The Intestinal Epithelium: Central Coordinator of Mucosal Immunity

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752

Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis

Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315

Pore-forming activity and structural autoinhibition of the gasdermin family

Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.-C., & Shao, F. (2016) · Nature · doi:10.1038/nature18590 · Cited by 2,771

Human nutrition, the gut microbiome and the immune system

Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200

Interrelation of Hypoxia-Inducible Factor-1 Alpha (HIF-1 α) and the Ratio between the Mean Corpuscular Volume/Lymphocytes (MCVL) and the Cumulative Inflammatory Index (IIC) in Ulcerative Colitis

Poenariu, I. S., Boldeanu, L., Ungureanu, B. S., Caragea, D. C., Cristea, O. M., Pădureanu, V., Siloşi, I., Ungureanu, A. M., Statie, R.-C., Ciobanu, A. E., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11123137 · Cited by 16

Severe gut mucosal injury induces profound systemic inflammation and spleen-associated lymphoid organ response

Wang, X., Du, C., Subramanian, S., Turner, L. E., Geng, H., Bu, H., & Tan, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1340442 · Cited by 16

Investigation into Potential Allergenicity and Digestion-Resistant Linear Epitopes of Fish Skin Gelatin in Cell-Cultured Meat Scaffolds

Wang, S., Lin, S., Liu, K., Jia, S., Liu, Q., & Sun, N. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c02336 · Cited by 16

Si-Ni-San alleviates intestinal and liver damage in ulcerative colitis mice by regulating cholesterol metabolism

Wang, A., Yang, X., Lin, J., Wang, Y., Yang, J., Zhang, Y., Tian, Y., Dong, H., Zhang, Z., & Song, R. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118715 · Cited by 16

Characterizing the effects of triclosan and triclocarban on the intestinal epithelial homeostasis using small intestinal organoids

Cheng, X., Shen, H., Zhang, W., Chen, B., Xu, S., & Wu, L. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135734 · Cited by 16

Regulatory Effect of Fucoidan Hydrolysates on Lipopolysaccharide-Induced Inflammation and Intestinal Barrier Dysfunction in Caco-2 and RAW264.7 Cells Co-Cultures

Fu, X., Huang, X., Tan, H., Huang, X., & Nie, S. (2024) · Foods · doi:10.3390/foods13223532 · Cited by 16

Changes in the small intestine mucosal immune barrier in Muscovy ducklings infected with Muscovy duck reovirus

Wu, Y., Liu, Z., Zhu, E., Li, M., Jiang, H., Luo, Y. H., Wang, Q., Wu, X., Wu, B., & Huang, Y. (2019) · Veterinary Microbiology · doi:10.1016/j.vetmic.2019.04.017 · Cited by 16

Integrated gut microbiota and metabolomic analysis reveals immunomodulatory effects of Echinacea extract and Astragalus polysaccharides

Li, S., Lin, R., Chen, J., Hussain, R., Zhang, S., Su, Y., Chan, Y., Ghaffar, A., & Shi, D. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.971058 · Cited by 16

Proteomics coupled with in vitro model to study the early crosstalk occurring between newly excysted juveniles of Fasciola hepatica and host intestinal cells

Becerro-Recio, D., Serrat, J., López-García, M., Sotillo, J., Simón, F., González‐Miguel, J., & Siles‐Lucas, M. (2022) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010811 · Cited by 15

Colonic Goblet Cell Carcinoid: Rarity of a Rarity! A Case Report and Review of Literature

Al‐Zawi, A. S. A., Khan, K. A., Shah, A., Asaad, A., Salter, V., Barron, M., Eldruki, S., Salih, V., & Alowami, S. O. (2020) · Chirurgia · doi:10.21614/chirurgia.115.1.102 · Cited by 16

Essential roles of the unfolded protein response in intestinal physiology

Hetz, C. A., Silva-Agüero, J. F., & Ellerby, L. (2024) · eGastroenterology · doi:10.1136/egastro-2024-100129 · Cited by 17

