Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works

HTSeq—a Python framework to work with high-throughput sequencing data

Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Calcium's Role in Mechanotransduction during Muscle Development

Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,548 · see citing works

MultiQC: summarize analysis results for multiple tools and samples in a single report

Ewels, P., Magnusson, M., Lundin, S., & Käller, M. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw354 · Cited by 10,143 · see citing works

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659 · see citing works

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works

Shared Principles in NF-κB Signaling

Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,814 · see citing works

Calcium Signaling

Clapham, D. E. (2007) · Cell · doi:10.1016/j.cell.2007.11.028 · Cited by 4,175 · see citing works

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586 · see citing works

The role of senescent cells in ageing

van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · see citing works

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · see citing works

30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology

Zhang, Q., Lenardo, M. J., & Baltimore, D. (2017) · Cell · doi:10.1016/j.cell.2016.12.012 · Cited by 1,979 · see citing works

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Baughman, J. M., Perocchi, F., Girgis, H. S., Plovanich, M. E., Belcher-Timme, C. A., Sancak, Y., Bao, X., Strittmatter, L., Goldberger, O., Bogorad, R., et al. (2011) · Nature · doi:10.1038/nature10234 · Cited by 1,926 · see citing works

Calcium oscillations increase the efficiency and specificity of gene expression

Dolmetsch, R. E., Xu, K., & Lewis, R. S. (1998) · Nature · doi:10.1038/31960 · Cited by 1,896 · see citing works

Mitochondria as sensors and regulators of calcium signalling

Rizzuto, R., De Stefani, D., Raffaello, A., & Mammucari, C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3412 · Cited by 1,781 · see citing works

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/386855a0 · Cited by 1,754 · see citing works

Senescence-associated β-galactosidase is lysosomal β-galactosidase.

Lee, B. Y., Han, J. A., Im, J. S., Morrone, A., Johung, K., Goodwin, E. C., Kleijer, W. J., DiMaio, D., & Hwang, E. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00199.x · Cited by 1,444 · see citing works

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Stefani, D. D., Raffaello, A., Teardo, E., Szabò, I., & Rizzuto, R. (2011) · Nature · doi:10.1038/nature10230 · Cited by 1,431 · see citing works

The mitochondrial calcium uniporter is a highly selective ion channel

Kirichok, Y., Krapivinsky, G., & Clapham, D. E. (2004) · Nature · doi:10.1038/nature02246 · Cited by 1,409 · see citing works

Mitochondria and calcium: from cell signalling to cell death

Duchen, M. R. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00057.x · Cited by 1,261 · see citing works

Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages

Fink, S. L., & Cookson, B. T. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00751.x · Cited by 1,114 · see citing works

Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin

Rizzuto, R., Simpson, A. W. M., Brini, M., & Pozzan, T. (1992) · Nature · doi:10.1038/358325a0 · Cited by 931 · see citing works

Senescence-messaging secretome: SMS-ing cellular stress

Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909 · see citing works

The origins of age-related proinflammatory state

Ferrucci, L., Corsi, A., Lauretani, F., Bandinelli, S., Bartali, B., Taub, D. D., Guralnik, J. M., & Longo, D. L. (2005) · Blood · doi:10.1182/blood-2004-07-2599 · Cited by 908 · see citing works

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

Kofoed, E. M., & Vance, R. E. (2011) · Nature · doi:10.1038/nature10394 · Cited by 894 · see citing works

Regulation of mitochondrial dehydrogenases by calcium ions

Denton, R. M. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.01.005 · Cited by 885 · see citing works

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

Perocchi, F., Gohil, V. M., Girgis, H. S., Bao, X. R., McCombs, J. E., Palmer, A. E., & Mootha, V. K. (2010) · Nature · doi:10.1038/nature09358 · Cited by 881 · see citing works

Ion Channels in Innate and Adaptive Immunity

Feske, S., Wulff, H., & Skolnik, E. Y. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112212 · Cited by 764 · see citing works

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

Sancak, Y., Markhard, A. L., Kitami, T., Kovács-Bogdán, E., Kamer, K. J., Udeshi, N. D., Carr, S. A., Chaudhuri, D., Clapham, D. E., Li, A. A., et al. (2013) · Science · doi:10.1126/science.1242993 · Cited by 666 · see citing works

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

Pan, X., Liu, J., Nguyen, T. T. M., Liu, C., Sun, J., Teng, Y., Fergusson, M. M., Rovira, I. I., Allen, M. D., Springer, D., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2868 · Cited by 645 · see citing works

Tissue biology perspective on macrophages

Okabe, Y., & Medzhitov, R. M. (2015) · Nature Immunology · doi:10.1038/ni.3320 · Cited by 633 · see citing works

Age-related inflammatory cytokines and disease

Brüünsgaard, H., & Pedersen, B. K. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00056-5 · Cited by 608 · see citing works

NFAT, immunity and cancer: a transcription factor comes of age

Müller, M., & Rao, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2818 · Cited by 601 · see citing works

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

Csordás, G., Golenár, T., Seifert, E. L., Kamer, K. J., Sancak, Y., Perocchi, F., Moffat, C., Weaver, D., de la Fuente, S., Bogorad, R. L., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.020 · Cited by 491 · see citing works

Motif module map reveals enforcement of aging by continual NF-κB activity

Adler, A. S., Sinha, S., Kawahara, T. L. A., Zhang, J. Y., Segal, E., & Chang, H. Y. (2007) · Genes & Development · doi:10.1101/gad.1588507 · Cited by 466 · see citing works

