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Cited by 133Skin Protection and AgingNonmelanoma Skin Cancer StudiesDermatology and Skin Diseases

Broad-spectrum sunscreens provide better protection from solar ultraviolet-simulated radiation and natural sunlight-induced immunosuppression in human beings

Moyal, Dominique D., Fourtanier, Anny M.·2008·Journal of the American Academy of Dermatology
DOI 10.1016/j.jaad.2007.04.035
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Abstract

Background It is well established that ultraviolet (UV) radiation induces immunomodulatory effects that may be involved in skin cancer. Recent studies have shown that UVA (320-400 nm) and UVB (290-320 nm) radiation are immunosuppressive. As a result, sunscreens, which mainly absorb UVB, may be less effective in preventing UV radiation-induced immunosuppression than broad-spectrum products. Objective We sought to study the effects of UVA exposure on human delayed-type hypersensitivity (DTH) response and compare the efficacy of sunscreens having different levels of sun-protection factor (SPF) and UVA protection against both solar-simulated radiation and outdoor real-life sunlight exposure conditions. Methods DTH was assessed using a kit which includes 7 recall antigens that most of the participants encountered during childhood immunization. Evaluation of DTH test response was made 48 hours after test application before and after UV exposure with or without sunscreens. Results In unprotected participants, the response to DTH tests was significantly reduced irrespective of UV types of exposure (full-spectrum UVA, long UVA, solar-simulated radiation). A UVB sunscreen failed to protect from solar-simulated radiation-induced immunosuppression. In contrast, a broad-spectrum sunscreen with the same SPF but providing a high protection in the UVA range significantly reduced local UV-induced immunosuppression and prevented the distant effects. In the outdoor study, as compared with DTH responses obtained before sun exposure, no alteration of immune response was detected when the skin was protected by a broad-spectrum sunscreen having a high protection level in the UVA (SPF 25, UVA protection factor 14). Conversely a broad-spectrum sunscreen with lower protection against UVA (SPF 25, UVA protection factor 6) failed to prevent UV-impaired response. Limitations These results have been obtained after repeated exposure. Additional experiments obtained under acute exposure are in progress. Conclusion These findings clearly demonstrated the role of UVA in the induction of photoimmunosuppression together with the need for sunscreen products providing efficient photoprotection throughout the entire UV spectrum.

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Crossref · 10.1016/j.jaad.2007.04.035

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  • Broad spectrum sunscreens can attenuate the immunosuppressive effects of UV rays.

    “Similarly, broad spectrum sunscreens can attenuate the immunosuppressive effects of UV rays (53)”

    From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [53]

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Authors
Moyal, D. D., & Fourtanier, A. M.
Affiliations
L'Oréal (France) (FR)
Corresponding author
Moyal, Dominique D.
ORCID
Fourtanier, Anny M.
Venue
Journal of the American Academy of Dermatology
Publisher
Elsevier BV
Published
2008-05
Volume
58
Issue
5
Pages
S149-S154
ISSN
0190-9622 (ISSN-L)
DOI
10.1016/j.jaad.2007.04.035
OpenAlex
W1973106980
Cited by
133
References
20
Citations by year
2026: 5 · 2025: 2 · 2024: 8 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 8 · 2013: 11 · 2012: 6
FWCI
12.15
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of the American Academy of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
broad-spectrum sunscreen, UVA protection, UV-induced immunosuppression, delayed-type hypersensitivity, simulated solar radiation, sun protection factor, UVA protection factor, skin cancer prevention, photoprotection
MeSH terms
Absorption, Adolescent, Adult, Female, Humans, Hypersensitivity, Delayed, Immune Tolerance, Male, Radiation Dosage, Skin, Skin Neoplasms, Sunlight, Sunscreening Agents, Ultraviolet Rays

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