Mutual interaction of microbiota and host immunity during health and diseases

Wu, D., Zhang, Y., Dong, S., & Zhong, C. (2021) · Biophysics Reports · doi:10.52601/bpr.2021.200045 · Cited by 16

Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation

Xu, J., Li, S., Jin, W., Zhou, H., Zhong, T., Cheng, X., Fu, Y., Xiao, P., Cheng, H., Wang, D., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.162701 · Cited by 17

TLR/MyD88-Mediated Inflammation Induced in Porcine Intestinal Epithelial Cells by Ochratoxin A Affects Intestinal Barrier Function

Yoon, J. W., Shin, S., Park, J., Lee, B. R., & Lee, S. I. (2023) · Toxics · doi:10.3390/toxics11050437 · Cited by 14

Understanding the cellular dynamics, engineering perspectives and translation prospects in bioprinting epithelial tissues

Derman, İ. D., Moses, J. C., Rivera, T., & Ozbolat, I. T. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.09.025 · Cited by 15

Inflammasome activation links enteric Salmonella Typhimurium infection to a rapid, cytokine-dependent increase in intestinal mucin release

Han, X., Allaire, J. M., Crowley, S. M., Chan, J. J., Lau, K., Zhang, C., Hirota, S. A., Bergstrom, K., Knodler, L. A., & Vallance, B. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2413372 · Cited by 15

Listeria monocytogenes Establishes Commensalism in Germ-Free Mice Through the Reversible Downregulation of Virulence Gene Expression

Cho, K., Spasova, D. S., Hong, S., Eunju, O., Surh, C. D., Im, S., & Kim, K. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.666088 · Cited by 15

Patient Derived Colonoids as Drug Testing Platforms–Critical Importance of Oxygen Concentration

Skovdahl, H. K., Gopalakrishnan, S., Svendsen, T. D., Granlund, A. V. B., Bakke, I., Ginbot, Z., Thorsvik, S., Flatberg, A., Sporsheim, B., Ostrop, J., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.679741 · Cited by 15

Advances in Nanomedicines for Interaction with the Intestinal Barrier

Lin, S., Wu, F. Q., Cao, Z., & Liu, J. (2022) · Advanced NanoBiomed Research · doi:10.1002/anbr.202100147 · Cited by 15

Effects of Immune Cells on Intestinal Stem Cells: Prospects for Therapeutic Targets

Ma, L., Yu, J., Zhang, H., Zhao, B. T., Zhang, J., Yang, D., Luo, F., Wang, B., Jin, B., & Liu, J. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10347-7 · Cited by 15

Moniezia benedeni Infection Restrain IgA+, IgG+, and IgM+ Cells Residence in Sheep (Ovis aries) Small Intestine

Han, L.-X., Yao, W., Pan, J., Wang, B., He, W., Fan, X., Wang, W., & Zhang, W. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.878467 · Cited by 15

Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis

Yan, X., Lin, X., Wu, J., Zheng, L., Liu, Y., Wu, F., Lin, Y., Lu, Y., Huang, C., Shen, B., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04233-5 · Cited by 14

Microbiome Studies in Non-human Primates

Brenchley, J. M., & Ortiz, A. M. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-021-00584-9 · Cited by 16

The metabolic impact of bacterial infection in the gut

Chaukimath, P., Frankel, G. M., & Visweswariah, S. S. (2022) · FEBS Journal · doi:10.1111/febs.16562 · Cited by 14

New insights into bacterial mechanisms and potential intestinal epithelial cell therapeutic targets of inflammatory bowel disease

Liang, B., Wu, C., Wang, C., Sun, W., Chen, W., Hu, X., Liu, N., & Xing, D. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1065608 · Cited by 15

Western diet components that increase intestinal permeability with implications on health