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

Plovanich, M., Bogorad, R. L., Sancak, Y., Kamer, K. J., Strittmatter, L., Li, A. A., Girgis, H. S., Kuchimanchi, S., Groot, J. D., Speciner, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055785 · Cited by 463 · see citing works

Age‐related changes in the gut microbiota influence systemic inflammation and stroke outcome

Spychala, M. S., Venna, V. R., Jandzinski, M., Doran, S. J., Durgan, D. J., Ganesh, B. P., Ajami, N. J., Putluri, N., Graf, J., Bryan, R. M., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25250 · Cited by 435 · see citing works

Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study

Leng, S., Chaves, P., Koenig, K., & Walston, J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50315.x · Cited by 387 · see citing works

Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process

Dinarello, C. A. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.447s · Cited by 385 · see citing works

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

Hara, H., Tsuchiya, K., Kawamura, I., Fang, R., Hernández-Cuellar, E., Shen, Y., Mizuguchi, J., Schweighoffer, E., Tybulewicz, V. L. J., & Mitsuyama, M. (2013) · Nature Immunology · doi:10.1038/ni.2749 · Cited by 382 · see citing works

Interaction of calcineurin with substrates and targeting proteins

Li, H., Rao, A., & Hogan, P. G. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.09.011 · Cited by 372 · see citing works

The molecular era of the mitochondrial calcium uniporter

Kamer, K. J., & Mootha, V. K. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4039 · Cited by 367 · see citing works

Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex

Fan, M., Zhang, J., Tsai, C.-W., Orlando, B. J., Rodriguez, M. X., Xu, Y., Liao, M., Tsai, M.-F., & Feng, L. (2020) · Nature · doi:10.1038/s41586-020-2309-6 · Cited by 307 · see citing works

Architecture of the mitochondrial calcium uniporter

Oxenoid, K., Dong, Y., Cao, C., Cui, T., Sancak, Y., Markhard, A. L., Grabarek, Z., Kong, L., Liu, Z., OuYang, B., et al. (2016) · Nature · doi:10.1038/nature17656 · Cited by 295 · see citing works

The role of mitochondria in stem cell fate and aging

Zhang, H., Menzies, K. J., & Auwerx, J. H. (2018) · Development · doi:10.1242/dev.143420 · Cited by 285 · see citing works

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

Osorio, F. G., Bárcena, C., Soria-Valles, C., Ramsay, A. J., de Carlos, F., Cobo, J., Fueyo, A., Freije, J. M. P., & López-Otín, C. (2012) · Genes & Development · doi:10.1101/gad.197954.112 · Cited by 276 · see citing works

(1,3)-β-Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages

Kankkunen, P., Teirilä, L., Rintahaka, J., Alenius, H. T., Wolff, H. J., & Matikainen, S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903019 · Cited by 274 · see citing works

The Genotype-Tissue Expression (GTEx) project

Lonsdale, J., Thomas, J., Salvatore, M., Phillips, R., Lo, E., Shad, S., Hasz, R., Walters, G., Garcia, F., Young, N., et al. (2013) · Nature Genetics · doi:10.1038/ng.2653 · Cited by 263 · see citing works

Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation

Schappe, M. S., Szteyn, K., Stremska, M. E., Mendu, S. K., Downs, T. K., Seegren, P. V., Mahoney, M. A., Dixit, S., Krupa, J. K., Stipes, E. J., et al. (2018) · Immunity · doi:10.1016/j.immuni.2017.11.026 · Cited by 251 · see citing works

Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans

Donato, A. J., Black, A. D., Jablonski, K. L., Gano, L. B., & Seals, D. R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00438.x · Cited by 237 · see citing works

Activity of the mitochondrial calcium uniporter varies greatly between tissues

Fieni, F., Lee, S. B., Jan, Y. N., & Kirichok, Y. (2012) · Nature Communications · doi:10.1038/ncomms2325 · Cited by 231 · see citing works

NF-κB signaling in skin aging

Wang, Y., Wang, L., Wen, X., Hao, D., Zhang, N., He, G., & Jiang, X. L. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111160 · Cited by 231 · see citing works

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

van Beek, A. A., Van den Bossche, J., Mastroberardino, P. G., de Winther, M. P. J., & Leenen, P. J. M. (2019) · Trends in Immunology · doi:10.1016/j.it.2018.12.007 · Cited by 207 · see citing works

Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging

Ziegler, D. V., Vindrieux, D., Goehrig, D., Jaber, S., Collin, G., Griveau, A., Wiel, C., Bendridi, N., Djebali, S., Farfariello, V., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-20993-z · Cited by 195 · see citing works

MCU encodes the pore conducting mitochondrial calcium currents

Chaudhuri, D., Sancak, Y., Mootha, V. K., & Clapham, D. E. (2013) · eLife · doi:10.7554/elife.00704 · Cited by 181 · see citing works

Tissue-resident macrophages: guardians of organ homeostasis

Nobs, S. P., & Köpf, M. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.04.007 · Cited by 172 · see citing works

Ca2+ Stores and Ca2+ Entry Differentially Contribute to the Release of IL-1β and IL-1α from Murine Macrophages

Brough, D., Feuvre, R. A. L., Wheeler, R. D., Solovyova, N. A., Hilfiker, S., Rothwell, N. J., & Verkhratsky, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3029 · Cited by 168 · see citing works

