The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
PCSK9 Modulates the Secretion But Not the Cellular Uptake of Lipoprotein(a) Ex Vivo
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Multiple studies of LDLR in cells, animal models, and humans have provided inconsistent or conflicting results.
“Multiple studies of the LDL receptor (LDLR) in cells27-34, animal models25,32,35,36, and humans10,28,37-48 have provided inconsistent or conflicting results.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [34]
Other studies have found no influence of LDLR on cellular Lp(a) binding or uptake in vitro.
“However, other studies have found no influence of LDLR on cellular Lp(a) binding or uptake in vitro31-34.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [34]
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Citations
Cites
Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events
Sabatine, M. S., Giugliano, R. P., Wiviott, S. D., Raal, F. J., Blom, D. J., Robinson, J., Ballantyne, C. M., Somaratne, R., Legg, J., Wasserman, S. M., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500858 · Cited by 1,509
Self-citationLipoprotein(a): resurrected by genetics
Kronenberg, F., & Utermann, G. (2013) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02592.x · Cited by 521
Khera, A. V., Everett, B. M., Caulfield, M. P., Hantash, F. M., Wohlgemuth, J., Ridker, P. M., & Mora, S. (2014) · Circulation · doi:10.1161/circulationaha.113.004406 · Cited by 461
Flagged first, then by citations
Research works printed but not linked: 20
- Robinson, 2015, Efficacy and safety of alirocumab in reducing lipids and cardiovascular events, N Engl J Med, 372, 1489, 10.1056/NEJMoa1501031 · DOI · Paper page
- Ballantyne, 2015, Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia, Am J Cardiol, 115, 1212, 10.1016/j.amjcard.2015.02.006 · DOI
- Marais, 2015, PCSK9 inhibition in LDL cholesterol reduction: genetics and therapeutic implications of very low plasma lipoprotein levels, Pharmacol Ther, 145, 58, 10.1016/j.pharmthera.2014.07.004 · DOI
- Lambert, 2014, Normalization of low-density lipoprotein receptor expression in receptor defective homozygous familial hypercholesterolemia by inhibition of PCSK9 with alirocumab, J Am Coll Cardiol, 64, 2299, 10.1016/j.jacc.2014.07.995 · DOI
- Raal, 2014, Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of more than 1,300 patients in 4 phase II trials, J Am Coll Cardiol, 63, 1278
- Lamon-Fava, 2014, Lipoprotein(a) metabolism, Curr Opin Lipidol, 25, 189, 10.1097/MOL.0000000000000070 · DOI
- Alonso, 2014, Lipoprotein(a) levels in hypercholesterolemia: an important predictor of cardiovascular disease independent of the type of LDL receptor mutation, J Am Coll Cardiol, 63, 1982, 10.1016/j.jacc.2014.01.063 · DOI · Paper page
- Erqou, 2009, Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality, JAMA, 302, 412, 10.1001/jama.2009.1063 · DOI · Paper page
- Rader, 1994, The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate, J Clin Invest, 93, 2758, 10.1172/JCI117292 · DOI
- Tsimikas, 2012, Lipoprotein(a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop targeted therapies, J Am Coll Cardiol, 60, 716, 10.1016/j.jacc.2012.04.038 · DOI
- Romagnuolo, 2015, Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor, J Biol Chem, 290, 11649, 10.1074/jbc.M114.611988 · DOI · Paper page
- Lambert, 2014, Elevated plasma PCSK9 level is equally detrimental for patients with nonfamilial hypercholesterolemia and heterozygous familial hypercholesterolemia, irrespective of low-density lipoprotein receptor defects, J Am Coll Cardiol, 63, 2365, 10.1016/j.jacc.2014.02.538 · DOI
- Croyal, 2015, Effects of extended-release nicotinic acid on apolipoprotein (a) kinetics in hypertriglyceridemic patients, Arterioscler Thromb Vasc Biol, 35, 2042, 10.1161/ATVBAHA.115.305835 · DOI
- Etxebarria, 2015, Functional characterization and classification of frequent low-density lipoprotein receptor variants, Hum Mutat, 36, 129, 10.1002/humu.22721 · DOI · Paper page
- Reblin, 1997, Cellular uptake of lipoprotein[a] by mouse embryonic fibroblasts via the LDL receptor and the LDL receptor-related protein, J Lipid Res, 38, 2103, 10.1016/S0022-2275(20)37140-6 · DOI · Paper page
- Niemeier, 1999, Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitro, Arterioscler Thromb Vasc Biol, 19, 552, 10.1161/01.ATV.19.3.552 · DOI
- Stein, 2013, Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia, Circulation, 128, 2113, 10.1161/CIRCULATIONAHA.113.004678 · DOI · Paper page
- Rader, 1995, The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans, J Clin Invest, 95, 1403, 10.1172/JCI117794 · DOI · Paper page
- Tavori, 2015, On the function and homeostasis of PCSK9: reciprocal interaction with LDLR and additional lipid effects, Atherosclerosis, 238, 264, 10.1016/j.atherosclerosis.2014.12.017 · DOI · Paper page
- Tavori, 2013, Loss of plasma proprotein convertase subtilisin/kexin 9 (PCSK9) after lipoprotein apheresis, Circ Res, 113, 1290, 10.1161/CIRCRESAHA.113.302655 · DOI
Cited by
Sorted by citations
Lipoprotein(a), PCSK9 Inhibition, and Cardiovascular Risk: Insights From the FOURIER Trial
O’Donoghue, M. L., Fazio, S., Giugliano, R. P., Stroes, E. S. G., Kanevsky, E., Gouni-Berthold, I., Im, K., Lira Pineda, A., Wasserman, S. M., Češka, R., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.037184 · Cited by 984
Statin therapy increases lipoprotein(a) levels
Tsimikas, S., Gordts, P. L. S. M., Nora, C., Yeang, C., & Witztum, J. L. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz310 · Cited by 512
Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): From bench to bedside
Bao, X., Liang, Y., Chang, H., Cai, T., Feng, B., Gordon, K., Zhu, Y., Shi, H., He, Y., & Xie, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01690-3 · Cited by 187
Thedrez, A., Blom, D. J., Ramin-Mangata, S., Blanchard, V., Croyal, M., Chemello, K., Nativel, B., Pichelin, M., Cariou, B., Bourane, S., et al. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.117.310217 · Cited by 105
Self-citationShapiro, M. D., Minnier, J., Tavori, H., Kassahun, H., Flower, A., Somaratne, R., & Fazio, S. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.010932 · Cited by 70
Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening
Khan, T. G., Bragazzi Cunha, J., Raut, C., Burroughs, M., Vyas, H. S., Leix, K., Goonewardena, S. N., Smrcka, A. V., Speliotes, E. K., & Emmer, B. T. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119174 · Cited by 6
Metadata
- Authors
- Villard, E. F., Thedrez, A., Blankenstein, J., Croyal, M., Tran, T.-T.-T., Poirier, B., Le Bail, J.-C., Illiano, S., Nobécourt, E., Krempf, M., Blom, D. J., Marais, A. D., Janiak, P., Muslin, A. J., Guillot, E., & Lambert, G.
- Venue
- JACC: Basic to Translational Science
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 1
- Issue
- 6
- Pages
- 419-427
- ISSN
- 2452-302X
- PMC
- PMC5753417
- Cited by
- 113
- References
- 3
- Language
- en
- Licence
- Funders
- Amgen
- Pfizer
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