1016/j.it.2018.01.005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