Evolutionary Diversity of the Mitochondrial Calcium Uniporter

Bick, A. G., Calvo, S. E., & Mootha, V. K. (2012) · Science · doi:10.1126/science.1214977 · Cited by 158 · see citing works

Chapter 17 Zymosan‐Induced Peritonitis as a Simple Experimental System for the Study of Inflammation

Cash, J. L., White, G. E., & Greaves, D. R. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(09)05417-2 · Cited by 129 · see citing works

BART: a transcription factor prediction tool with query gene sets or epigenomic profiles

Wang, Z., Civelek, M., Miller, C. L., Sheffield, N. C., Guertin, M. J., & Zang, C. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty194 · Cited by 116 · see citing works

Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

Rausser, S., Trumpff, C., McGill, M. A., Junker, A., Wang, W., Ho, S., Mitchell, A., Karan, K. R., Monk, C. E., Segerstrom, S. C., et al. (2021) · eLife · doi:10.7554/elife.70899 · Cited by 106 · see citing works

Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis

Gu, L., Larson‐Casey, J. L., Andrabi, S. A., Lee, J. H., Meza‐Perez, S., Randall, T. D., & Carter, A. B. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101307 · Cited by 100 · see citing works

Purinergic and Calcium Signaling in Macrophage Function and Plasticity

Desai, B. N., & Leitinger, N. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00580 · Cited by 97 · see citing works

Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference

Gherardi, G., Nogara, L., Ciciliot, S., Fadini, G. P., Blaauw, B., Braghetta, P., Bonaldo, P., Stefani, D. D., Rizzuto, R., & Mammucari, C. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0191-7 · Cited by 86 · see citing works

mitoXplorer, a visual data mining platform to systematically analyze and visualize mitochondrial expression dynamics and mutations

Yim, A., Koti, P. S., Bonnard, A., Marchianò, F., Dürrbaum, M., Garcı́a-Pérez, C., Villaveces, J. M., Gamal, S., Cardone, G., Perocchi, F., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1128 · Cited by 75 · see citing works

The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter

Garg, V., Suzuki, J., Paranjpe, I., Unsulangi, T., Boyman, L., Milescu, L. S., Lederer, W. J., & Kirichok, Y. (2021) · eLife · doi:10.7554/elife.69312 · Cited by 72 · see citing works

BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells

Berry, C. T., Liu, X., Myles, A., Nandi, S., Chen, Y. H., Hershberg, U., Brodsky, I. E., Cancro, M. P., Lengner, C. J., May, M. J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.038 · Cited by 71 · see citing works

Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter

Wang, Y., Han, Y., She, J., Nguyen, N. X., Mootha, V. K., Bai, X., & Jiang, Y. (2020) · eLife · doi:10.7554/elife.60513 · Cited by 71 · see citing works

The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation

Yoast, R. E., Emrich, S. M., Zhang, X., Xin, P., Arige, V., Pathak, T., Benson, J. C., Johnson, M. T., Abdelnaby, A. E., Lakomski, N., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101174 · Cited by 68 · see citing works

Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis

Rimessi, A., Pozzato, C., Carparelli, L., Rossi, A., Ranucci, S., Fino, I. D., Cigana, C., Talarico, A., Wieckowski, M. R., Ribeiro, C. M. P., et al. (2020) · Science Advances · doi:10.1126/sciadv.aax9093 · Cited by 62 · see citing works

Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

Wang, C., Jacewicz, A., Delgado, B. D., Baradaran, R., & Long, S. B. (2020) · eLife · doi:10.7554/elife.59991 · Cited by 60 · see citing works

Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo

Tufi, R., Gleeson, T. P., von Stockum, S., Hewitt, V. L., Lee, J. J., Terriente-Félix, A., Sánchez-Martínez, Á., Ziviani, E., & Whitworth, A. J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.033 · Cited by 58 · see citing works

The structure of the MICU1‐MICU2 complex unveils the regulation of the mitochondrial calcium uniporter

Wu, W., Shen, Q., Zhang, R., Qiu, Z., Wang, Y., Zheng, J., & Jia, Z. (2020) · The EMBO Journal · doi:10.15252/embj.2019104285 · Cited by 51 · see citing works

Formation of a Complex of the Catalytic Subunit of Pyruvate Dehydrogenase Phosphatase Isoform 1 (PDP1c) and the L2 Domain Forms a Ca 2+ Binding Site and Captures PDP1c as a Monomer

Türkan, A., Hiromasa, Y., & Roche, T. E. (2004) · Biochemistry · doi:10.1021/bi048901y · Cited by 50 · see citing works

Mapping of POP1-binding Site on Pyrin Domain of ASC

Srimathi, T., Robbins, S. L., Dubas, R. L., Chang, H., Cheng, H., Röder, H., & Park, Y. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801589200 · Cited by 49 · see citing works

Mitochondrial Calcium Uptake Is Instrumental to Alternative Macrophage Polarization and Phagocytic Activity

Tedesco, S., Scattolini, V., Albiero, M., Bortolozzi, M., Avogaro, A., Cignarella, A., & Fadini, G. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194966 · Cited by 45 · see citing works

Mito Hacker: a set of tools to enable high-throughput analysis of mitochondrial network morphology