Jaquez-Durán, G., & Arellano-Ortiz, A. L. (2023) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000801 · Cited by 15

Obesity under the moonlight of c-MYC

Nevzorova, Y. A., & Cubero, F. J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1293218 · Cited by 16

The coming future: The role of the oral–microbiota–brain axis in aroma release and perception

Xi, Y., Yu, M., Li, X., Zeng, X., & Li, J. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13303 · Cited by 15

Comparison of iPSC-derived human intestinal epithelial cells with Caco-2 cells and human in vivo data after exposure to Lactiplantibacillus plantarum WCFS1

Janssen, A. W. F., van der Lugt, B., Duivenvoorde, L. P. M., Vos, A. P., Bastiaan‐Net, S., Tomassen, M. M. M., Verbokkem, J. A. C., Blok-Heimerikx, E., Hooiveld, G. J. E. J., van Baarlen, P., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-74802-w · Cited by 14

The OSMR Gene Is Involved in Hirschsprung Associated Enterocolitis Susceptibility through an Altered Downstream Signaling

Bachetti, T., Rosamilia, F., Bartolucci, M., Santamaria, G., Mosconi, M., Sartori, S., Filippo, M. R. D., Duca, M. D., Obino, V., Avanzini, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083831 · Cited by 14

Chewing the Fat with Microbes: Lipid Crosstalk in the Gut

Lemons, J. M. S., & Liu, L. (2022) · Nutrients · doi:10.3390/nu14030573 · Cited by 14

Risk of Gastrointestinal Adverse Events in Cancer Patients Treated With Immune Checkpoint Inhibitor Plus Chemotherapy: A Systematic Review and Meta-Analysis

Yang, W., Men, P., Xue, H., Jiang, M., & Luo, Q. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00197 · Cited by 14

Clump sequencing exposes the spatial expression programs of intestinal secretory cellsPreprint

Manco, R., Averbukh, I., Porat, Z., Halpern, K. B., Amit, I., & Itzkovitz, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.05.237917 · Cited by 14

Sertraline and Citalopram Actions on Gut Barrier Function

Eyzaguirre‐Velásquez, J., González-Toro, M. P., González‐Arancibia, C., Escobar-Luna, J., Beltrán, C. J., Bravo, J. A., & Julio‐Pieper, M. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06702-8 · Cited by 13

Rational design of oral delivery nanosystems for hypoglycemic peptides

Peng, T., Shao, X., Li, L., Liu, H., Song, W., Hou, J., Zhong, H., Ding, Y., & Huang, Y. (2023) · Nano Today · doi:10.1016/j.nantod.2023.102031 · Cited by 13

Immunoenhancing and antioxidant potentials of kimchi, an ethnic food from Korea, as a probiotic and postbiotic food

Nugroho, D., Thinthasit, A., Surya, E., Hartati, H., Oh, J.-S., Jang, J.-G., Benchawattananon, R., & Surya, R. (2024) · Journal of Ethnic Foods · doi:10.1186/s42779-024-00232-8 · Cited by 13

Urolithin B protects mice from diet-induced obesity, insulin resistance, and intestinal inflammation by regulating gut microbiota composition

Chen, P., Wang, R., Lei, J., Feng, L., & Zhou, B. (2024) · Food & Function · doi:10.1039/d4fo02545h · Cited by 13

Pathogenic mechanisms in the evolution of food allergy

Martínez‐Blanco, M., Mukhatayev, Z., & Chatila, T. A. (2024) · Immunological Reviews · doi:10.1111/imr.13398 · Cited by 16

Defatted Rice Bran Supplementation in Diets of Finishing Pigs: Effects on Physiological, Intestinal Barrier, and Oxidative Stress Parameters

Fan, L., Huang, R., Wu, C., Cao, Y., Du, T., Pu, G., Wang, H., Zhou, W., Li, P., & Kim, S. W. (2020) · Animals · doi:10.3390/ani10030449 · Cited by 16

