Maternal Exposure to Childhood Trauma Is Associated During Pregnancy With Placental-Fetal Stress Physiology

Moog, Nora K.; Buss, Claudia; Entringer, Sonja; Shahbaba, Babak; Gillen, Daniel L.; Hobel, Calvin J.; Wadhwa, Pathik D.

doi:10.1016/j.biopsych.2015.08.032

Cited by 129Maternal Mental Health During Pregnancy and PostpartumChild Abuse and TraumaStress Responses and Cortisol

Maternal Exposure to Childhood Trauma Is Associated During Pregnancy With Placental-Fetal Stress Physiology

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Moog, Nora K., Buss, Claudia, Entringer, Sonja, Shahbaba, Babak, Gillen, Daniel L., Hobel, Calvin J., Wadhwa, Pathik D.·2016·Biological Psychiatry

DOI 10.1016/j.biopsych.2015.08.032PMC PMC4777678

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Abstract

Background The effects of exposure to childhood trauma (CT) may be transmitted across generations; however, the time period(s) and mechanism(s) have yet to be clarified. We address the hypothesis that intergenerational transmission may begin during intrauterine life via the effect of maternal CT exposure on placental-fetal stress physiology, specifically placental corticotropin-releasing hormone (pCRH).Methods The study was conducted in a sociodemographically diverse cohort of 295 pregnant women. CT exposure was assessed using the Childhood Trauma Questionnaire. Placental CRH concentrations were quantified in maternal blood collected serially over the course of gestation. Linear mixed effects and Bayesian piece-wise linear models were employed to test hypothesized relationships.Results Maternal CT exposure (CT+) was significantly associated with pCRH production. Compared with nonexposed women, CT+ was associated with an almost 25% increase in pCRH toward the end of gestation, and the pCRH trajectory of CT+ women exhibited an approximately twofold steeper increase after the pCRH inflection point at 19 weeks gestation.Conclusions To the best of our knowledge, this finding represents the first report linking maternal CT exposure with placental-fetal stress physiology, thus identifying a potential novel biological pathway of intergenerational transmission that may operate as early as during intrauterine life.

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Only three studies have examined childhood stress effects on prenatal HPA activity; one supported lasting biological effects and two contested them.
“To our knowledge, only three studies have examined the effect of childhood stress on prenatal HPA activity, with a potential role of lasting biological effects supported (n = 295; Moog et al., 2016) and contested (n = 123; Noll et al., 2007; n = 58; Karakash et al., 2016).”
From Childhood stress and birth timing among African American women: cortisol as biological mediator (2017) · cites this paper as Moog et al., 2016
The finding that childhood stress may promote HPA activation is consistent with an association between childhood trauma and peripheral CRH.
“which is consistent with the finding of an association between childhood trauma and peripheral CRH (Moog et al., 2016).”
From Childhood stress and birth timing among African American women: cortisol as biological mediator (2017) · cites this paper as Moog et al., 2016

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Authors: Moog, N. K., Buss, C., Entringer, S., Shahbaba, B., Gillen, D. L., Hobel, C. J., & Wadhwa, P. D.
Affiliations: University of California, Irvine (US)
Cedars-Sinai Medical Center (US)
Corresponding author: Wadhwa, Pathik D.
ORCID: Moog, Nora K.
Buss, Claudia
Entringer, Sonja
Shahbaba, Babak
Gillen, Daniel L.
Wadhwa, Pathik D.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2016-05
Volume: 79
Issue: 10
Pages: 831-839
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2015.08.032
PMC: PMC4777678
OpenAlex: W1228738336
Cited by: 129
References: 95
Citations by year: 2026: 7 · 2025: 9 · 2024: 14 · 2023: 16 · 2022: 11 · 2021: 21 · 2020: 14 · 2019: 6 · 2018: 14 · 2017: 14 · 2016: 3
FWCI: 11.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: US PHS (RO1 HD-060628, PO1 HD-047609, R01 HD-041696, R29 HD-33506, RO1 MH-105538, R01 NS-41298)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: childhood trauma, intergenerational transmission, pregnancy, intrauterine life, placenta
MeSH terms: Adult, Bayes Theorem, Child, Child Abuse, Corticotropin-Releasing Hormone, Female, Fetal Diseases, Humans, Longitudinal Studies, Placenta Diseases, Pregnancy, Prospective Studies, Surveys and Questionnaires, Socioeconomic Factors, Stress, Physiological, Stress, Psychological, Linear Models, Maternal Exposure

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Maternal Exposure to Childhood Trauma Is Associated During Pregnancy With Placental-Fetal Stress Physiology

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