Rohani, A., Kashatus, J. A., Sessions, D. T., Sharmin, S., & Kashatus, D. F. (2020) · Scientific Reports · doi:10.1038/s41598-020-75899-5 · Cited by 43 · see citing works

CALIMA: The semi-automated open-source calcium imaging analyzer

Radstake, F. D. W., Raaijmakers, E. A. L., Lüttge, R., Zinger, S., & Frimat, J. (2019) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2019.104991 · Cited by 42 · see citing works

Inhibition of the mitochondrial calcium uniporter prevents IL-13 and allergen-mediated airway epithelial apoptosis and loss of barrier function

Sebag, S. C., Koval, O. M., Paschke, J. D., Winters, C. J., Comellas, A. P., & Grumbach, I. M. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.12.003 · Cited by 37 · see citing works

MICU1 Confers Protection from MCU-Dependent Manganese Toxicity

Wettmarshausen, J., Goh, V., Huang, K., Arduíno, D. M., Tripathi, U., Leimpek, A., Cheng, Y., Pittis, A. A., Gabaldón, T., Mokranjac, D., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.037 · Cited by 34 · see citing works

The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration

Feno, S., Munari, F., Reane, D. V., Gissi, R., Hoang, D.-H., Castegna, A., Chazaud, B., Viola, A., Rizzuto, R., & Raffaello, A. (2021) · Science Signaling · doi:10.1126/scisignal.abf3838 · Cited by 33 · see citing works

Mitochondrial Ca2+ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing

Seegren, P. V., Downs, T. K., Stremska, M. E., Harper, L. R., Cao, R., Olson, R. J., Upchurch, C. M., Doyle, C. A., Kennedy, J. A., Stipes, E. J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108411 · Cited by 32 · see citing works

Patch-Clamp Analysis of the Mitochondrial Calcium Uniporter

Garg, V., & Kirichok, Y. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9018-4_7 · Cited by 15 · see citing works

Analysis of Calcium Control of Canonical NF-κB Signaling in B Lymphocytes

Berry, C. T., May, M. J., & Freedman, B. D. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1669-7_9 · Cited by 4 · see citing works

Redox regulation: mechanisms, biology and therapeutic targets in diseases

Li, B., Ming, H., Qin, S., Nice, E. C., Dong, J., Du, Z., & Huang, C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02095-6 · Cited by 364 · see citing works

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276 · see citing works

Targeting immunosenescence and inflammaging: advancing longevity research

Nguyen, T. Q. T., & Cho, K. A. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01527-9 · Cited by 94 · see citing works

Multifaceted mitochondria in innate immunity

Marques, E., Kramer, R., & Ryan, D. G. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00008-3 · Cited by 88 · see citing works

Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations

Karpuzoglu, E., Holladay, S. D., & Gogal, R. M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1704203 · Cited by 43 · see citing works

Macrophage Intracellular “Calcium Oscillations” Triggered Through In Situ Mineralization Regulate Bone Immunity to Facilitate Bone Repair

Zhao, J., Zhang, K., Wang, L., Zhu, Z., Jiang, D., Zuo, Y., Yang, J., & Jia, W. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202316224 · Cited by 39 · see citing works

Osteogenic Induction and Anti‐Inflammatory Effects of Calcium‐Chlorogenic Acid Nanoparticles Remodel the Osteoimmunology Microenvironment for Accelerating Bone Repair

Liu, Q., Zhang, S., Shi, L., Shi, J., Sun, C., Wang, J., Zhou, W., Zhou, H., Shan, F., Wang, H., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401114 · Cited by 34 · see citing works

The Dual Role of Cellular Senescence in Macrophages: Unveiling the Hidden Driver of Age-Related Inflammation in Kidney Disease

Wang, Y., Li, T., Wang, F., Yao, X., Bai, Q., Su, H.-W., Li, J., Li, W., & Tan, R. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.104404 · Cited by 29 · see citing works

Targeted mitochondrial nanomaterials in biomedicine: Advances in therapeutic strategies and imaging modalities

Chen, Z., Chen, L., Lyu, T., Weng, S., Xie, Y., Jin, Y., Wu, O., Jones, M., Kwan, K. Y.-H., Makvnadi, P., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.08.008 · Cited by 28 · see citing works

The ageing immune system as a driver of systemic ageing

Jang, I. H., Niedernhofer, L. J., Robbins, P. D., & Camell, C. D. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01269-3 · Cited by 33 · see citing works

Calcium signaling hypothesis: A non-negligible pathogenesis in Alzheimer’s disease

Wang, M., Zhang, H., Liang, J., Huang, J., Wu, T., & Chen, N. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.01.007 · Cited by 25 · see citing works

The role of macrophage plasticity in neurodegenerative diseases

Ma, H., Zhu, M., Chen, M., Li, X., & Feng, X. (2024) · Biomarker Research · doi:10.1186/s40364-024-00624-7 · Cited by 24 · see citing works

Upregulation of Mitochondrial Sirt3 and Alleviation of the Inflammatory Phenotype in Macrophages by Estrogen

Barcena, M. L., Christiansen, C., Aslam, M., Haritonow, N., Ladilov, Y. V., & Regitz‐Zagrosek, V. (2024) · Cells · doi:10.3390/cells13171420 · Cited by 24 · see citing works

Harmonizing Magnetic Mitohormetic Regenerative Strategies: Developmental Implications of a Calcium–Mitochondrial Axis Invoked by Magnetic Field Exposure