Diurnal changes in the murine small intestine are disrupted by obesogenic Western Diet feeding and microbial dysbiosis

Martchenko, S. E., Prescott, D., Martchenko, A., Sweeney, M. E., Philpott, D. J., & Brubaker, P. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-98986-7 · Cited by 13

Feeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot (Scophthalmus maximus)

He, J., Wang, Z., Zhao, Y., Yang, J., Zhang, Y., Liu, Q., & Yang, D. (2021) · Fish and Shellfish Immunology Reports · doi:10.1016/j.fsirep.2021.100037 · Cited by 13

Jejunum-derived NF-κB reporter organoids as 3D models for the study of TNF-alpha-induced inflammation

Daghero, H., Doffe, F., Varela, B., Yozzi, V., Verdes, J. M., Crispo, M., Bollati‐Fogolín, M., & Pagotto, R. (2022) · Scientific Reports · doi:10.1038/s41598-022-18556-3 · Cited by 13

Set up of an in vitro model to study early host-parasite interactions between newly excysted juveniles of Fasciola hepatica and host intestinal cells using a quantitative proteomics approach

González‐Miguel, J., Becerro-Recio, D., Sotillo, J., Simón, F., & Siles‐Lucas, M. (2020) · Veterinary Parasitology · doi:10.1016/j.vetpar.2020.109028 · Cited by 13

Microbiome analysis, the immune response and transplantation in the era of next generation sequencing

Kanangat, S., & Skaljic, I. (2021) · Human Immunology · doi:10.1016/j.humimm.2021.07.009 · Cited by 14

β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

Yue, B., Gao, R., Zhao, L., Liu, D., Lv, C., Wang, Z., Ai, F., Zhang, B., Yu, Z., Geng, X., et al. (2025) · Advanced Science · doi:10.1002/advs.202411052 · Cited by 12

Tuhuaiyin alleviates imiquimod-induced psoriasis via inhibiting the properties of IL-17-producing cells and remodels the gut microbiota

Di, T., Zhao, J., Wang, Y., Lin, H., Guo, X., Han, X., Chen, Z., Li, P., & Lu, C. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111884 · Cited by 12

Longitudinal analysis of exposure to a low concentration of oxytetracycline on the zebrafish gut microbiome

Kayani, M. U. R., Kan, Y., Qiu, Y., Yu, X., Chen, L., & Huang, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.985065 · Cited by 12

Potentially probioticLimosilactobacillus reuterifrom human milk strengthens the gut barrier in T84 cells and a murine enteroid model

Anjum, J., Quach, A., Wongkrasant, P., Nazir, S., Tariq, M., Barrett, K. E., & Zaidi, A. (2022) · Journal of Applied Microbiology · doi:10.1093/jambio/lxac029 · Cited by 12

Rhei Radix et Rhizoma in Xuanbai-Chengqi decoction strengthens the intestinal barrier function and promotes lung barrier repair in preventing severe viral pneumonia induced by influenza A virus

Guo, L.-F., Bao, W., Yang, S., Liu, Y., Lyu, J., Wang, T., Lu, Y., Li, H., Zhu, H., & Chen, D. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117231 · Cited by 12

Tissue niches and immunopathology through the lens of spatial tissue profiling techniques

Reguant, A. P., Kroh, S., & Hauser, A. E. (2023) · European Journal of Immunology · doi:10.1002/eji.202350484 · Cited by 14

Protective effect of crocin on peroxidation‐induced oxidative stress and apoptosis in IPEC‐J2 cells

Wang, J., Song, H., Huang, Y., Yang, C., Wu, Y., Lin, R., Xiao, T., & Lin, W. (2024) · Environmental Toxicology · doi:10.1002/tox.24216 · Cited by 12

The epithelial C15ORF48/miR-147-NDUFA4 axis is an essential regulator of gut inflammation, energy metabolism, and the microbiome

