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Cited by 193Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesGenetics and Neurodevelopmental Disorders

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.

Autism Spectrum Disorder and Autistic Traits in the Avon Longitudinal Study of Parents and Children: Precursors and Early Signs

Bolton, Patrick F., Golding, Jean, Emond, Alan, Steer, Colin D.·2012·Journal of the American Academy of Child & Adolescent Psychiatry
DOI 10.1016/j.jaac.2011.12.009
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Abstract

Objective To chart the emergence of precursors and early signs of autism spectrum disorder (ASD) and autistic traits in the Avon Longitudinal Study of Parents and Children, a prospective longitudinal cohort study of the surviving offspring of 14,541 pregnant women from southwestern England with an expected delivery date between April 1991 and December 1992.Method Parents' contemporaneous reports of their infant's development (241 questionnaire responses collected up to 30 months of age) were examined in relation to the diagnosis of autism spectrum disorder by age 11 years (n = 86) and a measure of autistic traits, derived by factor analysis.Results Among the children later diagnosed with ASD, concerns about vision and hearing were more often reported in the first year, and differences in social, communication, and fine motor skills were evident from 6 months of age. Repetitive behaviors and differences in play, imitation, and feeding habits were reported in the second year. Differences in temperament emerged at 24 months of age and bowel habit by 30 months. All of these early signs were strongly associated with the presence of autistic traits in the rest of the population and these differences were often evident in the first year of development. Over the first 30 months of development, the best predictors of both later ASD and autistic traits included the Social Achievement and Communication scores from the Denver Developmental Screening Test, measures of communicative skills (Vocabulary and Combines Words) from the MacArthur Infant Communicative Development Inventories, and a repetitive behavior score.Conclusions Precursors, early signs, and other developmental differences were reported in the first year of development among children from the general population who later developed autism spectrum disorder and subtler autistic traits. Other differences emerged and unfolded as development progressed. The findings confirm the long-held suspicion that early differences underscore the multifaceted nature of autism spectrum disorder and the broader autism phenotype, and highlight the centrality of impairments in social communication skills.

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  1. Carey, 1977, Infant Temperament Questionnaire
  2. Fullard, 1978, Toddler Temperament Scale

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Metadata

Authors
Bolton, P. F., Golding, J., Emond, A., & Steer, C. D.
Affiliations
  • King's College London (GB)
  • University of Bristol (GB)
Corresponding author
Bolton, Patrick F.
ORCID
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
2012-03
Volume
51
Issue
3
Pages
249-260.e25
ISSN
0890-8567 (ISSN-L)
DOI
10.1016/j.jaac.2011.12.009
OpenAlex
W1987493092
Semantic Scholar
fffebc596a5d2c6b2a057fb0c6dd3dcc368c98b6
Cited by
193
References
53
Citations by year
2026: 6 · 2025: 11 · 2024: 12 · 2023: 7 · 2022: 15 · 2021: 14 · 2020: 10 · 2019: 18 · 2018: 10 · 2017: 17 · 2016: 31 · 2015: 9 · 2014: 15 · 2013: 11 · 2012: 6
FWCI
6.28
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
  • Explore Bristol Research (submittedVersion)
Funders
  • Wellcome Trust (092731)
  • National Institute for Health and Care Research (NF-SI-0510-10268)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, autistic traits, early signs of autism, infant development, social communication skills, repetitive behavior, temperament, Denver Developmental Screening Test, autism phenotype, Avon Longitudinal Study of Parents and Children
MeSH terms
Child, Child Development, Developmental Disabilities, Child Development Disorders, Pervasive, Child, Preschool, Communication, Factor Analysis, Statistical, Female, Humans, Infant, Male, Parents, Play and Playthings, Pregnancy, Prospective Studies, Social Behavior, Stereotyped Behavior, Age of Onset, Infant Behavior, Early Diagnosis

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