Franco‐Obregón, A. (2023) · Bioengineering · doi:10.3390/bioengineering10101176 · Cited by 24 · see citing works

Metabolic homeostasis of tissue macrophages across the lifespan

Wculek, S. K., Forisch, S., Miguel, V., & Sancho, D. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.04.017 · Cited by 23 · see citing works

Mitochondria-targeted co-assembled nanosystem with multimodal mitochondrial DNA level control to alleviate inflammation and promote chronic wound healing

Mao, X., Wang, C., Yu, S., Zhang, K., Wang, Z., Du, J., Kong, Y., Bianco, A., Ge, S., & Ma, B. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.123981 · Cited by 22 · see citing works

Immune aging impairs muscle regeneration via macrophage-derived anti-oxidant selenoprotein P

Hoang, D.-H., Bouvière, J., Galvis, J., Moullé, P., Mercier, O., Migliavacca, E., Ghosh, A., Juban, G., Liot, S., Stuelsatz, P., et al. (2025) · EMBO Reports · doi:10.1038/s44319-025-00516-3 · Cited by 20 · see citing works

Therapeutic restoration of mitochondria–endoplasmic reticulum cross talk for osteoarthritis

Hou, M., Ma, Y., Deng, Y., Wu, Y., Zhu, Y., Liu, Y., Li, X., Yu, L., He, Z., Wang, Y., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2426992122 · Cited by 20 · see citing works

Melatonin, BAG-1 and cortisol circadian interactions in tumor pathogenesis and patterned immune responses

Anderson, G. (2023) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2023.00176 · Cited by 19 · see citing works

Single-nucleus profiling of mouse inner ear aging uncovers cell type heterogeneity and hair cell subtype-specific age-related signatures

Xia, M., Zhang, F., Ma, J., Li, Y., Jia, G., Wu, M., Lou, Y., Liu, Y., Li, L., Li, H., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115781 · Cited by 18 · see citing works

Shikonin ameliorated LPS-induced acute lung injury in mice via modulating MCU-mediated mitochondrial Ca2+ and macrophage polarization

Huang, B., Shu-Ru, L., Le-xin, C., Liang-Liang, B., Li, C., Xu, C., Ming-Jun, L., Jia-Xin, Z., En-Xin, Z., & Zhang, X. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156043 · Cited by 17 · see citing works

Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments

Tanwar, J., Ahuja, K., Sharma, A., Sehgal, P., Ranjan, G., Sultan, F., Agrawal, A., D’Angelo, D., Priya, A., Yenamandra, V. K., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002895 · Cited by 15 · see citing works

The importance of mitochondria and mitochondrial calcium signaling in health and disease: an updated outlook on inflammation

Morciano, G., Pellielo, G., Agyapong, E. D., Pellegrino, C., Patergnani, S., Franceschini, D., Koutsikos, K., Rigon, L., Pinton, P., & Rimessi, A. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07783-1 · Cited by 17 · see citing works

The interaction between dysfunction of vasculature and tauopathy in Alzheimer's disease and related dementias

Huang, C., Wei, Z., Zheng, N., Yan, J., Zhang, J., Ye, X., & Zhao, W. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14618 · Cited by 14 · see citing works

Unraveling the role of calcium in the osteogenic behavior of mesoporous bioactive glass nanoparticles

García-Perdiguero, J. C., Gómez‐Cerezo, N., Gisbert-Garzarán, M., Manzano, M., & Vallet‐Regí, M. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.04.005 · Cited by 13 · see citing works

Tumor-Associated Senescent Macrophages, Their Markers, and Their Role in Tumor Microenvironment

Pukhalskaia, T. V., Yurakova, T. R., Bogdanova, D. A., & Demidov, O. N. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924050055 · Cited by 12 · see citing works

Mitochondrial calcium uniporter complex: Unveiling the interplay between its regulators and calcium homeostasis

Guo, J., Wang, Y., Shi, C., Zhang, D., Zhang, Q., Wang, L., & Gong, Z. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111284 · Cited by 12 · see citing works

Nanoparticle‐based therapeutic strategies for mitochondrial dysfunction in cardiovascular disease

Suzuki, I., Xing, H., Giblin, J., Ashraf, A., & Chung, E. J. (2024) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37668 · Cited by 10 · see citing works

Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging

Zhang, H., Muhetarijiang, M., Chen, R. J., Hu, X., Han, J., Zheng, L., & Chen, T. (2024) · Aging and Disease · doi:10.14336/ad.2024.0058 · Cited by 11 · see citing works

The Role of mtDNA Mutations in Atherosclerosis: The Influence of Mitochondrial Dysfunction on Macrophage Polarization

Fedotova, E. I., Berezhnov, A. V., Popov, D. Y., Shitikova, E. Y., & Vinokurov, A. Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031019 · Cited by 10 · see citing works

Calcium acts as a critical determinant of mitochondria-nuclear networking driven retrograde signaling

Ahuja, K., & Motiani, R. K. (2025) · Cell Calcium · doi:10.1016/j.ceca.2025.103017 · Cited by 9 · see citing works

Red ginseng extract enhances mitochondrial function and alleviates immunosenescence in T cells

Lee, H. Y., Tian, J., Nga, H. T., Nguyen, T. L., Moon, J. S., Jang, H. J., Abdillah, A. M., Lee, J., Ju, S. H., Lee, S. H., et al. (2025) · Journal of Ginseng Research · doi:10.1016/j.jgr.2025.05.004 · Cited by 9 · see citing works