Xiong, M., Liu, Z., Wang, B., Sokolich, T., Graham, N. M., Chen, M., Wang, W.-L., & Boldin, M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315944121 · Cited by 12

Current Research on the Role of Isomaltooligosaccharides in Gastrointestinal Health and Metabolic Diseases

Rini, D. M., Xu, W., & Suzuki, T. (2024) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2024.29.2.93 · Cited by 12

Cellular Plasticity in Gut and Liver Regeneration

Kim, M., Park, Y., Kim, Y. S., & Ko, S. (2024) · Gut and Liver · doi:10.5009/gnl240005 · Cited by 12

Unveiling the hidden culprit: How the brain-gut axis fuels neuroinflammation in ischemic stroke

Ma, B. D. Y., Chan, T. Y. H., & Lo, B. (2024) · Surgical Neurology International · doi:10.25259/sni_703_2024 · Cited by 14

IUPHAR review: Targeted therapies of signaling pathways based on the gut microbiome in autism spectrum disorders: Mechanistic and therapeutic applications

Mamun, A. A., Geng, P., Wang, S., Shao, C., & Xiao, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107559 · Cited by 15

Mechanisms of Endogenous HIV-1 Reactivation by Endocervical Epithelial Cells

Gornalusse, G. G., Valdez, R., Fenkart, G., Vojtech, L. N., Ballweber-Fleming, L., Pandey, U., Hughes, S. M., Levy, C., Cruz, E. J. D., Calienes, F. L., et al. (2020) · Journal of Virology · doi:10.1128/jvi.01904-19 · Cited by 12

Modulating the gut–liver axis and the pivotal role of the faecal microbiome in cirrhosis

Woodhouse, C., Singanayagam, A., & Patel, V. (2020) · Clinical Medicine · doi:10.7861/clinmed.2020-0676 · Cited by 12

Effect of inactivated nature‐derived microbial composition on mouse immune system

González‐Rodríguez, M. I., Nurminen, N., Kummola, L., Laitinen, O. H., Oikarinen, S., Parajuli, A., Salomaa, T., Mäkelä, I., Roslund, M. I., Sinkkonen, A., et al. (2021) · Immunity Inflammation and Disease · doi:10.1002/iid3.579 · Cited by 12

Effect of PDCA circulation nursing intervention on prognosis of patients with severe pneumonia.

Bai, L., Yang, L., Shi, X., & Huang, W. (2022) · PubMed Central · Cited by 12

Gastrointestinal Manifestations of Immunodeficiency: Imaging Spectrum

Itani, M., Kaur, N., Roychowdhury, A., Mellnick, V. M., Lubner, M. G., Dasyam, A. K., Khanna, L., Prasad, S. R., & Katabathina, V. S. (2022) · Radiographics · doi:10.1148/rg.210169 · Cited by 12

A Genomics-Based Semirational Approach for Expanding the Postbiotic Potential of Collagen Peptides Using Lactobacillaceae

Lee, J., Hwang, H. W., Jin, H., Lee, J.-E., Kang, N. J., & Lee, D. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c01251 · Cited by 13

Human intestinal epithelial cells can internalize luminal fungi via LC3-associated phagocytosis

Cohen‐Kedar, S., Barda, E. S., Rabinowitz, K. M., Keizer, D., Abu-Taha, H., Schwartz, S., Kaboub, K., Baram, L., Sadot, E., White, I. D., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1142492 · Cited by 12

The link between gut microbiota and multiple sclerosis from the perspective of barrier function

Ren, J., Niu, Z., Wang, J., Guo, J., Hao, H.-J., Gao, F., Liu, R., & Wang, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1652796 · Cited by 13

Role of Ion Channels in the Chemotransduction and Mechanotransduction in Digestive Function and Feeding Behavior

Zhu, Z., Wu, Y., Liu, Z., Li, Y., & Jiang, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169358 · Cited by 11

