The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Intergenerational Transmission of Maternal Childhood Maltreatment Exposure: Implications for Fetal Brain Development
Open accessAbstract
Objective Growing evidence suggests the deleterious consequences of exposure to childhood maltreatment (CM) not only might endure over the exposed individual's lifespan but also might be transmitted across generations. The time windows, mechanisms, and targets of such intergenerational transmission are poorly understood. The prevailing paradigm posits that mother-to-child transmission of the effects of maternal CM likely occurs after her child's birth. The authors seek to extend this paradigm and advance a transdisciplinary framework that integrates the concepts of biological embedding of life experiences and fetal origins of health and disease risk.Method The authors posit that the period of embryonic and fetal life represents a particularly sensitive time for intergenerational transmission; that the developing brain represents a target of particular interest; and that stress-sensitive maternal-placental-fetal biological (endocrine, immune) pathways represent leading candidate mechanisms of interest.Results The plausibility of this model is supported by theoretical considerations and empirical findings in humans and animals. The authors synthesize several research areas and identify important knowledge gaps that might warrant further study.Conclusion The scientific and public health relevance of this effort relates to achieving a better understanding of the "when," "what," and "how" of intergenerational transmission of CM, with implications for early identification of risk, prevention, and intervention.
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“as findings [57] show that an intergenerational impact of child maltreatment can be observed shortly after birth.”
From Psychoanalytic Interventions with Abusive Parents: An Opportunity for Children’s Mental Health (2022) · cites this paper as [57]
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“In line with what has been observed in rodent studies [131], these effects might not be restricted to one’s own lifespan but may also be transmitted to offspring [132].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [132]
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Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., Koss, M. P., & Marks, J. S. (1998) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(98)00017-8 · Cited by 18,943
Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256
Self-citationAnda, R. F., Felitti, V. J., Bremner, J. D., Walker, J. D., Whitfield, C., Perry, B. D., Dube, S. R., & Giles, W. H. (2006) · European archives of psychiatry and clinical neuroscience · doi:10.1007/s00406-005-0624-4 · Cited by 4,292
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791
Self-citationGenetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Cross-Disorder Group of the Psychiatric Genomics Consortium (2013) · Nature Genetics · doi:10.1038/ng.2711 · Cited by 2,263
Miller, G. E., Chen, E., & Parker, K. J. (2011) · Psychological Bulletin · doi:10.1037/a0024768 · Cited by 1,785
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
Self-citationAllele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447
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Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms
Yehuda, R., & Lehrner, A. (2018) · World Psychiatry · doi:10.1002/wps.20568 · Cited by 730
A Meta-Analysis of Maternal Prenatal Depression and Anxiety on Child Socioemotional Development
Madigan, S. L., Oatley, H., Racine, N. M., Fearon, P. R. M., Schumacher, L., Akbari, E. M., Cooke, J. E., & Tarabulsy, G. M. (2018) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2018.06.012 · Cited by 456
Life Course Approaches to the Causes of Health Disparities
Jones, N. L., Gilman, S. E., Cheng, T. L., Drury, S. S., Hill, C. V., & Geronimus, A. T. (2019) · American Journal of Public Health · doi:10.2105/ajph.2018.304738 · Cited by 440
Rudolph, M. D., Graham, A. M., Feczko, E., Miranda-Dominguez, O., Rasmussen, J. M., Nardos, R., Entringer, S., Wadhwa, P. D., Buss, C., & Fair, D. A. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0128-y · Cited by 374
Self-citationPregnancy as a period of risk, adaptation, and resilience for mothers and infants
Davis, E. P., & Narayan, A. J. (2020) · Development and Psychopathology · doi:10.1017/s0954579420001121 · Cited by 297
“Further, childhood maltreatment also is associated with alterations in placental–fetal stress physiology, including significantly steeper increases in placental CRH across gestation (Buss et al., 2017; Moog et al., 2018).”
Background
Metadata
- Authors
- Buss, C., Entringer, S., Moog, N. K., Toepfer, P., Fair, D. A., Simhan, H. N., Heim, C. M., & Wadhwa, P. D.
- Affiliations
- University of California, Irvine (US)
- Humboldt-Universität zu Berlin (DE)
- Oregon Health & Science University (US)
- University of Pittsburgh (US)
- Corresponding author
- Buss, Claudia
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 56
- Issue
- 5
- Pages
- 373-382
- ISSN
- 0890-8567 (ISSN-L)
- PMC
- PMC5402756
- OpenAlex
- W2593056494
- Cited by
- 250
- References
- 118
- Citations by year
- 2026: 10 · 2025: 38 · 2024: 24 · 2023: 36 · 2022: 35 · 2021: 32 · 2020: 25 · 2019: 22 · 2018: 23 · 2017: 5
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH091351, R01MH105538)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD060628)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- child abuse, intergenerational transmission, maternal childhood maltreatment, fetal brain development, biological embedding, placenta, maternal stress, maternal immune activation, endocrine pathways, prenatal stress exposure, developmental origins of health and disease
- MeSH terms
- Brain, Child, Child Abuse, Child Development, Female, Humans, Mothers, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Stress, Psychological, Fetal Development
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