The role of mitochondrial uncoupling in the regulation of mitostasis after traumatic brain injury

Hubbard, W. B., Velmurugan, G. V., & Sullivan, P. G. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105680 · Cited by 9 · see citing works

The Preparation of Biomass-Derived Carbon Dots and Its Application Prospect in the Field of Vascular Stent Coating

Duan, H., Wang, Y., Zhang, Z., Akram, A., Chen, L., & Li, J. (2024) · Coatings · doi:10.3390/coatings14111432 · Cited by 8 · see citing works

Synthetic anticoagulant octaparin targets mitochondrial cardiolipin-GSDMD axis to rescue redox homeostasis in sepsis

Zhang, S., Feng, C., Yu, N., Fang, R., Zhang, Y., Chen, S., Cao, L., & Zhang, J. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103877 · Cited by 8 · see citing works

Small Extracellular Vesicles From Human Amniotic Membrane Mesenchymal Stem Cells Rejuvenate Senescent β Cells and Cure Age‐Related Diabetes in Mice

Xiao, L., Zhang, Z., Li, T., Jiang, Y., Liu, Y., Lv, T., Qin, L., Zhu, Y., & Tang, W. (2025) · Aging Cell · doi:10.1111/acel.70327 · Cited by 9 · see citing works

Insights into the therapeutic strategies for aging and aging-associated diseases

Dong, R., Wu, Q., Kan, J., Fu, C., Sorrentino, V., Chow, A., Lei, Y., Wu, D., Xu, Z., Du, J., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02662-z · Cited by 9 · see citing works

Aging and immunity: the age-old tangoPreprint

Fernández-Maestre, I., Harris, A. S., & Amor, C. (2025) · Genes & Development · doi:10.1101/gad.352644.125 · Cited by 8 · see citing works

ECM stiffness regulates calcium influx into mitochondria via tubulin and VDAC1 activity

Kim, M., Han, K., Choi, G., Ahn, S.-H., Suh, J., & Kim, T. (2024) · Animal Cells and Systems · doi:10.1080/19768354.2024.2393811 · Cited by 7 · see citing works

The network structural entropy for single-cell RNA sequencing data during skin aging

Liu, Z., Lin, H., Li, X., Xue, H., Lu, Y., Xu, F., & Shuai, J. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae698 · Cited by 7 · see citing works

Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation

Han, H., Yu, D., Liu, Y., Jia, H., & Liu, W. (2025) · Science Advances · doi:10.1126/sciadv.adz4126 · Cited by 7 · see citing works

Intracellular Calcium as a Regulator of Polarization and Target Reprogramming of Macrophages

Pogonyalova, M. Y., Popov, D. Y., & Vinokurov, A. Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411901 · Cited by 5 · see citing works

Antisenescence Expansion of Mesenchymal Stem Cells Using Piezoelectric β-Poly(vinylidene fluoride) Film-Based Culture

Xu, L., Ren, W., Long, Y., Yang, B., Chen, L., Chen, W., Chen, S., Cao, Y., Wu, D., Qu, J., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c12725 · Cited by 5 · see citing works

Informing the Cannabis Conjecture: From Life’s Beginnings to Mitochondria, Membranes and the Electrome—A Review

Nunn, A. V. W., Guy, G. W., & Bell, J. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713070 · Cited by 5 · see citing works

Nanomedicine strategies for enhancing calcium overload in cancer therapy: A focus on regulating cellular function

Li, J., Shi, D., Wang, B., Li, M., Tian, Q., & Wei, W. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102927 · Cited by 4 · see citing works

Exploring the nexus between inflammation and mobility through the lens of healthy aging: current scenario and future perspectives

Patusco, R., Gyasi, K., & Kaufmann, A. (2026) · Aging Clinical and Experimental Research · doi:10.1007/s40520-025-03278-z · Cited by 5 · see citing works

Mitochondria-associated endoplasmic reticulum membranes and calcium ion exchange: A novel direction for aging and neurodegenerative diseases

Yang, Y., Chen, M., Ding, L., Liu, J., Luo, J., Yan, R., Ning, J., Xie, S., Li, X., Ren, Z., et al. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00857 · Cited by 3 · see citing works

Essential metal elements and their coordination-derived nanostructures: regulatory mechanisms and applications in cancer immunotherapy

Li, Q.-Q., Wu, H., (12946), Y. Z., & Ma, M. (2026) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2026.218165 · Cited by 3 · see citing works

A bibliometric analysis: Ca2+ fluxes and inflammatory phenotyping by flow cytometry in peripheral blood mononuclear cells

Brun, C., Chalet, L., Moulin, F., Bochaton, T., Ducreux, S., Paillard, M., & Silva, C. C. D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1272809 · Cited by 3 · see citing works

Identification of diagnostic genes and the miRNA‒mRNA‒TF regulatory network in human oocyte aging via machine learning methods

Luo, X., Liang, M., Zhang, D., & Huang, B. (2024) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-024-03311-6 · Cited by 2 · see citing works

Mitochondrial Dysfunction in Renal Aging: A Vicious Cycle Driving Kidney Disease Progression

Yu, W., Ouyang, Q., Liu, W., Jia, L., & Wang, B. (2026) · Antioxidants and Redox Signaling · doi:10.1177/15230864251410936 · Cited by 3 · see citing works