Reconstructed human intestinal comet assay, a possible alternative in vitro model for genotoxicity assessment

Hughes, C. O., Lim, H. K., Tan, J. C. W., Leavesley, D. I., & Smith, B. P. C. (2023) · Mutagenesis · doi:10.1093/mutage/gead011 · Cited by 11

Key elements determining the intestinal region-specific environment of enteric neurons in type 1 diabetes

Bagyánszki, M., & Bódi, N. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i18.2704 · Cited by 11

Hydrochlorothiazide-induced glucose metabolism disorder is mediated by the gut microbiota via LPS-TLR4-related macrophage polarization

Luo, J., Ren, H., Chen, M., Zhao, Q. C., Yang, N., Liu, Q., Gao, Y., Zhou, H.-H., Huang, W., & Zhang, W. (2023) · iScience · doi:10.1016/j.isci.2023.107130 · Cited by 12

Nur77 as a novel regulator of Paneth cell differentiation and function

Cui, C., Wang, X., Zheng, Y., Wu, L., Li, L., Wei, H., & Peng, J. (2024) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.09.001 · Cited by 11

Bifidobacterium longum subsp. longum XZ01 delays the progression of colon cancer in mice through the interaction between the microbial spatial distribution and tumour immunity

Chen, Y., Wu, J., Cai, K., Xiao, X., Chen, Y., Zhang, X., Deng, S., Pei, C., Chen, Y., Xie, Z., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114283 · Cited by 11

I’ve looked at gut from both sides now: Gastrointestinal tract involvement in the pathogenesis of SARS-CoV-2 and HIV/SIV infections

Pandrea, I., Brooks, K., Desai, R. P., Tare, M., Brenchley, J. M., & Apetrei, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.899559 · Cited by 11

The gut microbiome and allergic rhinitis; refocusing on the role of probiotics as a treatment option

Li, J., Fang, F., Mei, M., & Wu, D. (2022) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-022-07694-z · Cited by 12

Altered intestinal microbiome and epithelial damage aggravate intestinal graft-versus-host disease

Gao, F., Wu, H., Wang, L., Zhao, Y., & Huang, H. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2221821 · Cited by 11

Feasibility evaluation of fermented peanut meal to replace soybean meal in the diet of common carp (Cyprinus carpio): Growth performance, serum biochemistry, intestinal health and microflora composition

Fan, Z., Cheng, M., Wang, L., Li, C., Wu, D., Li, J., Cheng, Z., Zhang, H., & Li, W. (2023) · Aquaculture Reports · doi:10.1016/j.aqrep.2023.101675 · Cited by 11

A High Efficient Method to Isolate Exosomes from Small Intestinal Epithelium

Xia, F., Ding, F., Lv, Y., Di, W., Sheng, Y., & Ding, G. (2019) · Molecular Biotechnology · doi:10.1007/s12033-019-00163-9 · Cited by 11

Barrier therapies supporting the biology of the mucosal barrier- medical devices for common clinical mucosal disorders

McCullough, R. W. (2020) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2020.02.02 · Cited by 11

Single-Cell Transcriptional Profiling of the Intestinal Epithelium

Capdevila, C., Calderon, R. I., Bush, E. C., Sheldon-Collins, K., Sims, P. A., & Yan, K. S. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0747-3_8 · Cited by 9

Colonization of Germ-Free Piglets with Mucinolytic and Non-Mucinolytic Bifidobacterium boum Strains Isolated from the Intestine of Wild Boar and Their Interference with Salmonella Typhimurium

Šplı́chalová, A., Pechar, R., Killer, J., Splichalova, Z., Bunešová, V., Vlková, E., Salmonová, H. Š., & Šplı́chal, I. (2020) · Microorganisms · doi:10.3390/microorganisms8122002 · Cited by 11

Allergy‐related diseases and early gut fungal and bacterial microbiota abundances in children