Workshop report on inflammaging: mechanisms, markers, and intervention strategies

Liu, C. H., Avula, L. R., Divi, R. L., Dwyer, J. T., Liu, Q., PrabhuDas, M., Satyamitra, M. M., Tandon, P., & Tilahun, M. E. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkaf380 · Cited by 2 · see citing works

Calcium signaling in microglial immune functions: current understanding and implications for disease

Lifton, A. R., DeMeulenaere, K. E., & Prakriya, M. (2026) · Current Opinion in Immunology · doi:10.1016/j.coi.2026.102819 · Cited by 2 · see citing works

Sirtuin-1 Regulates Mitochondrial Calcium Uptake Through Mitochondrial Calcium Uptake 1 (MICU1)

Zhang, X., Liu, S., Su, Y., Zhang, L., Guo, T., & Xuemin, W. (2025) · Life · doi:10.3390/life15020174 · Cited by 2 · see citing works

Mitochondrial Ca 2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

Gray, J., Halemirle, G., Ferrán, B., Rose, H., Redwine, T. L., Pham, S., Hagy, B., Pranay, A., Giorgione, J. R., Hussong, S. A., et al. (2025) · The Journal of Physiology · doi:10.1113/jp287618 · Cited by 2 · see citing works

A novel AluYb8 insertion-associated non-coding RNA, lncMUTYH, impairs mitochondrial function and dampens the M2-like polarization of macrophages

Dong, G., Xuewen, Y., Liang, Y., Chen, J., Wang, J., Jiang, F., Wang, C., Guo, W., & Wang, Y. (2023) · Free Radical Research · doi:10.1080/10715762.2023.2299333 · Cited by 2 · see citing works

Matrix viscoelasticity drives cell cluster formation to counteract cellular senescence

Wang, X., Song, L., Zhao, J., Xiong, Y., Jin, R., & He, J. H. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00174a · Cited by 1 · see citing works

Optogenetic engineered macrophages for light-induced M1 polarization and enhanced chemo-immunotherapy in melanoma models

He, K., Jiang, H., Zhang, W., Yang, N., Li, S., Wang, Y., Zhang, J., Li, X., Tan, L., Yang, G., et al. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114770 · Cited by 1 · see citing works

Unraveling the Interactive Role of Mitochondrial Dysfunction in Promoting Macrophage Polarization in Pulmonary Fibrosis

Zou, J., Jian, J., Ge, D., Zhou, B., & Zhang, J. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70586 · Cited by 1 · see citing works

ED-71 prevents glucocorticoid-induced bone loss by inhibiting type H vascular endothelial cell senescence through maintaining mitochondria-associated membrane-mediated calcium homeostasis

Wang, X., Zhang, W., Liu, T., Rong, X., Ren, Q., Guan, S., & Li, M. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112298 · Cited by 1 · see citing works

In Situ Ca 2+ -Reinforced Full-Active Hydrogels for the Treatment of Rheumatoid Arthritis by Modulating the NF-κB and NLRP3 Pathways

Wang, M., Liu, K., She, P., Gao, T., Shi, Z., Wang, Y., Ding, X., Yang, Y., Yin, D., Shen, W. H., et al. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c23763 · Cited by 1 · see citing works

MSC-derived exosomes ameliorate systemic lupus erythematosus by reprogramming macrophage mitochondrial homeostasis via the CMPK2-cGAS-STING axis

Zang, J., Chu, J., Sun, W., Yang, C., Qu, Z., Bie, H., Wang, Y., Guo, J., & Xu, D. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04320-6 · Cited by 1 · see citing works

Simultaneous Determination of Calcium (II) and Magnesium (II) by Dual-Calibrated Solid-State Potentiometric Sensors

Jiang, D., Zhang, M., & Wang, Q. (2026) · Analytical Letters · doi:10.1080/00032719.2026.2694734 · Cited by 1 · see citing works

Dopamine-induced mitochondrial dysfunction activates cGAS-sTING to drive IL-6 secretion in macrophages

Daniali, M., Channer, B., Curley, E. O., Amirfallah, A., Kist, T., Montilla, J., Kosashvili, S., Sheldon, L., Stauch, K. L., Jackson, J. G., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.118118 · Cited by 1 · see citing works

Age-dependent Dysferlin Accumulation in Macrophages Promotes STAT1 Activation via Calcium Influx, Impairing MyogenesisPreprint

Tominaga, K., & Tominaga, N. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.02.679938 · Cited by 1 · see citing works

Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitabilityPreprint

Carneiro-Nascimento, S., Wei, C., Gutterman, A., & Levy, D. (2026) · eLife · doi:10.7554/elife.109888 · Cited by 1 · see citing works

Identification of secretory protein related Biomarkers for Primary Biliary Cholangitis based on Machine Learning and experimental validationPreprint

Xu, Z., Cai, Y., Liu, Y., Xu, J., Guo, S. J., Zhou, L., Ji, Y., Zhan, L., & Cheng, L. (2024) · Research Square · doi:10.21203/rs.3.rs-4907809/v1

Tumor-associated senescent macrophages, their markers and their role in the tumor microenvironment (review)

Pukhalskaia, T. V., Yrakova, T. R., Bogdanova, D. A., & Demidov, O. N. (2024) · Biochemistry (Moscow) · doi:10.31857/s0320972524050058

The effect of hypotensive drugs on mouse macrophage response to Staphylococcus aureus depends on the type of cell line

Felkle, D., Kaleta, K., Sobocińska, W., Zięba, K., Czaja, J., Zyzdorf, A., Jarczyński, M., Walczewska, M., Nowak, B., Skalska, P., et al. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107760

Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitability

Nascimento, S. G., Wei, C., Gutterman, A., & Levy, D. (2026) · eLife · doi:10.1101/2025.10.01.679335

Mitochondrial calcium shapes B cell signaling and mitochondrial function

Taskiran, H., Czeslik, E., Stark, L., Kläsener, K., Schnalzger, T., Ruland, J., Reth, M. G., & Jellusova, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1710128

Identification of secretory protein related biomarkers for primary biliary cholangitis based on machine learning and experimental validation

Xu, Z., Cai, Y., Liu, Y. W., Xu, J., Guo, S., Zhou, L., Ji, Y., Zhan, L., & Cheng, L. (2025) · Open Life Sciences · doi:10.1515/biol-2025-1192

Multi-omics analysis identifies mitochondrial dysfunction in CD83+ macrophages as a key event in diabetic peripheral neuropathy progression

Lin, Y., Shen, Y., Wu, J., Wang, Y., Zhao, Y., Yao, C., Lin, J., Zhao, H., Zhang, H., Chen, Y., et al. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107262

Synergistic effects of circulating monocyte accumulation and cardiometabolic abnormalities on all-cause mortality: implications for predictive, preventive and personalised medicine

Wu, D., Lan, Y., Feng, B., Ding, X., Wu, C., Chen, S., Miao, C., Balmer, L. A., Li, X., Wu, S., et al. (2026) · The EPMA Journal · doi:10.1007/s13167-026-00439-6

Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitabilityPreprint

Carneiro-Nascimento, S., Wei, C., Gutterman, A., & Levy, D. (2026) · eLife · doi:10.7554/elife.109888.1

Mitochondrial transplant activates Ca2+/TFAP2A to promote hDPSCs-mediated dentin-pulp regeneration

Zhan, P., Zhang, X., Xie, Z., Chen, L., Huang, S., Huang, Q., Lin, Z., & Wang, R. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-026-04949-y

The microenvironmental mechanism of postoperative recurrence in cervical spondylotic myelopathy: regulation by the glial scar–inflammation axis

Sun, Y., & Zhang, Q. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1774739

Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitabilityPreprint

Carneiro-Nascimento, S., Wei, C., Gutterman, A., & Levy, D. (2026) · eLife · doi:10.7554/elife.109888.2

It’s Not Rewarding for Mitochondria: Dopamine-Induced Mitochondrial Dysfunction Activates cGAS-STING to Drive IL-6 Secretion in MacrophagesPreprint

Daniali, M., Channer, B., Curley, E. O., Amirfallah, A., Kist, T., Montilla, J., Kosashvili, S., Sheldon, L., Stauch, K. L., Jackson, J. G., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.23.719926

Aging-Associated Decline in Macrophage STAT6-OXPHOS Programs Promotes Tumor-Like Multinucleated SyncytiaPreprint

Wu, L.-Y., Liao, H., Chen, C. Y., Chou, C., Huang, T. H. ‐., & Hung, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.18.726012

Mitochondrial calcium uptake drives organelle remodeling to promote inflammasome-dependent cytokine release

Gherardi, G., Spinelli, F., Sbrissa, M., Quagliata, M., Luisetto, R., Scanu, A., Vezzoli, E., Carraro, M., Casey, A. M., Fonseca, T. B., et al. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01769-8

Small intracellular vesicle-liposome fusogenic nanoplatform sIVs-LPs@Hes: Nebulized delivery targeting pulmonary inflammatory microenvironment to improve ALI

Bichao, L. U., Su, J., Long, Y., Liu, X., Fu, T., Mao, N., Miao, W. A. N. G., Guo, W., Yi, K., Zhou, S., et al. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103305

Mitochondrial Ca2+ signaling: A metabolic rheostat defining tumor and immune cell fate

Bura, A. E., Rolong, A., Paget, C., & Guéguinou, M. (2026) · Trends in Immunology · doi:10.1016/j.it.2026.05.012

Aging reprograms the functional, epigenetic, and metabolic landscape of macrophagesPreprint

Suresh, M., Tapia-Belmonte, F., Weselman, B. T., Li, X., Durr, M., Duchovny, I., Yanitza, G.-M., Hepp, M. I., Noonepalle, S. K. R., Salas-Burgos, A., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10155437/v1

Ultrasound-Activated Metal–Organic Frameworks Incorporated Polyacrylonitrile Nanofibers Promote Macrophage Inflammation

Dai, S., Kawata, N., Nabil, A., & Ebara, M. (2026) · Nanomaterials · doi:10.3390/nano16140853

Orally activatable membrane fusion-mitochondria hitchhiking on intestinal macrophages for targeted therapy of bacterial meningitis and neuroinflammation

Wang, X., Sun, X., Li, H., Zhang, J., Yi, Q., & Wu, Y. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.08.003

Canonical complement C3a–C3AR1 signalling in ageing and age-related disease: Cellular mechanisms, tissue-specific effects and translational challenges

Thapa, R., Bhat, A. A., Fuloria, N. K., Varghese, N., Narain, K., Biswas, A., Biswas, S., Bhatia, S., Gan, S. H., & Fuloria, S. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103367

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Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

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