Schei, K., Simpson, M. R., Øien, T., Salamati, S., Rudi, K., & Ødegård, R. A. (2021) · Clinical and Translational Allergy · doi:10.1002/clt2.12041 · Cited by 11

NOD2/CARD15 polymorphisms (P268S, IVS8+158, G908R, L1007fs, R702W) among Kuwaiti patients with Crohn's disease

Abdelnaby, H., Ndiaye, N. C., D’Amico, F., Fouad, A. M., Hassan, S. A. M., Elshafey, A., Hashash, W. A., Faisal, M., Alshamali, Y., Al-Taweel, T., et al. (2021) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_613_20 · Cited by 11

Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues

Callaghan, N. I., Durland, L. J., Ireland, R. G., Santerre, J. P., Simmons, C. A., & Huyer, L. D. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00246-3 · Cited by 10

Modelling Human Gut‐Microbiome Interactions in a 3D Bioelectronic Platform

Moysidou, C., van Niekerk, D. C., Stoeger, V., Pitsalidis, C., Draper, L. A., Withers, A. M., Hughes, K., McCoy, R. S. A., Acharya, R., Hill, C., et al. (2024) · Small Science · doi:10.1002/smsc.202300349 · Cited by 11

Pro-inflammatory T cells-derived cytokines enhance the maturation of the human fetal intestinal epithelial barrier

Giugliano, F. P., Keuper-Navis, M., Ouahoud, S., Garcia, T. M., Kreulen, I. A. M., Ferrantelli, E., Meisner, S., Vermeulen, J. L. M., van Roest, M., Billaud, J.-N., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109909 · Cited by 11

Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4+CD8αα+ intraepithelial T cells

Rodriguez-Marino, N. C., Royer, C. J., Rivera-Rodriguez, D. E., Seto, E., Gracien, I., Jones, R. M., Scharer, C. D., Gracz, A. D., & Cervantes‐Barragán, L. (2024) · Mucosal Immunology · doi:10.1016/j.mucimm.2024.08.010 · Cited by 9

Estrogen Receptor β Alleviates Colitis by Inhibiting Ferroptosis in Intestinal Epithelial Cells

Li, J., Chen, Y., Li, S., Zhang, X., Cheng, Y., Fu, X., Li, J., & Zhu, L. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s492290 · Cited by 10

A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity

Pérez, M. G., Gillan, V., Anderson, W. M., Gerbe, F., Herbert, F., McNeilly, T. N., Maizels, R. M., Jay, P., Devaney, E., & Britton, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1558132 · Cited by 10

Role of Pyroptosis in inflammatory bowel disease

Xiao, Z., Xie, J., Zhao, X., Chen, X., Lu, Y., Xu, Y., Wu, M., An, L., & Li, Q. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114619 · Cited by 10

A Promising Insight: The Potential Influence and Therapeutic Value of the Gut Microbiota in GI GVHD

Li, J., Zhang, X., Chen, Y., Zheng, Q., Zhao, M., & Jiang, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2124627 · Cited by 10

Esculentoside A could attenuate apoptosis and inflammation in TNBS-induced ulcerative colitis via inhibiting the nuclear translocation of NF-κB

Liu, Y., Wei, W., Liang, S., Fang, H., & Cao, J. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-2675 · Cited by 10

Interleukin‐22 Ameliorates Dextran Sulfate Sodium‐Induced Colitis through the Upregulation of lncRNA‐UCL to Accelerate Claudin‐1 Expression via Sequestering miR‐568 in Mice

He, C., Chen, Z., Huang, J., Gan, R., Wang, J., Wang, L., Li, D., & Yao, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8543720 · Cited by 10

Adaptation of the gut holobiont to malnutrition during mouse pregnancy depends on the type of nutritional adversity

Connor, K. L., Bloise, E., DeSantis, T. Z., & Lye, S. J. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109172 · Cited by 10

Putative intestinal permeability markers do not correlate with cardiometabolic health and gut microbiota in humans, except for peptides recognized by a widely used zonulin ELISA kit

Arango-González, Á. M., Lara-Guzmán, O. J., Rivera, D. A., Álvarez, R., Serrano, D. S., Muñoz-Durango, K., Escobar, J. S., & Sierra, J. A. (2022) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.09.026 · Cited by 12

Experimental bacterial dysbiosis with consequent immune alterations increase intrarectal SIV acquisition susceptibility

Ortiz, A. M., Baker, P. J., Langner, C. A., Simpson, J., Stacy, A., Flynn, J. K., Starke, C. E., Vinton, C. L., Fennessey, C. M., Belkaid, Y., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112020 · Cited by 10

Cannabidiol - Help and hype in targeting mucosal diseases

Moniruzzaman, M., Janjua, T. I., Martin, J. H., Begun, J., & Popat, A. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.11.010 · Cited by 10

SLE serum induces altered goblet cell differentiation and leakiness in human intestinal organoids

Hensel, I. V., Éliás, S., Steinhauer, M., Stoll, B., Benfatto, S., Merkt, W., Krienke, S., Lorenz, H., Haas, J., Wildemann, B., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00023-3 · Cited by 12

Alterations in metabolome and microbiome: new clues on cathelicidin-related antimicrobial peptide alleviates acute ulcerative colitis

Jiang, N., Liu, Z., Wang, H., Zhang, L., Li, M., Li, G., Li, C., Wang, B., Zhao, C., & Liu, L. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1306068 · Cited by 12

Zonulin is a marker of epithelial and endothelial barrier functions in non-communicable diseases (narrative review)

Zybina, N. N., Nikonov, E. L., Герштейн, Е. С., Memdli, Z. Z., Stilidi, I. S., & Кушлинский, Н. Е. (2022) · Russian Journal of Evidence-Based Gastroenterology · doi:10.17116/dokgastro20221101128 · Cited by 13

Death‐associated protein kinases and intestinal epithelial homeostasis

Chen, H., & MacDonald, J. A. (2022) · The Anatomical Record · doi:10.1002/ar.25022 · Cited by 10

Qingchang suppository ameliorates mucosal inflammation in ulcerative colitis by inhibiting the differentiation and effector functions of Th1 and Th17 cells

Cao, H., Liu, H., Xiaoling, D., Shi, B., Yuan, J., Shan, J., & Lin, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118865 · Cited by 9

Revolutionizing IBD research with on-chip models of disease modeling and drug screening

Yılmaz, B., Hacıosmanoğlu, N., Jordi, S. B. U., Yılmaz, B., & İnci, F. (2024) · Trends in biotechnology · doi:10.1016/j.tibtech.2024.10.002 · Cited by 9

Microbiome and Gut Immunity: The Epithelium

Günther, C., & Haller, D. (2026) · Springer eBooks · doi:10.1007/978-3-032-26410-7_7

Guardians of Intestinal Homeostasis: Focus on Intestinal Epithelial Cells

Elbrashy, M. M., Metwally, H., & Kishimoto, T. (2024) · Journal of Cellular Immunology · doi:10.33696/immunology.6.186 · Cited by 2

Intestinal epithelial cells: At the interface of the microbiota and mucosal immunity

Soderholm, A. T., & Pedicord, V. A. (2019) · Immunology · doi:10.1111/imm.13117 · Cited by 281

Epithelial immunity: priming defensive responses in the intestinal mucosa

Pardo‐Camacho, C., González-Castro, A. M., Rodiño‐Janeiro, B. K., Pigrau, M., & Vicario, M. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00215.2016 · Cited by 34

Epithelial regulation of microbiota-immune cell dynamics

Didriksen, B. J., Eshleman, E. M., & Alenghat, T. (2024) · Mucosal Immunology · doi:10.1016/j.mucimm.2024.02.008 · Cited by 54